論文

• Takashi Kanamori, Akihiro Takamura, Nobuhiro Tago, Yoshiaki Masaki, Akihiro Ohkubo, Mitsuo Sekine, Kohji Seio. Fluorescence enhancement of oligodeoxynucleotides modified with green fluorescent protein chromophore mimics upon triplex formation., Org. Biomol. Chem., Vol. 15, pp. 1190-1197, Jan. 2017.
• Yu Ito, Yoshiaki Masaki, Takashi Kanamori, Akihiro Ohkubo, KOHJI SEIO, MITSUO SEKINE. Synthesis of 5-[3-(2-aminopyrimidin-4-yl)aminopropyn-1-yl]uracil derivative that recognizes Ade-Thy base pairs in double-stranded DNA, Bioorg. Med. Chem. Lett., Vol. 26, pp. 194-196, Jan. 2016.
• Nobuhiro Tago, Yoshiaki Masaki, Takashi Kanamori, Akihiro Ohkubo, KOHJI SEIO, MITSUO SEKINE. A New Microfluidic Phase-Transfer Reaction Using HPLC Guard Columns as the Reactor for the N3 Protection of Uridine Derivatives, SYNLETT, Vol. 26, pp. 2578-2582, Nov. 2015.
• Ohkubo, Kenji Yamada, Yu Ito, Kiichi Yoshimura, Koichiro Miyauchi, Takashi Kanamori, Yoshiaki Masaki, KOHJI SEIO, HIDEYA YUASA, Mitsuo. Synthesis and Triplex-forming Properties of Oligonucleotides Capable of Recognizing Corresponding DNA Duplexes Containing Four Base Pairs, Nucleic Acids Res., Vol. 43, No. 12, pp. 5675-5686, May 2015.
• Takahito Tomori, Yuya Miyatake, Takashi Kanamori, Yoshiaki Masaki, Akihiro Ohkubo, KOHJI SEIO, MITSUO SEKINE. Synthesis of peptide nucleic acids containing pyridazine derivatives as cytosine and thymine analogs, and their duplexes with complementary oligodeoxynucleotides, ORG. LETT., Vol. 17, 6, pp. 1609-1612, Mar. 2015.
• munefumi tokugawa, Kazuhei Kaneko, Masanori Saito, Takashi Kanamori, Yoshiaki Masaki, Akihiro Ohkubo, KOHJI SEIO, MITSUO SEKINE. Synthesis of responsive fluorescent Nucleobases 7-(Benzofuran-2-yl)-7- deazahypoxanthine and 7-(benzofuran-2-yl)-7-deazaguanine using cross-coupling reaction, CHEM. LETT., Vol. 44, pp. 64-66, Jan. 2015.
• Takashi Kanamori, Hiroki Ohzeki, Yoshiaki Masaki, Akihiro Ohkubo, MITSUO SEKINE, KOHJI SEIO. Controlling the fluorescence of benzofuran-modified uracil residues in oligonucleotides by triple-helix formation, Chembiochem, Vol. 16, 1, pp. 167-176, Jan. 2015.
• Rie Yatsunami, Ai Ando, Yang Zhang, Shinichi Takaichi, Masahiro Kohno, Yuriko Matsumura, Hiroshi Ikeda, Toshiaki Fukui, Kaoru Nakasone, Nobuyuki Fujita, MITSUO SEKINE, Tomonori Takashina, Satoshi Nakamura. Identification of carotenoids from the extremely halophilic archaeon Haloarcula japonica, Frontiers in Microbiology, Vol. 5, pp. 100-105, 2014.
• I. Okamoto, K. Seio, M. Sekine. Improved Synthesis of Oligonucleotides Containing 2-Thiouridine Derivatives by Use of Diluted Iodine Solution., Tetrahedron Lett., Vol. 47, pp. 583-585, 2006.
• Hirosuke Tsunoda, Akihiro Ohkubo, Haruhiko Taguchi, Kohji Seio, Mitsuo Sekine. Synthesis and Properties of DNA Oligomers Containing 2'-Deoxycytidine-N-Oxide, Nucleic Acids Res. Symposium Ser., Vol. 50, pp. 189-190, 2006.
• Ryuta Tawarada, Kohji Seio, Mitsuo Sekine. Synthesis and Properties of Artificial Base Pairs by Use of Halogen Bonds, Nucleic Acids Res. Symposium Ser., Vol. 50, pp. 121-122, 2006.
• Haruhiko Taguchi, Akihiro Ohkubo, Kohji Seio, Mitsuo Sekine. Synthesis of Deoxycytidine Derivative and Their Use for the Selective Photo Crosslinking with 5-Methylcytosine, Nucleic Acids Res. Symposium Ser., Vol. 50, pp. 57-58, 2006.
• Masahiro Mizuta, Ken-ichi Miyata, Kohji Seio, Tomofumi Santa, Mitsuo Sekine. Synthesis of Fluorescent Cyclic Cytosine Nucleosides and Their Fluorescent Properties pon Incorporation into Oligonucleotides, Nucleic Acids Res. Symposium Ser., Vol. 50, pp. 19-20, 2006.
• Hisao Saneyoshi, Ken-ichi Miyata, Kohji Seio, Mitsuo Sekine. 1,1-Dihydroperoxycyclododecane as a new, crystalline non-hygroscopic oxidizer for the chemical synthesis of oligodeoxyribonucleotides, Tetrahedron Lett., Vol. 47, pp. 8945-8947, 2006.
• Kohji Seio, Takeshi Sasami, Ryuuta Tawarada, Mitsuo Sekine. Synthesis of 2'-O-methyl-RNAs incorporating a 3-deazaguanine, and UV melting and computational studies on its hybridization properties, Nucleic Acids Res., Vol. 34, pp. 4324-4334, 2006.
• Eri Utagawa, Kohji Seio, Mitsuo Sekine. Use of 1,4-Anhydroerythritol Structures as a Key Skeleton of New Hydroxyl Protecting Groups Removable by Self-cyclization under Oxidative Conditions, J. Org. Chem., Vol. 71, pp. 7668-7677, 2006.
• MITSUO SEKINE. Synthesis and biological properties of new phosmidosine analogs having an N-acylsulfamate linkage, Nucleosides, Nucleotides & Nucleic Acids, Vol. 25, pp. 647-654, 2006.
• Kenichi Miyata, Akio Kobori, Ryuji Tamamushi, Akihiro Ohkubo, Haruhiko Taguchi, Kohji Seio, Mitsuo Sekine. Conformational Studies of 4-N-Carbamoyldeoxycytidine Derivatives and Synthesis and Hybridization Properties of Oligodeoxyribonucleotides Incorporating these Modified Bases, Eur. J. Org. Chem., Vol. 16, pp. 3626-3637, 2006.
• Okamoto, K. Seio, M. Sekine. Triplex Forming Ability of Oligonucleotides Containing 2'-O-Methyl-2-thiouridine or 2-Thiothymidine., Chem. Lett., Vol. 35, pp. 136-137, 2006.
• A. Ohkubo, K. Aoki, H. Taguchi, K. Seio, M. Sekine. Development of New N-Unprotected Phosphoramidite Building Blocks Having a Silyl-Type Linker, Nucleic Acids Symposium Ser., Vol. 49, pp. 127-128, 2005.
