論文

• Kosuke Sato, Kohji Seio, Mitsuo Sekine. Squaryl Group as a New Mimic of Phosphate Group in Modified Oligodeoxynucleotides: Synthesis and Properties of New Oligodeoxynucleotide Analogues Containing an Internucleotidic Squaryldiamide Linkage, J. Am. Chem. Soc, Vol. 124, No. 43, pp. 12715-12724., 2002.
• Tomohisa Moriguchi, Norio Asai, Kazuisa Okada, Kohji Seio, Takuma Sasaki, Mitsuo Sekine. First Synthesis and Anti-Cancer Activity of Phosmidosine and Its Related Compounds, J. Org. Chem, Vol. 67, No. 10, pp. 3290-3300, 2002.
• Akio Kobori, Ken-ichi Miyata, Masatoshi Ushioda, Kohji Seio, Mitsuo Sekine. A New Method for the Synthesis of Oligodeoxynucleotides Containing 4-N-Alkoxycarbonyldeoxycytidine Derivatives and Their Hybridization Property, J. Org. Chem, Vol. 67, No. 2, pp. 476-485, 2002.
• Yu-ichi Sato, Gosuke Tateno, Kohji Seio, Mitsuo Sekine. Substituent and Solvent Effects of TMS-triflate mediated C1'-Epimerization of alpha-Thymidine to beta-Thymidine, Eur. J. Org. Chem, pp. 4583-4593, 2002.
• Miyaji K, Masaki Y, Seio K. Inhibitory Effects on RNA Binding and RNase H Induction Activity of Prodrug-Type Oligodeoxynucleotides Modified with a Galactosylated Self-Immolative Linker Cleavable by β-Galactosidase, Bioconjugate Chemistry, Oct. 2024.
• Noguchi M, Miyauchi A, Masaki Y, Sakaki M, Lei XF, Kobayashi-Tanabe M, Miyazaki A, Aoki T, Yoshida H, Seio K, Kim-Kaneyama Jr. Hic-5 antisense oligonucleotide inhibits advanced hepatic fibrosis and steatosis in vivo, JHEP Reports, Vol. 6, Aug. 2024.
• Takayuki Kanagawa, Shigetoshi Tachibana, Yoshiaki Masaki, Kohji Seio. Synthesis and Conformational Analyses of Cyclonucleoside Having 13-Membered Ring Bridging Nucleobase and 5′-Position via a Linker Containing Sulfonamide, Org. Lett., Vol. 25, Oct. 2023.
• Kanagawa T, Koyoma A, Masaki Y, Seio K. Alteration of target cleavage patterns and off-target reduction of antisense oligonucleotides incorporating 2- N-carbamoyl- or (2-pyridyl)guanine, Org Biomol Chem ., June 2023.
• Tomori T, Uekusa K, Koyama A, Kanagawa T, Masaki Y, Seio K. Synthesis of 2'-O-[3-(N-methylsulfamoyl)propan-1-yl]ribothymidine as a potentially applicable 2'-modified nucleoside for antisense oligonucleotides, Bioorg Med Chem ., Vol. 73, Nov. 2022.
• Masaki Y, Tabira A, Hattori S, Wakatsuki S, Seio K. Insertion of a methylene group into the backbone of an antisense oligonucleotide reveals the importance of deoxyribose recognition by RNase H, Org. Biomol Chem., Vol. 20, Oct. 2022.
• Masaki Y, Onishi Y, Seio K. Quantification of synthetic errors during chemical synthesis of DNA and its suppression by non-canonical nucleosides, Sci Rep., Vol. 12, July 2022.
• Okamura H, Trinh GH, Dong Z, Masaki Y, Seio K, Nagatsugi F.. Selective and stable base pairing by alkynylated nucleosides featuring a spatially-separated recognition interface, Nucleic Acids Res., Mar. 2022.
• Masaki Y, Maruyama A, Yoshida K, Tomori T, Kishimura T, Seio K.. Oligodeoxynucleotides Modified with 2'- O-(Cysteinylaminobutyl)carbamoylethylribothymidine Residues for Native Chemical Ligation with Peptide at Internal Positions, Bioconjug. Chem., Feb. 2022.
• Kishimura T, Tomori T, Masaki Y, Seio K.. Synthesis of 2′-O-alkylcarbamoylethyl-modified oligonucleotides with enhanced nuclease resistance that form isostable duplexes with complementary RNA, Bioorg Med Chem Lett., Mar. 2021.
• Yuko Hara, Yoshitaka Mizobe, Yukiko U. Inoue, Yasumasa Hashimoto, Norio Motohashi, Yoshiaki Masaki, Kohji Seio, Shin’ichi Takeda, Tetsuya Nagata, Matthew J. A. Wood, Takayoshi Inoue, Yoshitsugu Aoki. Novel EGFP reporter cell and mouse models for sensitive imaging and quantification of exon skipping, June 2020.
• Seio K, Yamaguchi K, Yamazaki A, Kanamori T, Masaki Y.. Transcription of DNA duplex containing deoxypseudouridine and deoxypseudoisocytidine, and inhibition of transcription by triplex forming oligonucleotide that recognizes the modified duplex, Nucleosides, Nucleotides & Nucleic Acids, Mar. 2020.
• Takeshita L, Yamada Y, Masaki Y, Seio K.. Synthesis of Deoxypseudouridine 5′-Triphosphate Bearing the Photoremovable Protecting Group at the N1 Position Capable of Enzymatic Incorporation to DNA, J. ORG. CHEM., Vol. 7, Jan. 2020.
• Masaki Y, Yamamoto K, Yoshida K, Maruyama A, Tomori T, Iriyama Y, Nakajima H, Kanaki T, Seio K.. Modification of oligonucleotides with weak basic residues via the 2′-O-carbamoylethyl linker for improving nuclease resistance without loss of duplex stability and antisense activity, Org. Biomol Chem., Apr. 2019.
• Seio K, Shiozawa T, Sugiyama D, Ohno K, Tomori T, Masaki Y.. 31P NMR Study on the Reactions of Amino Acids and Sugar Derivatives with Pyrophosphorous Acid as a Possible Prebiotic Phosphonylating Agent, Bull. Chem. Soc. Jpn., Vol. 92, No. 4, pp. 905-911, Apr. 2019.
• Takashi Kanamori, Masaki Y, Oda Y, Ohzeki H, Ohkubo A, Sekine M, Seio K.. DNA triplex-based fluorescence turn-on sensors for adenosine using a fluorescent molecular rotor 5-(3-methylbenzofuran-2-yl) deoxyuridine, Org. Biomol Chem., Jan. 2019.
• Masaki Y, Inde T, Maruyama A, Seio K.. Tolerance of N2-heteroaryl modifications on guanine bases in a DNA G-quadruplex, Org. Biomol Chem., Vol. 17, pp. 859-866, Jan. 2019.
