論文

• Cho, J., Hiramoto, M., Masaike, Y., Satoshi Sakamoto, Imai, Y., Imai, Y., Hiroshi Handa, Imai, T.. UGGT1 retains proinsulin in the endoplasmic reticulum in an arginine dependent manner, Biochem. Biophys. Res. Commun., vol. 527, p. 668-675, May 2020.
• Shunpei Tateno, Midori Iida, Satoshi Fujii, Miki Katayama, Haruka Tokuyama, Junichi Yamamoto, Takumi Ito, Satoshi Sakamoto, Hiroshi Handa, Yuki Yamaguchi. Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide , Scientific Reports, Volume 10, Number 4012, Mar. 2020.
• Sekino, M., Kuwahata, A., Fujita, S., Matsuda, S., Kaneko, M., Chikaki, S., Sakamoto, S., Saito, I., Hiroshi Handa, Kusakabe, M.. Development of an optimized dome-shaped magnet for rapid magnetic immunostaining, Development of an optimized dome-shaped magnet for rapid magnetic immunostaining, Vol. 10, pp. 025317, Feb. 2020.
• Sekino, M., Kuwahata, A., Yoshibe, A., Imai, K., Kaneko, M., Chikaki, S., Saito, I., Tsuruma, A., Sakamoto, S., Handa, H., Matsuda, A., Kusakabe, M.. Development of an automatic magnetic immunostaining system for rapid diagnosis of cancer metastasis, Development of an automatic magnetic immunostaining system for rapid diagnosis of cancer metastasis, Vol. 10, pp. 015106, Jan. 2020.
• Ando, H., Sato, T., Ito, T., Yamamoto, J., Sakamoto, S., Nitta, N., Asatsuma-Okumura, T., Shimizu, N., Mizushima, R., Aoki, I., Imai, T., Yamaguchi, Y., Berk, A.J., Hiroshi Handa. Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation, iScience, Apr. 2019.
• Tatsuya Onishi, Sachiko Matsuda, Yuki Nakamura, Junko Kuramoto, Akinori Tsuruma, Satoshi Sakamoto, Shunichi Suzuki, Daiichiro Fuchimoto, Akira Onishi, Shinichi Chikaki, Miki Kaneko, Akihiro Kuwahata, Masaki Sekino, Hiroshi Yasuno, Naohiro Hanyu, Tomoko Kurita, Hiroyuki Takei, Takashi Sakatani, Kanae Taruno, Seigo NakamuraTetsu Hayashida, Hiromitsu Jinno, Moriaki Kusakabe, Hiroshi Handa, Kaori Kameyama, Yuukou Kitagawa. Magnetically-promoted rapid immunofluorescence staining for frozen tissue sections., J. Histochem. Cytochem., vol. 67, p. 575-587, Apr. 2019.
• Yasuaki kabe, Satoshi Sakamoto, Mamoru Hatakeyama, Yuki Yamaguchi, Makoto Suematsu, Makoto Itonaga, Hiroshi Handa. Application of high-performance magnetic nano-beads to biological sensing devices, Anal. Bioanal. Chem., Vol. 411, p. 1825-1837, Jan. 2019.
• Yasuaki Kabe, Makoto Suematsu, Satoshi Sakamoto, Miwa Hirai, Ikko Koike, Takako Hishiki, Atsushi Matsuda, Yuichi Hasegawa, Koji Tsujita, Masayuki Ono, Naoko Minegishi, Atsushi Hozawa, Yoshinori Murakami, Michiaki Kubo, Makoto Itonaga, Hiroshi Handa. Development of a highly-sensitive device for counting the number of disease-specific exosomes in human sera, Clin. Chem., Vol. 64, p. 1463-1473, July 2018.