• H. Saneyoshi, K. Seio, M. Sekine. A General Method for the Synthesis of 2'-O-Cyanoethylated Oligoribonucleotides Having Promising Hybridization Affinity for DNA and RNA and Enhanced Nuclease Resistance, J. Org. Chem., Vol. 70, pp. 10453-10460, 2005.
• K. Seio, T. Miyashita, K. Sato, M. Sekin, MITSUO SEKINE. Synthesis and Properties of New Nucleotide Analogs Having a Squaryl Amide Moiety as a New Phosphate Isoster, Eur. J. Org. Chem., pp. 5163-5170, 2005.
• E. Utagawa, K. Seio, M. Sekine. A New Protecting Group for the 5'-Hydroxyl Group Having O-S Single BOnd Oxidatively Cleavable under Mild Conditions,, Nucleosides Nucleotides, Nucleic Acids, Vol. 24, pp. 5-7,927-929, 2005.
• B. Karwowski, K. Seio, M. Sekine. 4,5-bis(ethoxycarbonyl)-[1,3]dioxolan-2-yl as a new orthoester-type protecting group for the 2'-hydroxyl function in the chemical synthesis of RNA, Nucleosides, Nucleotides, Nucleic Acids, Vol. 24, pp. 1111-1114, 2005.
• K. Seio, M. Mizuta, T. Terada, M. Sekine. Use of Ferrocene Scaffolds as Pendant Groups in Hairpin-Type Pyrrole-Imidazole Polyamide Molecules Showing Sequence-Selective Binding to DNA Duplexes.,, J. Org. Chem., Vol. 70, pp. 10311-10322, 2005.
• A. Ohkubo, K. Sakamoto, K. Miyata, H. Taguchi, K. Seio, M. Sekine. Convenient Synthesis of N-Unprotected Deoxynucleoside 3'-Phosphoramidite Building Blocks by Selective Deacylation of N-Acylated Species and Their Facile Conversion to Other N-Functionalized Derivatives, Org. Lett., Vol. 7, pp. 5389-5392, 2005.
• A. Ohkubo, K. Aoki, Y. Ezawa, Y. Sato, H. Taguchi, K. Seio, M. Sekine. Synthesis of Oligodeoxyribonucleotides Containing Hydroxymethylphosphonate Bonds in the Phosphoramidite Method and Their Hybridization Properties., Tetrahedron Lett., Vol. 46, pp. 8953-8957, 2005.
• A. Ohkubo, R. Kasuya, K. Sakamoto, H. Taguchi, K. Seio, M. Sekine. Analysis by Use of Protected Oligonucleotides Probes., Nucleic Acids Symposium Ser., Vol. 49, pp. 19-20, 2005.
• K. Seio, T. Sasami, A. Ohkubo, M. Sekine. Synthesis and Hybridization Properties of 2'-O-Methyl-RNA Incorporating 3-Deazaguanine Derivatives, Nucleic Acids Symposium Ser., Vol. 49, pp. 21-22, 2005.
• H. Taguchi, T. Narita, K. Seio, M. Sekine. Synthesis of 2'- or 3'-O-Heteroaryl Substituted Nucleic Acid Derivatives and Their Biological Properties, Nucleic Acids Symposium Ser., Vol. 49, pp. 113-114, 2005.
• I. Okamoto, K. Seio, M. Sekine. SNPs Analysis by Use of Oligonucleotides Containing 2'-O-Methyl-2-thiouridines., Nucleic Acids Symposium Ser., Vol. 49, pp. 123-124, 2005.
• Mitsuo Sekine, Kazuhiro Okada, Kohji Seio, Hideaki Kakeya, Hiroyuki Osada, Tadashi Sasaki. Synthesis of Chemically Stabilized Phosmidosine Analogs and the Structure-Activity Relationship of Phosmidosine, J. Org. Chem., Vol. 69, pp. 314-326, 2004.
• Akihiro Ohkubo, Kohji Seio, Mitsuo Sekine. A New Strategy for the Synthesis of Oligodeoxynucleotides Directed toward Perfect O-Selective Internucleotidic Bond Formation without Base Protection, Tetrahedron Lett., Vol. 45, pp. 363-366, 2004.
• Akihiro Ohkubo, K. Aoki, Kohji Seio, Mitsuo Sekine. A New Approach for Pyrophosphate Bond Formation Starting from Phosphoramidite Derivatives by Use of 6-Trifluoromethyl-1-hyroxybenzotriazole-Mediated O-N Phosphoryl Migration, Tetrahedron Lett., Vol. 45, pp. 979-982, 2004.
• Tomohisa Moriguchi, Kazuhisa Okada, Kohji Seio, Mitsuo Sekine. Synthesis and Stability of 1-Phenylethenyl Phosphate Derivatives and Their Phosphoryl Transer Activity, Lett. Org. Chem., Vol. １, pp. 140-144, 2004.
• Kohji Seio, Tadashi Sasaki, Mitsuo Sekine. Fine-Tuning of Acid Susceptibility of 4, 4ﾕ-Dimethoxytrityl Ether Derivatives by a Methoxy Group Introduced via a Styryl Substituent, Lett. Org. Chem., Vol. 1, pp. 159-162, 2004.
• Mitsuo Sekine, M. Tobe, T. Nagayama, Takeshi Wada. Synthesis of N-(Trimethylsilylethoxycarbonyl)-deoxycytidine and Deoxyadenosine Derivatives as Key Intermediates for the DNA Synthesis Using Fluoride Ion-Promoted Deprotection Strategy, Lett. Org. Chem., Vol. １, pp. 179-182, 2004.
• Tomohisa Moriguchi, Kazuhisa Okada, Kohji Seio, Mitsuo Sekine. Synthesis of Enol Adenosine 5'-Phosphate Derivatives by the Perkow Reaction of a Silylated Adenosine 5'-Phosphonate Derivative with a-Halo Ketones, Lett. Org. Chem., Vol. ３, pp. 246-248, 2004.
• K. Sato, Ryuya Tawarada, Kohji Seio, Mitsuo Sekine. Synthesis and Structural Properties of New Oligodeoxynucleotide Analogues Containing a 2,5-Internucleotidic Squaryldiamide Linkage Capable of Formation of a Watson-Crick Base Pair with Adenine and a Wobble Base Pair with Guanine at the 3-Downstream Junction Site, Eur. J. Org. Chem., pp. 2142-2150, 2004.
• Mitsuo Sekine, Kazuhisa Okada, Kohji Seio. Hideaki Kakeya, Hiroyuki Osada, Tadashi Sasaki. Structure-Activity Relationship of Phosmidosine: Importance of 7,8-dihydro-8-oxoadenosine Residue for Antitumor Activi, Bioorg. Biomed. Chem., Vol. 12, pp. 5193-5201, 2004.
• Kohji Seio, Eri Utagawa, Mitsuo Sekine. New Protected Protecting Groups for the Oligodeoxyribonucleotide Syntheisi by a Combined Use of a 2-(Hydroxymethyl)benzoyl Skeleton and an Oxidatively Cleavable 4-Methoxytritylthio Group, Helv. Chim. Acta, Vol. 87, pp. 2318-2333, 2004.
