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Title
Japanese:Boron-Based Drug Design 
English:Boron-Based Drug Design 
Author
Japanese: 潘鉉承, 中村浩之.  
English: Hyun Seung Ban, Hiroyuki Nakamura.  
Language English 
Journal/Book name
Japanese:The Chemical Record 
English:The Chemical Record 
Volume, Number, Page Vol. 15    No. 3    pp. 616-635
Published date Mar. 2015 
Publisher
Japanese: 
English: 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
DOI https://doi.org/10.1002/tcr.201402100
Abstract The use of the element boron, which is not generally observed in a living body, possesses a high potential for the discovery of new biological activity in pharmaceutical drug design. In this account, we describe our recent developments in boron-based drug design, including boronic acid containing protein tyrosine kinase inhibitors, proteasome inhibitors, and tubulin polymerization inhibitors, and ortho-carborane-containing proteasome activators, hypoxiainducible factor 1 inhibitors, and topoisomerase inhibitors. Furthermore, we applied a closododecaborate as a water-soluble moiety as well as a boron-10 source for the design of boron carriers in boron neutron capture therapy, such as boronated porphyrins and boron lipids for a liposomal boron delivery system.

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