論文

• Yoshiaki Masaki, Hugo Itou, Yuki Oda, Kazufumi Yamazaki, Nobuhiro Tago, Kentaro Ohno, Nozomi Ishii, Hirosuke Tsunoda, Takashi Kanamori, Akihiro Ohkubo, Mitsuo Sekine, Kohji Seio. Enzymatic synthesis and reverse transcription of RNAs incorporating 2'-O-carbamoyl uridine triphosphate, Chemical Communications, Sept. 2016.
• T. Yamada, Y. Masaki, N. Okaniwa, T. Kanamori, A. Ohkubo, H. Tsunoda, K. Seio, M. Sekine. Synthesis and properties of oligonucleotides modified with 2 '-O-(2-carboxyethyl)nucleotides and their carbamoyl derivatives, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 12, No. 33, pp. 6457-6464, 2014.
• K. Yamada, Y. Masaki, H. Tsunoda, A. Ohkubo, K. Seio, M. Sekine. A new modified cytosine base capable of base pairing with guanine using four hydrogen bonds, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 12, No. 14, pp. 2255-2262, 2014.
• Y. Masaki, R. Miyasaka, K. Hirai, T. Kanamori, H. Tsunoda, A. Ohkubo, K. Seio, M. Sekine. Properties of 5- and/or 2-modified 2 '-O-cyanoethyl uridine residue: 2 '-O-cyanoethyl-5-propynyl-2-thiouridine as an efficient duplex stabilizing component, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 12, No. 7, pp. 1157-1162, 2014.
• K. Seio, M. Tokugawa, H. Tsunoda, A. Ohkubo, F. Arisaka, M. Sekine. Assembly of pyrene-modified DNA/RNA duplexes incorporating a G-rich single strand region, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol. 23, No. 24, pp. 6822-6824, Dec. 2013.
• K. Seio, T. Kanamori, M. Tokugawa, H. Ohzeki, Y. Masaki, H. Tsunoda, A. Ohkubo, M. Sekine. Fluorescent properties of oligonucleotides doubly modified with an indole-fused cytosine analog and 2-aminopurine, BIOORGANIC & MEDICINAL CHEMISTRY, Vol. 21, No. 11, pp. 3197-3201, June 2013.
• K. Seio, M. Tokugawa, T. Kanamori, H. Tsunoda, A. Ohkubo, M. Sekine. Synthesis and properties of cationic 2 '-O- N-(4-aminobutyl)carbamoyl modified oligonucleotides, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol. 22, No. 7, pp. 2470-2473, Apr. 2012.
• T. Harakawa, H. Tsunoda, A. Ohkubo, K. Seio, M. Sekine. Development of an efficient method for phosphorodiamidate bond formation by using inorganic salts, Bioorganic & Medicinal Chemistry Letters, Vol. 22, No. 3, pp. 1445-1447, Feb. 2012.
• A. Ohkubo, N. Tago, A. Yokouchi, ; Y. Nishino, K. Yamada, H. Tsunoda, K. Seio, M. Sekine. Synthesis of 5 '-terminal capped oligonucleotides using O-N phosphoryl migration of phosphoramidite derivatives, ORGANIC LETTERS, Vol. 14, No. 1, pp. 10-13, Jan. 2012.
• K. Seio, S. Kurohagi, E. Kodama, Y. Masaki, H. Tsunoda, A. Ohkubo, M. Sekine. Short-RNA selective binding of oligonucleotides modified using adenosine and guanosine derivatives that possess cyclohexyl phosphates as substituents, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 10, No. 5, pp. 994-1006, 2012.
• T. Kanamori, Y. Masaki, M. Mizuta, H. Tsunoda, A. Ohkubo, M. Sekine, K. Seio. DNA duplexes and triplex-forming oligodeoxynucleotides incorporating modified nucleosides forming stable and selective triplexes, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 10, No. 5, pp. 1007-1013, 2012.
• Y. Masaki, R. Miyasaka, K. Hirai, H. Tsunoda, A. Ohkubo, K. Seio, M. Sekine. Prediction of the stability of modified RNA duplexes based on deformability analysis: Oligoribonucleotide derivatives modified with 2 '-o-cyanoethyl-5-propynyl-2-thiouridine as a promising component, CHEMICAL COMMUNICATIONS, Vol. 48, No. 58, pp. 7313-7315, 2012.
• A. Ohkubo, Y. Nishino, Y. Ito, H. Tsunoda, K. Seio, M. Sekine. Formation of new base pairs between inosine and 5-methyl-2-thiocytidine derivatives, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 10, No. 10, pp. 2008-2010, 2012.
• A. Ohkubo, A. Yokouchi, K. Yamada, H. Tsunoda, K. Seio, M. Sekine. Synthesis and properties of oligonucleotides having 5 '-terminal 2,2,7-trimethylguanosine cap analogues, NUCLEIC ACID THERAPEUTICS, Vol. 21, No. 5, pp. A39-A40, Oct. 2011.
• H. Tsunoda, T. Kudo, Y. Masaki, A. Ohkubo, K. Seio, M. Sekine. Biochemical behavior of N-oxidized cytosine and adenine bases in DNA polymerase-mediated primer extension reactions, NUCLEIC ACIDS RESEARCH, Vol. 39, No. 7, pp. 2995-3004, Apr. 2011.
• S. Q. Cao, I. Okamoto, H. Tsunoda, A. Ohkubo, K. Seio, M. Sekine. Synthesis and triplex-forming properties of oligonucleotides containing thio-substituted C-nucleoside 4-thiopseudoisocytidine, TETRAHEDRON LETTERS, Vol. 52, No. 3, pp. 407-410, Jan. 2011.
• A. Ohkubo, Y. Nishino, A. Yokouchi, Y. Ito, Y. Noma, Y. Kakishima, Y. Masaki, H. Tsunoda, K. Seio, M. Sekine. Stable triplex formation using the strong stacking effect of consecutive thionucleoside moieties, CHEMICAL COMMUNICATIONS, Vol. 47, No. 46, pp. 12556-12558, 2011.
• H. Tsunoda, T. Kudo, A. Ohkubo, K. Seio, M. Sekine. Synthesis of oligodeoxynucleotides using fully protected deoxynucleoside 3 '-phosphoramidite building blocks and base recognition of oligodeoxynucleotides incorporating N-3-cyano-ethylthymine, MOLECULES, Vol. 15, No. 11, pp. 7509-7531, Nov. 2010.
• A. Ohkubo, T. Sakaue, H. Tsunoda, K. Seio, M. Sekine. Synthesis and hybridization properties of oligonucleotides incorporating bi- and tricyclic cytosine derivatives, Chemistry letters, Vol. 39, No. 7, pp. 726-727, July 2010.
• A. Ohkubo, Y. Kuwayama, Y. Nishino, H. Tsunoda, K. Seio, M. Sekine. Oligonucleotide synthesis involving deprotection of amidine-type protecting groups for nucleobases under acidic conditions, ORGANIC LETTERS, Vol. 12, No. 11, pp. 2496-2499, June 2010.
• Seio Kohji, Miyazaki Kazuya, Kurohagi Sayako, Masaki Yoshiaki, Tsunoda Hirosuke, Ohkubo Akihiro, Sekine Mitsuo. Synthesis and properties of terminally modified oligonucleotides capable of short-RNA selective hybridization., Nucleic acids symposium series (2004), No. 53, pp. 13-4, Sept. 2009.  公式リンク  
  
