Home >

news Help

Publication Information


Title
Japanese: 
English:Depth estimation of tumor invasion in early gastric cancer using scattering of circularly polarized light: Monte Carlo Simulation study 
Author
Japanese: 西沢 望, 口丸 高弘.  
English: Nozomi Nishizawa, Takahiro Kuchimaru.  
Language English 
Journal/Book name
Japanese: 
English:Journal of Biophotonics 
Volume, Number, Page Vol. 15        p. 202200062
Published date June 5, 2022 
Publisher
Japanese: 
English: 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
Official URL https://onlinelibrary.wiley.com/doi/10.1002/jbio.202200062
 
DOI https://doi.org/10.1002/jbio.202200062
Abstract Quantitative depth estimation of tumor invasion in early gastric cancer by scattering of circularly polarized light is computationally investigated using the Monte Carlo method. Using the optical parameters of the human stomach wall and its carcinoma, the intensity and circular polarization of light scattered from pseudo-healthy and cancerous tissues were calculated over a wide spectral range. Large differences in the circular polarization with opposite signs, together with the large intensity, are obtained at wavelengths 600 nm and 950 nm. At these two wavelengths, the sampling depth of the biological tissues can be modulated by tuning the detection angle. In bi-layered pseudo-tissues with a cancerous layer on a healthy layer and vice versa, the degree of circular polarization of scattered light shows systematic changes depending on the thickness and depth of the cancerous layer, which indicates the feasibility of in vivo quantitative estimation of cancer progression in early gastric cancer.

©2007 Tokyo Institute of Technology All rights reserved.