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Title
Japanese: 
English:Design of CO-releasing Extracellular Scaffold using in-vivo Protein Crystals 
Author
Japanese: 田部 博康, 下位 卓也, 藤田 健太, 安部 聡, 井尻宏志, 辻本 将彦, 口丸 高弘, 近藤 科江, 森 肇, 北川 進, 上野 隆史.  
English: H. Tabe, T. Shimoi, K. Fujita, S. Abe, H. Ijiri, M. Tsujimoto, T. Kuchimaru, S. Kizaka-Kondoh, Hajime Mori, S. Kitagawa, T. Ueno.  
Language English 
Journal/Book name
Japanese: 
English:Chemistry Letters 
Volume, Number, Page Vol. 44    No. 3    pp. 342-344
Published date Mar. 2015 
Publisher
Japanese: 
English:The Chemical Society of Japan 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
Abstract A crystalline protein assembly of cypovirus polyhedra was engineered to develop a carbon monoxide (CO) releasing extracellular scaffold by immobilizing ruthenium carbonyls. The molecular design includes introduction of a hexahistidine tag to the C-terminus and provides immobilization of about 2-fold more Ru carbonyls per protein monomer and effectively releases three times more CO for activation of nuclear factor kappa B (NF-κB) in living cells relative to wild-type polyhedra with Ru carbonyls.

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