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Title
Japanese: 
English:Effect of formalin fixing on chromophore saliency maps derived from multi-spectral macropathology skin images 
Author
Japanese: Aloupogianni Eleni, 鈴木 裕之, Takaya Ichimura, Atsushi Sasaki, Hiroto Yanagisawa, Tetsuya Tsuchida, 石川 雅浩, Naoki Kobayashi, 小尾 高史.  
English: Eleni Aloupogianni, Hiroyuki Suzuki, Takaya Ichimura, Atsushi Sasaki, Hiroto Yanagisawa, Tetsuya Tsuchida, Masahiro Ishikawa, Naoki Kobayashi, Takashi Obi.  
Language English 
Journal/Book name
Japanese: 
English:Proceedings of SPIE--The International Society for Optical Engineering 
Volume, Number, Page Volume 11603       
Published date Feb. 15, 2021 
Publisher
Japanese: 
English:The International Society for Optical Engineering 
Conference name
Japanese: 
English:SPIE Medical Imaging 2021: Digital Pathology 
Conference site
Japanese: 
English:Online Only 
File
Official URL https://doi.org/10.1117/12.2581926
 
DOI https://doi.org/10.1117/12.2581926
Abstract Evaluation of tissue margins and hemodynamics is necessary during macropathology of skin lesions. This study aims to produce saliency maps of skin chromophores from ex-vivo specimens and observe the effect of formalin fixation on the maps. We used a multi-spectral imaging system with narrow-band illumination to capture various skin lesions. Saliency maps were produced with three different methods adapted from the literature by utilizing spectral absorption and absorption slope. Saliency maps derived from fixed and unfixed tissue were registered and subsequently compared in terms of correlation and histogram similarity. Preliminary results show high dissimilarity between maps of fixed and unfixed tissue, highlighting the influence of formalin fixing on hemodynamics, while relative distribution of melanin remained mostly unaffected.

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