論文

• Chikanori Kuramori, Motoki Azuma, Kanako Kume, Yuki Kaneko, Atsushi Inoue, Yuki Yamaguchi, Yasuaki Kabe, Takamitsu Hosoya, Masahiro Kizaki, Makoto Suematsu, Hiroshi Handa. Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus, Biochem. Biophys. Res. Commun., 379, 2, 519-525, Feb. 2009.
• T. Hosoya, J. Yomoda, M. Muraki, N. Kataoka, T. Hosoya, M. Suzuki, M. Hagiwara, H. Kimura. Combination of Clk family kinase and SRp75 modulates alternative splicing of Adenovirus E1A, Genes Cell, Vol. 13, No. 3, pp. 233-244, Mar. 2008.
• S. Ohno, M. Matsui, T. Yokogawa, M. Nakamura, T. Hosoya, T. Hiramatsu, M. Suzuki, N. Hayashi, K. Nishikawa. Site-selective Post-translational Modification of Proteins Using an Unnatural Amino Acid, 3-Azidotyrosine., J. Biochem., Vol. 141, No. 3, pp. 335-343, 2007.
• T. Hiramatsu, Y. Guo, T. Hosoya. Azidodifluoromethyl-3H-diazirin-3-yl group as an all-in-one functional group for radioisotope-free photoaffinity labeling., Org. Biomol. Chem., Vol. 5, No. 18, pp. 2916-2919, 2007.
• M. Abe, S. Ohno, T. Yokogawa, T. Nakanishi, F. Arisaka, T. Hosoya, T. Hiramatsu, M. Suzuki, T. Ogasawara, T. Sawasaki, K. Nishikawa, M. Kitamura, H. Hori, Y. Endo. Detection of structural changes in a cofactor binding protein by using a wheat germ cell-free protein synthesis system coupled with unnatural amino acid probing., Proteins, Vol. 67, No. 3, pp. 643-652, 2007.
• T. Hosoya, K. Sumi, H. Doi, M. Wakao, M. Suzuki. Rapid methylation on carbon frameworks useful for the synthesis of ¹¹CH₃-incorporated PET tracers: Pd(0)-mediated rapid coupling of methyl iodide with an alkenyltributylstannanes leading to a 1-methylalkene., Org. Biomol. Chem., Vol. 4, No. 3, pp. 410-415, 2006.
• Y. Cui, H. Takamatsu, T. Kakiuchi, H. Ohba, Y. Kataoka, C. Yokoyama, H. Onoe, Yu. Watanabe, T. Hosoya, M. Suzuki, R. Noyori, H. Tsukada, Y. Watanabe. Neuroprotection by a Central Nervous System-Type Prostacyclin Receptor Ligand Demonstrated in Monkeys Subjected to Middle Cerebral Artery Occlusion and Reperfusion: A Positron Emission Tomography Study., Stroke, Vol. 37, No. 11, pp. 2830-2836, 2006.
• T. Fukuhara, T. Hosoya, S. Shimizu, K. Sumi, T. Oshiro, Y. Yoshinaka, M. Suzuki, N. Yamamoto, L. A. Herzenberg, L. A. Herzenberg, M. Hagiwara. Utilization of host SR protein kinases and RNA splicing machinery during viral replication., Proc. Natl. Acad. Sci. USA, Vol. 103, No. 30, pp. 11329-11333, 2006.
• T. Hosoya, T. Hiramatsu, T. Ikemoto, H. Aoyama, T. Ohmae, M. Endo, M. Suzuki. Design of dantrolene-derived probes for radioisotope-free photoaffinity labeling of proteins involved in the physiological Ca²⁺ release from sarcoplasmic reticulum of skeletal muscle., Bioorg. Med. Chem. Lett., Vol. 15, No. 5, pp. 1289-1294, 2005.
