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Title
Japanese:CycPeptMPDB：包括的な環状ペプチド膜透過率データベースの開発 
English: 
Author
Japanese: 李 佳男, 柳澤 渓甫, 杉田 昌岳, 藤江 拓哉, 大上 雅史, 秋山 泰.  
English: Jianan Li, Keisuke Yanagisawa, Masatake Sugita, Takuya Fujie, Masahito Ohue, Yutaka Akiyama.  
Language Japanese 
Journal/Book name
Japanese:研究報告バイオ情報学（BIO） 
English: 
Volume, Number, Page 2022-BIO-74    38    1-8
Published date June 29, 2023 
Publisher
Japanese:情報処理学会 
English: 
Conference name
Japanese:情報処理学会 第143回MPS・第74回BIO合同研究発表会 
English: 
Conference site
Japanese:沖縄県 
English: 
Abstract Recently, cyclic peptide drugs have attracted much attention because they can aim targets such as intracellular protein-protein interactions that are difficult to be tackled by conventional small-molecule drugs or antibody drugs. However, cyclic peptides generally have the disadvantage of low membrane permeability. This remains a major challenge in the development of peptide drugs that can be orally administered and inhibit intracellular targets. Although there were many studies measuring the permeability of cyclic peptides, a comprehensive database that brings together these data in a unified format is not yet available. Therefore, this study collected a total of 7334 cyclic peptide structure and experimentally measured membrane permeability data comprehensively from 45 papers and 2 pharmaceutical company patents. We compiled them into CycPeptMPDB（http://cycpeptmpdb.com）, the world's first cyclic peptide membrane permeability database. To unambiguously represent structures of cyclic peptides, which are more complex than small-molecule compounds, CycPeptMPDB also contains a unified sequence representation of all peptides generated using the HELM notation. In addition to basic data storage, CycPeptMPDB provides several supporting functions such as searching, data analysis, and downloading.

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