X-ray diffraction and vibrational spectroscopic studies of the intermolecular interactions on the grinding and compaction behaviours of lopinavir and ritonavir crystals.
英文:
X-ray diffraction and vibrational spectroscopic studies of the intermolecular interactions on the grinding and compaction behaviours of lopinavir and ritonavir crystals.
著者
和文:
Arif Budi Setianto,
Yuda Prasetya Nugraha,
Veinardi Suendo,
Ahmad Ainurofiq,
Hidehiro Uekusa,
Sundani Nurono. Soewandhi.
英文:
Arif Budi Setianto,
Yuda Prasetya Nugraha,
Veinardi Suendo,
Ahmad Ainurofiq,
Hidehiro Uekusa,
Sundani Nurono. Soewandhi.
Lopinavir (LPV) and ritonavir (RTV) are anti-viral drugs used in combination and commonly prepd. through hot-melt extrusion techniques. Mech. processes are greatly involved, including blending and milling. Therefore, the crystal behavior of LPV and RTV under the mech. process is an interesting study. Here, the LPV, RTV, and their mixts. were processed by two different treatments: grinding and compression processes. The solid-state properties of the drugs were evaluated by powder x-ray diffraction (PXRD) differential scanning calorimetry (DSC), Fourier transform IR spectroscopy (FTIR), Raman spectroscopy. Single-crystal XRD anal. was also carried out to confirm the packing structure in the crystal lattice. It was obsd. that LPV was very sensitive to the grinding process, where it tends to form an amorphous solid in both the pure and mixt. forms. On the other hand, RTV has a very stable cryst. structure and was able to retain its crystallinity even under grinding. Both LPV and RTV were obsd. to be quite stable under compression, where both retained their cryst. form with only slight changes in their d-spacing values. This study highlighted the mol. origin of LPV and RTV crystal behavior after grinding and compression processes. [on SciFinder(R)]
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