論文

• KIKUO KISHIMOTO, Rehana Afrin, Masato Nakaji, Hiroshi Sekiguchi, David Lee, Atsushi Ikai. Forced Extension of Delipidated Red Blood Cell Cytoskeleton with Little indication of Spectrin Unfolding, Cytoskeleton, Wiley Periodicals Inc., No. 69, pp. 101-112, Feb. 2012.
• ATSUSHI IKAI. Direct detection of cellular adaptation to local cyclic stretching at the single cell level by atomic force microscopy, Biophys J. 2011 Feb 2;100(3):564-572, Vol. 100, Number 3, 2011.
• 猪飼篤. Nano-Biomechanics : タンパク質を引張ってみませんか, 生物物理, 日本生物物理学会, Vol. 50, No. 2, Feb. 2010.
• 猪飼篤. 表面固定されたポリペプチドおよび細胞の力学操作, 表面科学 : hyomen kagaku = Journal of the Surface Science Society of Japan, 日本表面科学会, Vol. 31, No. 2, Jan. 2010.
• ATSUSHI IKAI. Direct manipulation of intracellular stress fibres using a hook-shaped AFM probe, Nnotechnology, Vol. 21, p. 385102, 2010.
• ATSUSHI IKAI. Micro-scoop for Manipulation of Micro Objects: Use of Fabricated Cantilever with Atomic Force Microscope, Small, Vol. 6, pp. 2853-2857, 2010.
• ATSUSHI IKAI. Tensile Mechanics of α-Helical Coil Springs, Advance in Polymer Sciences, Vol. 232, pp. 65-96, 2010.
• 関口博史, 荒川秀雄, 杉山滋, 猪飼篤. リガンドで修飾された高分子を用いた生体分子間相互作用力測定法, 表面科学, Vol. 27, No. 8, pp. 436-441, Aug. 2006.
• Rehana Afrin, Atsushi Ikai. Force profiles of protein pulling with or without cytoskeletal links studied by AFM, Biochem. Biophys. Res. Commun., Vol. 348, pp. 238-244, 2006.
• Atsushi Ikai, Rehana Afrin. Probability of Receptor Unbinding During Ligand Assisted Tether Elongation from the Red Cell Membrane, e-J. Surf. Sci. Nanotech., Vol. 4, pp. 273-275, 2006.
• Katsunori Tagami, Masaru Tsukada Rehana Afrin, Hiroshi Sekiguchi, Atsushi Ikai. Discontinuous Force Compression Curve of Single Bovine Carbonic Anhydrase Molecule Originated from Atomistic Slip, e-J. Surf. Sci. Nanotech., Vol. 4, pp. 552-558, 2006.
• 関口博史, 荒川秀雄, 杉山滋, 猪飼篤. リガンドで修飾された高分子を用いた生体分子間相互作用 力測定法, 表面科学, Vol. 27, pp. 436-441, 2006.
• Hiroshi Sekiguchi, Atsushi Ikai, Hideo Arakawa, Shigeru Sugiyama. AFM analysis of interaction forces between bio- molecules using ligand-functionalized polymers, e-J. Surf. Sci. Nanotech., Vol. 4, pp. 149-154, 2006.
• Rehana Afrin, Mohammed T. Alam, Atsushi Ikai. Pre-transition and Progressive Softening of Bovine Carbonic Anhydrase II as Probed by Single Molecule Atomic Force Microscopy, Protein Science, Vol. 14, pp. 1447-1457, 2005.
• Atsushi Ikai. Local rigidity of a single protein molecule, Biophysical Chemistry, Vol. 116, pp. 187-191, 2005.
• Atsushi Ikai. Nanomechanics of Protein-Based Biostructures, JSAPI, Vol. 11, pp. 4-15, 2005.
• Kodama, T., Ohtani, H., Arakawa, H., Ikai, A.. Mechanical perturbation-induced fluorescence change of green fluorescent protein., Applied Physics Letters, Vol. 86, pp. 86043901-1 - 043901-3, 2005.
• 猪飼　篤. 原子間力顕微鏡による生体構造のナノ力学測定, 高分子論文集, Vol. 61, pp. 595-600, 2004.
• Rehana Afrin, Takafumi Yamada, Atsushi Ikai. Analysis of force curves obtained on the live cell membrane using chemically modified AFM probes, Ultramicroscopy, Vol. 100, pp. 187-195, 2004.
• Afrin, R., Okazaki, S., Ikai, A.. Force spectroscopy of covalent bond rupture vs. protein extraction., Applied Surface Science (2004) 238:47-50., Vol. 238, pp. 47-50, 2004.
• Yamada, T., Afrin, R., Arakawa, H., Ikai, A.. High sensitivity detection of protein molecules picked up on a probe of atomic force microscope based on the fluorescence detection by a total internal reflection fluorescence microscope, FEBS Letters (2004) 569:59-64., Vol. 569, pp. 59-64, 2004.
