論文

• 関口博史, 荒川秀雄, 杉山滋, 猪飼篤. リガンドで修飾された高分子を用いた生体分子間相互作用力測定法, 表面科学, Vol. 27, No. 8, pp. 436-441, Aug. 2006.
• Hiroshi Sekiguchi, Hideo Arakawa, Hideki Taguchi, Takeshi Ito, Ryohei Kokawa, Atsushi Ikai. Specific Interaction between GroEL and Denatured Protein Measuredby Compression-Free Force Spectroscopy, Biophysical Journal, Vol. 85, pp. 484–490, July 2003.
• HIDEO ARAKAWA. Frequency shift feedback imaging in liquid for biological molecules, Applied Surface Science, Vol. 210, pp. 61-67, 2003.
• HIDEO ARAKAWA. Self-oscillation technique for AFM in liquids, Applied Surface Science, Vol. 210, pp. 68-72, 2003.
• HIDEO ARAKAWA. Extraction of Membrane Proteins from a Living Cell Surface Using the Atomic Force Microscope and Covalent Crosslinkers, Cell Biochemistry and Biophysics, Vol. 39, pp. 101-117, 2003.
• HIDEO ARAKAWA. Inhibition of Human Pepsin and Gastricsin by a 2 -Macroglobulin, Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 18, No. 3, pp. 219-224, 2003.
• HIDEO ARAKAWA. Quantification of cell adhesion force with AFM: distribution of vitronectin receptors on a living MC3T3-E1 cell, Ultramicroscopy, Vol. 97, pp. 359-364, 2003.
• 荒川秀雄. AFMを用いた蛋白質の力学測定, 電子顕微鏡, Vol. 38, pp. 86-89, 2003.
• A. Ikai, A. Idiris, H. Sekiguchi, H. Arakawa, S. Nishida. Intra- and intermolecular mechanics of proteins and polypeptides studied by AFM: with applications, Applied Surface Science, Vol. 188, pp. 506, Mar. 2002.  公式リンク  
  
