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Title
Japanese: 
English:Osmotic stress induces the formation of migrasome-like vesicles 
Author
Japanese: 吉川 晃生, 齊藤 彰吾, 門之園 哲哉, 田中 祐圭, 大河内 美奈.  
English: Koki Yoshikawa, Shogo Saito, Tetsuya Kadonosono, Masayoshi Tanaka, Mina Okochi.  
Language English 
Journal/Book name
Japanese: 
English:FEBS Letters 
Volume, Number, Page Volume 598    Issue 4    Page 437-445
Published date Feb. 9, 2024 
Publisher
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English: 
Conference name
Japanese: 
English: 
Conference site
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English: 
Abstract Migrasomes are extracellular vesicles that form on the retraction fibers ofmigrating cells. In this study, we report the formation of migrasome-like vesi-cles enriched in tetraspanin 4 and containing cytoplasmic components inresponse to hypoosmotic stress. When migrating cells were subjected tohypoosmotic stress, vesicles with a size distribution of 0.5 to 2 lm formed onthe retraction fibers, and vanished in a few minutes. The vesicles are rich incholesterol, and their number was reduced when cells were pretreated withlipoprotein-deficient serum. The formation of migrasome-like vesicles uponhypoosmotic stress may provide biophysical cues regarding the cellularresponse to this external stimulus in cells and tissues.

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