Journal Paper

• Daiki Nakatsu, Rina Kunishige, Yuki Taguchi, Naeko Shinozaki-Narikawa, Kishiko Osaka, Kayo Yokomizo, Mami Ishida, Shunsuke Takei, Shoko Yamasaki, Keita Hagiya, Kotaro Hattori, Tadashi Tsukamoto, Masayuki Murata, Fumi Kano. BMP4-SMAD1/5/9-RUNX2 pathway activation inhibits neurogenesis and oligodendrogenesis in Alzheimer’s patients’ iPSCs in senescence-related conditions, Stem Cell Reports, Vol. 18, Page 1-18, Feb. 2023.
• Rina Kunishige, Masayuki Murata, Fumi Kano. Targeted protein degradation by Trim-Away using cell resealing coupled with microscopic image-based quantitative analysis, Frontiers in Cell and Developmental Biology, Vol. 10, Dec. 2022.  Official location  
• Yoshiyuki Noguchi, Fumi Kano, Nobuhiko Maiya, Chisako Iwamoto, Shoko Yamasaki, Yosuke Otsubo, Daiki Nakatsu, Rina Kunishige, Masayuki Murata. Microscopic image-based covariation network analysis for actin scaffold-modified insulin signaling, iScience, pp. 102724, July 2021.  Official location  
• Kazuhiro Shiizaki, Asako Tsubouchi, Yutaka Miura, Kinya Seo, Takahiro Kuchimaru, Hirosaka Hayashi, Yoshitaka Iwazu, Marina Miura, Batpurev Battulga, Nobuhiko Ohno, Toru Hara, Rina Kunishige, Mamiko Masutani, Keita Negishi, Kazuomi Kario, Kazuhiko Kotani, Toshiyuki Yamada, Daisuke Nagata, Issei Komuro, Hiroshi Itoh, Hiroshi Kurosu, Masayuki Murata, Makoto Kuro-o. Calcium phosphate microcrystals in the renal tubular fluid accelerate chronic kidney disease progression, The Journal of Clinical Investigation, June 2021.  Official location  
• Rina Kunishige, Mai Mizoguchi, Asako Tsubouchi, Kenjiro Hanaoka, Yutaka Miura, Hiroshi Kurosu, Yasuteru Urano, Makoto Kuro-o, Masayuki Murata. Calciprotein particle-induced cytotoxicity via lysosomal dysfunction and altered cholesterol distribution in renal epithelial HK-2 cells, Scientific Reports, Vol. 10, No. 1, Dec. 2020.  Official location  
• RinaKunishige, Fumi Kano, Masayuki Murata. The cell resealing technique for manipulating, visualizing, and elucidating molecular functions in living cells, Biochimica et Biophysica Acta (BBA) - General Subjects, Vol. 1864, No. 2, pp. 129329, Feb. 2020.  Official location  
• Rina Kunishige, Fumi Kano, Masayuki Murata. 特集 生体膜のバイオロジー Ⅴ.新技術 セミインタクト細胞リシール技術を用いた細胞機能解析, 生体の科学, June 2018.  Official location  
• Yuki Taguchi, Koichi Imaoka, Michiyo Kataoka, Akihiko Uda, Daiki Nakatsu, Sakuya Horii-Okazaki, Rina Kunishige, Fumi Kano, Masayuki Murata. Yip1A, a Novel Host Factor for the Activation of the IRE1 Pathway of the Unfolded Protein Response during Brucella Infection, PLOS Pathogens, Vol. 11, No. 3, pp. e1004747, Mar. 2015.  Official location  

Book

• Fumi Kano, Rina Kunishige. 共変動ネットワーク解析法とリシール細胞技術を基盤とするAI主導の創薬・細胞医薬支援プラットフォーム創成, 革新的AI創薬, 株式会社エヌティーエス, July 2022.

Domestic Conference (Not reviewed / Unknown)

