論文

• T. Takahashi, A. Ueno, H. Mihara. Nucleobase amino acids incorporated into the HIV-1 nucleocapsid protein increased the binding affinity and specificity for a hairpin RNA, ChemBioChem, Vol. 6, No. 3, pp. 543-549, 2002.
• T. Takahashi, A. Ueno, H. Mihara. Construction of RNA-binding proteins having nucleobase amino acids based on HIV-1 nucleocapsid protein, Peptides: the Wave of the Future, pp. 518-519, 2002.
• I. Kumagai, T. Takahashi, K. Hamasaki, A. Ueno, H. Mihara. HIV-1 Rev peptides conjugated with peptide nucleic acids and their efficient binding to RRE RNA, Bioorg. Med. Chem Lett., No. 11, pp. 1169-1172, 2001.
• T. Takahashi, I. Kumagai, K. Hamasaki, A. Ueno, H. Mihara. Design of peptides with L-a-nucleobase amino acids and their selective recognition of RNA, Peptide Science, pp. 81-82, 2001.
• G. Balasundaram, T. Takahashi, A. Ueno, H. Mihara. Construction of peptide conjugates with peptide nucleic acids containing an anthracene probe and their interactions with DNA, Bioorganic and Medicinal Chemistry, No. 9, pp. 1115-1121, 2001.
• T. Takahashi, K. Hamasaki, A. Ueno, H. Mihara. Construction of peptides with nucleobase amino acids: design and synthesis of the nucleobase-conjugated peptides derived from HIV-1 Rev and their binding properties to HIV-1 RRE RNA, Bioorganic and Medicinal Chemistry, Vol. 4, No. 9, pp. 991-1000, 2001.
• Yusuke Maeda, Toshiki Sawada, Tsuyoshi Takahashi, Hideya Yuasa, Hisakazu Mihara. Affinity Control of Monosaccharide Conjugated Peptides against Lectins with a Set of Amino Acid Substitutions on α‑Helical Structure, Bioconjugate Chem., Vol. 31, No. 11, pp. 2533−2540, Oct. 2020.
• Hiroshi Tsutsumi, Hiroyuki Ohkusa, Hyejin Park, Tsuyoshi Takahashi, HIDEYA YUASA, Hisakazu Mihara. Gold Nanoparticles Conjugated with Monosaccharide-modified Peptide for Lectin Detection, Bioorganic & Medicinal Chemistry Letters, Vol. 22, No. 22, pp. 6825-6827, Sept. 2012.  公式リンク  
  