• Kohji Seio, M. Mizuta, T. Terada, Mitsuo Sekine. Synthesis and Properties of a Pyrrole-Imidazole Polyamide Having a Ferrocene Dicarboxylic Amide Linker, Tetrahedron Lett., Vol. 45, pp. 6783-6786, 2004.
• A. Strasser, A. Dickmanns, U. Schmidt, E. Penka, H. Urlaub, Mitsuo Sekine, R. Luehrmann, R. Ficner. Crystallization and Preliminary Crystallographic Data of the m3G cap-Binding Domain of Human snRNP Import Factor Snurportin 1, Acta Cryst。 Acta Cryst. Section D, Vol. 60, pp. 1628-1631, 2004.
• Mitsuo Sekine, Kazuhisa Okada, Kohji Seio, Tadashi Sasaki, Hideaki Kakeya, Hiroyuki Osada. Synthesis of a Biotin-Conjugate of Phosmidosine O-Ethyl Ester as a G1 Arrest Antitumor Drug, Bioorg. Biomed. Chem., Vol. １２, pp. 6343-6349, 2004.
• Ken-ichi Miyata, R. Tamamushi, Akihiro Ohkubo, H. Taguchi, Kohji Seio, Mitsuo Sekine. Synthesis and Hybridization Affinity of Oligodeoxyribonucleotides Incorporating 4-N-(N-arylcarbamoyl)deoxycytidine Derivatives, Tetrahedron Lett., Vol. 45, pp. 9365-9368, 2004.
• Hisao Saneyoshi, Keigo Tamaki, Kohji Sekio, Mitsuo Sekine. Synthesis and Properties of 2'-O-Cyanoethylated RNA Derivatives, Nucleic Acids Symp. Series, Vol. 48, pp. 13-14, 2004.
• Kohji Seio, Takeshi Sasami, Mitsuo Sekine. Synthesis and Base Recognition Ability of Oligoribonucleotides Incorporating 2-O-methyl-3-Deazaguanosine, Nucleic Acids Symp. Series, Vol. 48, pp. 65-66, 2004.
• M. Tsunoda, Y. Kusakabe, N. Tanaka, S. Ohno, M. Nakamura, T. Senda, Mitsuo Sekine, T. Yokogawa, K. Nishikawa, T. Nakamura. Three-dimensional Structure of the Ternary Complex of Yeast Tyrosyl-tRNA Synthetase, Nucleic Acids Symp. Series, Vol. 48, pp. 155-156, 2004.
• Masahiro Mizuta, Takeshi Terada, Kohji Seio, Mitsuo Sekine. Properties of Ferrocene-polyamide Compounds as Redox Active DNA binding Molecules toward SNPs Detection, Nucleic Acids Symp. Series, Vol. 48, pp. 237-238, 2004.
• 清尾康志, 関根光雄. 2-チオウリジンを利用したアンチセンス核酸の化学合成と性質 , 生物工学会誌, Vol. 82, pp. 139-141, 2004.
• Kohji Seio, Tadashi Sasaki, M. Baba, Mitsuo Sekine. Bezodithiol-2-yl Substituted Nucleosides as Lead Compounds Having Anti-BVDV Activity: Implication for Anti-HCV Agents, J. Med. Chem., Vol. 47, pp. 5265-5275, 2004.
• Akihiro Ohkubo, Kohji Seio, Mitsuo Sekine. O-Selectivity and Utility of Phosphorylation Mediated by Phosphite Triester Intermediates in N-Unprotected Phosphoramidite Method, J. Am. Chem. Soc., Vol. 126, pp. 5265-5275, 2004.
• Morihiro Aoyagi, Masatoshi Ushioda, Kohji Seio, Mitsuo Sekine. A new 2',3'-cis diol protecting group required for the solid-phase synthesis of capped oligonucleotide derivatives, Nucleic Acids Res. Supplement, Vol. 3, pp. 149-150, 2003.
• 関根光雄. ＤＮＡの革新的化学合成法, 化学工業, Vol. 5, pp. 373-377, 2003.
• M. Sekine, A. Ohkubo, K. Seio. A Proton-Block Strategy in the Phosphoramidite Approach: A New N-Unprotected Method for the Synthesis of Oligodeoxynucleotides Based on the Principle of Simple Acid-Base Reactions., J. Org. Chem., Vol. 68, pp. 5478-5492, 2003.
• Kazuhisa Okada, Haruhiko Taguchi, Kohji Seio, Hideaki Kakeya, Hiroyuki Osada, Takuma Sasaki, Mitsuo Sekine. Synthesis and biological properties of stable phosmidosine analogs, Nucleic Acids Res. Supplement, Vol. 3, pp. 105-106, 2003.
• Kohji Seio, Hisashi Ukawa, Koh-ichiro Shohda, Mitsuo Sekine. Important factors stabilizing stacking interaction between 3-nitropyrrole and natural nucleobases revealed by ab initio calculations, Nucleic Acids Res. Supplement, Vol. ３, pp. 49-50, 2003.
• Itaru Okamoto, Koh-ichiroh Shohda, Kohji Seio, Mitsuo Sekine. Synthesis and properties of 2'-O-alkylated 2-thiouridine derivatives and oligonucleotides containing 2'-O-alkylated 2-thiouridine derivatives, Nucleic Acids Res. Supplement, Vol. 3, pp. 147-148, 2003.
• 和田猛, 関根光雄. 官能基選択的ホスホニル化反応を用いる新規核酸合成法の開発, 有機合成化学協会誌, Vol. 61, No. 10, pp. 961-973, 2003.
• M. Sekine, M. Ushioda, T. Wada, K. Seio. Synthesis of TMG-capped RNA-DNA chimeric oligonucleotides. , Tetrahedron Lett., Vol. 44, pp. 1703-1707, 2003.
• T. Moriguchi, T. Wada, M. Sekine. Synthesis and Properties of Oligodeoxynucleotides Having an N-Phosphoryl Group. , Eur. J. Org. Chem., pp. 2260-2267, 2003.
• K. Seio, K. Kumura, M. Sekine. Enhanced Stereoselectivity in Internucleotide Linkage Formation by the Effective Use of Intrinsically Chiral Ribose Miety of Nucleoside., J. Org. Chem., Vol. 68, pp. 3849-3859, 2003.
• Itaru Okamoto, Koh-ichiroh Shohda, Kohji Seio, Mitsuo Sekine. A New Route to 2ﾕ-O-Alkyl-2-thiouridine Derivatives via 4-O-Protection of the Uracil Base and Hybridization Properties of Oligonucleotides Incorporating These Modified Nucleoside Derivatives, J. Org. Chem., Vol. 68, pp. 9971-9982, 2003.
• K. Takahashi, K. Seio, M. Sekine, O. Hino, M. Esashi. A Photochemical/Chemical Direct Method of Synthesizing High-Performance Deoxyribonucleic Acid Chips for Rapid and Parallel Gene Analysis, Sensors and Actuators, B: Chemical, Vol. 83(1-3), pp. 67-76, 2002.
• M. Ushioda, M. Kadokura, T. Moriguchi, A. Kobori, M. Aoyagi, K. Seio, M. Sekine. A New Finding in Connection with Side Reaction Associated with 5'-Terminal Pyrophosphorylation of Oligodeoxynucleotides on Polymer Supports: Selective Si-O Bond Cleavage by Strong Nucleophilicity of 4-Nitro-6-(triluoromethyl)-1H-1,2,3-benzotriazol-1-ol, Helv. Chim. Acta., Vol. 85, pp. 2930-2945, 2002.
