論文

• Miki Nagase, Hikaru Ando, Yoshiaki Beppu, Hidetake Kurihara, Souta Oki, Fumimasa Kubo, Kazuki Yamamoto, Takashi Nagase, Shinya Kaname, Yoshihiro Akimoto, Hiroshi Fukuhara, Tatsuo Sakai, Shigehisa Hirose, Nobuhiro Nakamura. Glomerular Endothelial Cell Receptor Adhesion G-Protein-Coupled Receptor F5 (ADGRF5) and the Integrity of the Glomerular Filtration Barrier, Journal of the American Society of Nephrology, 35, 10, 1366-1380, Oct. 2024.
• Hiroko Matsumoto, Hisako Miyagi, Nobuhiro Nakamura, Yasuhiro Shiga, Toshihiro Ohta, Shoko Fujiwara, Mikio Tsuzuki. Carbonic anhydrase inhibitor induces otic hair cell apoptosis via an intrinsic pathway and ER stress in zebrafish larvae, Toxicology Reports, Vol. 8, p. 1937-1947, Nov. 2021.
• Anastasia Georgiadi, Valeria Lopez-Salazar, Rabih El- Merahbi, Rhoda Anane Karikari, Xiaochuan Ma, André Mourão, Katarina Klepac, Lea Bühler, Ana Jimena Alfaro, Isabell Kaczmarek, Adam Linford, Madeleen Bosma, Olga Shilkova, Olli Ritvos, Nobuhiro Nakamura, Shigehisa Hirose, Maximilian Lassi, Raffaele Teperino, Juliano Machado, Marcel Scheideler, Arne Dietrich, Arie Geerlof, Annette Feuchtinger, Andreas Blutke, Katrin Fischer, Timo Dirk Müller, Katharina Kessler, Torsten Schöneberg, Doreen Thor, Silke Hornemann, Michael Kruse, Peter Nawroth, Olga Pivovarova-Ramich, Andreas Friedrich Hermann Pfeiffer, Michael Sattler, Matthias Blüher, Stephan Herzig. Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue., Nature communications, May 2021.  公式リンク  
  
• Doshun Ito, Hinata Kawamura, Akira Oikawa, Yuta Ihara, Toshio Shibata, Nobuhiro Nakamura, Tsunaki Asano, Shun-Ichiro Kawabata, Takashi Suzuki, Shinji Masuda. ppGpp functions as an alarmone in metazoa, Communications Biology, Nov. 2020.  公式リンク  
  