• Kimura A., Kitajima, M., Nishida, K., Serada, S., Fujimoto, M., Naka, T., Fujii-Kuriyama, Y., Satoshi Sakamoto, Takumi Ito, HIROSHI HANDA, Tanaka, T., Yoshimura, A, Suzuki, H.. NQO1 inhibits TLR-dependent production of selective cytokines by promoting PDLIM2-mediated degradation of IkB-z, J. Exp. Med., Vol. 215, No. 8, p. 2197-2209, June 2018.
• Kaneko, M., Chikaki, S., Matsuda, S., Kuwahata, A., Namita, M., Saito, I., Sakamoto, S., Kusakabe, M., Sekino, M.. Development of magnet configurations for magnetic immunostaining, AIP ADVANCES, Vol. 8, 056732, Jan. 2018.
• Tomoyuki Mori, Takumi Ito, Shujie Liu, Hideki Ando, Satoshi Sakamoto, Yuki Yamaguchi, Etsuko Tokunaga, Norio Shibata, Hiroshi Handa. Structural basis of thalidomide enantiomer binding to cereblon, Scientific Reports, 8, 1, 1294, Jan. 2018.
• Boccitto, M., Lee, N., Satoshi Sakamoto, Spruce, L. A., Handa, H., Clardy, J., Seeholzer, S. H., Kalb R. G.. The Neuroprotective Marine Compound Psammaplysene A Binds the RNA Binding Protein HNRNPK, Mar. Drugs, Vol. 15, No. 8, 246, Aug. 2017.
• S. Mukai, S. Moriya, M. Hiramoto, H. Kazama, H. Kokuba, X.-F. Che, T. Yokoyama, S. Sakamoto, A. Sugawara, T. Sunazuka, S. Ōmura, H. Handa, T. Itoi, K. Miyazawa. Macrolides sensitize EGFR-​TKI-​induced non-​apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines, Int. J. Oncol., Vol. 48, p. 45-54, Jan. 2016.
• Pérez-Perarnau, A., Preciado, S., Palmeri, C. M., Moncunill-Massaguer, C., Iglesias-Serret, D., González-Gironès, D. M., Miguel, M., Satoki Karasawa, Sakamoto, S, Cosialls, A. M., Rubio-Patiño, C., Saura-Esteller, J., Ramón, R., Caja, L., Fabregat, I., Pons, G., HIROSHI HANDA, Albericio, F., Gil, J., Lavilla, R.. A trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitins, Angew. Chem. Int. Ed., Vol. 53, p. 10150-10154, Sept. 2014.
• Satoshi Sakamoto, Kenshi Omagari, Yoshinori Kita, Yusuke Mochizuki, Yasuyuki Naito, Shintaro Kawata, Sachiko Matsuda, Osamu Itano, Hiromitsu Jinno, Hiroya Takeuchi, Yuki Yamaguchi, Yuko Kitagawa, Hiroshi Handa. Magnetically Promoted Rapid Immunoreactions Using Functionalized Fluorescent Magnetic Beads: A Proof of Principle, Clinical Chemistry, American Association for Clinical Chemistry, Vol. 60, No. 4, pp. 610-620, Jan. 2014.