• T. Sawada, M. Tsuchiya, T. Takahashi, Hiroshi Tsutsumi, H. Mihara. Cell-Adhesive Hydrogels Composed of Peptide Nanofibers Responsive to Biological Ions, Polymer Journal, Vol. 44, pp. 651-657, Apr. 2012.
• T. Sawada, K. Ishiguro, T. Takahashi, H. Mihara. A novel beta-loop scaffold of phage-displayed peptides for highly specific affinities, Molecular Biosystems, Vol. 7, pp. 2558-2562, June 2011.
• T. Sawada, K. Ishiguro, T. Takahashi, H. Mihara. A Novel Peptide Array Using a Phage Display System for Protein Detection, Chemistry Letters, Vol. 40, pp. 508-509, Apr. 2011.
• Tempei Shimizu, Yasushi Kanamori, Takao Furuki, Takahiro Kikawada, Takashi Okuda, Tsuyoshi Takahashi, Hisakazu Mihara, Minoru Sakurai. Desiccation-induced structuralization and glass formation of Group3 LEA protein model peptides, Biochemistry, 49, 1093-1104, 2010.
• Tsuyoshi Takahashi, Kosuke Tada, HISAKAZU MIHARA. RNA aptamers selected against amyloid β-peptide (Aβ) inhibit the aggregation of Aβ, Molecular Biosystems, Royal Society of Chemistry, Vol. 5, pp. 986-991, Sept. 2009.
• Toshiki Sawada, Tsuyoshi Takahashi, Hisakazu Mihara. Affinity-Based Screening of Peptides Recognizing Assmbly Stated of Self-Assembling Peptide Nanomaterials, Journal of the American Chemical Society, Vol. 131, pp. 14434-14441, Sept. 2009.
• Mariejoy Therese Jumawid, Tsuyoshi Takahashi, Toshimasa Yamazaki, Hiroshi Ashigai, HISAKAZU MIHARA. Selection and structural analysis of de novo proteins from an α3β3 genetic library, Protein Science, The Protein Society, Vol. 18, pp. 384-398, Jan. 2009.
• Tsuyoshi Takahashi, HISAKAZU MIHARA. Peptide and Protein Mimetics Inhibiting Amyloid β-Peptide Aggregation, Accounts of Chemical Research, American Chemical Society, Vol. 41, No. 10, pp. 1309-1318, Oct. 2008.
• T. Takahashi, K. Ohta, H. Mihara. Embedding the Amyloid β-Peptide Sequence in Green Fluorescent Protein Inhibits Aβ Oligomerization, ChemBioChem, Vol. 8, pp. 985-988, Aug. 2007.
• J. Sato, Tsuyoshi Takahashi, H. Oshima, S. Matsumura, HISAKAZU MIHARA. Design of Peptides That Form Amyloid-like Fibrils Capturing Amyloid β1-42 Peptides., Chem. Eur. J., Vol. 13, pp. 7745-7752, 2007.
• S. Watanabe, K.-Y. Tomizaki, Tsuyoshi Takahashi, K. Usui, K. Kajikawa, HISAKAZU MIHARA. Interactions Between Peptides Containing Nucleobase Amino Acids and T7 Phages Displaying S. cerevisiae Proteins, Biopolymers (Peptide Science), Vol. 88, No. 2, pp. 131-140, 2007.
• Tsuyoshi Takahashi, Yana Dewi, HISAKAZU MIHARA. Utilization of L-α-Nucleobase Amino Acids (NBAs) as a Protein Engineering Tool: Construction of NBA Modified HIV-1 Protease Analogues and Enhancement of Dimerization Induced by Nucleobase Interaction, ChemBioChem, Vol. 7, pp. 729-732, May 2006.
• Hideo Miyanishi, Tsuyoshi Takahashi, HISAKAZU MIHARA. De Novo Design of Peptides with L-alpha-Nucleobase Amino Acids and Their Binding Properties to the P22 boxB RNA and Its Mutants, Bioconjugate Chemistry, Vol. 15, pp. 694-698, 2004.
• G. Balasundaram, T. Takahashi, A. Ueno, H. Mihara. Synthesis of PNA-peptide conjugates and their interactions with DNA, Peptides for the New Millennium, pp. 790-791, 2000.
• H. Kuribayashi, T. Takahashi, K. Nagata, A. Ueno, H. Mihara. Construction of two-stranded a-helix peptides based on influenza virus M1 protein selectively bound to RNA, Bioorg. Med. Chem. Lett., No. 1010, pp. 2227-2230, 2000.
• T. Takahashi, I. Kumagai, K. Hamasaki, A. Ueno, H. Mihara. Design and synthesis of peptides containing nucleobase amino acids and their interaction with RNA, Peptide Science, pp. 397-398, 2000.
• I. Kumagai, T. Takahashi, K. Hamasaki, A. Ueno, H. Mihara. Construction of HIV Rev peptides containing peptide nucleic acid that bind HIV RRE IIB RNA, Bioorg. Med. Chem. Lett., No. 10, pp. 377-379, 2000.
• T. Takahashi, A. Ueno, H. Mihara. Combination of a-helix peptides with intercalator anthracene for reporting peptide-DNA interaction, Peptides; Frontiers of Peptide Science, pp. 130-131, 1999.
• T. Takahashi, I. Kumagai, K. Hamasaki, A. Ueno, H. Mihara. Design of artificial peptides that recognize the HIV RRE IIB RNA, Nucleic Acids Symp. Ser., No. 42, pp. 271-272, 1999.
• H. Kuribayashi, T. Takahashi, K. Nagata, A. Ueno, H. Mihara. Interaction of basic peptides derived from influenza virus M1 protein with DNA/RNA, Peptide Science, pp. 413-414, 1999.
• H. Kuribayashi, T. Takahashi, K. Watanabe, K. Nagata, A. Ueno, H. Mihara. Interaction of peptides from influenza virus matrix protein with nucleic acids, Nucleic Acids Symp. Ser., No. 39, pp. 63-64, 1998.