• HIDEO ARAKAWA. Tapping and contact mode imaging of native chromosomes and extraction of genomic DNA using AFM tips, Applied Surface Science, Vol. 188, pp. 499-505, 2002.
• HIDEO ARAKAWA. Limited proteolysis of a2-macroglobulin by cathepsin D and structural changes in the inhibitor, Biomedical Research - Tokyo, Vol. 23, No. 4, pp. 199, 2002.
• HIDEO ARAKAWA. Nanotechnology and Protein Mechanics; A Review of the work from Biodynamics Laboratory of Tokyo Institute of Technology, J.Biol.Phys., Vol. 28, pp. 561-572, 2002.
• HIDEO ARAKAWA. Quantification of Cell Adhesion Interactions by AFM: Effects of LPS/PMA on the adhesion of C6 glioma cell to collagen type I, Applied Surface Science, Vol. 188, pp. 493-498, 2002.
• HIDEO ARAKAWA. Intra- and intermolecular mechanics of proteins and polypeptides studied by AFM: with applications, Applied Surface Sciece, Vol. 188, pp. 506-512, 2002.
• HIDEO ARAKAWA. Quantification of Fibronectin and Cell Surface Interactions by AFM, Colloids and Surfaces B: Biointerfaces, Vol. 25, pp. 33-43, 2002.
• HIDEO ARAKAWA. Reversible stretching of a monomeric unit in a dimeric bovine carbonic anhydrase B with the atomic force microscope, Ultramicroscopy, Vol. 91, pp. 253-259, 2002.
• Takafumi Yamada, Hideo Arakawa, Takaharu Okajima, Takayoshi Shimada, Atsushi Ikai. Use of AFM for imaging and measurement of the mechanical properties of light-convertible organelles in plants, Ultramicroscopy, Vol. 91, pp. 261-268, 2002.
• Hiroshi Sekiguchi, Hideo Arakawa, Takaharu Okajima, Atsushi Ikai. Non-destructive Force Measurement in Liquid Using Atomic Force Microscope, Applied Surface Science, Vol. 188, pp. 489-492, 2002.
• Tong Wang, Hideo Arakawa, Atsushi Ikai. Force measurement and inhibitor binding assay of monomer and engineered dimer of bovine carbonic anhydrase B, Biochemical and Biophysical Research Communications, Vol. 285, pp. 9-14, 2001.
• K.Mitsui, K.Nakajima, H.Arakawa, M.Hara, A.Ikai. Dynamic Measurement of Single Protein's Mechanical Properties, Biochem Biophys Res Commun, Vol. 272, pp. 55-63, 2000.
• S.Takeda, S.Kirihara, H.Arakawa, A.Ikai, F.Arisaka. Comparative imaging of the baseplate of bacteriophage T4 with atomic force microscopy and electron microscopy, Research Communications in Biochemistry, Cell & Molecular Biology, Vol. 3, pp. 181-192, 1999.
• T.Osada, S.Takezawa, A.Itoh, H.Arakawa, M.Ichikawa, A.Ikai. The distribution of sugar chains on the vomeronasal epithelium observed with the atomic force microscope., Chemical Senses, Vol. 24, pp. 1-6, 1999.
• Toshiya Osada, Hideo Arakawa, Masumi Ichikawa, Atsushi Ikai. Atomic force microscopy of histological sections using a new electron beam etching method, J.Microsc., Vol. 189, pp. 43-49, 1998.
• Eiro Muneyuki, Daichi Okuno, Masasuke Yoshida, Atsushi Ikai, Hideo Arakawa. A new system for the measurement of electrogenicity produced by ion pumps using a thin polymer film, FEBS Lett., Vol. 427, pp. 109-114, 1998.
• HIDEO ARAKAWA. The structure difference of proteins isolated on substrate with different techniques as studied by the atomic force microscope, Scanning, Vol. 18, pp. 275-280, 1996.
• HIDEO ARAKAWA. Trypsin-like endopeptidase(s) naturally entrapped in human blood a2-macroglobulin, Biomedical Research, Vol. 17, pp. 347-350, 1996.
• HIDEO ARAKAWA. FT-IR study on thermal denaturation processes of Ovomacroglobulin and α2-macroglobulin, J. Mol. Struc., Vol. 384, pp. 149-157, 1996.
• HIDEO ARAKAWA. Inhibition and entrapment of aspartic proteinases by α2-macroglobulin, Adv. Exp. Med. Biol., Vol. 362, pp. 305-313, 1995.
• HIDEO ARAKAWA. Scanning Tunneling Imaging of Bio-organic Molecules and Their Tunneling Properties : Fatty acids, Their Derivatives and Cholesteryl Stearate, Jpn. J. Appl. Phys., Vol. 34, pp. 3368-3372, 1995.
• 荒川秀雄, 雨宮慶幸, 木原　裕, 猪飼　篤. Dynamics of Proteinase Trapping by α2-Macrglobulin, PHOTON FACTORY NEWS, Vol. 12, pp. 17-20, 1995.
• Hideo Arakawa, Takuji Urisaka, Masaru Shimizu, Atsushi Ikai. Kinetics of Proteinase Trapping by α₂M, Annals New York Academy of Science, Vol. 737, pp. 419-420, 1994.
• HIDEO ARAKAWA. Imaging of Neurons by AFM, J. Vac. Sci. Technol. B, Vol. 12, pp. 1470-1473, 1994.
