Home >

news Help

Publication Information


Title
Japanese: 
English:Nonlinear electrical impedance spectroscopy of viruses using very high electric fields created by nanogap electrodes 
Author
Japanese: 羽月竜治, 本田文江, 梶谷雅之, 山本貴富喜.  
English: Ryuji Hatsuki, Ayae Honda, Masayuki Kajitani, Takatoki Yamamoto.  
Language English 
Journal/Book name
Japanese: 
English:Frontiers in Microbiology 
Volume, Number, Page Vol. 6        pp. 940-947
Published date Sept. 7, 2015 
Publisher
Japanese: 
English:Frontiers Media S.A. 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
Official URL http://journal.frontiersin.org/article/10.3389/fmicb.2015.00940/full
 
DOI https://doi.org/10.3389/fmicb.2015.00940
Abstract Our living sphere is constantly exposed to a wide range of pathogenic viruses, which can be either known, or of novel origin. Currently, there is no methodology for continuously monitoring the environment for viruses in general, much less a methodology that allows the rapid and sensitive identification of a wide variety of viruses responsible for communicable diseases. Traditional approaches, based on PCR and immunodetection systems, only detect known or specifically targeted viruses. We here describe a simple device that can potentially detect any virus between nanogap electrodes using nonlinear impedance spectroscopy. Three test viruses, differing in shape and size, were used to demonstrate the general applicability of this approach: baculovirus，tobacco mosaic virus, and influenza virus. We show that each of the virus types responded differently in the nanogap to changes in the electric field strength, and the impedance of the virus solutions differed depending both on virus type and virus concentration. These preliminary results show that the three virus types can be distinguished and their approximate concentrations determined. Although further studies are required, the proposed nonlinear impedance spectroscopy method may achieve a sensitivity comparable to that of more traditional, but less versatile, virus detection systems.

©2007 Tokyo Institute of Technology All rights reserved.