著書

• 三原久和, 高橋剛, 富崎欣也. とことんやさしい タンパク質の本、東京工業大学大学院生命理工学研究科編、29.ペプチドは小さなタンパク質、46.人工タンパク質の分子設計、51.プロテインチップでタンパク質を検出, 日本工業新聞社, pp. 72-73、110-111、122-123, 2007.

国際会議発表 (査読有り)

• Ryuichi Uozumi, Tsuyoshi Takahashi, HISAKAZU MIHARA. Design of beta-Hairpin Peptides Having Nucleobase Amino Acids (NBAs) and, Peptide Science 2007 (S. Aimoto & S. Ono, Eds.), The Japanese Peptide Society, pp. 471-472, Mar. 2008.
• Tsuyoshi Takahashi, K. Ohta, HISAKAZU MIHARA. Construction of Green Fluorescent Protein (GFP) Variants That Interact with Amyloid β-Peptide., The Japanese Peptide Society, Peptide Science 2006, pp. 9, 2006.

国内会議発表 (査読有り)

• 土谷正樹, 澤田敏樹, 高橋 剛, 三原久和. 機能性バイオマテリアル構築を目的としたカルシウムイオン応答性自己組織化ペプチドナノファイバーの構築, 第91日本化学会春季年会, Mar. 2011.
• 古木隆生, 清水天平, S. Charkrabortee, 畑中理恵, 高橋剛, 黄川田隆洋, 奥田隆, 三原久和, A. Tunnacliffe, 櫻井実. グループ３LEAタンパク質の22-merモデルペプチドが示すタンパク質凝集抑制効果, 低温生物工学会誌, Vol. 57, pp. 139-142, 2011.
• Takao Furuki, Tempei Shimizu, Tsuyoshi Takahashi, Hisakazu Mihara, Takahiro Kikawada, Takashi Okuda, Minoru Sakurai. Model Study of the Desiccation-induced Vitrification of Group-3 Late Embrogenesis Abundant Proteins, Cryobiol. Cryotech., 56, 1, 27-30, June 2010.
• T. Shimizu, Y. Kanamori, T. Furuki, T. Okuda, T. Kikawada, T. Takahashi, H. Mihara, M. Sakurai. Model study of the desiccation-induced structural transformations of Group-3 Late Embryogenesis Abundant (G3LEA) proteins, Cryobiol. Cryotech., Vol. 53, pp. 101-105, 2007.

その他の論文・著書など

• 高橋 剛, 三原久和. アミロイドタンパク質をはかる, バイオ研究のフロンティア２．酵素・タンパク質をはかる・とらえる・利用する, 工学図書, pp. 54-64, Feb. 2009.
• 高橋 剛, 三原久和. 生体反応を司るらせん・たんぱく質のらせん構造, 化学と教育, Vol. 55, No. 7, pp. 356-359, July 2007.
• 高橋 剛, 松村幸子, 三原久和. アミロイドβペプチド（Aβ）を標的とした人工タンパク質・ペプチドの設計とAβ集, 生物物理, Vol. 47, No. 4, pp. 228-234, Apr. 2007.

学位論文

• Design and Synthesis of Peptides and Proteins Conjugated with L-α-Nucleobase Amino Acids and Their Selective Recognition of RNA,  本文,  Doctor of Engineering,  Tokyo Institute of Technology,  2001/--/--, 

[ BibTeX 形式で保存 ]    [ 論文・著書をCSV形式で保存 ]    [ 特許をCSV形式で保存 ]