• Kaori Ando, Hisao Saneyoshi, Kohji Seio, Mitsuo Sekine. A theoretical study on the elimination reaction of acrylonitrile from 2′-O-cyanoethylated nucleosides by Bu4NF, Tetrahedron, Vol. 75, No. 1, 1-9, Jan. 2019.
• Yoshiaki Masaki, Keishi Yamamoto, Takeshi Inde, Keita Yoshida, Atsuya Maruyama, Tetsuya Nagata, Jun Tanihata, Shin'ichi Takeda, Mitsuo Sekine, Kohji Seio. Synthesis of 2'-O-(N-methylcarbamoylethyl) 5-methyl-2-thiouridine and its application to splice-switching oligonucleotides, Bioorganic & Medicinal Chemistry Letters, Dec. 2018.
• Yoshiaki Masaki, Yusuke Iriyama, Hiroyuki Nakajima, Yusuke Kuroda, Tatsuro Kanaki, Satoshi Furukawa, Mitsuo Sekine, Kohji Seio. Application of 2′-O-(2-N-Methylcarbamoylethyl) Nucleotides in RNase H-Dependent Antisense Oligonucleotides, Nucleic Acid Ther., Vol. 28, No. 5, Sept. 2018.
• K. Seio, T. Kanamori, Y. Masaki. Synthesis of Fluorescent Nucleic Acids bearing Nucleobases Modified with Heteroaryl Group and Fluorophores, JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, Vol. 76, No. 8, pp. 792-801, Aug. 2018.
• Takeshi Inde, Shuhei Nishizawa, Yuusaku Hattori, Takashi Kanamori, Hideya Yuasa, Kohji Seio, Mitsuo Sekine, Akihiro Ohkubo. Synthesis of and triplex formation in oligonucleotides containing 2’-deoxy-6-thioxanthosine, July 2018.
• Takahito Tomori, Kento Nagaoka, Leo Takeshita, Takashi Shiozawa, Yuya Miyatake, Yoshiaki Masaki, Mitsuo Sekine, Kohji Seio. Deoxynucleoside Triphosphate Containing Pyridazin-3-one Aglycon as a Thymidine Triphosphate Substitute for Primer Extension and Chain Elongation by Klenow fragments, J. Org. Chem., Vol. 83, No. 15, pp. 8353–8363, June 2018.
• Kohji Seio, Takashi Kanamori, Yoshiaki Masaki. Solvent- and environment-dependent fluorescence of modified nucleobases, Tetrahedron Lett., Vol. 59, No. 21, pp. 1977-1985, May 2018.
• Inde, Takeshi, Nishizawa, Shuhei, Hattori, Yuusaku, Kanamori, Takashi, Yuasa, Hideya, Seio, Kohji, Sekine, Mitsuo, Ohkubo, Akihiro, KOHJI SEIO. Synthesis of and triplex formation in oligonucleotides containing 2 '-deoxy-6-thioxanthosine, Bioorganic & Medicinal Chemistry, Vol. 26, No. 13, pp. 3785-3790, 2018.  公式リンク  
  
• K. Ohno, D. Sugiyama, L. Takeshita, T. Kanamori, Y. Masaki, M. Sekine, K. Seio. Synthesis of photocaged 6-O-(2-nitrobenzyl) guanosine and 4-O-(2-nitrobenzyl)uridine triphosphates for photocontrol of the RNA transcription reaction, BIOORGANIC & MEDICINAL CHEMISTRY, Vol. 25, No. 21, pp. 6007-6015, Nov. 2017.
• T. Inde, Y. Masaki, A. Maruyama, Y. Ito, N. Makio, Y. Miyatake, T. Tomori, M. Sekine, K. Seio. Synthesis of oligonucleotides containing 2-N-heteroarylguanine residues and their effect on duplex/triplex stability, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 15, No. 39, pp. 8371-8383, Oct. 2017.
• K. Seio, M. Tokugawa, K. Kaneko, T. Shiozawa, Y. Masaki. A systematic study of the synthesis of 2'-deoxynucleosides by Mitsunobu reaction, SYNLETT, Vol. 28, No. 15, pp. 2014-2017, Sept. 2017.
• Takashi Kanamori, Akihiro Takamura, Nobuhiro Tago, Yoshiaki Masaki, Akihiro Ohkubo, Mitsuo Sekine, Kohji Seio. Fluorescence enhancement of oligodeoxynucleotides modified with green fluorescent protein chromophore mimics upon triplex formation., Org. Biomol. Chem., Vol. 15, pp. 1190-1197, Jan. 2017.
• Masaki Yoshiaki, Sekine Mitsuo, Seio Kohji. Deformability Calculation for Estimation of the Relative Stability of Chemically Modified RNA Duplexes., Current protocols in nucleic acid chemistry, Vol. 68, pp. 7.27.1-7.27.10, 2017.  公式リンク  
  
• Kohji Seio, Yurie Ohno, Kentaro Ohno, Leo Takeshita, Takashi Kanamori, Yoshiaki Masaki, Mitsuo Sekine. Photo-controlled binding of MutS to photo-caged DNA duplexes incorporating 4-O-(2-nitrobenzyl) or 4-O-[2-(2-nitrophenyl)propyl]thymidine, Bioorganic & Medicinal Chemistry Letters, Vol. 26, 19, Page 4861-4863, Oct. 2016.
• Yoshiaki Masaki, Hugo Itou, Yuki Oda, Kazufumi Yamazaki, Nobuhiro Tago, Kentaro Ohno, Nozomi Ishii, Hirosuke Tsunoda, Takashi Kanamori, Akihiro Ohkubo, Mitsuo Sekine, Kohji Seio. Enzymatic synthesis and reverse transcription of RNAs incorporating 2'-O-carbamoyl uridine triphosphate, Chemical Communications, Sept. 2016.
• Munefumi Tokugawa, Yoshiaki Masaki, Jan Christian Canggadibrata, Kazuhei Kaneko, Takashi Shiozawa, Takashi Kanamori, Morten Grøtli, L. Marcus Wilhelmsson, Mitsuo Sekine, Kohji Seio. 7-(Benzofuran-2-yl)-7-deazadeoxyguanosine as a fluorescence turn-ON probe for single-strand DNA binding protein, Chemical Communications, Vol. 52, 3809-3812, Sept. 2016.
• Yu Ito, Yoshiaki Masaki, Takashi Kanamori, Akihiro Ohkubo, KOHJI SEIO, MITSUO SEKINE. Synthesis of 5-[3-(2-aminopyrimidin-4-yl)aminopropyn-1-yl]uracil derivative that recognizes Ade-Thy base pairs in double-stranded DNA, Bioorg. Med. Chem. Lett., Vol. 26, pp. 194-196, Jan. 2016.