• Kodama, T., Ohtani, H., Arakawa, H., Ikai, A. Atomic force microscope equipped with confocal laser scanning microscope for the spectroscopic measurement of the contact area in liquid., Chemical Physics Letters, Vol. 385, pp. 507-511, 2004.
• Takigami S, Wakabayashi Y, Ohsako S, Ohkura S, Okamura H, Ikai A, Ichikawa M, Osada T.. Fetal development of vomeronasal system in the goat., Brain Res Dev Brain Res., Vol. 149, pp. 113-120, 2004.
• T. Okajima, H. Arakawa, M. T. Alam, H. Sekiguchi, A. Ikai. Dynamics of a partially stretched protein molecule studied using an atomic force microscope, Biophysical Chemistry, Vol. 104, pp. 51-61, 2004.
• Saito R, Sato T, Ikai A, Tanaka N.. Structure of bovine carbonic anhydrase II at 1.95 A resolution., Acta Crystallogr D Biol Crystallogr. (2004) 60 792-795, Vol. 60, pp. 792-795, 2004.
• Satoko Ohta, Mohammad Taufiq Alam, Hideo Arakawa, Atsushi Ikai. Origin of Mechanical Strength of Bovine Carbonic Anhydrase Studied by Molecular Dynamics Simulation ., Biophys. J., Vol. 87, pp. 4007-4020, 2004.
• Kodama, T., Ohtani, H., Arakawa, H., Ikai, A.. Development of confocal laser scanning microscope/atomic force microscope sytem for force curve measurement., Jpn. J. Appl. Phys.43 4580 - 4583 (2004)., Vol. 43, pp. 4580-4583, 2004.
• Atsushi Ikai. Nanomechanics of Protein-Based Biostructures, Jpn. J. Applied Physics, Vol. 43, pp. 7365-7375, 2004.
• Hiroshi Sekiguchi, Hideo Arakawa, Hideki Taguchi, Takeshi Ito, Ryohei Kokawa, Atsushi Ikai. Specific Interaction between GroEL and Denatured Protein Measuredby Compression-Free Force Spectroscopy, Biophysical Journal, Vol. 85, pp. 484–490, July 2003.
• Ikai, A., Afrin, R., Sekiguchi, H., Okajima, T., Alam, M.T., Nishida, S. Methods in Single Protein Stretching using the Atomic Force Microscope, Current Protein and Polypeptide Science, Vol. 4, pp. 181-193, 2003.
• Afrin R., Arakawa, H., Osada, T., Ikai, A.. Extraction of Membrane Proteins from Living Cell Surface Using the Atomic Force Microscope and Covalent Crosslinkers, Cell Biochemistry and Biophysics, Vol. 39, pp. 101-118, 2003.
• Sekiguchi, H., Arakawa, H., Taguchi, H., Itoh, T., Kokawa, R.and Atsushi Ikai. Specific Interaction between GroEL and Denatured Protein Measured by Non-pushing Force Spectroscopy, Biophys. J., Vol. 85, pp. 484-490, 2003.
• Hertadi, R., Gruswitz, F., Silver, L., Koide, A., Koide, S., Arakawa, H., Ikai, A.. Unfolding Mechanics of Multiple OspA Substructures Investigated with Single Molecule Force Spectroscopy., J Mol Biol., Vol. 333, pp. 993-1002, 2003.
• H. Sekiguchi, T. Okajima, H. Arakawa, S. Maeda, A. Takashima, A. Ikai. Frequency Shift Feedback Imaging in Liquid for Biological Molecules, Appl. Surf. Sci., Vol. 210, pp. 61-67, 2003.
• T. Okajima, H. Sekiguchi, H. Arakawa, A. Ikai. Self-oscillation technique for AFM in liquids Appl., Appl. Surf. Sci., Vol. 210, pp. 68-72, 2003.
• Idiris A, Ohtsubo K, Yoza K, Osada T, Nakamichi N, Matsumura T, Ikai A.. Molecular cloning and structural characterization of the hagfish proteinase inhibitor of the alpha-2-macroglobulin family, J Protein Chem., Vol. 22, pp. 89-98, 2003.
• A. Ikai, A. Idiris, H. Sekiguchi, H. Arakawa, S. Nishida. Intra- and intermolecular mechanics of proteins and polypeptides studied by AFM: with applications, Applied Surface Science, Vol. 188, pp. 506, Mar. 2002.  公式リンク  
  
