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Title
Japanese:Practical Enantioselective Synthesis of Axially Chiral Biaryl Diphosphonates and Dicarboxylates by Cationic Rhodium(I)/Segphos-Catalyzed Double [2 + 2 + 2] Cycloaddition. 
English:Practical Enantioselective Synthesis of Axially Chiral Biaryl Diphosphonates and Dicarboxylates by Cationic Rhodium(I)/Segphos-Catalyzed Double [2 + 2 + 2] Cycloaddition. 
Author
Japanese: Goushi Nishida, Shuichiro Ogaki, Yukinori Yusa, Tohru Yokozawa, Keiichi Noguchi, Ken. Tanaka.  
English: Goushi Nishida, Shuichiro Ogaki, Yukinori Yusa, Tohru Yokozawa, Keiichi Noguchi, Ken. Tanaka.  
Language English 
Journal/Book name
Japanese:Organic Letters 
English:Organic Letters 
Volume, Number, Page Vol. 10    No. 13    pp. 2849-2852
Published date 2008 
Publisher
Japanese:American Chemical Society 
English:American Chemical Society 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
DOI https://doi.org/10.1021/ol801013v
Abstract A cationic rhodium(I)/Segphos complex catalyzes a [2 + 2 + 2] cycloaddn. of internal 1,6-diynes MeC竕｡CCH2XCH2C竕｡CMe (X = O, NTs, 4-BrC6H4SO2N) with a phosphonate- or ester-substituted 1,3-butadiyne RC竕｡CC竕｡CR [R = P(O)(OEt)2, CO2Et] leading to C2-sym. axially chiral biaryl diphosphonates or dicarboxylates, resp., e.g. I [R = P(O)(OEt)2, CO2Et], in high yields with outstanding ee's. The use of a phosphonate- or ester-substituted 1,3-butadiyne as a cycloaddn. partner and Segphos as a ligand is crucial for the success of this transformation. [on SciFinder(R)]

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