• Nobuhiro Tago, Yoshiaki Masaki, Takashi Kanamori, Akihiro Ohkubo, KOHJI SEIO, MITSUO SEKINE. A New Microfluidic Phase-Transfer Reaction Using HPLC Guard Columns as the Reactor for the N3 Protection of Uridine Derivatives, SYNLETT, Vol. 26, pp. 2578-2582, Nov. 2015.
• N. Tago, A. Katolik, N. E. Clark, E. J. Montemayor, K. Seio, M. Sekine, P. J. Hart, M. J. Damha. Design, synthesis, and properties of phosphoramidate 2 ',5 '-linked branched RNA: Toward the rational design of inhibitors of the RNA lariat debranching enzyme, OURNAL OF ORGANIC CHEMISTRY, Vol. 80, No. 20, pp. 10108-10118, Oct. 2015.
• Ohkubo, Kenji Yamada, Yu Ito, Kiichi Yoshimura, Koichiro Miyauchi, Takashi Kanamori, Yoshiaki Masaki, KOHJI SEIO, HIDEYA YUASA, Mitsuo. Synthesis and Triplex-forming Properties of Oligonucleotides Capable of Recognizing Corresponding DNA Duplexes Containing Four Base Pairs, Nucleic Acids Res., Vol. 43, No. 12, pp. 5675-5686, May 2015.
• Takahito Tomori, Yuya Miyatake, Takashi Kanamori, Yoshiaki Masaki, Akihiro Ohkubo, KOHJI SEIO, MITSUO SEKINE. Synthesis of peptide nucleic acids containing pyridazine derivatives as cytosine and thymine analogs, and their duplexes with complementary oligodeoxynucleotides, ORG. LETT., Vol. 17, 6, pp. 1609-1612, Mar. 2015.
• munefumi tokugawa, Kazuhei Kaneko, Masanori Saito, Takashi Kanamori, Yoshiaki Masaki, Akihiro Ohkubo, KOHJI SEIO, MITSUO SEKINE. Synthesis of responsive fluorescent Nucleobases 7-(Benzofuran-2-yl)-7- deazahypoxanthine and 7-(benzofuran-2-yl)-7-deazaguanine using cross-coupling reaction, CHEM. LETT., Vol. 44, pp. 64-66, Jan. 2015.
• Takashi Kanamori, Hiroki Ohzeki, Yoshiaki Masaki, Akihiro Ohkubo, MITSUO SEKINE, KOHJI SEIO. Controlling the fluorescence of benzofuran-modified uracil residues in oligonucleotides by triple-helix formation, Chembiochem, Vol. 16, 1, pp. 167-176, Jan. 2015.
• Yoshiaki Masaki, Takeshi Inde, Tetsuya Nagata, Jun Tanihata, Takashi Kanamori, Kohji Seio, Shin'ichi Takeda, Mitsuo Sekine. Enhancement of exon skipping in mdx52 mice by 2′-O-methyl-2-thioribothymidine incorporation into phosphorothioate oligonucleotides, Med. Chem. Commun., Vol. 6, Page 630-633, Nov. 2014.
• Masaki Yoshiaki, Yamada Takeshi, Saneyoshi Hisao, Ohkubo Akihiro, Seio Kohji, Sekine Mitsuo. Synthesis and Exon-Skipping Activity of Chemically Modified RNAs, Chemical Biology of Nucleic Acids: Fundamentals and Clinical Applications, pp. 497-510, Mar. 2014.  公式リンク  
  
• KOHJI SEIO, Takashi Kanamori, Sekine, M.. Synthesis of branched DNA using oxidatively cleavable tritylsulfenyl as a hydroxy protecting group, Current Protocols in Nucleic Acid Chemistry, Vol. 2014, pp. 2.18.1-2.18.19, 2014.
• T. Yamada, Y. Masaki, N. Okaniwa, T. Kanamori, A. Ohkubo, H. Tsunoda, K. Seio, M. Sekine. Synthesis and properties of oligonucleotides modified with 2 '-O-(2-carboxyethyl)nucleotides and their carbamoyl derivatives, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 12, No. 33, pp. 6457-6464, 2014.
• K. Yamada, Y. Masaki, H. Tsunoda, A. Ohkubo, K. Seio, M. Sekine. A new modified cytosine base capable of base pairing with guanine using four hydrogen bonds, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 12, No. 14, pp. 2255-2262, 2014.
• Y. Masaki, R. Miyasaka, K. Hirai, T. Kanamori, H. Tsunoda, A. Ohkubo, K. Seio, M. Sekine. Properties of 5- and/or 2-modified 2 '-O-cyanoethyl uridine residue: 2 '-O-cyanoethyl-5-propynyl-2-thiouridine as an efficient duplex stabilizing component, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 12, No. 7, pp. 1157-1162, 2014.
• Ohkubo, Akihiro, Seio, Kohji, Sekine, Mitsuo, KOHJI SEIO. Development of New Methods for Synthesis of Artificial Nucleic Acids having Various Functional Groups, Journal of Synthetic Organic Chemistry Japan, Vol. 72, No. 8, pp. 899-909, 2014.  公式リンク  
  
• Y. Iijima, S. Kojima, E. Kodama, S. Kurohagi, T. Kanamori, Y. Masaki, A. Ohkubo, M. Sekine, K. Seio. Modified oligodeoxynucleotide primers for reverse-transcription of target RNAs that can discriminate among length variants at the 3 '-terminus, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 11, No. 47, pp. 8276-8282, Dec. 2013.
• K. Seio, M. Tokugawa, H. Tsunoda, A. Ohkubo, F. Arisaka, M. Sekine. Assembly of pyrene-modified DNA/RNA duplexes incorporating a G-rich single strand region, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol. 23, No. 24, pp. 6822-6824, Dec. 2013.
• A. Ohkubo, Y. Kondo, M. Suzuki, H. Kobayashi, T. Kanamori, Y. Masaki, K. Seio, K. Nagai, M. Sekine. Chemical synthesis of U1 snRNA derivatives, ORGANIC LETTERS, Vol. 15, No. 17, pp. 4386-4389, Sept. 2013.
• K. Yamada, A. Ohkubo, Y. Esaka, T. Kanamori, Y. Masaki, K. Seio, M. Sekine. Base recognition of gap sites in DNA-DNA and DNA-RNA duplexes by short oligonucleotides, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol. 23, No. 11, pp. 3448-3451, June 2013.
• K. Seio, T. Kanamori, M. Tokugawa, H. Ohzeki, Y. Masaki, H. Tsunoda, A. Ohkubo, M. Sekine. Fluorescent properties of oligonucleotides doubly modified with an indole-fused cytosine analog and 2-aminopurine, BIOORGANIC & MEDICINAL CHEMISTRY, Vol. 21, No. 11, pp. 3197-3201, June 2013.