• K. Sato, K. Seio, M. Sekine. Squaryl Group as a New Mimic of Phosphate Group in Modified Oligodeoxynucleotides: Synthesisi and Properties of New Oligodeoxynucleotide Analogues Containing an Internucleotidic Squaryl Amide Linkage., J. Am. Chem. Soc., Vol. 124, pp. 12715-12724, 2002.
• Kohji Seio, Eri Utagawa, Mitsuo Sekine. A New Protecting Group for 5'-Hydroxyl Function of Nucleotides in Oligonucleotide Synthesis without Acid Treatment Utilizing Unique Properties of Tritylthio Group, Nucleic Acids Research Supplement, Vol. 2, pp. 27-28, 2002.
• Akihiro Ohkubo, Yusuke Ezawa, Kohji Seio, Mitsuo Sekine. A New Strategy for the Synthesis of Oligodeoxynucleotides in the Phosphoramidite Method without Base Protection via Phosphite Intermediates, Nucleic Acids Research Supplement, Vol. 2, pp. 29-30, 2002.
• Kenichi Miyata, Akio Kobori, Kohji Seio, Mitsuo Sekine. Hybridization Ability and Base Pair Geometry of Modified Deoxycytidine Derivatives Having a 4-N-Carbamoyl Group, Nucleic Acids Research Supplement, Vol. 2, pp. 161-162, 2002.
• Hisashi Ukawa, Kohji Seio, Mitsuo Sekine. Computational Analysis of Stacking Interactions betwee 3-Nitropyrrole and Natural Nucleobases, Nucleic Acids Research Supplement, Vol. 2, pp. 173-174, 2002.
• Shun-ichi Kawahara, Mitsuo Sekine, Kazunari Taira, Hideyuki Kobayashi, Tadafumi Uchimaru. Theoretical Study of Substitution Effect of the hydrogen Bond Stability of 9-Methylguanine Derivatives and 1-Methylcytosine, Nucleic Acids Research Supplement, Vol. 2, pp. 191-192, 2002.
• Akio Kobori, Ken-ichi Miyata, Masatoshi Ushioda, Kohji Seio, Mitsuo Sekine. A New Silyl Ether-Type Linker Useful for the Automated Synthesis of Oligonucleotides Having Base-Labile Protecting Groups, Chem. Lett., pp. 2-3, 2002.
• Akio Kobori, Kenichi Miyata, Masatoshi Ushioda, Kohji Seio, Mitsuo Sekine. A New Method for the Synthesis of Oligodeoxynucleotides Containing 4-N-Alkoxycarbonyldeoxycytidine Derivatives and Their Hybridization Property., J. Org. Chem., Vol. 67, pp. 476-485, 2002.
• T. Moriguchi, N. Asai, K. Okada, K. Seio, T. Sasaki, M. Sekine. First Synthesis and Anticancer Activity of Phosmidosine and Its Related Compounds, J. Org. Chem., Vol. 67, pp. 3290-3300, 2002.
• Y. Sato, G. Tateno, K. Seio, M. Sekine. A Convenient Method for the Conversion of and beta;-Thymidine to and alpha;-Thymidine Based on TMSOTf-Mediated C1'-Epimerization, Tetrahedron Lett., Vol. 43, pp. 3251-3254, 2002.
• S. Kawahara; T. Uchimaru; K.Taira; M. Sekine.. An Ab Initio Study of the Hydrogen Bond Energy of Base Pairs Formed between Substituted 9-Methylguanine Derivatives and 1-Methylcytosine., J. Phys. Chem. (A), Vol. 106, No. 13, pp. 3207-3212, 2002.
• R.Ishitani; O. Nureki; S. Fukai; T. Kijimoto; N. Nameki; M. Watanabe; H. Kondo ; M. Sekine; N. Okada; S. Nishimura;, S. Yokoyama. Crystal structure of archaeosine tRNA-guanine transglycosylase., J. Mol. Biol., Vol. 318, No. 3, pp. 665-677, 2002.
• Kousuke Sato, Kohji Seio, Mitsuo Sekine. Synthesis and Properties of a New Nucleotide Analogue Containing Squaryl Group, Nuceic Acids Res., Supplement, pp. 121-122, 2001.
• Takeshi Wada, Akihiro Ohkubo, Akira Mochizuki, Mitsuo Sekine. 2-(Azidomethyl)benzoyl as a new protecting group in nucleosides, Tetrahedron Lett., Vol. 42, pp. 1069-1072, 2001.
• Mitsuo Sekine, Osamu Kurasawa, Koh-ichiroh Shohda, Khoji Seio, Takeshi Wada. Synthesis and Conformational Properties of Dinucleoside Triester Derivative Involving Cyclonucleotide Bridge Structure, Eur. J. Org. Chem., pp. 1989-1999, 2001.
• Shun-ichi Kawahara, Tadafumi Uchimaru, Kazunari Taira, Mitsuo Sekine. Ab-Initio Evaluation of the Substitution Effect of the Hydrogen-Bond Energy of the Watson-Crick Type Base-Pair Between 1-Methyluracil and Substituted 9-Methyladenine Derivatives, J. Phys. Chem. (A), Vol. 105, pp. 3894-3898, 2001.
• Shun-ichi Kawahara, Akio Kobori, Mitsuo Sekine, Tadafumi Uchimaru, Kazunori Taira. Ab initio Molecular Orbital Evaluation of the Hydrogen Bond Energy of Base Pairs Formed between Substituted 1-Methylcytosine Derivatives and 9-Methylguanine, Nuceic Acids Res., Supplement, pp. 29-30, 2001.
• Akihiro Ohkubo, Kohji Seio, Mitsuo Sekine. A New Coupling Method for the Synthesis of Oligodeoxyribonucleotides Based on Protection by Protonation of Nnucleoside Bbases, Nuceic Acids Res., Supplement, pp. 77-78, 2001.
• K. Negishi, D. Maehara, S. Nakamura, D. Loakes, l. Worth, Jr. R. M. Schaaper, K. Seio, M. Sekine, T. Negishi. Binding Specificities of the Mismatch Binding Protein, MutS, to Oligonucleotides Containing Modified bases, Nuceic Acids Res., Supplement, pp. 221-222, 2001.
• M. Sekine, T. Moriguchi, T. Wada, K. Seio. Total Synthesis of Agrocin 84 and Phosmidosine as Naturally Occurring Nucleotidic Antibiotics Having P-N Bond Linkages, J. Org. Synth. Chem. Jpn., Vol. 59, No. 11, pp. 1109-1119, 2001.
• Kadokura, T. Wada, K. Seio, T. Moriguchi, J. Huber, R. Luhrmann, M. Sekine. Solid-Phase Synthesis of a 5-Terminal TMG-Capped Trinucleotide Block of U1 snRNA, Tetrahedron Lett., Vol. 42, pp. 8853-8856, 2001.
• Shun-ichi Kawahara, Akio Kobori, Mitsuo Sekine, Kazunari Taira, Tadafumi Uchimaru. Theoretical Study of the Hydrogen Bond Energy of Base Pairs Formed between Substituted 1-Methylcytosine Derivatives and 9-Methylguanine, J. Phys. Chem. (A), Vol. 105, pp. 10596-1061, 2001.
