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Title
Japanese: 
English:Fission yeast Swi5 protein, a novel DNA recombination mediator 
Author
Japanese: Haruta, N., Akamatsu, Y., 筒井康博, 黒川裕美子, 村山泰斗, Arcangioli, B., 岩崎博史.  
English: Haruta, N., Akamatsu, Y., Yasuhiro Tsutsui, Yumiko Kurokawa, Yasuto Murayama, Arcangioli, B., Hiroshi Iwasaki.  
Language English 
Journal/Book name
Japanese:DNA Repair 
English:DNA Repair 
Volume, Number, Page Vol. 7    No. 1    pp. 1-9
Published date Jan. 2008 
Publisher
Japanese: 
English: 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
Official URL http://www.scopus.com/inward/record.url?eid=2-s2.0-36549080101&partnerID=MN8TOARS
 
DOI https://doi.org/10.1016/j.dnarep.2007.07.004
Abstract The Schizosaccharomyces pombe Swi5 protein forms two distinct protein complexes, Swi5-Sfr1 and Swi5-Swi2, each of which plays an important role in the related but functionally distinct processes of homologous recombination and mating-type switching, respectively. The Swi5-Sfr1 mediator complex has been shown to associate with the two RecA-like recombinases, Rhp51 (spRad51) and Dmc1, and to stimulate in vitro DNA strand exchange reactions mediated by these proteins. Genetic analysis indicates that Swi5-Sfr1 works independently of another mediator complex, Rhp55-Rhp57, during Rhp51-dependent recombinational repair. In addition, mutations affecting the two mediators generate distinct repair spectra of HO endonuclease-induced DNA double strand breaks, suggesting that these recombination mediators differently regulate recombination outcomes in an independent manner.

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