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Title
Japanese: 
English:Proteolytic activation of UmuD and MucA proteins for SOS mutagenesis. 
Author
Japanese: Shiba, T., 岩崎博史, Nakata, A., Shinagawa, H..  
English: Shiba, T., Hiroshi Iwasaki, Nakata, A., Shinagawa, H..  
Language English 
Journal/Book name
Japanese:Basic life sciences 
English:Basic life sciences 
Volume, Number, Page Vol. 52        pp. 351-354
Published date 1990 
Publisher
Japanese: 
English: 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
Official URL http://www.scopus.com/inward/record.url?eid=2-s2.0-0025033236&partnerID=MN8TOARS
 
Abstract SOS mutagenesis in Escherichia coli requires the functions of the umuD, C genes, or their functional analogues mucA, B derived from a plasmid pKM101, and the recA gene. However, mere derepression of these SOS genes does not increase the ability of the cell to perform mutagenesis. Activation of RecA protein to a form (RecA*) that mediates cleavage of the LexA repressor is required for mutagenesis. We present evidence that UmuD and MucA are proteolytically processed by RecA* and that the processed products are the active forms involved in mutagenesis.

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