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Title
Japanese: 
English:The differentiated and conserved roles of Swi5-Sfr1 in homologous recombination 
Author
Japanese: Argunhan Bilge, 村山 泰斗, 岩崎 博史.  
English: Argunhan, B., Murayama, Y., Hiroshi Iwasaki.  
Language English 
Journal/Book name
Japanese:FEBS Letters 
English:FEBS Letters 
Volume, Number, Page Vol. 591    No. 14    pp. 2035-2047
Published date May 2017 
Publisher
Japanese: 
English: 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
Official URL http://www.scopus.com/inward/record.url?eid=2-s2.0-85019093050&partnerID=MN8TOARS
 
DOI https://doi.org/10.1002/1873-3468.12656
Abstract Homologous recombination (HR) is the process whereby two DNA molecules that share high sequence similarity are able to recombine to generate hybrid DNA molecules. Throughout evolution, the ability of HR to identify highly similar DNA sequences has been adopted for numerous biological phenomena including DNA repair, meiosis, telomere maintenance, ribosomal DNA amplification and immunological diversity. Although Rad51 and Dmc1 are the key proteins that promote HR in mitotic and meiotic cells, respectively, accessory proteins that allow Rad51 and Dmc1 to effectively fulfil their functions have been identified in all examined model systems. In this Review, we discuss the roles of the highly conserved Swi5-Sfr1 accessory complex in yeast, mice and humans, and explore similarities and differences between these species.

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