• Kubo F, Ariestanti donna maretta, Oki Souta, Taku Fukuzawa, Demizu R, Sato Tomoya, Rahmaningsih Mara Sabirin, Hirose shigehisa, Nobuhiro Nakamura. Loss of the adhesion G-protein coupled receptor ADGRF5 in mice induces airway inflammation and the expression of CCL2 in lung endothelial cells., Respiratory Research, Vol. 20, Jan. 2019.
• Hiroko Matsumoto, Shoko Fujiwara, Hisako Miyagi, Nobuhiro Nakamura, Yasuhiro Shiga, Toshihiro Ohta, Mikio Tsuzuki. Carbonic Anhydrase Inhibitors Induce Developmental Toxicity During Zebrafish Embryogenesis, Especially in the Inner Ear, Marine Biotechnology, Vol. 19, No. 5, Page 430-440, Oct. 2017.
• Harada K, Masako Kato, Nobuhiro Nakamura. USP19-Mediated Deubiquitination Facilitates the Stabilization of HRD1 Ubiquitin Ligase., Int. J. Mol. Sci., Nov. 2016.
• Miyagi H, Nag K, Sultana N, Munakata K, Hirose S, Nakamura N. Characterization of the zebrafish cx36.7 gene promoter: its regulation of cardiac-specific expression and skeletal muscle-specific repression, Gene, Vol. 577, No. 2, pp. 265-274, Feb. 2016.
• Donna Maretta Ariestanti, Hikaru Ando, SHIGEHISA HIROSE, Nobuhiro Nakamura. Targeted disruption of Ig-Hepta/Gpr116 causes emphysema-like symptoms that are associated with alveolar macrophage activation, Journal of Biological Chemistry, The American Society for Biochemistry and Molecular Biology, Vol. 290, No. 17, pp. 11032-11040, Apr. 2015.
• Kakon Nag, Naznin Sultana, Akira Kato, A Dranik, Nobuhiro Nakamura, Koichi Kutsuzawa, Shigehisa Hirose, Toshihiro Akaike. Ligand-induced internalization, recycling, and resensitization of adrenomedullin receptors depend not on CLR or RAMP alone but on the receptor complex as a whole, Gen Comp Endocrinol, 212, 156-162, Feb. 2015.
• Nakamura N, Harada K, Kato M, Hirose S. Ubiquitin-specific protease 19 regulates the stability of the E3 ubiquitin ligase MARCH6, Experimental Cell Research, Vol. 328, No. 1, p. 207-216, Oct. 2014.
• Fukuzawa T, Ishida J, Kato A, Ichinose T, Ariestanti DM, Takahashi Tomoya, Ito Kunitoshi, Abe J, Suzuki T, Wakana S, Fukamizu A, Nobuhiro Nakamura, hirose shige. Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D., PLOS One, Vol. 8, No. 7, e69451, July 2013.
• Ito yusuke, Kobayashi S, Nobuhiro Nakamura, Esaki M, Miyagi H, Hoshijima K, Hirose S. Close association of carbonic anhydrase (CA2a & CA15a), Na+/H+ exchanger (Nhe3b), and ammonia transporter Rhcg1 in zebrafish ionocytes responsible for Na+ uptake, Front. Physio., Vol. 4, Article 59, Apr. 2013.
• Zhao B, Ito Kunitoshi, Iyengar PV, Hirose S, Nobuhiro Nakamura. MARCH7 E3 ubiquitin ligase is highly expressed in developing spermatids of rats and its possible involvement in head and tail formation, Histochem. Cell Biol, Vol. 139, No. 3, pp. 447-460, Mar. 2013.
• Fukuda H, Hirata T, Nakamura N, Kato A, Kawahara K, Wakabayashi S, Chang MH, Romero MF, Hirose S.. Identification and properties of a novel variant of NBC4 (Na(+)/HCO(3)- co-transporter 4) that is predominantly expressed in the choroid plexus., Biochem J, Vol. 450, No. 1, pp. 179-87, Feb. 2013.
• Han SO, Xiao K, Kim J, Wu JH, Wisler JW, Nobuhiro Nakamura, Freedman NJ, Shenoy SK. MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β2-adrenergic receptors, J Cell Biol, Vol. 199, No. 5, pp. 817-830, Nov. 2012.
• Yogo K, Tojima H, Ohno JY, Ogawa T, Nobuhiro Nakamura, SHIGEHISA HIROSE, Takeya T, Kohsaka T. Identification of SAMT family proteins as substrates of MARCH11 in mouse spermatids, Histochem. Cell Biol., Vol. 137, No. 1, pp. 53-65, Jan. 2012.
• Iyengar PV, Hirota T, hirose S, Nobuhiro Nakamura. Membrane-associated RING-CH 10 (MARCH10 Protein) is a microtubule-associated E3 ubiquitin ligase of the spermatid flagella, J. Biol. Chem., Vol. 286, No. 45, pp. 39082-39090, Nov. 2011.
• Kaori Saito, Nobuhiro Nakamura, Yusuke Ito, Kazuyuki Hoshijima, Masahiro Esaki, Boqiang Zhao, Shigehisa Hirose. Identification of zebrafish FXYD11a protein that is highly expressed in ion-transporting epithelium of the gill and skin and its possible role in ion homeostasis, Frontiers in Physiology, Vol. 1, No. 129, Aug. 2010.
• Nakada T, Westhoff CM, Yoko Yamaguchi, Susumu Hyodo, X Li, Takayuki Muro, Kato A, Nakamura N, Hirose S.. Rhesus glycoprotein p2 (Rhp2) is a novel member of the Rh family of ammonia transporters highly expressed in shark kidney, J. Biol. Chem., 285, 4, 2653-64, Jan. 2010.
• Aihara Takeshi, Nobuhiro Nakamura, Shinji Honda, SHIGEHISA HIROSE. A novel potential role for gametogenetin-binding protein 1 (GGNBP1) in mitochondrial morphogenesis during spermatogenesis in mice., Biology of Reproduction, Vol. 80, No. 4, pp. 762-770, Apr. 2009.
• Masahiro Esaki, Kazuyuki Hoshijima, Nobuhiro Nakamura, Keijiro Munakata, Mikiko Tanaka, Kayoko Ookata, Kazuhide Asakawa, Koichi Kawakami, Weiyi Wang, Eric S. Weinberg. Mechanism of development of ionocytes rich in vacuolar-type H+-ATPase in the skin of zebrafish larvae, Dev. Biol., 329, 116-129, 2009.
• Nobuhiro Nakamura, Shigehisa Hirose. Regulation of mitochondrial morphology by USP30, a deubiquitinating enzyme present in the mitochondrial outer membrane, Mol. Biol. Cell, Vol. 19, No. 5, pp. 1903-1911, May 2008.
• Morokuma Y, Nobuhiro Nakamura, Akira Kato, Notoya M, yoko yamamoto, Sakai Y, 福田英一, Yamashina S, Hirata Y, SHIGEHISA HIROSE. MARCH-XI, a novel transmembrane ubiquitin ligase implicated in ubiquitin-dependent protein sorting in developing spermatids, J. Biol. Chem., Vol. 282, No. 34, pp. 24806-24815, Aug. 2007.  公式リンク  
  