• K. Yamada, Y. Hattori, T. Inde, T. Kanamori, A. Ohkubo, K. Seio, M. Sekine. Remarkable stabilization of antiparallel DNA triplexes by strong stacking effects of consecutively modified nucleobases containing thiocarbonyl groups, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol. 23, No. 3, pp. 776-778, Feb. 2013.
• Satoshi Hara, T. Nojima, KOHJI SEIO, MASASUKE YOSHIDA, TORU HISABORI. DNA-maleimide: An improved maleimide compound for electrophoresis-based titration of reactive thiols in a specific protein, Biochimica Et Biophysica Acta-General Subjects, Vol. 1830, pp. 3077-3081, Jan. 2013.  公式リンク  
  
• T. Nojima, Hiroki Konno, N. Kodera, KOHJI SEIO, HIDEKI TAGUCHI, MASASUKE YOSHIDA. Nano-Scale Alignment of Proteins on a Flexible DNA Backbone, Plos One, Vol. 7, Dec. 2012.  公式リンク  
  
• K. Seio, M. Tokugawa, T. Kanamori, H. Tsunoda, A. Ohkubo, M. Sekine. Synthesis and properties of cationic 2 '-O- N-(4-aminobutyl)carbamoyl modified oligonucleotides, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol. 22, No. 7, pp. 2470-2473, Apr. 2012.
• T. Harakawa, H. Tsunoda, A. Ohkubo, K. Seio, M. Sekine. Development of an efficient method for phosphorodiamidate bond formation by using inorganic salts, Bioorganic & Medicinal Chemistry Letters, Vol. 22, No. 3, pp. 1445-1447, Feb. 2012.
• A. Ohkubo, N. Tago, A. Yokouchi, ; Y. Nishino, K. Yamada, H. Tsunoda, K. Seio, M. Sekine. Synthesis of 5 '-terminal capped oligonucleotides using O-N phosphoryl migration of phosphoramidite derivatives, ORGANIC LETTERS, Vol. 14, No. 1, pp. 10-13, Jan. 2012.
• A. Ohkubo, Y. Nishino, Y. Ito, H. Tsunoda, K. Seio, M. Sekine. Formation of new base pairs between inosine and 5-methyl-2-thiocytidine derivatives, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 10, No. 10, pp. 2008-2010, 2012.
• K. Seio, S. Kurohagi, E. Kodama, Y. Masaki, H. Tsunoda, A. Ohkubo, M. Sekine. Short-RNA selective binding of oligonucleotides modified using adenosine and guanosine derivatives that possess cyclohexyl phosphates as substituents, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 10, No. 5, pp. 994-1006, 2012.
• Y. Masaki, R. Miyasaka, K. Hirai, H. Tsunoda, A. Ohkubo, K. Seio, M. Sekine. Prediction of the stability of modified RNA duplexes based on deformability analysis: Oligoribonucleotide derivatives modified with 2 '-o-cyanoethyl-5-propynyl-2-thiouridine as a promising component, CHEMICAL COMMUNICATIONS, Vol. 48, No. 58, pp. 7313-7315, 2012.
• T. Kanamori, Y. Masaki, M. Mizuta, H. Tsunoda, A. Ohkubo, M. Sekine, K. Seio. DNA duplexes and triplex-forming oligodeoxynucleotides incorporating modified nucleosides forming stable and selective triplexes, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 10, No. 5, pp. 1007-1013, 2012.
• A. Ohkubo, A. Yokouchi, K. Yamada, H. Tsunoda, K. Seio, M. Sekine. Synthesis and properties of oligonucleotides having 5 '-terminal 2,2,7-trimethylguanosine cap analogues, NUCLEIC ACID THERAPEUTICS, Vol. 21, No. 5, pp. A39-A40, Oct. 2011.
• T. Yamada, N. Okaniwa, H. Saneyoshi, A. Ohkubo, K. Seio, T. Nagata, Y. Aoki, S. Takeda, M. Sekine. Synthesis of 2 '-O- 2-(N-methylcarbamoyl)ethyl ribonucleosides using oxa-michael reaction and chemical and biological properties of oligonucleotide derivatives incorporating these modified ribonucleosides, JOURNAL OF ORGANIC CHEMISTRY, Vol. 76, No. 9, pp. ç, May 2011.
• H. Tsunoda, T. Kudo, Y. Masaki, A. Ohkubo, K. Seio, M. Sekine. Biochemical behavior of N-oxidized cytosine and adenine bases in DNA polymerase-mediated primer extension reactions, NUCLEIC ACIDS RESEARCH, Vol. 39, No. 7, pp. 2995-3004, Apr. 2011.
• S. Q. Cao, I. Okamoto, H. Tsunoda, A. Ohkubo, K. Seio, M. Sekine. Synthesis and triplex-forming properties of oligonucleotides containing thio-substituted C-nucleoside 4-thiopseudoisocytidine, TETRAHEDRON LETTERS, Vol. 52, No. 3, pp. 407-410, Jan. 2011.
• A. Ohkubo, Y. Nishino, A. Yokouchi, Y. Ito, Y. Noma, Y. Kakishima, Y. Masaki, H. Tsunoda, K. Seio, M. Sekine. Stable triplex formation using the strong stacking effect of consecutive thionucleoside moieties, CHEMICAL COMMUNICATIONS, Vol. 47, No. 46, pp. 12556-12558, 2011.
• M. Sekine, Y. Oeda, Y. Iijima, H. Taguchi, A. Ohkubo, K. Seio. Synthesis and hybridization properties of 2 '-O-methylated oligoribonucleotides incorporating 2 '-O-naphthyluridines, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 9, No. 1, pp. 210-218, 2011.
• H. Tsunoda, T. Kudo, A. Ohkubo, K. Seio, M. Sekine. Synthesis of oligodeoxynucleotides using fully protected deoxynucleoside 3 '-phosphoramidite building blocks and base recognition of oligodeoxynucleotides incorporating N-3-cyano-ethylthymine, MOLECULES, Vol. 15, No. 11, pp. 7509-7531, Nov. 2010.
• K. Yamada, H. Taguchi, A. Ohkubo, K. Seio, M. Sekine. Synthesis and biochemical properties of oligodeoxynucleotides acylated by the chemically stable 2-(trimethylsilyl)benzoyl (TMSBz) group at the 5 ' or 3 ' terminus, Tetrahedron letters, Vol. 51, No. 39, pp. 5173-5176, Sept. 2010.
• A. Ohkubo, T. Sakaue, H. Tsunoda, K. Seio, M. Sekine. Synthesis and hybridization properties of oligonucleotides incorporating bi- and tricyclic cytosine derivatives, Chemistry letters, Vol. 39, No. 7, pp. 726-727, July 2010.