• Takeshi Wada, Akio Kobori, Shun-ichi Kawahara, Mitsuo Sekine. Synthesis and Hybridization Ability of Oligodeoxyribo-nucleotides Incorporating N-Acyldeoxycytidine Derivatives., Eur. J. Org. Chem., pp. 4583-4593, 2001.
• Kohji Seio, Mitsuo Sekine. Synthesis of Pentathymidylate Using a 4-Monomethoxytritylthio (MMTrS) Group as a 5'-Hydroxyl Protecting Group: Toward Oligonucleotide Synthesis without Acid Treatment, Tetrahedron Lett., Vol. 42, pp. 8657-8660, 2001.
• Takeshi Wada, Akira Mochizuki, Seiichiro Higashiya, Hiroyuki Tsuruoka, Shun-ichi Kawahara, Masahide Ishikawa, Mitsuo Sekine. Synthesis and properties of 2-azidodeoxyadenosine and its incorporation into oligodeoxynucleotides, Tetrahedron Letters, Vol. 42, No. 52, pp. 9215-9219, 2001.
• Yuichi Sato, Gohsuke Tateno, Kohji Seio, Mitsuo Sekine. Substituent and Solvent Effects of TMS-triflate mediated C1'-Epimerization of beta-Thymidine to alpha-Thymidine, Eur. J. Org. Chem., pp. 4583-4593, 2001.
• Shun-ichi Kawahara, Tadafumi Uchimaru, Mitsuo Sekine. The Hydrogen Bond Energy on Mismatched Base Pair Formation between Uracil Derivatives and Guanine in the Gas Phase and in the Aqueous-phase, J. Mol. Struct.(THEOCHEM), Vol. 530, pp. 109-117, 2000.
• Hiroshi Matsuo, Tomohisa Moriguchi, Toshimitsu Takagi, Takahiro Kusakabe, Stephen Buratowski, Mitsuo Sekine, Yoshimasa Kyogoku, Gerhard Wagner. Efficient Synthesis of ¹³C, ¹⁵N-Labeled RNA Containing the Cap Structure m⁷GpppA, J. Am. Chem. Soc., Vol. 122, No. 11, pp. 2417-2421, 2000.
• 関根光雄. コンホメーション固定による人工機能核酸の合成, 有機合成化学協会誌, Vol. 58, No. 1, pp. 2-13, 2000.
• Kohji Seio, Takeshi Wada, Mitsuo Sekine. Synthesis and Properties of Oligodeoxythymidylates Incorporating an Artificial Bend Motif, Helv. Chim. Acta, Vol. 83, pp. 162-180, 2000.
• Katsutoshi Ushioda, Michinori Kadokura, Tomohisa Moriguchi, Takeshi Wada, Kohji Seio, Mitsuo Sekine. Solid-Phase Synthesis of Deoxyribonucelotides Having a Cap Structure Analogue, Nucleic Acids Symposium Ser., Vol. 44, pp. 123-124, 2000.
• Shun-ichi Kawahara, Kazunari Taira, Mitsuo Sekine, Tadafumi Uchimaru. Evaluation of the Hydrogen Bond Energy of Base Pairs Formed between Substituted 9-Methyladenine Derivatives and 1-Methyluracil by Use of Molecular Orbital Theory, Nucleic Acids Symposium Ser., Vol. 44, pp. 237-238, 2000.
• Tomohisa Moriguchi, Terukazu Yanagi, Masao Kunimori, Takeshi Wada, Mitsuo Sekineitsuo. Synthesis and Properties of Aminoacylamido-AMP:Chemical Optimization for the Construction of an N-Acyl Phosphoramidate Linkage, J. Org. Chem., Vol. 165, pp. 8229-8238, 2000.
• Mitsuo Sekine, Osamu Kurasawa, Koh-ichiroh Shohda, Khoji Seio, Takeshi Wada. Synthesis and Properties of Oligonucleotides Having a Phosphorus Chiral Center by Incorporation of Conformationally Rigid 5'-Cyclouridylic Acid Derivatives, J. Org. Chem., Vol. 65, pp. 6515-6524, 2000.
• Michinori Kadokura, Takeshi Wada, Kohji Seio, Mitsuo Sekine. Synthesis of 4-Thiouridine, 6-Thioinosine and 6-Thioguanosine 3',5-O-Bisphosphates as Donor Molecules for RNA Ligation and Their Application to the Synthesis of Photoactivatable TMG-Gapped U1 RNA Fragments, J. Org. Chem., Vol. 65, pp. 5104-5113, 2000.
• Hiroyuki Tsuruoka, Koh-ichiroh Shohda, Takeshi Wada, Mitsuo Sekine. Synthesis and Conformational Properties of Oligonucleotides Incorporating 2'-O-phosphorylated Ribonucleotide as Structural Motifs of Pre-tRNA Splicing Intermediate, J. Org. Chem., Vol. 65, pp. 7479-7494, 2000.
• Yuichi Satoh, Gousuke Tateno, Takeshi Wada, Kohji Seio, Mitsuo Sekine. Chemical Synthesis of Hydroxymethylphosphonate of a-DNA, Nucleic Acids Symposium Ser., Vol. 44, pp. 131-132, 2000.
• Koh-ichiroh Shohda, Itaru Okamoto, Takeshi Wada, Kohji Seio, Mitsuo Sekine. Synthesis and Properties of 2'-O-Methyl-2-thiouridine and Oligoribonucleotides Containing 2'-O-Methyl-2-thiouridine, Bioorg. Med. Chem. Lett., Vol. 10, pp. 1795-1798, 2000.
• Mitsuo Sekine, Osamu Kurasawa, Koh-ichiroh Shohda, Kohji Seio, Takeshi Wada. Synthesis and Properties of Oligodeoxynucleotides Incorporating a Conformationally Ridid Uridine Unit Having a Cyclic Structure at the 5'-Terminal Site, J. Org. Chem., Vol. 65, No. 12, pp. 3571-3578, 2000.
• Tomohisa Moriguchi, Norio Asai, Takeshi Wada, Kohji Seio, Takuma Sasaki, Mitsuo Sekine. Synthesis and Antitumor Activities of Phosmidosine A and its N-Acylated Derivative, Tetrahedron Lett., Vol. 41, pp. 5881-5885, 2000.
• Y. Noguchi, A. Ishii, A. Matsushima, D. Haishi, K. Yasumuro, T. Moriguchi et al., MITSUO SEKINE. Isolation of Biuopterin-a-glucoside from Spirulina (Arthrospira) platensis and Its Physiologic Function, Mar. Biotechnol, Vol. 1, pp. 207-210, 1999.
• M. Sekine, T. Hata. Chemical Synthesis of Oligonucleotides by Use of Phenylthio Group, Current Organic Chemistry, Vol. 3, pp. 25-66, 1999.
• K. Shohda, I. Okamoto, T. Wada, M. Sekine. Synthesis and Properties of Oligonucleotides COntaining 2'-O-Methyl-2-thiouridine, Nucleic Acids Symposium Series, Vol. 42, pp. 161-162, 1999.