• Nishida, S., Ikai, A.. Combination of AFM with an objective-type TIRFM (total internal reflection fluorescence microscope) for nano-manipulation of single cells, Ultramicroscopy, Vol. 91, pp. 269-274, 2002.
• Ikai, A., Afrin, R., Itoh, A., Thogersen, H.C., Hayashi, Y., Osada, T.. Force Measurements for Membrane Protein Manipulation, Colloids and Surfaces, Colloids and Surfaces, B: Biointerfaces, Vol. 23, pp. 165-171, 2002.
• Kim, H., Arakawa, H., Osada, T., Ikai, A.. Mechanical identification of the core structure of bovine carbonic anhydrase B by atomic force microscope, Ultramicroscopy, Vol. 91, pp. 253-259, 2002.
• Sun, Y., Arakawa, H., Osada, T., Ikai A.. Tapping and Contact Mode Imaging of Native Chromosomes and Extraction of Genomic DNA using AFM Tips, Applied Surface Science, Vol. 188, pp. 499-505, 2002.
• Kim, H., Arakawa, H., Osada, T., Ikai, A... Quantification of Cell Adhesion Interactions by AFM: Effects of LPS/PMA on the adhesion of C6 glioma cell to collagen type I, Applied Surface Science, Vol. 188, pp. 493-498, 2002.
• Gad, M., Awai, K., Shimojima, M., Yamaryo, Y., Shimada, H., Masuda, T., Talamiya, K., Ikai, A., Ohta, H.. Accumulation of Plant Galactolipid Affects Cell Morphology of Escherichia coli, Biochem. Biophys. Res. Commun., Vol. 286, pp. 114-118, 2002.
• Rukman Hertadi, Atsushi Ikai. Unfolding Mechanics of Holo and Apo Calmodulins studied by Atomic Force Microscope, Protein Science, Vol. 11, pp. 1532-1538, 2002.
• Ikai, A.. Nanomechanics of Proteins with Applications, Superlattices and Microstructures, Vol. 31, pp. 43-62, 2002.
• Atsushi Ikai, Alimjan Idiris, Tong Wang, M.Taufiq Alam, Rehana Afrin, Kim Hyonchol, Hiroshi Sekiguchi, Shuhei Nishida, Hideo Arakawa, Toshiya Osada. Nanotechnology and Protein Mechanics, Journal of Bilogical Physics, Vol. 28, pp. 561-572, 2002.
• Rehana Afrin, Atsushi Ikai. Development of mapping and extraction methods of cell surface proteins,, Biorheology (Japanese Society of Biorheology), Vol. 16, pp. 23-26, 2002.
• Hiroshi Sekiguchi, Hideo Arakawa, Takaharu Okajima, Atsushi Ikai. Non-destructive Force Measurement in Liquid Using Atomic Force Microscope, Applied Surface Science, Vol. 188, pp. 489-492, 2002.
• Kim, H., Arakawa, H., Osada, T., Ikai, A.. Quantification of Cell Adhesion Interactions by AFM: Effects of LPS/PMA on the adhesion of C6 glioma cell to collagen type I, Applied Surface Science, Vol. 188, pp. 493-498, 2002.
• Takafumi Yamada, Hideo Arakawa, Takaharu Okajima, Takayoshi Shimada, Atsushi Ikai. Use of AFM for imaging and measurement of the mechanical properties of light-convertible organelles in plant, Ultramicroscopy, Vol. 91, pp. 261-268, 2002.
• Atsushi Ikai, Alimjan Idiris, Hiroshi Sekiguchi Hideo Arakawa, Shuhei Nishida. Intra- and Intermolecular Mechanics of Proteins and Polypeptides Studied by AFM: with Applications, Applied Surface Science, Vol. 188, pp. 506-512, 2002.
• Athauda, S.B.P., Nishigai, M., Arakawa, H., Ikai, A., Takahashi, K. Limited proteolysis of alpha-2-macroglobulin by cathepsin D and structural chages in the inhibitor, Biomedical Res., Vol. 23, pp. 199-201, 2002.
• Matsuoka, M, Osada, T, Yoshida-Matsuoka J., Ikai, A., Ichikawa, M., Norita, M., Costanzo, R.. A comparative immunocytochemical study of development and regeneration of　chemosensory neurons in the rat vomeronasal system,, Brain Research, Vol. 946, pp. 52-63, 2002.
• Gad, M, KOICHIRO AWAI, Mie Shimojima, Yoshiki Yamaryo, Shimada, H, Masuda, T, KEN-ICHIRO TAKAMIYA, ATSUSHI IKAI, HIROYUKI OHTA. Accumulation of plant galactolipid affects cell morphology of Escherichia coli, Biochemical and Biophysical Research Communications, Vol. 286, No. 1, pp. 114-118, Aug. 2001.  公式リンク  
  
