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Title
Japanese: 
English:Holistic cost-effectiveness analysis of anticancer drug regimens in Japan 
Author
Japanese: FumioTeramae, Naoya Yamaguchi, Tomohiro Makino, 仙石 愼太郎, 児玉耕太.  
English: FumioTeramae, Naoya Yamaguchi, Tomohiro Makino, Shintaro Sengoku, Kota Kodama.  
Language English 
Journal/Book name
Japanese: 
English:Drug Discovery Today 
Volume, Number, Page        
Published date Feb. 1, 2020 
Publisher
Japanese: 
English:Elsevier Current Trends 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
DOI https://doi.org/10.1016/j.drudis.2019.11.009
Abstract Japan officially introduced cost-effectiveness analysis (CEA) in 2019, whereas some countries, such as England, Sweden, Canada, and Australia, have experience with health technology assessment (HTA). Therefore, there are few reports that comprehensively examine the situation of health economic evaluation in Japan. In this paper, we review the health economic evaluation systems among those countries. We also conducted a case study that investigated the time-trend of cost, effectiveness, and incremental cost-effectiveness ratio (ICER) for anticancer drug regimens in Japan. We found a time-trend ICER for breast cancer (BC). Additionally, molecular targeting drugs for BC had a positive effect on the ICER, and both small molecular-targeting drugs and monoclonal antibodies (mAb) had a higher ICER for BC compared with conventional drugs. Finally, we discuss a possible way to implement a health economic evaluation system in Japan.

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