• Rina Kunishige, 野口 誉之, 米谷 信彦, Daiki Nakatsu, Masayuki Murata, Fumi Kano. 薬剤に対する細胞応答を超早期に捉える新規タンパク質ネットワーク解析法, 第50回日本毒性学会学術年会, June 2023.
• Daiki Nakatsu, Rina Kunishige, Yuki Taguchi, Naeko Shinozaki-Narikawa, Kishiko Osaka, Kayo Yokomizo, Mami Ishida, Shunsuke Takei, Shoko Yamasaki, Keita Hagiya, Kotaro Hattori, Tadashi Tsukamoto, Masayuki Murata, Fumi Kano. Establishing a Model of Neurogenesis Defects in Alzheimer's Disease using Patient-Derived iPSCs and Screening for Neurogenesis Recovery Compounds, The 75th Annual Meeting of the Japan Society for Cell Biology, June 2023.
• Rina Kunishige, Masayuki Murata, Fumi Kano. リシール細胞技術によるTrim-Away標的タンパク質分解と解析系の構築, ⽇本ケミカルバイオロジー学会 第17回年会, May 2023.
• Rina Kunishige, 野口 誉之, 米谷 信彦, Daiki Nakatsu, Masayuki Murata, Fumi Kano. シグナル伝達系タンパク質の時空間ダイナミクスを捉える新規ネットワーク解析法の開発と薬効評 価への応用, 第147回日本薬理学会関東部会, Mar. 2023.
• Rina Kunishige, 野口 誉之, 米谷 信彦, Daiki Nakatsu, Masayuki Murata, Fumi Kano. 「細胞状態」の時空間的変化を活写する共変動ネットワーク解析法による薬効評価, 第96回日本薬理学会年会, Dec. 2022.
• Fumi Kano, Rina Kunishige. リシール細胞技術を用いた細胞内環境改変法と共変動ネットワークを用いたフェノタイプ解析, 第95回日本生化学会大会, Nov. 2022.
• Rina Kunishige, Yoshiyuki Noguchi, Nobuhiko Maiya, Daiki Nakatsu, Masayuki Murata, Fumi Kano. Transient formation of actin domain mediates insulin-induced glycogen synthesis: application of a novel Covariation Network analysis, 第95回日本生化学会大会, Nov. 2022.
• Nobuhiko Maiya, Yoshiyuki Noguchi, Fumi Kano, Chisako Iwamoto, Shoko Yamasaki, Yosuke Otsubo, Daiki Nakatsu, Rina Kunishige, Masayuki Murata. Development of signal pathway analysis method utilizing intracellular localization information of protein, The 49th Annual Meeting of the Japanese Society of Toxicology, July 2022.
• Rina Kunishige, Yoshiyuki Noguchi, Nobuhiko Maiya, Daiki Nakatsu, Masayuki Murata, Fumi Kano. Transient formation of actin domain mediates insulin signaling: application of PLOM-CON analysis, 第74回日本細胞生物学会大会, June 2022.
• Yoshiyuki Noguchi, Rina Kunishige, Nobuhiko Maiya, Daiki Nakatsu, Masayuki Murata, Fumi Kano. PLOM-CON analysis: revealing the dynamics of intracellular protein localization and modifications, 第74回日本細胞生物学会大会, June 2022.
• 野口 誉之, Fumi Kano, 米谷 信彦, 岩本 智沙子, 山崎 聖子, 大坪 洋介, Daiki Nakatsu, Rina Kunishige, Masayuki Murata. 蛋白質の細胞内局在情報を活用したシグナル伝達系分析手法の開発, 日本薬学会第142年会, Mar. 2022.
• Fumi Kano, Rina Kunishige. オルガネラ形態変化の再構成と分子機序解明を可能にするリシール細胞技術と共変動ネットワーク解析法, 第44回分子生物学会年会, Dec. 2021.
• Rina Kunishige, Yuki Sonoda, 村上真隆, Fumi Kano, Masayuki Murata. セミインタクト細胞リシール技術を用いた細胞機能解析・評価系の開発, 日本ケミカルバイオロジー学会第１４回年会, June 2019.

Other Publication

• Fumi Kano, Rina Kunishige. セミインタクト細胞リシール技術を用いた新しい細胞編集・細胞デザイン, 細胞, Vol. 54, No. 4, pp. 12-15, Apr. 2022.

Patent

• Fumi Kano, Masayuki Murata, Rina Kunishige. 解析システム、解析装置、解析プログラム、及び解析方法. Patent. Published. 国立大学法人東京工業大学, 国立大学法人東京大学. 2023/07/12. PCT/JP2023/025772. 2024/01/18. WO 2024/014489. 2024.
• Fumi Kano, Masayuki Murata, Rina Kunishige. リシール細胞セット及びその製造方法. Patent. Published. 国立大学法人東京工業大学, 国立大学法人東京大学. 2022/10/14. 特願2022-165180. 2024/04/26. 特開2024-058679. 2024.

Degree

• Calciprotein particle により尿細管上皮細胞に誘導される細胞機能障害機構の解明,  Outline,  The University of Tokyo, 

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