• Shuji Iida, Kensuke Imai, Sachiko Matsuda, Osamu Itano, Mamoru Hatakeyama, Satoshi Sakamoto, Daisuke Kokuryo, Koji Okabayashi, Takashi Endo, Yoshiyuki Ishii, Hirotoshi Hasegawa, Ichio Aoki, Hiroshi Handa, Yuko Kitagawa. In vivo identification of sentinel lymph nodes using MRI and size-controlled and monodispersed magnetite nanoparticles, Journal of Magnetic Resonance Imaging, Vol. 38, No. 6, pp. 1346–1355, Nov. 2013.
• Vipul Gupta, Shujie Liu, Hideki Ando, Ryohei Ishii, Shumpei Tateno, Yuki Kaneko, Masato Yugami, Satoshi Sakamoto, Yuki Yamaguchi, Osamu Nureki, Hiroshi Handa. Salicylic acid induces mitochondrial injury by inhibiting ferrochelatase heme biosynthesis activity, Mol. Pharmacol., Vol. 84, No. 6, pp. 824-833, Nov. 2013.
• Teruya Enomoto, Masa-aki Kawano, Hajime Fukuda, Wataru Sawada, Takamasa Inoue, Kok Chee Haw, Yoshinori Kita, Satoshi Sakamoto, Yuki Yamaguchi, Takeshi Imai, Mamoru Hatakeyama, Shigeyoshi Saito, Adarsh Sandhu, Masanori Matsui, Ichio Aoki, Hiroshi Handa. Viral protein-coating of magnetic nanoparticles using simian virus 40 VP1, J. Biotechnol., Vol. 167, No. 1, pp. 8-15, Aug. 2013.
• Teruya Enomoto, Masaaki Kawano, Hajime Fukuda, Wataru Sawada, Takamasa Inoue, Kok Chee Haw, Yoshinori Kita, Satoshi Sakamoto, Takeshi Imai, Mamoru Hatakeyama, Shigeyoshi Saito, Adarsh Sandhu, Masanori Matsui, Ichio Aoki, Hiroshi Handa. Viral protein-coating of magnetic nanoparticles using simian virus 40 VP1, Journal of Biotechnology, Vol. 167, No. 1, pp. 8-15, Aug. 2013.
• Kentaro Hotta, Akihiro Nashimoto, Eiji Yasumura, Masafumi Suzuki, Motoki Azuma, Yosuke Iizumi, Daisuke Shima, Ryusuke Nabeshima, Masaki Hiramoto, Akira Okada, Kumiko Sakata-Sogawa, Makio Tokunaga, Takumi Ito, Hideki Ando, Satoshi Sakamoto, Yasuaki Kabe, Shinichi Aizawa, Takeshi Imai, Yuki Yamaguchi, Hajime Watanabe, Hiroshi Handa. Vesnarinone suppresses TNFα mRNA expression by inhibiting valosin-containing protein, Mol. Pharmacol., Vol. 83, No. 5, pp. 930-938, May 2013.
• Satoki Karasawa, Motoki Azuma, Takeshi Kasama, Satoshi Sakamoto, Yasuaki Kabe, Takeshi Imai, Yuki Yamaguchi, Keisuke Miyazawa, Hiroshi Handa. Vitamin K2 Covalently Binds to Bak and Induces Bak-Mediated Apoptosis, Molecular Pharmacology, Vol. 83, No. 3, pp. 613-620, Mar. 2013.
• Satoshi Sakamoto, Mamoru Hatakeyama, Takumi Ito, Hiroshi Handa. Tools and methodologies capable of isolating and identifying a target molecule for a bioactive compound, Bioorganic & Medicinal Chemistry, Vol. 20, No. 6, pp. 1990–2001, Mar. 2012.
• Naoya Maekawa, Masaki Hiramoto, Satoshi Sakamoto, Motoki Azuma, Takumi Ito, Marie Ikeda, Michitaka Naitou, Hukum P. Acharya, Yuichi Kobayashi, Makoto Suematsu, Hiroshi Handa, Takeshi Imai. High-performance affinity purification for identification of 15-deoxy-Δ^12,14-PGJ₂ interacting factors using magnetic nanobeads, Biomedical Chromatography, Vol. 25, No. 4, pp. 466–471, Apr. 2011.