• M.T.Alam, A. Ikai. Detection of Two Conformers of Bovine Carbonic Anhydrase by Atomic Force Microsope, Applied Physics A 72 S121-S124 (2001), Vol. 72, pp. S121-124, 2001.
• T. Wang, H. Arakawa, A. Ikai. Force-Extension measurements and inhibitor binding assay of monomer and engineered dimers of bovine carbonic anhydrase B, Biochem. Biophys. Res. Commun., Vol. 285, pp. 9-14, 2001.
• A. Ikai, Y. Alimujiang. Force-Extension Curve of Dimerized Poly-glutamic Acid, Applied Physics, Applied Physics A, Vol. 72, pp. S1127-S120, 2001.
• A.Idiris, M.T.Alam, A.Ikai. Spring Mechanics of Alpha-Helical Polypeptide, Protein Engineering, Vol. 13, pp. 763-760, 2000.
• K.Mitsui, K. Nakajima, H.Arakawa, M.Hara, A. Ikai. Dynamic Mearsurement of Single Protein's Mechanical Properties,, Biochem. Biophys. Res. Commun. vol. 272 (2000) 55-63, Vol. 272, pp. 55-63, 2000.
• Ikai, A., Wang, T. Protein Stretching IV. Analysis of the Force-Extension Curves., Jpn. J. Appl. Phys., Vol. 39, pp. 3784-3788, 2000.
• Ikai, A., Ookata, K., Shimizu, M., Nakamichi, N., Ito, M., Matsumura, T.. A recombinant bait region mutant of human　alpha-2-macroglobulin exhibiting an altered proteinase-inhibiting spectrum, Cytotechnology, Vol. 31, pp. 53-60, 1999.
• 猪飼篤. 原子間力顕微鏡による染色体微小領域からの遺伝子DNAの採取・贈幅・塩基配列解析, 精密工学誌, Vol. 65, pp. 191-195, 1999.
• Ikai, A., Takezawa, S., Itoh, A., Arakawa, H., Ichikawa, M., Matsumura, T.. A recombinant bait region mutant of human alpha-2-macroglobulin exhibiting an altered proteinase-inhibiting spectrum, Cytotechnology, Vol. 31, pp. 51-60, 1999.
• Tong Wang, Atsushi Ikai. Protein Stretching III. Force expention curves of tethered bovine carbonic anhydrase B to the silicon substrate under native, intermediate and denaturing conditions., Jap. J. Appl. Phys., Vol. 38, pp. 3912-3917, 1999.
• Takeda, S., Kirihara, S., Arakawa, H., Ikai, A., Arisaka, F.. Comparative imaging of the baseplate of bacteriophage T4 with atomic force microscopy and electron microscopy. , Res. Commun. in Biochemistry, Cell and Molecular Biology 3, 181-192 (1999), Vol. 3, pp. 181-192, 1999.
• Osada T, Ikai A, Costanzo RM, Matsuoka M, Ichikawa M. Continual neurogenesis of vomeronasal neurons in vitro. , Neurobiol., Vol. 40, pp. 226-233, 1999.
• Osada, T., Takezawa, S., Itoh, A., Arakawa, H., Ichikawa, M., Ikai, A. . The distribution of sugar chains on the vomeronasal epithelium observed with the atomic force microscope. , Chemical　Senses, Vol. 24, pp. 1-6, 1999.
• Xue-ming Xu, Atsushi Ikai. Single-Copy Genomic DNA from a Nanometer Region of hromosomes: A New and Potential Application of AFM in Genomic Research, Biochm. Biophys. Res. Commun., Vol. 248, pp. 744-748, 1998.
• IKAI A, Mitsui K, Tokuoka H, Xu XM. Mechanical measurements of a single protein molecule and human chromosomes by atomic force microscopy, Materials Science and Engineering: C, Vol. 4, Page 233-240, Apr. 1997.