• A. Ohkubo, Y. Kuwayama, Y. Nishino, H. Tsunoda, K. Seio, M. Sekine. Oligonucleotide synthesis involving deprotection of amidine-type protecting groups for nucleobases under acidic conditions, ORGANIC LETTERS, Vol. 12, No. 11, pp. 2496-2499, June 2010.
• Y. Masaki, R. Miyasaka, A. Ohkubo, K. Seio, M. Sekine. Linear relationship between deformability and thermal stability of 2 '-O-modified RNA hetero duplexes, JOURNAL OF PHYSICAL CHEMISTRY B, Vol. 114, No. 7, pp. 2517-2524, Feb. 2010.
• Y. Masaki, A. Ohkubo, K. Seio, M. Sekine. Synthesis of 6-N-(benzothiazol-2-yl)deoxyadenosine and its exciton-coupled circular dichroism, BIOORGANIC & MEDICINAL CHEMISTRY, Vol. 18, No. 2, pp. 567-572, Jan. 2010.
• K. Seio, M. Shiraishi, E. Utagawa, A. Ohkubo, M. Sekine. Synthesis of oligodeoxynucleotides using the oxidatively cleavable 4-methoxytritylthio (MMTrS) group for protection of the 5 '-hydroxyl group, NEW JOURNAL OF CHEMISTRY, Vol. 34, No. 5, pp. 984-992, 2010.
• Y. Oeda, Y. Iijima, H. Taguchi, A. Ohkubo, K. Seio, M. Sekine. Microwave-Assisted Synthesis of 2 '-O-Aryluridine Derivatives, ORGANIC LETTERS, Vol. 11, No. 24, pp. 5582-5585, Dec. 2009.
• K. Seio, R. Tawarada, T. Sasami, M. Serizawa, M. Ise, A. Ohkubo, M. Sekine. Synthesis and hybridization of 2 '-O-methyl-RNAs incorporating 2 '-O-carbamoyluridine and unique participation of the carbamoyl group in U-G base pair, BIOORGANIC & MEDICINAL CHEMISTRY, Vol. 17, No. 20, pp. 7275-7280, Oct. 2009.
• Seio Kohji, Miyazaki Kazuya, Kurohagi Sayako, Masaki Yoshiaki, Tsunoda Hirosuke, Ohkubo Akihiro, Sekine Mitsuo. Synthesis and properties of terminally modified oligonucleotides capable of short-RNA selective hybridization., Nucleic acids symposium series (2004), No. 53, pp. 13-4, Sept. 2009.  公式リンク  
  
• K. Yamada, H. Taguchi, A. Ohkubo, K. Seio, M. Sekine. Synthesis and properties of nucleoside derivatives acylated by chemically stable 2-(trimethylsilyl)benzoyl group, Bioorganic & Medicinal Chemistry, Vol. 17, No. 16, pp. 5928-5932, Aug. 2009.
• A. Ohkubo, K. Sasaki, Y. Noma, H. Tsunoda, K. Seio, M. Sekine. Efficient solid-phase synthesis of oligodeoxynucleotides having a 5 '-terminal 2,2,7-trimethylguanosine pyrophosphate linkage, BIOORGANIC & MEDICINAL CHEMISTRY, Vol. 17, No. 13, pp. 4819-4824, July 2009.
• M. Mizuta, K. Seio, A. Ohkubo, M. Sekine. Fluorescence Properties of Pyrimidopyrimidoindole Nucleoside dC(PPI) Incorporated into Oligodeoxynucleotides, JOURNAL OF PHYSICAL CHEMISTRY B, Vol. 113, No. 28, pp. 9562-9569, July 2009.
• T. Sasami, R. Tawarada, A. Ohkubo, M. Sekine, K. Seio. Computational evaluation of the stability of 2 '-O-methyl-RNA/RNA duplexes incorporating 3-deazaguanine derivatives by ab initio calculations and a molecular dynamics simulation, JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM, Vol. 899, No. 1-3, pp. 54-60, Apr. 2009.
• A. Ohkubo, Y. Noma, K. Aoki, H. Tsunoda, K. Seio, M. Sekine. Introduction of 3 '-Terminal Nucleosides Having a Silyl-Type Linker into Polymer Supports without Base Protection, JOURNAL OF ORGANIC CHEMISTRY, Vol. 74, No. 7, pp. 2817-2823, Apr. 2009.
• I. Okamoto, S. Q. Cao, H. Tanaka, K. Seio, M. Sekine. Synthesis of 4-Thiopseudoisocytidine and 4-Thiopseudouridine as Components of Triplex-forming Oligonucleotides, CHEMISTRY LETTERS, Vol. 38, No. 2, pp. 174-175, Feb. 2009.
• T. Sasami, Y. Odawara, A. Ohkubo, M. Sekine, K. Seio. Synthesis of oligodeoxynucleotides incorporating 2-N-carbamoylguanine and evaluation of the hybridization properties, BIOORGANIC & MEDICINAL CHEMISTRY, Vol. 17, No. 3, pp. 1398-1403, Feb. 2009.
• K. Miyata, R. Tamamushi, H. Tsunoda, A. Ohkubo, K. Seio, M. Sekine. Synthesis and Triplex Formation of Oligonucleotides Containing 8-Thioxodeoxyadenosine, Organic Letters, Vol. 11, No. 3, pp. 605-608, Feb. 2009.
• K. Seio, Y. Takaku, K. Miyazaki, S. Kurohagi, Y. Masaki, A. Ohkubo, M. Sekine. Synthesis of terminally modified oligonucleotides and their hybridization dependence on the size of the target RNAs, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 7, No. 11, pp. 2440-2451, 2009.
• A. Ohkubo, R. Kasuya, K. Miyata, H. Tsunoda, K. Seio, M. Sekine. New thermolytic carbamoyl groups for the protection of nucleobases, ORGANIC & BIOMOLECULAR CHEMISTRY, Vol. 7, No. 4, pp. 687-694, 2009.
• R. Tawarada, K. Seio, M. Sekine. Mechanistic studies on oxidative condensation of a thymidine 3 '-H-phosphonate derivative with 3 '-O-acetylthymidine, Arkivoc, Vol. 3, pp. 264-273, 2009.
• K. Seio, M. Mizuta, K. Tasaki, K. Tamaki, A. Ohkubo, M. Sekine. Hybridization-dependent fluorescence of oligodeoxynucleotides incorporating new pyrene-modified adenosine residues, BIOORGANIC & MEDICINAL CHEMISTRY, Vol. 16, No. 17, pp. 8287-8293, Sept. 2008.
• M. Mizuta, J. I. Banba, T. Kanamori, R. Tawarada, A. Ohkubo, M. Sekine, K. Seio. New nucleotide pairs for stable DNA triplexes stabilized by stacking interaction, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 130, pp. 9622-+, July 2008.
