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Title
Japanese:Sulfonated Pyrene as a Photoregulator for Single-Stranded DNA Looping 
English:Sulfonated Pyrene as a Photoregulator for Single-Stranded DNA Looping 
Author
Japanese: Jie Xu, Shunichi Miyamoto, Sachiko Tojo, Kiyohiko Kawai.  
English: Jie Xu, Shunichi Miyamoto, Sachiko Tojo, Kiyohiko Kawai.  
Language English 
Journal/Book name
Japanese:Chemistry - A European Journal 
English:Chemistry - A European Journal 
Volume, Number, Page Vol. 26    No. 22    pp. 5075-5084
Published date Feb. 16, 2020 
Publisher
Japanese:Wiley-VCH Verlag GmbH & Co. KGaA 
English:Wiley-VCH Verlag GmbH & Co. KGaA 
Conference name
Japanese: 
English: 
Conference site
Japanese: 
English: 
DOI https://doi.org/10.1002/chem.202000184
Abstract Controlling the conformation and function of biomols. through photoregulators holds great promise as a spatiotemporally controllable tool for disease control. In addition, introducing photoregulators into biomols. has also found applications in constructing smart nanomaterials. In spite of the astonishing advances that have been made in the past few years, realizing highly controllable and efficient regulation over the conformation and function of biomols. under physiol. conditions is still challenging. Herein, sulfonated pyrene SPy was synthesized and used as a photoregulator to control the looping of single-stranded DNAs (ssDNAs) in aqueous solution Due to its water solubility, SPy merits use in the study of biomols. in aqueous solution The looping of the doubly SPy-modified ssDNAs is stimulated by irradiation and regulated by SPy. Photoionization generates the radical cation of SPy (SPy.+). The association of SPy.+ with its neutral counterpart, SPy, gives rise to the dimer radical cation of SPy (SPy2.+). During the association process, the stabilization energy released to form SPy2.+ provides a driving force for the looping of ssDNAs. Conversely, the formed loop conformations were trapped by the formation of SPy2.+, and this allowed the looping dynamics to be investigated. The results reported herein suggest potential of SPy as a photoregulator for controlling the conformation and function of biomols. under physiol. conditions.

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