• M. Suzuki, H. Doi, T. Hosoya, B. Langstrom, Y. Watanabe. Rapid methylation on Carbon Frameworks Leading to the Synthesis of a PET Tracer Capable of Imaging a Novel CNS-type Prostacyclin Receptor in Living Human Brain., Trends Anal. Chem., Vol. 23, No. 8, pp. 595-607, 2004.
• M. Muraki, B. Ohkawara, T. Hosoya, H. Onogi, J. Koizumi, T. Koizumi, K. Sumi, J. Yomoda, M. V. Murray, H. Kimura, K. Furuichi, H. Shibuya, A. R. Krainer, M. Suzuki, M. Hagiwara. Manipulation of alternative splicing by a newly developed inhibitor of Clks., J. Biol. Chem., Vol. 279, No. 23, pp. 24246-24254, 2004.
• T. Hosoya, T. Hiramatsu, T. Ikemoto, M. Nakanishi, H. Aoyama, A. Hosoya, T. Iwata, K. Maruyama, M. Endo, M. Suzuki. Novel bifunctional probe for radioisotope-free photoaffinity labeling: compact structure comprised of photospecific ligand ligation and detectable tag anchoring units., Org. Biomol. Chem., Vol. 2, No. 5, pp. 637-641, 2004.
• T. Hosoya, M. Wakao, Y. Kondo, H. Doi, M. Suzuki. Rapid methylation of terminal acetylenes by the Stille coupling of methyl iodide with alkynyltributylstannanes: a general protocol potentially useful for the synthesis of short-lived ¹¹CH₃-labeled PET tracers with a 1-propynyl group., Org. Biomol. Chem., Vol. 2, No. 1, pp. 24-27, 2004.
• T. Hosoya, H. Aoyama, T. Ikemoto, Y. Kihara, T. Hiramatsu, M. Endo, M. Suzuki. Dantrolene Analogues Revisited: General Synthesis and Specific Functions Capable of Discriminating Two Kinds of Ca²⁺ Release from Sarcoplasmic Reticulum of Mouse Skeletal Muscle., Bioorg. Med. Chem., Vol. 11, No. 5, pp. 663-673, 2003.
• T. Hosoya, H. Aoyama, T. Ikemoto, T. Hiramatsu, Y. Kihara, M. Endo, M. Suzuki. [¹²⁵I]-N-[(3-Azido-5-iodo)benzyl]dantrolene and [¹²⁵I]-N-{[3-iodo-5-(3-trifluoromethyl-3H-diazirin-3-yl)]benzyl}dantrolene: Photoaffinity Probes Specific for the Physiological Ca²⁺ Release from Sarcoplasmic Reticulum of Skeletal Muscle., Bioorg. Med. Chem. Lett., Vol. 12, No. 22, pp. 3263-3265, 2002.
• H. Takamatsu, H. Tsukada, Yu. Watanabe, Y.-L. Cui, Y. Kataoka, T. Hosoya, M. Suzuki, Y. Watanabe. Specific ligand for a central type prostacyclin receptor attenuates neuronal damage in a rat model of focal cerebral ischemia., Brain Res., Vol. 925, No. 2, pp. 176-182, 2002.
• M. Ikenoya, H. Hidaka, T. Hosoya, M. Suzuki, N. Yamamoto, Y. Sasaki. Inhibition of Rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor., J. Neurochem., Vol. 81, No. 1, pp. 9-16, 2002.
• T. Hamura, T. Hosoya, H. Yamaguchi, Y. Kuriyama, M. Tanabe, M. Miyamoto, Y. Yasui, T. Matsumoto, K. Suzuki. Facile access to versatile polyaromatic building blocks: selectively protected benzocyclobutenedione derivatives via regioselective [2 + 2] cycloaddition of alpha-alkoxybenzyne and ketene silyl acetal., Helv. Chim. Acta., Vol. 85, No. 11, pp. 3589-3604, 2002.
• T. Ikemoto, T. Hosoya, H. Aoyama, Y. Kihara, M. Suzuki. Effects of dantrolene and its derivatives on the Ca²⁺ release in the sarcoplasmic reticulum of mouse skeletal muscle fibres., Br. J. Pharmacol., Vol. 134, No. 4, pp. 729-736, 2001.