• ATSUSHI IKAI. STM and AFM of Bio/organic molecules and structures, Surface Science Reports, Vol. 26, pp. 261-332, 1996.
• Muhammed Gad, Atsushi Ikai. Dynamic Observation of Yeast Cells with Atomic Force Microscopy, Biophys. J., Vol. 69, pp. 2226-2233, 1995.
• ATSUSHI IKAI. Inhibition of CathePsin E by a 2-Macroglobulin and the ResultingStructural Changes in the Inhibitor, J. Biochem, No. 113, pp. 526, 1993.
• ATSUSHI IKAI. A Receptor Mediated Delivery of HIV-1 Derived Peptide Vaccine, Biochem Biophys Res Commun, Vol. 194, pp. 1155, 1993.
• ATSUSHI IKAI. Atomic Force Microscopy of Bacteriophage T4 and Its Tube-BasePlate Complex, FEBS Letters, No. 326, pp. 39, 1993.
• ATSUSHI IKAI. Direct Kinetics of Bait Region Cleavage of a-2-Macroglobulin by a Rapid Quenching Method, FEBS Letters, No. 326, pp. 80, 1993.
• ATSUSHI IKAI. A Receptor mediated Antigen Delivery and Incorporation System : Administration of a 2-Macroglobulin-Cytochrome c Conjugate Induced High Concentrations of Antibodies against Cytochrome c in Mice, Biochem Biophys Res Commun, No. 191, pp. 1326, 1993.
• ATSUSHI IKAI. Isolation and Characterlzation of a Novel Serine Proteinase Complexed with a 2-Macroglobulin from Porcine Castric Mucosa, J. Biol Chem, No. 268, pp. 527, 1993.
• ATSUSHI IKAI. High Resolution Images of Cell Surface Using a Tapping-Model Atomic Force Microscope, Jpn. J. Appl Physics, No. 32, pp. 1711, 1993.
• ATSUSHI IKAI. Structure and Properties of the 26S Protease Complex from Chick Skeletal Muscle, Biochemistry and Molecular Biology International, No. 30, pp. 121, 1993.
• ATSUSHI IKAI. Entrapment and Inhibition of Numan ImmunodeficiencY Virus Proteinase by a2-Macroglobulin and Structural Changes in the Inhibitor, J. Biochem, No. 113, pp. 742, 1993.
• ATSUSHI IKAI. Nanometric Scale Biosample Observation Using a Photon Scanning Tunneling Microscope, Jpn. J. of Appl. Phys., pp. 31, 1992.
• ATSUSHI IKAI. X-ray scattering study of hagfish protease inhibitor, a protein structurally related to complement and alpha-2-macroglubulin, Biochemistry, pp. 30, 1991.
• ATSUSHI IKAI. Structure of α┣D22┫D2-Macroglubulin from the Arthropod ┣DBLimulus polyphemus(/)-┫DB, J. Biol. Chem., pp. 266, 1991.
• ATSUSHI IKAI. Electron microscopic demonstration of a common structural motif in human complement factor C3 and rat α┣D21┫D2-inhibitor 3(murinoglobulin), FEBS Letters., pp. 260, 1990.
• ATSUSHI IKAI. Internal Structure of Ovomacroglobulin, J. Biol. Chem., pp. 256, 1990.
• ATSUSHI IKAI. α┣D22┫D2-Macroglobulin Traps a Proteinase in the Midregion of Its Arms : an immunoelectron micro-scopic study, J. Biol. Chem., pp. 264, 1989.
• ATSUSHI IKAI. Structural Dynamics of Alpha-2-Macroglobulin and Fatty Acid Synthetase Studied by Time-Resolved X-Ray Small Angle Scattering Experiment, Photon Factory Activity Report, pp. 132, 1988.
• ATSUSHI IKAI. Structure of Fatty Acid Sysnthetase from the Harderian Gland of Guinea Pig, J. Mol. Biol., pp. 203, 1988.