• A. Ohkubo, Y. Kuwayama, T. Kudo, H. Tsunoda, K. Seio, M. Sekine. O-selective condensation using P-N bond cleavage in RNA synthesis without base protection, Organic letters, Vol. 10, No. 13, pp. 2793-2796, July 2008.
• I. Okamoto, K. Seio, M. Sekine. Study of the base discrimination ability of DNA and 2 '-O-methylated RNA oligomers containing 2-thiouracil bases towards complementary RNA or DNA strands and their application to single base mismatch detection, BIOORGANIC & MEDICINAL CHEMISTRY, Vol. 16, No. 11, pp. 6034-6041, June 2008.
• H. Saneyoshi, K. Tamaki, A. Ohkubo, K. Seio, M. Sekine. Synthesis and hybridization properties of 2 '-O-(tetrazol-5-yl)ethyl-modified oligonucleotides, TETRAHEDRON, Vol. 64, No. 19, pp. 4370-4376, May 2008.
• A. Ohkubo, R. Kasuya, K. Aoki, A. Kobori, H. Taguchi, K. Seio, M. Sekine. Efficient synthesis of functionalized oligodeoxyribonucleotides with base-labile groups using a new silyl linker, BIOORGANIC & MEDICINAL CHEMISTRY, Vol. 16, No. 9, pp. 5345-5351, May 2008.
• K. Taira, S. Nakamura, K. Nakano, D. Maehara, K. Okamoto, S. Arimoto, D. Loakes, L. Worth, R. M. Schaaper, K. Seio, M. Sekine, K. Negishi, T. Negishi. Binding of MutS protein to oligonucleotides containing a methylated or an ethylated guanine residue, and correlation with mutation frequency, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, Vol. 640, No. 1-2, pp. 107-112, Apr. 2008.
• A. Ohkubo, R. Kasuya, K. Sakamoto, K. Miyata, H. Taguchi, H. Nagasawa, T. Tsukahara, T. Watanobe, Y. Maki, K. Seio, M. Sekine. 'Protected DNA Probes' capable of strong hybridization without removal of base protecting groups, NUCLEIC ACIDS RESEARCH, Vol. 36, No. 6, pp. 1952-1964, Apr. 2008.
• H. Tsunoda, A. Ohkubo, H. Taguchi, K. Seio, M. Sekine. Synthesis and properties of DNA oligomers containing 2 '-deoxynucleoside N-oxide derivatives, JOURNAL OF ORGANIC CHEMISTRY, Vol. 73, No. 4, pp. 1217-1224, Feb. 2008.
• R. Tawarada, K. Seio, M. Sekine. Synthesis and properties of oligonucleotides with iodo-substituted aromatic aglycons: Investigation of possible halogen bonding base pairs, JOURNAL OF ORGANIC CHEMISTRY, Vol. 73, No. 2, pp. 383-390, Jan. 2008.
• M. Sumino, A. Ohkubo, H. Taguchi, K. Seio, M. Sekine. Synthesis and properties of oligodeoxynucleotides containing 5-carboxy-2'-deoxycytidines, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol. 18, No. 1, pp. 274-277, Jan. 2008.
• Saneyoshi Hisao, Okamoto Itaru, Masaki Yoshiaki, Ohkubo Akihiro, Seio Kohji, Mitsuo. Facile synthesis of 2 '-O-cyanoethyluridine by ring-opening reaction of 2,2 '-anhydrouridine with cyanoethyl trimethylsilyl ether in the presence of BF3 center dot Et2O, Tetrahedron Letters, Vol. 48, No. 48, pp. 8554-8557, Nov. 2007.  公式リンク  
  
• A. Ohkubo, K. Tanaka, H. Taguchi, K. Seio, H. Nagasawa, T. Tsukahara, M. Sekine. An effective method for the in situ synthesis of DNA-CPG conjugates using chemical ligation technology as tools for SNP analysis, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol. 17, No. 21, pp. 5969-5973, Nov. 2007.
• H. Saneyoshi, K. Ando, K. Seio, M. Sekine. Chemical synthesis of RNA via 2 '-O-cyanoethylated intermediates, TETRAHEDRON, Vol. 63, No. 45, pp. 11195-11203, Nov. 2007.
• E. Utagawa, A. Ohkubo, M. Sekine, K. Seio. Synthesis of branched Oligonucleotides with three different sequences using an oxidatively removable tritylthio group, JOURNAL OF ORGANIC CHEMISTRY, Vol. 72, No. 22, pp. 8259-8266, Oct. 2007.
• A. Ohkubo, H. Taguchi, K. Seio, H. Nagasawa, T. Tsukahara, M. Sekine. A new hydrophobic linker effective for the in situ synthesis of DNA-CPG conjugates as tools for SNP analysis, TETRAHEDRON LETTERS, Vol. 48, No. 29, pp. 5147-5150, July 2007.
• T. Sasami, Y. Odawara, A. Ohkubo, M. Sekine, K. Seio. Synthesis and hybridization properties of oligodeoxynucleotides incorporating 2-N-carbamoylguanine derivatives as guanine analogs, TETRAHEDRON LETTERS, Vol. 48, No. 30, pp. 5325-5329, July 2007.
• M. Mizuta, K. Seio, K. Miyata, M. Sekine. Fluorescent pyrimidopyrimidoindole nucleosides: Control of photophysical characterizations by substituent effects, JOURNAL OF ORGANIC CHEMISTRY, Vol. 72, No. 14, pp. 5046-5055, July 2007.
• B. Karwowski, K. Seio, M. Sekine. Chemical properties of 4,5-di(ethoxycarbonyl)-1,3-dioxolan-2-yl (DECDO) as a hydroxyl protecting group of the 2 '-hydroxyl function in ribonucleosides, JOURNAL OF HETEROCYCLIC CHEMISTRY, Vol. 44, No. 2, pp. 329-336, Apr. 2007.
• K. Seio, T. Sasami, A. Ohkubo, K. Ando, M. Sekine. Highly selective recognition of cytosine over uracil and adenine by a guanine analogue, 2-N-Acetyl-3-deazaguanine, in 2 '-O-Methyl-RNA/RNA and DNA duplexes, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 129, No. 5, pp. 1026-1027, Feb. 2007.
• K. Miyata, R. Mineo, R. Tamamushi, M. Mizuta, A. Ohkubo, H. Taguchi, K. Seio, T. Santa, M. Sekine. Synthesis and fluorescent properties of bi- and tricyclic 4-N-carbamoyldeoxycytidine derivatives, JOURNAL OF ORGANIC CHEMISTRY, Vol. 72, No. 1, pp. 102-108, Jan. 2007.