• Hideo Arakawa, Masaru Shimizu, Yoshiyuki Amemiya, Hiroshi Kihara, Atsushi Ikai. KINETICS OF THE CONFORMATIONAL CHANGE OF OVOMACROGLOBULIN, Photon Factory Activity Report, Vol. 12, pp. 295, 1994.
• Hideo Arakawa, Takuji Urisaka, Hirotsugu Tsuruta, Yoshiyuki Amemiya, Hiroshi Kihara, Atsushi Ikai. The Kinetics of Conformational Changes of α2-Macroglobulin Determined by Time Resolved X-ray Solution Scattering, FEBS Lett., Vol. 337, pp. 171-174, 1994.
• HIDEO ARAKAWA. Entrapment and Inhibition of Human Immunodeficieney Virus Proteinase by α2-Macroglobulin and Structural Changes in the Inhibitor, J. Biochem, Vol. 113, pp. 742-746, 1993.
• Hideo Arakawa, Takuji Urisaka, Masaru Shimizu, Yoshiyuki Amemiya, Hiroshi Kihara, Atsushi Ikai. The Kinetics of the Conformational Change of α2-Macroglobulin from the American Horseshoe Crab, Limulus, Photon Factory Activity Report, Vol. 11, pp. 350, 1993.
• 荒川秀雄, 猪飼　篤. 電子顕微鏡・免疫電子顕微鏡法, 「生命超分子システム」蛋白質核酸酵素増刊共立出版, Vol. 38, No. 7, pp. 1254-1265, 1993.
• HIDEO ARAKAWA. Inhibition of Cathepsin-E by alpha-2-Macroglobulin and the Resulting Structural Changes in the Inhibitor, J. Biochem, Vol. 113, pp. 526-530, 1993.
• HIDEO ARAKAWA. High Resolution Images of Cell Surface by a Tapping mode AFM , Jpn. J. Appl Phys, Vol. 32, pp. 1711-1714, 1993.
• HIDEO ARAKAWA. Isolation and Characterization of a Novel Serine Proteinase Complexed with α2-Macroglobulin from Porcine Gastric Mucosa , J. Biol. Chem, No. 268, pp. 527-533, 1993.
• Hideo Arakawa, Hirotsugu Tsuruta, Yoshiyuki Amemiya, Hiroshi Kihara, Atsushi Ikai. The Kinetics of the Conformational Change of α2-Macroglobulin Trapping Proteinase, Photon Factory Activity Report, Vol. 10, pp. 350, 1992.
• Arakawa, H., Umemura, K., Ikai, A.. Protein images obtained by STM, AFM and TEM, Nature, Vol. 358, pp. 171-173, 1992.
• HIDEO ARAKAWA. Interaction of medullasin and plasma inhibitors, Jpn. J. Inflammation, Vol. 12, pp. 361-367, 1992.
• Arakawa, H., Tsuruta, H., Amemiya, Y., Kihara, H., Ikai, A.. Kinetics of the Conformational Change of α2-Macroglobulin Observed with X-Ray Solution Scattering and Fluorescence, Biol. Chem. Hoppe-Seyler, Vol. 372, pp. 129-130, 1991.
• HIDEO ARAKAWA. Reaction of Proteinases with α2-Macroglobulin from the American horse-shoe-crab, Limulus polyphemus, Journal of Biological Chemistry, Vol. 266, pp. 19426-19431, 1991.
• Atsushi Ikai, Hideo Arakawa, Hiroyuki Kyushiki, Hiroshi Kihara, Hirotsugu Tsuruta, Katsuzo Wakabayashi, Yoshiyuki Ame. X-ray small angle scattering of α2-Macroglobulin after treatment with 2,4-dinitrophenyl thiocyanate, Photon Factory Activity Report, Vol. 7, pp. 136, 1989.
• Hideo Arakawa, Masaaki Nishigai, Atsushi Ikai. α2-Macroglobulin traps a proteinase in the mid-region of its arms, Journal of Biological Chemistry, Vol. 264, pp. 2350-2356, 1989.
• Ikai, A., Arakawa, H., Kyushiki, H., Kihara, H., Tsuruta, H., Wakabayashi, K., Amemiya, Y.. Structural Dynamics of Alpha-2-Macroglobulin and Fatty Acid Synthetase Studied by Time-Resolred X-ray Small Angle Scattering Experiment, Photon Factory Activity Report, Vol. 6, pp. 132, 1988.
• HIDEO ARAKAWA. Structural change of α2- and ovo-macroglobulins, Journal of Protein Chemistry, Vol. 6, pp. 81-93, 1987.
• 長田俊哉, 荒川秀雄, 西貝正明, 猪飼　篤. α2-マクログロブリン, 生物物理, Vol. 27, pp. 187-193, 1987.
• HIDEO ARAKAWA. A comparative molecular structural study of the third component and alpha-2-macroglobulin, Protides of the Biological Fluids, Vol. 35, pp. 441-448, 1987.
• Hideo Arakawa, Yutaka Muto, Yoji Arata, Atsushi Ikai. Proton nuclear magnetic resonance study of human α2-Macroglobulin, Biochemistry, Vol. 25, pp. 6785-6789, 1986.
• Hideo Arakawa, Toshiya Osada, Atsushi Ikai. Unusual properties of crocodilian ovomacroglobulin shown in its methylamine treatment and sulf-hydryl titration, Archives of Biochemistry and Biophysics, Vol. 244, pp. 447-453, 1986.

著書

• 荒川秀雄, 猪飼　篤. 電子顕微鏡, 新生化学実験構座(タンパク質III)東京化学同人, 新生化学実験構座(タンパク質III)東京化学同人, 1990.

学位論文

• How α2-macroglobulin traps proteinases,  本文,  Doctor of Science,  東京大学,  1989/--/--, 

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