• Mamoru Hatakeyama, Hiroshi Kishi, Yoshinori Kita, Kensuke Imai, Kosuke Nishio, Satoki Karasawa, Yuka Masaike, Satoshi Sakamoto, Adarsh Sandhu, Akihiro Tanimoto, Tatsuya Gomi, Eiichi Kohda, Masanori Abe, Hiroshi Handa. A two-step ligand exchange reaction generates highly water-dispersed magnetic nanoparticles for biomedical applications, Journal of Materials Chemistry, Vol. 21, No. 16, pp. 5959-5966, Mar. 2011.
• Yoshitaka Morimoto, Tsukasa Takamura, Sang Yoon Park, Satoshi Sakamoto, Shintaro Kawata, Hiroshi Handa, Adarsh Sandhu. Detection of 8 nm Diameter Superparamagnetic Beads by Magnetically-Induced Manipulation of Micrometer-Sized Magnetic Beads: A Novel Protocol for Magnetically-Labeled Biosensing, Japanese Journal of Applied Physics, Vol. 49, Page 04DL07, Apr. 2010.
• Yuka Masaike, Takeshi Takagi, Masataka Hirota, Joe Yamada, Satoru Ishihara, Tetsu M. C. Yung, Takamasa Inoue, Chika Sawa, Hiroshi Sagara, Satoshi Sakamoto, Yasuyuki Takahashi, Yuki Yamaguchi, Hiroshi Handa, Yasuaki Kabe. Identification of Dynamin-2-Mediated Endocytosis as a New Target of Osteoporosis Drugs, Bisphosphonates, Molecular Pharmacology, Vol. 77, No. 2, pp. 262-269, Feb. 2010.
• Satoshi Sakamoto, Yasuaki Kabe, Mamoru Hatakeyama, Yuki Yamaguchi, Hiroshi Handa. Development and application of high-performance affinity beads: toward chemical biology and drug discovery, Chem. Rec., 9, 1, 66-85, 2009.
• Masafumi Suzuki, Shoichiro Furukawa, Chikanori Kuramori, Chika Sawa, Yasuaki Kabe, Mitsuhiro Nakamura, Jun-ichi Sawada, Yuki Yamaguchi, Satoshi Sakamoto, Satoshi Inouye, Hiroshi Handa. Development of a chemical screening system using aqueorin-fused protein, Biochem. Biophys. Res. Commun., 368, 3, 600-605, Apr. 2008.
• K. Nishio, M. Ikeda, N. Gokon, S. Tsubouchi, H. Narimatsu, Y. Mochizuki, S. Sakamoto, A. Sandhu, M. Abe, H. Handa. Preparation of size-controlled (30-100nm) magnetite nanoparticles for biomedical applications., J. Magn. Magn. Mater., Vol. 310, pp. 2408-2410, 2007.
• Adarsh Sandhu, Yoshimich Kumagai, Adam Lapicki, Satoshi Sakamoto, Masanori Abe, Hiroshi Handa. High efficiency Hall effect micro-biosensor platform for detection of magnetically labeled biomolecules, Biosensors & Bioelectronics, Vol. 2, No. 9-10, pp. 2115-2120, 2007.
• Sakamoto, S., Sakazaki, H., Hagiwara, K., Kamada, K., Ishii, K., Noda, T., Inoue, M., Hirama, M.. A Formal Total Synthesis of (+)-Pinnatoxin A, Angew. Chem. Int. Ed., vol. 43, p. 6505-6510, Dec. 2004.

