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タイトル
和文: 
英文:1-Methyl-4-phenylpyridinium ion, a toxin that can cause parkinsonism, alters branched structures of DNA 
著者
和文: Iwaasa, M., Umeda, S., Ohsato, T., Takamatsu, C., Fukuoh, A., 岩崎博史, Shinagawa, H., Hamasaki, N., Kang, D..  
英文: Iwaasa, M., Umeda, S., Ohsato, T., Takamatsu, C., Fukuoh, A., Hiroshi Iwasaki, Shinagawa, H., Hamasaki, N., Kang, D..  
言語 English 
掲載誌/書名
和文:Journal of Neurochemistry 
英文:Journal of Neurochemistry 
巻, 号, ページ Vol. 82    No. 1    pp. 30-37
出版年月 2002年7月 
出版者
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会議名称
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開催地
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公式リンク http://www.scopus.com/inward/record.url?eid=2-s2.0-0036310432&partnerID=MN8TOARS
 
DOI https://doi.org/10.1046/j.1471-4159.2002.00996.x
アブストラクト During replication, human mitochondrial DNA (mtDNA) takes on a triple-stranded structure known as a D-loop, which is implicated in replication and transcription. 1-Methyl-4-phenylpyridinium ion (MPP+), a toxin inducing parkinsonism, inhibits mtDNA replication, possibly by resolving the D-loops. For initiation of mtDNA replication, mitochondria are thought to have another triple-stranded structure, an R-loop. The R-loop, which is resolved by a bacterial junction-specific helicase, RecG, is also resolved by MPP+. Because mitochondrial D-loops are likewise resolved by RecG, the D- and R-loops may share a similar branched structure. MPP+ resolves cruciform DNA in supercoiled DNA. MPP+ converts a stacked conformation to an extended conformation in a synthetic Holliday junction. This conversion is reversed by 1 mM Mg(2+), as is the resolution of the D-loops or cruciform DNA. These observations suggest that the junction structure of mitochondrial D- and R-loops is affected by MPP+.

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