The objectives of this study were to prep. and characterize a novel piperine-succinic acid multicomponent crystal phase and to evaluate the improvement in the soly. and dissoln. rate of piperine when prepd. in the multicomponent crystal formation. The solid-state characterization of the novel multicomponent crystal was performed by powder X-ray diffraction (XRD), differential scanning calorimetry (DSC), and Fourier transform-IR (FT-IR) spectroscopy. Soly. and dissoln. rate profiles were evaluated in distd. water. The phys. stability was evaluated under high relative humidity (75% and 100% RH). The detn. of the single crystal X-ray diffraction structure revealed that this novel multicomponent crystal was a cocryst. phase of piperine-succinic acid (2:1 molar ratio). The differential scanning calorimetry thermogram of the cocrystal showed a single and sharp endothermic peak at 110.49°C. The cocrystal resulted in greater soly. and a faster dissoln. rate of piperine than intact piperine. This improvement was a result of the formation of a channel structure in the cocrystal. In addn., the cocrystal was stable under a humid condition. [on SciFinder(R)]
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