• T. Moriguchi, N. Asai, T. Wada, M. Sekine. Synthesis of Nucleotide Antibiotics Having N-Acyl Phosphoramidate Linkages, Nucleic Acids Symposium Series, Vol. 42, pp. 15-16, 1999.
• Hiroyuki Tsuruoka, Takeshi Wada, Mitsuo Sekine. Selective and Facile 5'-De(thio)phosphorylation of Oligodeoxynucleotldes Having a 5'-Terminal Phosphorothioate Group by Simple Thermolysis, Tetrahedron Lett, Vol. 40, pp. 8411-8414, 1999.
• S. Kawahara, T. Wada, S. Kawauchi, T. Uchimaru, M. Sekine. Ab initio and Density Functional Studies of Substituent Effects of an A-U Base-Pair on the Stability of Hydrogen Bonding, J. Phys. Chem. (A), Vol. 103, pp. 8516-8523, 1999.
• T. Moriguchi, T. Yanagi, T. Wada, M. Sekine. 31P NMR Study on Aminoacylation of 5'-AMP and Its Analogs, J. Chem. Soc., Perkin I, pp. 1859-1866, 1999.
• T. Wada, F. Honda, Y. Sato, M. Sekine. First Synthesis of H-Phosphonate Oligonucleotides Bearing N-Unmodified Bases, Tetrahedron Lett., Vol. 40, pp. 915-918, 1999.
• M. Sekine, M. Kadokura, T. Satoh, T. Wada, K. Seio. The Chemical Synthesis of Hypermethylated Capped RNA on Polymer Supports, J. Mol. Science, Vol. 15, pp. 318, 1999.
• J. Huber, U. Cronshagen, M. Kadokura, C. Marshallsay, T. Wada, M. Sekine, R. L殄rmann. Snurportin 1, an m3G-cap-specific nuclear import receptor with a novel domain structure, EMBO J., Vol. 17, pp. 4114-4126, 1998.
• T. Wada, A. Kobori, S. kawahara, M. Sekine. Synthesis and Properties of Oligodeoxyribonucleotides Containing 4-N-Acetylcytosine Bases, Tetrahedron Lett., Vol. 39, pp. 6907-6910, 1998.
• K. Shohda, S. Kouguchi, T. Wada, M. Sekine. Synthesis and Incorporation of Conformationally Fixed Bend RNA Structural Motifs into Oligonucleotides, Nucleic Acids Symposium Ser., Vol. 39, pp. 91-92, 1998.
• T. Wada, A. Kobori, S. Kawahara, M. Sekine. Synthesis and Properties of DNA Oligomers Containing 4-N-Acylated Cytosine Bases, Nucleic Acids Symposium Ser., Vol. 39, pp. 23-24, 1998.
• K. Shohda, T. Wada, Mitsuo Sekine. Detailed Studies on Trimethylsilyl Triflate Mediated Glycosylation via a 3,5-O-(1,1,3,3-tetraisopropyl-disiloxan-1,3-diyl)-2-O-methylribofuranoside 1-O-Trichloroacetimidate Intermediate, Nucleosides Nucleotides, Vol. 17, pp. 2199-2210, 1998.
• T. Wada, A. Mochizuki, Y. Sato, M. SekineTetrahedron Lett.. Functionalization of Solid Supports with N-Unprotected Deoxyribonucleosides, Tetrahedron Lett., Vol. 39, pp. 5593-5596, 1998.
• T. Wada, A. Mochizuki, Y. Sato, M. Sekine. A Convenient Method for Phosphorylation Involving a Facile Oxidation of H-Phosphonate Monoesters via Bis(trimethylsilyl) Phosphites, Tetrahedron Lett., Vol. 39, pp. 7123-7126, 1998.
• T. Moriguchi, T. Yanagi, T. Wada, M. Sekine. Synthesis of New Aminoacyl-Adenylate Analogs Having an N-Acyl Phosphoramidate Linkage, Tetrahedron Lett., Vol. 39, pp. 3725-3728, 1998.
• Cronshagen, U.Kadokura, M. Marshallsay, C. Wada, T. Sekine, M.L殄rmann, R.. Direct Interaction of the S/R Domain and the Thiostrepton Domain in E. coli ribosomes, Nucleic Acids Symposium Ser., Vol. 39, pp. 157-158, 1998.
• S. Kawahara, T. Wada, S. Kawauchi, T. Uchimaru, M. Sekine. Theoretical Studies of Substituent Effects of Uracil Derivatives in A-U Base-Pair on the Stability of Hydrogen Bonding, Nucleic Acids Symposium Ser., Vol. 39, pp. 123-124, 1998.
• K. Seio, T. Wada, K. Sakamoto, S. Yokoyama, M. Sekine. Chemical Synthesis and Properties of Conformationally Fixed Diuridine Monophosphates as Building Blocks of RNA Turn Motif, J. Org. Chem., Vol. 63, pp. 1429-1443, 1998.
• T. Wada, Y. Sato, F. Honda, S. Kawahara, M. Sekine. Chemical Synthesis of Oligodeoxyribonucleotides Using N-Unprotected H-Phosphonate Monomers and Carbonium and Phosphonium Condensing Reagents : О-Selective Phosphonylation and Condensation, J. Am. Chem. Soc., Vol. 119, pp. 12710-12721, 1997.
• H. Tsuruoka, K. Shohda, T. Wada, M. Sekine. Kinetics and Mechanism of Facile and Selective Dephosphorylation and of 2'-Phosphorylated and 2'-Thiophosphorylated Dinucleotides : Neighboring 3'-5' Phosphodiester Promotes 2'-Dephosphorylation, J. Org. Chem., Vol. 62, pp. 2813, 1997.
• T. Moriguchi, T. Wada, M. Sekine. A New Type of Nucleoside-Sugar Conjugates : 6-N-Glycosyloxyphosphorylated Adenosine as Analogs of Agrocin 84., J. Org. Chem., Vol. 61, pp. 9223, 1996.
• S. Kawahara, T. Wada, M. Sekine. Unprecedented Mild Acid-Catalyzed Desilylation of the 2'-O-tert-Butyldimethylsilyl Group from Chemically Synthesized Oligoribonucleotide Intermediates via Neighboring Group Participation of the Internucleotidic Phosphate Residue, J. Am. Chem. Soc., Vol. 118, pp. 9461, 1996.
• M. Sekine, M. Kadokura, T. Satoh, K. Seio, T. Wada, U. Fischer, V. Sumpter, R. L殄rmann. The Chemical Synthesis of 5'-Terminal TMG-Capped Triribonucleotide m3GpppAmpUmpA of U1 RNA, J. Org. Chem., Vol. 61, pp. 4412, 1996.
• M. Sekine, H. Tsuruoka, S. Iimura, H. Kusuoku, T. Wada. Studies on Steric and Electronic Control of 2'-3' Phosphoryl Migration in 2'-Phosphorylated Uridine Derivatives and Its Application to the Synthesis of 2'-Phosphorylated Oligouridylates, J.Org.Chem, Vol. 61, pp. 4087-4100, 1996.
• K. Seio, T.Wada, K. Sakamoto, S. Yokoyama, M. Sekine. Chemical Synthesis and Conformational Properties of a New Cyclouridylic Acid Having an Having an Ethylene Bridge Between the Uracil 5-Position and 5'-Phosphate, J.Org.Chem., Vol. 61, pp. 1500, 1996.