• T. Hosoya, T. Hamura, Y. Kuriyama, M. Miyamoto, T. Matsumoto, K. Suzuki. Silicon-Directed Regioselective [2+2] Cycloaddition of alpha-Alkoxybenzyne and Ketene Silyl Acetals., Synlett, No. 4, pp. 520-522, 2000.
• S. Futagami, Y. Ohashi, K. Imura, T. Hosoya, K. Omori, T. Matsumoto, K. Suzuki. Total synthesis of ravidomycin: revision of absolute and relative stereochemistry., Tetrahedron Lett., Vol. 41, No. 7, pp. 1063-1067, 2000.
• K. Furuta, T. Hosoya, K. Tomokiyo, S. Okuda, A. Kuniyasu, H. Nakayama, T. Ishikawa, M. Suzuki. [³⁵S]S-[5-(4-benzoylphenyl)pentyl]glutathione: A Versatile Radioligand Targeting GS-X Pumps with the Ability of Photoaffinity Labeling., Bioorg. Med. Chem. Lett., Vol. 9, No. 18, pp. 2661-2666, 1999.
• T. Hosoya, E. Takashiro, Y. Yamamoto, T. Matsumoto, K. Suzuki. Total Syntheses of BE-12406 A and Its C(8)-Vinyl Analog., Heterocycles, Vol. 42, No. 1, pp. 397-414, 1996.
• T. Hosoya, Y. Ohashi, T. Matsumoto, K. Suzuki. On the Stereochemistry of Aryl C-Glycosides: Unusual Behavior of Bis-TBDPS Protected Aryl C-Olivosides., Tetrahedron Lett., Vol. 37, No. 5, pp. 663-666, 1996.
• T. Hosoya, T. Hasegawa, Y. Kuriyama, K. Suzuki. Stereospecificity in [2 + 2] Cycloaddition of Benzyne and Ketene Silyl Acetal., Tetrahedron Lett., Vol. 36, No. 19, pp. 3377-3380, 1995.
• T. Hosoya, Y. Kuriyama, K. Suzuki. Convenient Synthesis of Phthalides via Regioselective Baeyer-Villiger Oxidation of Benzocyclobutenones., Synlett, No. 6, pp. 635-638, 1995.
• T. Hosoya, T. Hasegawa, Y. Kuriyama, T. Matsumoto, K. Suzuki. [2 + 2] Cycloaddition of Benzyne and Ketene Silyl Acetal as an Efficient Route to Benzocyclobutenones., Synlett, No. 2, pp. 177-179, 1995.
• T. Hosoya, E. Takashiro, T. Matsumoto, K. Suzuki. First Total Synthesis of BE-12406 A., Tetrahedron Lett., Vol. 35, No. 26, pp. 4591-4594, 1994.
• T. Hosoya, E. Takashiro, T. Matsumoto, K. Suzuki. Total Synthesis of the Gilvocarcins., J. Am. Chem. Soc., Vol. 116, No. 3, pp. 1004-1015, 1994.
• T. Matsumoto, T. Hosoya, K. Suzuki. Total Synthesis and Absolute Stereochemical Assignment of Gilvocarcin M., J. Am. Chem. Soc., Vol. 114, No. 9, pp. 3568-3570, 1992.
• T. Matsumoto, T. Hosoya, K. Suzuki. O→C-Glycoside Rearrangement of Resorcinol Derivatives. Versatile Intermediates in the Synthesis of Aryl C-Glycosides., Synlett, No. 9, pp. 709-711, 1991.
• T. Matsumoto, T. Hosoya, M. Katsuki, K. Suzuki. New Efficient Protocol for Aryne Generation. Selective Synthesis of Differentially Protected 1,4,5-Naphthalenetriols., Tetrahedron Lett., Vol. 32, No. 46, pp. 6735-6736, 1991.
• T. Matsumoto, T. Hosoya, K. Suzuki. Improvement in O→C-Glycoside Rearrangement Approach to C-Aryl Glycosides: Use of 1-O-Acetyl Sugar as Stable but Efficient Glycosyl Donor., Tetrahedron Lett., Vol. 31, No. 32, pp. 4629-4632, 1990.