著書

• 坂本聡, 半田宏. 技術予測レポート2023 上巻 「健康寿命の延伸を目指す」日本の技術編, 日本能率協会総合研究所, ソレカラ社, Dec. 2013.
• 西尾広介, 坂本聡, 宇賀均, 倉森見典, 半田宏. 磁性ビーズのバイオ・環境技術への応用展開（普及版）, CMCテクニカルライブラリー―新材料・新素材シリーズ, シーエムシー出版, pp. 144-153, June 2012.
• Yasuaki Kabe, Mamoru Hatakeyama, Satoshi Sakamoto, KOSUKE NISHIO, Hiroshi Handa. Novel Applications of Affinity Beads, PROTEIN TARGETING WITH SMALL MOLECULES, Chemical Biology Techniques and Applications, Jhon Wiley & Sons. Inc., 2009.
• 半田宏, 和田忠士, 坂本聡. 診断学、１．ＭＥＭＳと診断 他, ＭＥＭＳ／ＮＥＭＳ工学全集, 株式会社テクノシステム, p. 212-217, 2009.

国際会議発表 (査読有り)

• Nakagomi, Madoka, Shudo, Koichi, Satoshi Sakamoto, Handa, Hiroshi, Iwamoto, Takeo, Matsuura, Tomokazu. A Novel Aromatic Carboxylic Acid Inhibits Luciferase Enzymatic Activity in Mammalian Cells by Acylation of an Active Regulatory Lysine Residue, 58th Annual Meeting of the Biophysical-Society, BIOPHYSICAL JOURNAL, CELL PRESS, Vol. 106, No. 2, pp. 263A-263A, Jan. 2014.
• Tsujita, K., Hasegawa, Y., Ono, M., Itonaga, M., Kabe, Y., Satoshi Sakamoto, Handa, H.. Single nanobeads detection by scanning laser spot for immunosensing, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, pp. 2297-2299, 2014.
• Tsujita, K., Hasegawa, Y., Ono, M., Itonaga, M., Satoshi Sakamoto, Hatakeyama, M., Handa, H.. Ultrahigh-sensitivity biomarker sensing system based on the combination of optical disc technologies and nanobead technologies, Japanese Journal of Applied Physics, Vol. 52, No. 9 PART3, 2013.

国際会議発表 (査読なし・不明)

• Satoshi Sakamoto, Takumi Ito, Yuki Yamaguchi, Hideki Ando, Hiroshi Handa. Biochemical analyses of CRBN, the target protein for immunomodulatory drugs (IMiDs), PACIFCHEM2015, Dec. 2015.
• Satoshi Sakamoto, Yuki Yamaguchi, Takumi Ito, Hiroshi Handa. Elucidation of the molecular mechanisms of action of bioactive natural products using high performance affinity beads, PACIFCHEM2015, Dec. 2015.

国内会議発表 (査読なし・不明)

• 荒川 翼, 山口 雄輝, 坂本 聡. 神経変性疾患の原因であるタンパク質凝集体を選択的に分解誘導するPROTACの開発を目指した研究, 第46回日本分子生物学会, Dec. 2023.
• 原口大和, 坂本聡, 山口雄輝. 二次元的スクリーニング解析を駆使した既存抗がん剤の新規作用機序の解明を目指した研究, 第45回日本分子生物学会, Dec. 2022.
• 原口大和, 坂本聡, 山口雄輝. ナノ磁性ビーズ精製とCRISPRライブラリースクリーニングによる薬剤標的分子の網羅的同定を目指した研究, 第44回日本分子生物学会, Dec. 2021.
• 小泉 純玲, 坂本 聡, 山口 雄輝. 抗がん作用を有するカンナビノイドの作用機序の解析, 日本薬学会第139年会, Feb. 2019.
• 坂本 聡, Gupta Vipul, 劉 舒捷, 安藤秀樹, 舘野峻平, 金子裕生, 湯上真人, 石井亮平, 濡木 理, 山口雄輝, 半田 宏. 抗炎症薬サリチル酸が示す生体内作用メカニズムの解析, 日本化学会年第97春季年会, Mar. 2017.
• 坂本 聡, 山口 雄輝, 半田宏. ターゲット因子の解析を基盤とする生物活性物質が示す作用機構の解明, 新学術領域研究「転写サイクル」冬の若手ワークショップ2017, Jan. 2017.
• 坂本 聡, 伊藤 拓水, 森 智行, 安藤 秀樹, 山口 雄輝, 箱嶋 敏雄, 半田 宏. CRBNに対するサリドマイド光学異性体の結合基盤解析, 日本ケミカルバイオロジー学会第11回年会, June 2016.
• 坂本 聡, 伊藤 拓水, 安藤 秀樹, 山口 雄輝, 半田 宏. IMiDs標的タンパク質CRBNの生化学的解析, 日本ケミカルバイオロジー学会第１０回年会, June 2015.
• 坂本 聡, 山口雄輝, 半田 宏. アフィニティビーズを利用した生物活性物質標的タンパク質の単離・同定・評価, 日本薬学会第135年会, Mar. 2015.
• 坂本 聡, Vipul Gupta, 劉 舒捷, 安藤 秀樹, 舘野 峻平, 金子 裕生, 湯上 真人, 石井 亮平, 濡木 理, 山口 雄輝, 半田 宏. 抗炎症薬サリチル酸の生体内作用機構の解析, 日本ケミカルバイオロジー学会第９回年会, June 2014.
• 坂本 聡, 唐澤 慧記, 東 基記, 笠間 健嗣, 宮澤 啓介, 山口 雄輝, 半田 宏. ビタミンK2が引き起こすがん細胞のアポトーシス誘導機構の解析, 日本化学会第９４春季年会, Mar. 2014.

