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Title
Japanese:マクロライド系抗生物質による消化管粘膜傷害の基礎的検討 
English: 
Author
Japanese: 徳永 仁, 岡村 恵子, 濱田 哲暢, 白木 伸明, 宮本 晋治, 藤井 淳子, 有森 和彦, 中野 眞汎.  
English: 徳永 仁, 岡村 恵子, 濱田 哲暢, Nobuaki Shiraki, 宮本 晋治, 藤井 淳子, 有森 和彦, 中野 眞汎.  
Language Japanese 
Journal/Book name
Japanese:医療薬学 
English: 
Volume, Number, Page Vol. 27    No. 4   
Published date July 2001 
Publisher
Japanese:日本医療薬学会 
English: 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
Abstract We investigated the cytotoxicity of erythromycin stearate, roxithromycin, clarithromycin and minocycline using lactate dehydrogenase (LDH) in cultured human intestinal epithelial cells Caco- 2, in vitro, and rat intestinal enzymes LDH and alkaline phosphatase (ALP) as end points of toxicity, in viro. The cytotoxicity after the addition of roxithromycin and clarithromycin to the Caco- 2 cells tended to be larger than that after the addition of erythromycin and minocycline. The intestinal toxicity induced by repeated 5 -day orally administered macrolide antibiotics was examined. The reduction in intestinal ALP after the administration of erythromycin and clarithromycin to rats tended to be larger than that after the addition of roxithromycin and minocycline. However, there were no significant changes in the intestinal LDH when macrolide antibiotics were orally administered. In addition, there were no significant changes or differences in either the body weight gain or the histological findings of the rat intestine. These results do not suggest any substantial risk for intestinal disorders related to the use of erythromycin, clarithromycin and roxithromycin.

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