This paper presents a new topology exploration and an optimization method for inverted "F" antenna. Conventional tiling method for generating antenna pattern is time consuming due to its large exploring space of 2N(N is number of tiles). In our new method, 12 kinds of tile blocks composed of 6 tiles are spread in 5 rows to form an antenna.When laying tile blocks, placement rules are determined and antennas with one-piece-shaped are selected as optimization targets by labeling. Adopting the above selection, an exploration space of antenna topologies is limited form 2^30 to 20000. Thus we can achieve a topology exploration over 50000 times more efficiently.