• K. Seio, T. Terada, M. Mizuta, A. Ohkubo, H. Taguchi, M. Sekine. Synthesis and hybridization properties of oligodeoxynucleotides with long-chain linkers, HELVETICA CHIMICA ACTA, Vol. 90, No. 10, pp. 1946-1965, 2007.
• M. Mizuta, K. Seio, K. Miyata, A. Ohkubo, H. Taguchi, M. Sekine. A pyrimidopyrimidoindole nucleoside (dC(PPI)): Photophysical properties and thermal stability of the modified DNA duplexes, NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, Vol. 26, No. 10-12, pp. 1335-1338, 2007.
• E. Utagawa, M. Sekine, K. Seio. cis-tetrahydrofuran-3,4-diol structure as a key skeleton of new protecting groups removable by self-cyclization under oxidative conditions, JOURNAL OF ORGANIC CHEMISTRY, Vol. 71, No. 20, pp. 7668-7677, Sept. 2006.
• K. Miyata, R. Tamamushi, A. Ohkubo, H. Taguchi, K. Seio, T. Santa, M. Sekine. Synthesis and properties of a new fluorescent bicyclic 4-N-carbamoyldeoxycytidine derivative, ORGANIC LETTERS, Vol. 8, No. 8, pp. 1545-1548, Apr. 2006.
• I. Okamoto, K. Shohda, K. Seio, M. Sekine. Incorporation of 2 '-O-methyl-2-thiouridine into oligoribonucleotides induced stable A-form structure, CHEMISTRY LETTERS, Vol. 35, No. 1, pp. 136-137, Jan. 2006.
• H. Taguchi, A. Ohkubo, M. Sekine, K. Seio, H. Kakeya, H. Osada, T. Sasaki. Synthesis and biological properties of new phosmidosine analogs having an N-acylsulfamate linkage, NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, Vol. 25, No. 4-6, pp. 647-654, 2006.
• K. Seio, T. Miyashita, K. Sato, M. Sekine. Synthesis and properties of new nucleotide analogues possessing squaramide moieties as new phosphate isosters, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Vol. 24, pp. 5163-5170, Dec. 2005.
• M. Sekine, M. Aoyagi, M. Ushioda, A. Ohkubo, K. Seio. Chemically stabilized phenylboranylidene groups having a dimethoxytrityl group as a colorimetrically detectable protecting group designed for cis-1,2-diol functions of ribonucleosides in the solid-phase synthesis of m(2)(2,2)G5 ' ppT, JOURNAL OF ORGANIC CHEMISTRY, Vol. 70, No. 21, pp. 8400-8408, Oct. 2005.
• K. Seio, H. Ukawa, K. Shohda, M. Sekine. Computational evaluation of intermolecular interactions of a universal base 3-nitropyrrole in stacked dimers and DNA duplexes, JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, Vol. 22, No. 6, pp. 735-746, June 2005.
• K. Seio, T. Negishi, K. Negishi, M. Sekine. Mild and facile deprotection for the synthesis of oligodeoxynucleotide incorporating a 6-O-ethyl-deoxyguanosine, LETTERS IN ORGANIC CHEMISTRY, Vol. 2, No. 2, pp. 179-183, Mar. 2005.
• Ohkubo, A, Taguchi, H, Seio, K, Sekine, M, KOHJI SEIO. O-selectivity and utility of phosphorylation mediated by phosphite triester intermediates in the N-unprotected phosphoramidite method., Abstracts of Papers of the American Chemical Society, Vol. 229, pp. U559-U560, 2005.  公式リンク  
  
• Miyata, K, Tamamushi, R, Ohkubo, A, Taguchi, H, Seio, K, Sekine, M, KOHJI SEIO. Synthesis and conformational analysis of 4-N-carbamoyldeoxycytidine derivatives., Abstracts of Papers of the American Chemical Society, Vol. 229, pp. U560, 2005.  公式リンク  
  
• K. Seio, T. Sasaki, K. Yanagida, M. Baba, M. Sekine. Synthesis of benzodithiol-2-yl-substituted nucleoside derivatives as lead compounds having anti-bovine viral diarrhea virus activity, JOURNAL OF MEDICINAL CHEMISTRY, Vol. 47, No. 21, pp. 5265-5275, Oct. 2004.
• A. Ohkubo, Y. Ezawa, K. Seio, M. Sekine. O-selectivity and utility of phosphorylation mediated by phosphite triester intermediates in the N-unprotected phosphoramidite method, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 126, No. 35, pp. 10884-10896, Sept. 2004.
• R. Tatsumi, K. Seio, M. Fujio, J. Katayama, T. Horikawa, K. Hashimoto, H. Tanaka. (+)-3-[2-(benzo[b]thiophen-2-yl)-2-oxoethyl]-1-azabicyclo[2.2.2]octane, as potent agonists for the alpha 7 nicotinic acetylcholine receptor, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol. 14, No. 14, pp. 3781-3784, July 2004.
• N. Hino, T. Suzuki, T. Yasukawa, K. Seio, K. Watanabe, T. Ueda. The pathogenic A4269G mutation in human mitochondrial tRNA(Ile) alters the T-stem structure and decreases the binding affinity for elongation factor Tu, GENES TO CELLS, Vol. 9, No. 3, pp. 243-252, Mar. 2004.
• K. Seio, E. Utagawa, M. Sekine. New protected protecting groups for the 5 '-hydroxy group of deoxynucleosides by use of 2-(hydroxymethyl)- and 2-[(methylamino)methyl]benzoyl skeletons and oxidatively cleavable tritylthio and (4-methoxytrityl)thio groups, HELVETICA CHIMICA ACTA, Vol. 87, No. 9, pp. 2318-2333, 2004.
• Mitsuo Sekine, Akihiro Ohkubo, Kohji Seui. Proton-block strategy for the synthesis of oligodeoxynucleotides without base protection, capping, and P-N bond cleavage reaction, J. Org. Chem., Vol. 68, No. 14, pp. 5478-5492, 2003.
• kohji Seio, Koh Kumura, Mitsuo Sekine. Enhanced stereoselectivity in internucleotidic bond formation by the use of the chiral ribose moiety of thymidine, J. Org. Chem, Vol. 68, No. 10, pp. 3849-3859, 2003.
• Kohji Seio, Hisashi Ukawa, Koh-ichiro Shohda, Mitsuo Sekine. Important factors stabilizing stacking interaction between 3-nitropyrrole and natural nucleobases revealed by ab intio calculations, Nucleic Acids Res. Suppl. , Vol. 3, pp. 49-50, 2003.
• T. Kohara, H. Tanaka, K. Kimura, H. Horiuchi, K. Seio, M. Arita, T. Fujimoto, I. Yamamoto. Synthesis of thieno[2,3-b][1,5]benzoxazepine derivatives, JOURNAL OF HETEROCYCLIC CHEMISTRY, Vol. 39, No. 1, pp. 163-171, Jan. 2002.
