The use of the element boron, which is not generally observed in a living body,
possesses a high potential for the discovery of new biological activity in pharmaceutical drug design.
In this account, we describe our recent developments in boron-based drug design, including
boronic acid containing protein tyrosine kinase inhibitors, proteasome inhibitors, and tubulin
polymerization inhibitors, and ortho-carborane-containing proteasome activators, hypoxiainducible
factor 1 inhibitors, and topoisomerase inhibitors. Furthermore, we applied a closododecaborate
as a water-soluble moiety as well as a boron-10 source for the design of boron carriers in boron neutron capture therapy, such as boronated porphyrins and boron lipids for a liposomal boron delivery system.