• Nobuhiro Nakamura, Yasuo Kimura, Masaki Tokuda, Shinji Honda, Shigehisa Hirose. MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology, EMBO Rep., Vol. 7, No. 10, pp. 1019-1022, Oct. 2006.
• Tateno, T., Nakamura N., Hirata Y., SHIGEHISA HIROSE. Role of C-terminus of Kir7.1 potassium channel in cell-surface expression, Cell Biol. Int., Vol. 30, No. 3, pp. 270-277, Mar. 2006.
• H Fukuda, N Nakamura, S Hirose. MARCH-III is a novel component of endosomes with properties similar to those of MARCH-II, J Biochem, Vol. 139, No. 1, pp. 137-145, Jan. 2006.
• Nobuhiro Nakamura, Fukuda H, Kato A, Hirose S. MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking, Molecular Biology of the Cell, Vol. 16, No. 4, pp. 1696-1710, Apr. 2005.
• Y Suzuki, Y Yasuoka, T Shimohama, M Nishikitani, N Nakamura, S Hirose, K Kawahara. Expression of the K⁺ channel Kir7.1 in developing rat kidney: role in K⁺ excretion, Kidney Int, Vol. 63, No. 3, pp. 969-975, Mar. 2003.
• K Miyamoto, N Nakamura, M Kashiwagi, S Honda, A Kato, S Hasegawa, Y Takei, S Hirose. RING finger, B-box, and coiled-coil (RBCC) protein expression in branchial epithelial cells of Japanese eel, Anguilla japonica, Eur. J. Biochem, Vol. 269, No. 24, pp. 6152-6161, Dec. 2002.
• K Ookata, A Tojo, Y Suzuki, N Nakamura, K Kimura, CS Wilcox, S Hirose. Localization of inward rectifier potassium channel Kir7.1 in the basal membrane of distal nephron, J. Am. Soc. Nephrol, Vol. 11, No. 11, pp. 1987-1994, Nov. 2000.
• N Nakamura, Y Suzuki, Y Ikeda Y, M Notoya, S Hirose. Complex structure and regulation of expression of the rat gene for inward rectifier potassium channel Kir7.1, J. Biol. Chem, Vol. 275, pp. 28276-28284, Sept. 2000.
• N Nakamura, Y Suzuki, H Sakuta, K Ookata, K Kawahara, S Hirose. Inwardly rectifying potassium channel Kir7.1 is highly expressed in the thyroid follicular cells, intestinal epithelial cells and choroid plexus epithelial cells: implication for a functional coupling with Na+,K+-ATPase, The 1st International Conference on Control and Diseases of Sodium Dependent Transport Proteins and Ion Channels, Control and Diseases of Sodium Dependent Transport Proteins and Ion Channels, Elsevier Science, Amsterdam, pp. 39-40, 2000.
• N Nakamura, Y Suzuki, H Sakuta, K Ookata, K Kawahara, S Hirose. Inwardly rectifying potassium channel Kir7.1 is highly expressed in the thyroid follicular cells, intestinal epithelial cells and choroid plexus epithelial cells: implication for a functional coupling with Na+,K+-ATPase, Biochem. J, Vol. 342, pp. 329-336, Sept. 1999.
• Y Suzuki Y, M Itakura, M Kashiwagi, N Nakamura, T Matsuki, H Sakuta, N Naito, K Takano, T Fujita, S Hirose. Identification by differential display of a hypertonicity-inducible inward rectifier pottasium channel highly expressed in chloride cells, J. Biol. Chem, Vol. 274, No. 16, pp. 11376-11382, Apr. 1999.