• M. Sekine, K. Seio, T. Wada, K. Sakamoto, S. Yokoyama. Chemical Synthesis and Properties of an Interresidually Cyclized Uridylyl (3'-5') uridine as a model of t RNA U turn Structure Having a Sharp Bend, J. Am. Chem. Soc., Vol. 116, pp. 4469, 1994.
• T. Wada, T. Moriguchi, M. Sekine. Synthesis and Properties of N-Phosphorylated Nucleosides, J. Am. Chem. Soc., Vol. 116, pp. 9901, 1994.
• M. Sekine, T. Mori, T. Wada. 2-(Trimethylsiyl)ethyl as a Phosphate Protecting Group in Oligonucleotide Synthesis, Tetrahedron Letters, No. 34, pp. 8289, 1993.
• M. Sekine, K. Seio, T. Satoh, K. Sakamoto, S. Yokoyama. Synthesis of Uridylyl (3'-5') uridine Derivatives Containing 5-(Methylaminomethyl) uridine as a Modified Nuleoside Found from E. coli Minor tRNA(Arg), Nucleosides & Nucleotides, Vol. １２, No. 12, pp. 305-321, 1993.
• M. Sekine, K. Seio. Synthesis and properties of N-Tritylthio Nucleoside Derivatives and Reductive Removal of the Tritylthio Group by Use of Tributyltin Hydride an Tris(trimethylsilyl)silane, J. Chem. Soc. Perkin Trans 1, pp. 3087, 1993.
• M. Sekine, S. Iimura, K. Furusawa. Syntesis of a New Class of 2'-Phosphorylated Oligoribonucleotides Capable of Conversiong to Oligoribonucleotides, J. Org. Chem., Vol. 58, pp. 3204, 1993.
• M. Sekine. General Method for the Preparation of N┣D13┫D1- and O┣D14┫D1-Sbustituted Uridine Derivative by Phase-transfer Reactions, J. Org. Chem., Vol. 54, pp. 2321-2326, 1989.
• T. Wada, N. Kobayashi, T. Mori, M. Sekine. Stereocontrolled Synthesis of Dithymidine Phosphorothioates by Use of a Functionalized 5'-Protecting Group Bearing an Imidazole Residue, Nucleosides Nucleotides, Vol. 17, pp. 351-364, 1988.
• M. Sekine, T. Hata. Synthesis of Short Oligoribonucleotides Bearing a 3'- or 5'-Terminal Phosphate by Use of 4,4', 4''-Tris(4,5-dichlorophtalimido) trityl, J. Am. Chem. Soc., Vol. 108, pp. 4581-4586, 1986.
• MITSUO SEKINE. Synthesis of Branched Ribonucleotides Related to the Mechanism of Splicing of Eukaryotic Messenger RNA, J. Am. Chem. Soc., Vol. 107, pp. 5813, 1985.
• MITSUO SEKINE. Synthesis of a Dodecaribonucleotide by Use of Fully Protected Ribonucleotide Building Blocks, J. Am. Chem. Soc., pp. 106, 1984.
• M. Sekine, T. Hata. Cyclic Orthoester Functions as New Protecting Groups in Nucleosides, J. Am. Chem. Soc., Vol. 105, pp. 2044-2049, 1983.
• M. Sekine, T. Hata. 4,4', 4''-Tris(benzoyloxy) trityl as a New Type of Base-Labile Group for Protection of Primary Hydroxyl Groups, J. Org. Chem., Vol. 48, pp. 3011-3014, 1983.
• M. Sekine, J. Matsuzaki, M. Satoh, T. Hata. Improved 3'-Phosphorylation of Guanosine Derivatives by O┣D16┫D1-Oxygen Protection, J. Org. Chem., Vol. 47, pp. 571-573, 1982.
• M. Sekine, M. Nakajima, T. Hata. Mechanism of the Perkow Reaction and the Kukhtin-Ramirez Reaction, J. Org. Chem., Vol. 46, pp. 4030-4034, 1981.
• M. Sekine, T. Hata. Reactions of Tris(trimethylsilyl)Phosphite with α-Halocarbonyl Compounds, J. Am. Chem. Soc., Vol. 78, pp. 1001-1002, 1978.
• T. Hata, M. Sekine. The Reaction of Silyl Phosphites with Diphenyl Disulfides. Synthesis of S-Phenyl Nucleoside Phosphorothioates, J. Am. Chem. Soc., Vol. 96, pp. 7363-7364, 1974.

著書

• KOHJI SEIO, Takashi Kanamori, Akihiro Ohkubo, MITSUO SEKINE. Synthesis and Fluorescence Properties of Nucleosides with Pyrimimidine-Type Base Moieties, Fluorescent Analogs of Biomolecular Building Blocks, July 2016.
• 清尾康志, 関根光雄. RNAの基礎知識、RNAi法とアンチセンス法, 講談社サイエンティフィック, pp. 1-8, 2005.
• 関根光雄. ＤＮＡの化学合成、”生物薬科学実験講座ー核酸”, 日本化学会編, Vol. 16, pp. 366-409, 2005.
• 関根光雄. 遺伝子分野で発揮される化学の力, 化学, Vol. 61, pp. 26-28, 2005.
• Mitsuo Sekine, Koh-ichiroh Shoda, Kohji Seio. Frontiers in Organic Chemistry, Creation of Conformationally Rigid Bent and Linear Nucleic Acids by 3-Dimentional Fixation of Conformation of Mono- and Di-nucleotide Building Blocks, Bentham Science Publishers LTD., pp. 103-128, 2005.
• 関根光雄. RNAi法とアンチセンス法, 講談社サイエンティフィック, 2005.
• Mitsuo Sekine. DNA Synthesis without Base Protection, Current Protocol in Nucleic Acid Chemistry, Current Protocol in Nucleic Acid Chemistry, pp. 3.10.1-3.10.15, 2004.
• 関根光雄. 遺伝子、”化学ってそういうこと！ー夢広がる分子の世界ー”, 化学同人, 化学同人, pp. 104-105, 2003.
• 関根光雄, 早川芳宏. ゲノムケミストリーを可能にする新技術、”ゲノムケミストリー”, 講談社サイエンティフィック, 講談社サイエンティフィック, pp. 1-21, 2003.
• 関根光雄. ゲノムケミストリー, 講談社サイエンティフィック, 2003.
• Mitsuo Sekine. N-Glycosylation, Glycoscience - Chemistry and Chemical biology, Glycoscience - Chemistry and Chemical biology, pp. 673-690, 2001.

その他の論文・著書など

• Akihiro Ohkubo, Kohji Seio, Mitsuo Sekine. DNA Synthesis without Base Protection Using the Phosphoramidite Approach, Current Protocol in Nucleic Acid Chemistry, Vol. 1, No. 3.15, pp. 1-20, 2006.
• 大木忠明, 矢野純一, 実吉尚郎, 清尾康志, 関根光雄. RNAケミストリー, 蛋白質・核酸・酵素, Vol. 51, pp. 1000-1006, 2006.
• 関根光雄. RNA医薬の化学修飾, 遺伝子医学Mook, Vol. 4, pp. 138-142, 2006.