• A. Ohkubo, K. Sasaki, Y. Noma, H. Tsunoda, K. Seio, M. Sekine. Efficient solid-phase synthesis of oligodeoxynucleotides having a 5 '-terminal 2,2,7-trimethylguanosine pyrophosphate linkage, BIOORGANIC & MEDICINAL CHEMISTRY, Vol. 17, No. 13, pp. 4819-4824, July 2009.
• A. Ohkubo, Y. Noma, K. Aoki, H. Tsunoda, K. Seio, M. Sekine. Introduction of 3 '-Terminal Nucleosides Having a Silyl-Type Linker into Polymer Supports without Base Protection, JOURNAL OF ORGANIC CHEMISTRY, Vol. 74, No. 7, pp. 2817-2823, Apr. 2009.
• K. Miyata, R. Tamamushi, H. Tsunoda, A. Ohkubo, K. Seio, M. Sekine. Synthesis and Triplex Formation of Oligonucleotides Containing 8-Thioxodeoxyadenosine, Organic Letters, Vol. 11, No. 3, pp. 605-608, Feb. 2009.
• A. Ohkubo, R. Kasuya, K. Miyata, H. Tsunoda, K. Seio, M. Sekine. New thermolytic carbamoyl groups for the protection of nucleobases, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 7, No. 4, pp. 687-694, 2009.
• A. Ohkubo, Y. Kuwayama, T. Kudo, H. Tsunoda, K. Seio, M. Sekine. O-selective condensation using P-N bond cleavage in RNA synthesis without base protection, Organic letters, Vol. 10, No. 13, pp. 2793-2796, July 2008.
• H. Tsunoda, A. Ohkubo, H. Taguchi, K. Seio, M. Sekine. Synthesis and properties of DNA oligomers containing 2 '-deoxynucleoside N-oxide derivatives, JOURNAL OF ORGANIC CHEMISTRY, Vol. 73, No. 4, pp. 1217-1224, Feb. 2008.

特許など

• 関根光雄, 清尾康志, 大窪章寛, 角田浩佑, 正木慶昭, 金森功吏, 山田　希, 山崎一史, 伊藤比祐吾. 2'-0-カルバモイル修飾ヌクレオシド三リン酸. 特許. 登録. 国立大学法人東京工業大学. 2013/07/23. 特願2013-152578. 2015/02/02. 特開2015-020994. 特許第6261027号. 2017/12/22 2017.

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