特許など

• 半田宏, 坂本聡. 蛍光性ポリマー微粒子及び蛍光標識セット. 特許. 公開. 国立大学法人東京工業大学, 多摩川精機株式会社. 2014/02/20. 特願2014-030228. 2015/08/27. 特開2015-155813. 2015. Aug.
• 勝亦 優, 半田宏, 坂本聡. 粒子の単分散状態維持方法及び分析対象物の検出方法. 特許. 公開. 国立大学法人東京工業大学, 凸版印刷株式会社. 2013/11/21. 特願2013-240897. 2015/06/04. 特開2015-102337. 2015. June
• 平瀬 匠, 中山 雅人, 半田 宏, 坂本 聡, 内藤 靖之. 被検物質の検出システム. 特許. 登録. 国立大学法人東京工業大学, 凸版印刷株式会社. 2013/07/02. 特願2014-523750. 2016/06/02. 再表2014/007248. 特許第6217936号. 2017/10/06 2017. Oct.
• 半田宏, 坂本聡, 河田 慎太郎. ポリマー微粒子の製造方法. 特許. 登録. 国立大学法人東京工業大学, 多摩川精機株式会社. 2013/03/29. 特願2013-071029. 2014/10/09. 特開2014-193972. 特許第6123053号. 2017/04/14 2017. Apr.
• 半田宏, 畠山 士, 坂本聡. 機能性物質包含微粒子を用いたバイオセンシング方法. 特許. 登録. 国立大学法人東京工業大学. 2011/11/29. 特願2011-260624. 2013/06/10. 特開2013-113735. 特許第5924571号. 2016/04/28 2016. Apr.
• 平瀬 匠, 勝亦 優, 土屋 真紀子, 星野 昭裕, 入江 新司, 中山 雅人, 半田宏, 坂本聡, 河田 慎太郎, 内藤 靖之. 標識磁性粒子を用いた被検物質の検出方法、及び被検物質の検出システム. 特許. 登録. 国立大学法人東京工業大学, 凸版印刷株式会社. 2011/03/10. 特願2011-053415. 2012/10/04. 特開2012-189453. 特許第5645020号. 2014/11/14 2014. Nov.
• 半田宏, 畠山 士, 坂本聡, 岸寛. ポリマー被覆フェライト微粒子および製造方法. 特許. 登録. 国立大学法人東京工業大学. 2010/10/28. 特願2011-538254. 2013/03/14. 特開（再表）2011/052205. 特許第5688807号. 2015/02/06 2015. Feb.
• 半田宏, 畠山　士, 坂本聡, 望月　勇輔, 河田　慎太郎. 蛍光分子を含有するポリマー粒子およびその製造方法. 特許. 登録. 国立大学法人東京工業大学. 2009/09/10. 特願2010-528640. 2012/02/02. 特開（再表）2010/029739. 特許第5574492号. 2014/07/11 2014.
• 半田宏, 畠山　士, 坂本聡, 政池　由佳, 西尾　広介, 北　善紀, 阿部正紀, 岸寛. 表面被覆無機物粒子の製造方法. 特許. 登録. 国立大学法人東京工業大学. 2008/07/25. 特願2009-524516. 2010/10/07. 特開（再表）2009/014201. 特許第5569837号. 2014/07/04 2014.

学位論文

• Synthetic Study of Pinnatoxin A,  本文,  Doctor of Science,  Tohoku University,  2003/03/--, 

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