特許など

• 関根光雄, 清尾康志, 大窪章寛, 角田浩佑, 正木慶昭, 金森功吏, 山田　希, 山崎一史, 伊藤比祐吾. 2'-0-カルバモイル修飾ヌクレオシド三リン酸. 特許. 登録. 国立大学法人東京工業大学. 2013/07/23. 特願2013-152578. 2015/02/02. 特開2015-020994. 特許第6261027号. 2017/12/22 2017.
• 清尾康志, 関根光雄, 宮崎　一也, 黒萩　早耶子, 兒玉　恵里佳. オリゴヌクレオチド誘導体. 特許. 公開. 国立大学法人東京工業大学. 2011/02/17. 特願2012-500643. 2013/06/17. 特開（再表）2011/102414. 2013.
• 清尾康志, 関根光雄, 角田　浩佑, 伊勢　美沙子, 八代　洵, 中原　雄二. シリル化ヌクレオシド合成法. 特許. 公開. 国立大学法人東京工業大学, 日本製紙ケミカル株式会社. 2009/10/14. 特願2009-237339. 2011/04/28. 特開2011-084495. 2011.
• 関根光雄, 清尾康志, 大窪章寛, 角田　浩佑, 工藤　智美. ヌクレオシドトリホスフェート誘導体. 特許. 公開. 国立大学法人東京工業大学. 2008/03/07. 特願2008-057295. 2009/09/24. 特開2009-215171. 2009.
• 清尾康志, 関根光雄, 高久　悠介, 宮崎　一也. オリゴヌクレオチド誘導体. 特許. 公開. 国立大学法人東京工業大学. 2008/02/12. 特願2008-030372. 2009/08/27. 特開2009-190983. 2009.
• 関根光雄, 山田　剛史, 実吉　尚郎, 清尾康志. ２’水酸基修飾リボヌクレオシド誘導体. 特許. 登録. 国立大学法人東京工業大学. 2007/03/08. 特願2008-503910. 2009/07/13. 特開(再表）2007/102581. 特許第5194256号. 2013/02/15 2013.
• 関根光雄, 実吉　尚郎, 宮田　健一, 清尾康志. 新規亜リン酸エステルの酸化方法. 特許. 公開. 国立大学法人東京工業大学. 2006/10/20. 特願2006-312193. 2008/05/01. 特開2008-100976. 2008.
• 清尾康志, 関根光雄, 高久　悠介. オリゴヌクレオチド誘導体. 特許. 公開. 国立大学法人東京工業大学. 2006/03/10. 特願2006-066135. 2007/09/20. 特開2007-238550. 2007.
• 関根光雄, 田口　晴彦, 山田　研, 清尾康志. エステル結合を有するヌクレオシド誘導体. 特許. 公開. 国立大学法人東京工業大学. 2006/03/06. 特願2006-059370. 2007/09/20. 特開2007-238462. 2007.
• 関根光雄, 清尾康志, 大窪章寛, 田中　邦彦. オリゴヌクレオチド固定化固相担体. 特許. 公開. 国立大学法人東京工業大学. 2006/03/10. 特願2006-066396. 2009/07/16. 特開2009-153381. 2009.
• 関根光雄, 清尾康志, 大窪章寛, 坂本　一石, 佐々見　武志. オリゴヌクレオチド誘導体、遺伝子検出用プローブ及びＤＮＡチップ. 特許. 登録. 国立大学法人東京工業大学. 2006/02/28. 特願2007-505962. 2008/08/07. 再表2006-093157. 特許第4882074号. 2011/12/16 2011.
• 関根光雄, KARWOWSKI, 清尾康志, 清尾　康志. RNA合成に有用な水酸基の新規保護基を有する化合物. 特許. 公開. 国立大学法人東京工業大学. 2005/09/08. 特願2005-260564. 2006/03/23. 特開2006-077013. 2006.
• 関根光雄, 宮下　拓平, 清尾康志. ピロリン酸アナログ及びピロリン酸アナログ合成方法. 特許. 公開. 国立大学法人東京工業大学. 2005/09/12. 特願2005-264155. 2007/03/29. 特開2007-077043. 2007.
• 関根光雄, 田口　晴彦, 成田　岳史, 清尾康志. ヌクレオシド誘導体及びその製造方法. 特許. 公開. 国立大学法人東京工業大学. 2005/09/16. 特願2005-270041. 2007/03/29. 特開2007-077109. 2007.
• 関根光雄, 寺田　武史, 清尾康志. 動的カチオン感受性部位を挿入した新規ヌクレオシド誘導体. 特許. 公開. 国立大学法人東京工業大学. 2005/09/09. 特願2005-261657. 2007/03/22. 特開2007-070308. 2007.
• 関根光雄, 清尾康志, 大窪章寛. 固体支持体及びDNAチップ. 特許. 公開. 国立大学法人東京工業大学. 2005/09/12. 特願2005-263722. 2007/03/29. 特開2007-078399. 2007.
• 関根光雄, 宮田　健一, 峯尾　良太, 清尾康志. ヌクレオシド誘導体. 特許. 登録. 国立大学法人東京工業大学. 2005/07/05. 特願2005-196680. 2007/01/25. 特開2007-015948. 特許第5017639号. 2012/06/22 2012.
• 関根光雄, 宮田　健一, 玉虫　隆二, 清尾康志. 置換カルバモイル基を保護基とした核酸の合成方法. 特許. 公開. 国立大学法人東京工業大学. 2005/03/09. 特願2005-064892. 2006/09/21. 特開2006-248931. 2006.
• 関根光雄, 清尾康志, 岡本　到, 尾島　晃司郎. ヌクレオシドホスホロアミダイト化合物. 特許. 公開. 国立大学法人東京工業大学. 2005/03/10. 特願2005-067121. 2006/09/21. 特開2006-248975. 2006.
• 関根光雄, 俵田　隆哉, 清尾康志. ヌクレオシド、ヌクレオシド誘導体、オリゴヌクレオチド、及びオリゴヌクレオチド会合体. 特許. 公開. 国立大学法人東京工業大学. 2005/03/10. 特願2005-067805. 2006/09/21. 特開2006-248987. 2006.
• 関根光雄, 玉木　継吾, 實吉　尚郎, 清尾康志. ２’－O－修飾ヌクレオシドの製造方法. 特許. 公開. 国立大学法人東京工業大学. 2005/03/09. 特願2005-064888. 2006/09/21. 特開2006-248930. 2006.
• 関根光雄, 實吉　尚郎, 清尾康志. リボヌクレオシドの２’水酸基の脱保護方法. 特許. 登録. 国立大学法人東京工業大学. 2005/03/09. 特願2005-064883. 2006/09/21. 特開2006-248929. 特許第4797156号. 2011/08/12 2011.
• 関根光雄, 清尾康志, 大窪章寛, 粕谷　林太郎. トリチル型化合物. 特許. 公開. 国立大学法人東京工業大学. 2005/03/10. 特願2005-066555. 2006/09/21. 特開2006-248956. 2006.

学位論文

• 有機リン化合物の新しい合成反応,  本文,  Doctor of Science,  東京工業大学,  1977/--/--, 
• ホスホロチオエートの合成と反応に関する研究,  Master of Science,  東京工業大学,  1974/--/--, 

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