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Title
Japanese: 
English:Mating-type switching by homology-directed recombinational repair: a matter of choice 
Author
Japanese: Geneviève Thon, 真木 孝尚, HABER JAMES EDWARD, 岩崎 博史.  
English: Geneviève Thon, Takahisa Maki, James E. Haber, Hiroshi Iwasaki.  
Language English 
Journal/Book name
Japanese: 
English:Current Genetics 
Volume, Number, Page Vol. 65    issue 2    pp. 351-362
Published date Oct. 31, 2018 
Publisher
Japanese: 
English:Springer 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
File
Official URL http://www.scopus.com/inward/record.url?eid=2-s2.0-85055980062&partnerID=MN8TOARS
 
DOI https://doi.org/10.1007/s00294-018-0900-2
Abstract In eukaryotes, all DNA transactions happen in the context of chromatin that often takes part in regulatory mechanisms. In particular, chromatin structure can regulate exchanges of DNA occurring through homologous recombination. Few systems have provided as detailed a view on this phenomenon as mating-type switching in yeast. Mating-type switching entails the choice of a template for the gene conversions of the expressed mating-type locus. In the fission yeast Schizosaccharomyces pombe, correct template choice requires two competing small recombination enhancers, SRE2 and SRE3, that function in the context of heterochromatin. These two enhancers act with the Swi2/Swi5 recombination accessory complex to initiate strand exchange in a cell-type-specific manner, from SRE2 in M cells and SRE3 in P cells. New research indicates that the Set1C complex, responsible for H3K4 methylation, and the Brl2 ubiquitin ligase, that catalyzes H2BK119 ubiquitylation, participate in the cell-type-specific selection of SRE2 or SRE3. Here, we review these findings, compare donor preference in S. pombe to the distantly related budding yeast Saccharomyces cerevisiae, and contrast the positive effects of heterochromatin on the donor selection process with other situations, where heterochromatin represses recombination.

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