著書

• 鈴木正昭, 土居久志, 細谷孝充, 塚田秀夫. 先端の分析法－理工学からナノ・バイオまで－／第10章 生体トモグラフィー／第1節 PET, エヌ・ティ－・エス, pp. 814-829, 2004.
• M. Suzuki, T. Hosoya, R. Noyori. Handbook of Organopalladium Chemistry for Organic Synthesis / Palladium-catalyzed rearrangements of oxygen functions., John Wiley & Sons, Vol. 2, pp. 2939-2954, 2002.

国内会議発表 (査読なし・不明)

• 戸田 収, 細谷 悟史, 遠藤 毅, 根岸 瑠美, 福島 慶子, 伊藤 由馬, 十川 久美子, PAXTON Thanai, 喜井 勲, 朴 明宣, 大野 敏, 竹内 真粧美, 横川 隆志, 西川 一八, 山下 克子, 徳永 万喜洋, 細谷 孝充, 林 宣宏. 神経細胞における生体膜ラフトの動作メカニズムの解明, 第35回日本分子生物学会年会, Dec. 2012.

その他の論文・著書など

• 細谷孝充. アジド基の特性を利用したnon-RI光親和性標識法の開発, 有機合成化学協会誌, Vol. 65, No. 9, pp. 842-851, 2007.
• 細谷孝充. 標的タンパク質探索の化学, 化学工業, Vol. 58, No. 5, pp. 345-350, 2007.
• 鈴木正昭, 土居久志, 細谷孝充. 生体可視化用分子プローブの創製と活用, オプトロニクス, Vol. 25, No. 3, pp. 94-100, 2006.
• 鈴木正昭, 土居久志, 細谷孝充. 脳化学：PET研究基盤を刷新するプローブ創製と ¹¹C新導入法, 神経研究の進歩, Vol. 49, No. 6, pp. 939-947, 2005.
• 鈴木正昭, 土居久志, 加藤孝一, 細谷孝充, 渡辺由美子, 渡辺恭良. 脳を探る分子プローブ設計：ヒト脳内IP₂受容体の分子イメージング, 日本神経精神薬理学雑誌, Vol. 24, No. 4, pp. 221-229, 2004.
• 鈴木正昭, 土居久志, 細谷孝充, 渡辺恭良. Positron Emission Tomography（PET）法による生体の分子イメージング研究と創薬・医療への応用, 生物物理, Vol. 44, No. 6, pp. 265-270, 2004.
• 鈴木正昭, 土居久志, 細谷孝充, B. Langstrom, 渡辺由美子, 渡辺恭良. 設計PGプローブによるヒト脳内IP₂受容体の分子イメージング, 細胞工学, Vol. 22, No. 2, pp. 167-171, 2003.
• 鈴木正昭, 土居久志, 細谷孝充, 渡辺恭良. 生体系の非破壊分析（９）：PET法による脳内中枢型プロスタサイクリン受容体の分子イメージング, 現代化学, Vol. 387, No. 6, pp. 46-54, 2003.
• 鈴木正昭, 古田享史, 細谷孝充. 「設計分子による生体機能制御ソフトの構築」を目指して, 有機合成化学協会誌, Vol. 55, No. 5, pp. 365-374, 1997.
• K. Suzuki, T. Matsumoto, T. Hosoya. Total Synthesis of the Gilvocarcins., J. Synth. Org. Chem., Jpn., Vol. 53, No. 11, pp. 1045-1054, 1995.
• 鈴木啓介, 松本隆司, 細谷孝充. ハイブリッド型抗腫瘍性化合物ギルボカルシン類の全合成, 化学と工業, Vol. 46, No. 7, pp. 1103-1105, 1993.

特許など

• 細谷孝充, 飯森　理絵, 井上　敏, 佐原　由依子. セレンテラジン類縁体及びその製造方法　. 特許. 登録. 国立大学法人東京工業大学, ＪＮＣ株式会社. 2010/02/08. 特願2010-549536. 2012/08/09. 特開（再表）2010/090319. 特許第5582505号. 2014/07/25 2014.
• 細谷孝充, 岡　光平, 井上　敏. セレンテラミド類縁体　. 特許. 登録. 国立大学法人東京工業大学, ＪＮＣ株式会社. 2010/02/08. 特願2010-549535. 2012/08/09. 特開（再表）2010/090318. 特許第5534346号. 2014/05/09 2014.
• 細谷孝充, 山岸　玄, 土居　久志, 渡辺　恭良. アリールＯ-グルコシドの製造方法. 特許. 公開. 国立大学法人東京工業大学, 独立行政法人理化学研究所. 2008/02/05. 特願2008-025704. 2009/08/20. 特開2009-184953. 2009.

学位論文

• Studies on Regio- and Stereoselective Synthesis of Aryl Glycoside Antibiotics.,  本文,  Doctor of Science,  Keio University,  1995/03/--, 

[ BibTeX 形式で保存 ]    [ 論文・著書をCSV形式で保存 ]    [ 特許をCSV形式で保存 ]