国際会議発表 (査読有り)

• Kazuki Yamamoto, Masako Kato, Yoshiaki Beppu, 長瀬美樹, Nobuhiro Nakamura. Mechanosensory activation of ADGRF5 and its effect on KLF2 gene expression, 18th TOIN International Symposium on Biomedical Engineering 2023, Dec. 2023.
• Shiyota Yamada, Nobuhiro Nakamura. Effects of cigarette smoke extracts on the expression of the G protein-coupled receptor Adgrf5 and KLF2 in mouse pulmonary endothelial cells, 18th TOIN International Symposium on Biomedical Engineering 2023, Dec. 2023.
• Fumimasa Kubo, Donna Maretta Ariestanti, Souta Oki, Rahmaningsih Mara Sabirin, 出水 遼太郎, Nobuhiro Nakamura. Adgrf5 deficient mice exhibit bronchial asthma- and fibrosis-like phenotypes, 12th Toin International Symposium on Biomedical Engineering, Nov. 2017.
• H Fukuda, N Nakamura, A Kato, S Hirose. Kdg2, a novel multidomain protein involved in the regulation of recycling endosomal trafficking., HUPO 2nd & IUBMB XIX World Congress, Mol. Cell. Proteomics, Vol. 2, No. 9, pp. 753, 2003.
• Nakamura N, 福田英一, Ikeda Y, SHIGEHISA HIROSE. Kdg1, a novel RING-finger membrane protein that localizes in the recycling endosome compartment., 42nd american society for cell biology annual meeting, Mol. Biol. Cell, Vol. 13S, pp. 397a-398a, Nov. 2002.

国内会議発表 (査読有り)

• 中村 信大, 山田 翔太, 山本 一輝, 長瀬美樹. 免疫制御を担う新規受容体分子の肺血管内皮細胞のニコチン応答と炎症応答に及ぼす影響, 喫煙科学研究財団研究助成発表会, July 2023.

国際会議発表 (査読なし・不明)

• Nobuhiro Nakamura. Targeted disruption of GPR116 (ADGRF5) impairs the integrity of the glomerular filtration barrier in mice., TOIN International Symposium on Biomedical Engineering 2022, Nov. 2022.
• Takuto Anno, Masako Kato, Eiichi Kikuchi, Nobuhiro Nakamura. Identification of MARCH2 as a Ubiquitinating Enzyme for Syntaxin-6 and the Effect of Ubiquitination onSubcellular Localization of Syntaxin-6, TOIN BME International Symposium 2021, Nov. 2021.
• Tomoya Sato, Masako Kato, Fumimasa Kubo, Nobuhiro Nakamura. Intracellular signaling Mechanism of G-protein coupled receptor ADGRF5, 13th Toin International Symposium on Biomedical Engineering, Oct. 2018.
• Xiaochuan Ma et al., Nobuhiro Nakamura, Hirose S, Anastasia Georgiadi, Stephan Herzig. FNDC4 Promotes Brown-Like Adipocyte Formation and Glucose Clearance via an Orphan G-protein Coupled Receptor, 77th Scientific Sessions of the American-Diabetes-Association, DIABETES, AMER DIABETES ASSOC, Vol. 66, A537, June 2017.
• A Georgiadi, S Seaman, O Ritvos, BS Croix, Nobuhiro Nakamura, SHIGEHISA HIROSE, M Scheideler, S Herzig, PA Böstrom. Fndc4, a highly identical ortholog of Irisin binds and activates a novel orphan receptor G-protein coupled receptor, Diabetologie und Stoffwechsel, Apr. 2016.
• Fukuda, Hidekazu, Hirata, Taku, Nobuhiro Nakamura, Kawahara, Katsumasa, Hirose, Shigehisa. Characterization of a novel variant of the Na+/HCO3- cotransporter 4 (NBC 4) expressed in rat choroid plexus, JOURNAL OF PHYSIOLOGICAL SCIENCES, SPRINGER JAPAN KK, Vol. 63, pp. S219-S219, 2013.
• Fukuda, Hidekazu, Hirata, Taku, Nobuhiro Nakamura, Kawahara, Katsumasa, Hirose, Shigehisa. Characterization of a novel variant of the Na+/HCO3- cotransporter 4 (NBC 4) expressed in rat choroid plexus, Journal of Physiological Sciences, Vol. 63, pp. S219, 2013.  公式リンク  
  
• Ito, Yusuke, Kobayashi, Sayako, Esaki, Masahiro, Nobuhiro Nakamura, Hoshijima, Kazuyuki, Hirose, Shigehisa. LOCALIZATION OF CARBONIC ANHYDRASES IN MITOCHONDRIA-RICH CELLS OF ZEBRAFISH, Journal of Physiological Sciences, Vol. 59, pp. 536, 2009.  公式リンク  
  
