Disopyramide (DPA) is as a class IA antiarrhythmic drug and its crystn. from cyclohexane at ambient condition yields lower melting form crystals which belong to the monoclinic centrosym. space group P21/n, having two mols. in an asym. unit. Crystal structure anal. of pure DPA revealed closely assocd. DPA mols. aggregates via amide-amide dimer synthon through the N-H···O hydrogen bond whereas the second amide hydrogen N-H engaged in an intramol. N-H···N hydrogen bond with N-nitrogen of 2-pyridine moieties. Crystn. of DPA and phthalic acid (PA) in 1: 1 stoichiometric molar ratio from acetone at ambient condition yielded block shape crystals of 1:1 DPA_PA salt. Its X-ray single crystal structure revealed the formation of salt by transfer of acidic proton from one of the carboxylic acidic groups of PA to the tertiary amino group of chain moiety (N3-nitrogen atom) of DPA mols. DPA_PA salt crystals belong to the monoclinic centrosym. space group P21/n, comprising one protonated DPA and one PA- anion (hydrogen phthalate counterion) in an asym. unit and linked by N-H···O and C-H···O hydrogen bonds. Pure DPA and DPA_PA salt were further characterized by differential calorimetric anal., thermal gravimetric anal., powder x-ray diffraction and IR spectroscopy. [on SciFinder(R)]
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