A novel multicomponent crystal (MC) of mefenamic acid (MA) and N-methyl-D-glucamine (MG) had been prepd. to improve the physicochem. properties of poorly sol. drugs, and was characterized for its physicochem. properties by powder X-ray diffraction anal., differential scanning calorimetry thermal anal., FT-IR spectroscopy, in vitro dissoln. rate, and phys. stability. In addn., the crystal structure was detd. by single-crystal X-ray diffraction anal. The differential scanning calorimetry thermogram of the MA-MG binary system exhibits a single and sharp endothermic peak at 151.20ツーC, which was attributed to the m.p. of a MC of MA-MG. FT-IR spectroscopy anal. showed the occurrence of solid-state interaction by involving proton transfer between MA and MG. The crystal structure anal. confirmed that MA-MG formed 1:1 ratio salt type MC. The formation of a MC of MA with MG significantly improved the dissoln. rate of MA in compared to intact MA, and also the crystal demonstrated a good stability under a high relative humidity. These good properties would be attributed to the layer structure of MA and MG in the crystal. [on SciFinder(R)]