• Nakamura Nobuhiro, Fukuda Hidekazu, Kato Akira, Hirose Shigehisa. Identification of a novel syntaxin-6-binding protein, Cell Structure and Function, Vol. 30, pp. 20, 2005.  公式リンク  
  
• Fukuda Hidekazu, Hirata Taku, Nakamura Nobuhiro, Wakabayashi S, Romero MF, Hirose Shigehisa. Molecular characterization and immunohistochemical localization of a bicarbonate transporter highly and predominantly expressed in rat choroid plexus epithelial cells, Faseb Journal, Vol. 19, No. 5, pp. A1645, 2005.  公式リンク  
  
• Y Suzuki, N Nakamura, H Sakuta, KTakano, T Fujita, S Hirose. Cloning and properties of a hypertonicity-inducible inward rectifier K+ channel from euryhaline eels, Proceedings of the 23rd Taniguchi Foundation Biophysics Symposium, Cell Volume Regulation, Elsevier Science, Amsterdam, pp. 159-166, July 1998.

国内会議発表 (査読なし・不明)

• 山田 翔太, 中村信大. タバコ煙抽出液処理によるマウス肺血管内皮細胞におけるGタンパク質共役型受容体Adgrf5の発現変動, 第45回日本分子生物学会年会, Dec. 2022.
• 中村 信大, 山田 翔太. 細胞外マトリックス異常を伴うノックアウトマウスを用いたGPCR分子の新機能解明を目指した研究, 第一回LiHubバイオマトリックスミニシンポジウム, Nov. 2022.
• 松本 聖慈, 加藤 真子, 中村 信大. A549細胞におけるUSP30-AS1の発現制御とUSP30の発現への影響の解析, 第９４回日本生化学大会, Nov. 2021.
• 菊地 英一, 加藤 真子, 安濃 拓人, 安濃 卓人, 中村 信大. E3ユビキチンリガーゼMARCH2によるSyntaxin-6のユビキチン化の解析, 第93回日本生化学会大会, Sept. 2020.
• 別府 義彬, 長瀬 美樹, 安東 輝, 栗原 秀剛, 久保 文雅, 沖 颯太, 坂井 健雄, 広瀬 茂久, 中村 信大. Gタンパク質共役型受容体Adgrf5の欠損による腎糸球体濾過障壁の構造異常, 第93回日本生化学会大会, Sept. 2020.
• 永沢 佑陽, 加藤 真子, 中村 信大. ヒトGタンパク質共役型受容体ADGRF5のタンパク質発現調節機構の解析, 第93回日本生化学会大会, Sept. 2020.
• 久保 文雅, Donna Ariestanti, 沖 颯太, 福澤拓, 出水 遼太郎, 佐藤朋哉, Rahmaningsih Sabirin, 広瀬茂久, 中村 信大. Gタンパク質共役型受容体ADGRF5の欠損は肺血管内皮細胞における炎症性分子の発現と喘息に似た表現圭を誘導する, 第91回日本生化学会大会, Sept. 2018.
• 久保 文雅, Donna Ariestanti, 沖 颯太, Rahmaningsih Sabirin, 出水 遼太郎, 中村 信大. Adgrf5欠損マウスは気管支喘息および肺線維症様の表現型を現す, 2017年度生命科学系学会合同年次大会, Dec. 2017.

その他の論文・著書など

• Nobuhiro Nakamura. Cigarette smoke attenuates p300‐mediated Nrf2 acetylation in macrophages: Is stabilizing Nrf2 enough to halt COPD progression?, Respirology, Vol. 26, No. 1, pp. 19-20, Jan. 2021.  公式リンク  
  
• Nobuhiro Nakamura. Ubiquitin System, International journal of molecular sciences, MDPI, Vol. 19, No. 4, Apr. 2018.
• Sultana N, Nobuhiro Nakamura, Hirose Shige, Kutsuzawa K, Akaike T, Nag K. Congenital heart disease and biotechnology: Connecting by connexin, Vol. 995, 85-112, July 2014.
• Nobuhiro Nakamura. Ubiquitination regulates the morphogenesis and function of sperm organelles, Cells, Vol. 2, No. 4, pp. 732-750, Dec. 2013.
• Nobuhiro Nakamura. The role of the transmembrane RING finger proteins in cellular and organelle function, Membranes, Vol. 1, No. 4, pp. 354-393, Dec. 2011.

学位論文

• Kdg1, a Membrane Protein of the Recycling Endosome with Ubiquitin Ligase Activity, Promotes Degradation of the Transferrin Receptor,  本文,  Doctor of Science,  Tokyo Institute of Technology,  2003/--/--, 

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