BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
巻, 号, ページ
Vol. 231
No. 3
pp. 566-569
出版年月
1997年2月
出版者
和文:
英文:
Academic Press
会議名称
和文:
英文:
開催地
和文:
英文:
アブストラクト
We refined scanning probe force microscopy to improve the sensitivity of force detection and control of probeposition. Force sensitivity was increased by incorporatinga cantilever with very low stiffness, 0.1pN/nm, which is over 1000-fold more flexible than is typically used in conventional atomic force microscopy. Thermal bending motions of the cantilever were reduced to less than 1 nm by exerting feed-back positioning with laser radiation pressure. The system was tested by measuring electrostatic repulsive forces or hydrophobic attractive forces in aqueous solutions. Subpiconewton intermolecular forces were resolved at controlled gaps in the nanometer range between the probe and a material surface. These levels of force and position sensitivity meet the requirements needed for future investigations of intermolecular forces between biological macromolecules such as proteins, lipids and DNA.
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