Gamma-Band Auditory Steady-State Response as a Neurophysiological Marker for Excitation and Inhibition Balance: A Review for Understanding Schizophrenia and Other Neuropsychiatric Disorders
著者
和文:
Mariko Tada,
Kenji Kirihara,
Daisuke Koshiyama,
Mao Fujioka,
Kaori Usui,
Takanori Uka,
小松三佐子,
Naoto Kunii,
Tsuyoshi Araki,
Kiyoto Kasai.
英文:
Mariko Tada,
Kenji Kirihara,
Daisuke Koshiyama,
Mao Fujioka,
Kaori Usui,
Takanori Uka,
Misako Komatsu,
Naoto Kunii,
Tsuyoshi Araki,
Kiyoto Kasai.
言語
English
掲載誌/書名
和文:
英文:
Clinical EEG and Neuroscience
巻, 号, ページ
Vol. 51
No. 4
pp. 234-243
出版年月
2019年7月
出版者
和文:
英文:
SAGE Publications
会議名称
和文:
英文:
開催地
和文:
英文:
アブストラクト
<jats:p>Altered gamma oscillations have attracted considerable attention as an index of the excitation/inhibition (E/I) imbalance in schizophrenia and other neuropsychiatric disorders. The auditory steady-state response (ASSR) has been the most robust probe of abnormal gamma oscillatory dynamics in schizophrenia. Here, we review recent ASSR studies in patients with schizophrenia and other neuropsychiatric disorders. Preclinical ASSR research, which has contributed to the elucidation of the underlying pathophysiology of these diseases, is also discussed. The developmental trajectory of the ASSR has been explored and may show signs of the maturation and disruption of E/I balance in adolescence. Animal model studies have shown that synaptic interactions between parvalbumin-positive GABAergic interneurons and pyramidal neurons contribute to the regulation of E/I balance, which is related to the generation of gamma oscillation. Therefore, ASSR alteration may be a significant electrophysiological finding related to the E/I imbalance in neuropsychiatric disorders, which is a cross-disease feature and may reflect clinical staging. Future studies regarding ASSR generation, especially in nonhuman primate models, will advance our understanding of the brain circuit and the molecular mechanisms underlying neuropsychiatric disorders.</jats:p>
各種検索
サポート
ヘルプ