著書

• 猪飼篤, 伏見 譲, 櫻井実. バイオサイエンスのための物理化学 第5版, 東京化学同人, 東京化学同人, 11-13章, 2015.
• 猪飼　篤. なっとくする生化学, 講談社, May 2003.
• 猪飼篤. はじめての物理化学, 東京化学同人, 東京化学同人, 2000.
• 猪飼　篤, 野島　博. 生化学分子生物学演習, 東京化学同人, 東京化学同人, 1996.
• 猪飼篤. 基礎の生化学, 東京化学同人, 東京化学同人, 1992.

国際会議発表 (査読なし・不明)

• KIKUO KISHIMOTO, David Lee, Yotaro Shinozawa, Kazuaki Inaba, Rehana Afrin, Atsushi Ikai. Mechanical Analysis of the Bio Cell Subjected to AFM Loading, Internattional Workshop on Biomedical Engineering & Biomechanics, Internattional Workshop on Biomedical Engineering & Biomechanics, Xi'an Jiaotong University, p. 33, Aug. 2011.
• David Lee, Kikuo Kishimoto, Atsushi Ikai, Kazuaki Inaba. MONTE CARLO SIMULATION STUDY OF A RED BLOOD CELL CYTOSKELETON UNDER AFM LOADING, Asian Pacific Conference for Materials and Mechanics 2009, Proceedings of Asian Pacific Conference for Materials and Mechanics 2009, JSME, pp. 1-4, Nov. 2009.
• KIKUO KISHIMOTO, David Lee, ATSUSHI IKAI, Machida Shinichi. Monte Carlo Simulation Study of a Red Blood Cell Cytoskeleton under AFM Loading, The 5th Tokyo Tech.-POSTECH-KUN Joint Workshop on Mechanical Engineering, The 5th Tokyo Tech.-POSTECH-KUN Joint Workshop on Mechanical Engineering, pp. 18-19, Sept. 2009.

国内会議発表 (査読なし・不明)

• 町田 真一, 中路 雅登, 中山 隆宏, Lee David, 関口 博史, 岸本 喜久雄, Afrin Rehana, 猪飼篤. 26pPSA-41 原子間力顕微鏡を用いた力学的計測による赤血球細胞骨格の構造解析(領域12ポスターセッション,領域12,ソフトマター物理,化学物理,生物物理), 日本物理学会講演概要集, 社団法人日本物理学会, Vol. 64, No. 2, July 2009.
• リー デビッド, 岸本 喜久雄, 猪飼篤, 町田 真一. OS1015 赤血球細胞骨格を対象にした原子間力顕微鏡引張試験の深針接続に関する確率解析(生体と材料力学,オーガナイズドセッション), M&M材料力学カンファレンス, 一般社団法人日本機械学会, Vol. 2009, No. 0, June 2009.
• 関口 博史, 日高 敦, 志賀 嘉仁, 猪飼篤, 長田 俊哉. 電気泳動したタンパク質のAFM力学測定による高感度検出, 表面科学 : hyomen kagaku = Journal of the Surface Science Society of Japan, 日本表面科学会, Vol. 30, No. 6, May 2009.
• 猪飼篤. 結び目構造を持つタンパク質の原子間力顕微鏡による延伸実験(結び目とソフトマター物理学:高分子のトポロジー、そして物理学、数学および生物学における関連する話題,研究会報告), 物性研究, 物性研究刊行会, Vol. 92, No. 1, Mar. 2009.

学位論文

• ,  Master of Science, 
• ,  本文,  Doctor, 

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