• A. Kobori, K. Miyata, M. Ushioda, K. Seio, M. Sekine. A new silyl ether-type linker useful for the automated synthesis of oligonucleotides having base-labile protective groups, CHEMISTRY LETTERS, Vol. 1, pp. 16-17, Jan. 2002.
• Kohji Seio, Eri Utagawa, Mitsuo Sekine. A new protecting group for 5'-hydroxyl function of nucleotides in oligonucleotide synthesis without acid treatment utilizing unique properties of tritylthio group, Nucleic Acids Research Supplement, Vol. 2, pp. 27-28, 2002.
• A. Kobori, K. Miyata, M. Ushioda, K. Seio, M. Sekine. A New Silyl Ether-Type Linker Useful for the Automated Synthesis of Oligonucleotides Having Base-Labile Protecting Groups, Chem. Lett., pp. 2-3, 2002.
• Masatoshi Ushioda, Michinori Kadokura, Tomohisa Moriguchi, Akio Kobori, Morihiro Aoyagi, Kohji Seio, Mitsuo Sekine. Unique pqrticupation of unprotected internucleotidic phosphodiester residues on unexpected cleavage reaction of the Si-O bond of the diisopropylsilandiyl group used as a linker for the solid-phase synthesis of 5'-terminal guanylated oligodeoxynucleotides, Helvetica Chimica Acta, Vol. 85, pp. 2930-2945, 2002.
• Akihiro Ohkubo, Kohji Seio, Mitsuo Sekine. A new strategy for the synthesis of oligodeoxynucleotides in the phosphoramidite method without base protection via phosphite intermediates, Nucleic Acids Research Supplement, Vol. 2, pp. 29-30, 2002.
• Kohji Seio, Eri Utagawa, Mitsuo Sekine. A new protecting group for 5'-hydroxyl function of nucleitides in oligonucleotide snthesis without acid treatment utilizing unique properties of tritylthio group, Nucleic Acid Research Supplement, Vol. 2, pp. 27-28, 2002.
• Sato, Y, Tateno, G, Seio, K, Sekine, M, KOHJI SEIO. Substituent and solvent effects of TMS triflate mediated C1 ' epimerization of beta-thymidine to alpha-thymidine, European Journal of Organic Chemistry, No. 1, pp. 87-93, 2002.  公式リンク  
  
• Kousuke Sato, Kohji Seio, Mitsuo Sekine. Synthesis and Properties of a New Nucleotide Analogue Containing Squaryl Group, Nuceic Acids Research Supplement No1, pp. 121-122, 2001.
• M. Sekine, T. Moriguchi, T. Wada, K. Seio. Total Synthesis of Agrocin 84 and Phosmidosine as Naturally Occurring Nucleotidic Antibiotics Having P-N Bond Linkages, J. Org. Synth. Chem. Jpn, Vol. 59, No. 11, pp. 1109-1119, 2001.
• M. Kadokura, T. Wada, K. Seio, T. Moriguchi, J. Huber, R. Luhrmann, M. Sekine. Solid-Phase Synthesis of a 5-Terminal TMG-Capped Trinucleotide Block of U1 snRNA, Tetrahedron Lett., Vol. 42, pp. 8853-8856, 2001.
• M. Sekine, O. Kurasawa, K. Shohda, K. Seio, T. Wada. Essential factors for stabilization of the predominant C3'-endo conformation in dinucleoties phosphotriester derivatives with cyclonucleotide bridge structures at the downstream 3'-position, Eur. J. Org., pp. 1989-1999, 2001.
• Kohji Seio, Mitsuo Sekine. Synthesis of pentathymidylate using a 4-monomethoxytritylthio (MMTrS) group as a 5'-hydroxyl protecting group: toward oligonucleotide synthesis without acid treatment, Tetrahedron Letters, Vol. 42, No. 49, pp. 8657-8660, 2001.
• K. Negishi, D. Maehara, S. Nakamura, D. Loakes, l. Worth, Jr. R. M. Schaaper, K. Seio, M. Sekine, T. Negishi. Binding Specificities of the Mismatch Binding Protein, MutS, to Oligonucleotides Containing Modified bases, Nuceic Acids Research Supplement No1, pp. 221-222, 2001.
• A. Ohkubo, K. Seio, M. Sekine. A New Coupling Method for the Synthesis of Oligodeoxyribonucleotides Based on Protection by Protonation of Nnucleoside Bbases, Nuceic Acids Research Supplement No1, pp. 77-78, 2001.
• Takahashi, K, Seio, K, Sekine, M, Hino, O, Esashi, M, KOHJI SEIO. Fabrication of directly synthesized DNA chip using photolithography for rapid and parallel gene analysis, Transducers '01: Eurosensors Xv, Digest of Technical Papers, Vols 1 and 2, pp. 326-329, 2001.  公式リンク  
  
• KOHJI SEIO. Solid-phase synthesis of deoxyribonucleotides having a cap structure analog, Nucleic　Acids Symp. Ser., Vol. 44, pp. 123-124, 2000.
• KOHJI SEIO. Synthesis and properties of oligonucleotides having a phosphorous chiral center by incorporation of conformationally rigid 5'-cyclouridylic acid derivatives, J. Org. Chem., Vol. 65, pp. 6515-6524, 2000.
• KOHJI SEIO. Synthesis of 4-thiouridine, 6-thiuridine and 6-thioguanosine 3', 5'-bisphosphates as donor molecule for RNA ligation and their application to the synthesis of photoactivatable TMG-capped U1 snRNA fragments, J. Org. Chem., Vol. 65, pp. 5104-5113, 2000.
• KOHJI SEIO. Synthesis and properties of oligodeoxynucleotides incorporating a conformationally rigid uridine unit having a cyclic structure at the 5'-terminal site, J. Org. Chem., Vol. 65, pp. 3571-3578, 2000.
• H. Narita, T. Moriguchi, K. Seio, M. Sekine, H. Miyaguchi, K. Sakamoto, S. Yokoyama. Synthesis of N-labeled peptidyl AMP, Nucleosides Nucleotides , Vol. 19, pp. 1993-2003, 2000.
• KOHJI SEIO. Synthesis and properties of oligothymidilates incorporating an artificial bend motif, Helvetica Chimica Acta, Vol. 83, pp. 162-180, 2000.
• KOHJI SEIO. Chemical synthesis of hydroxymethylphosophnate α-DNA, Nucleic Acids Sym. Ser., Vol. 44, pp. 31-32, 2000.
• KOHJI SEIO. synthesis and properties of 2'-O-methyl-2-thiouridine and oligoribonucleotides containing 2'-O-methyl-2-thiouridine, Bioorg. Med. chem. Lett., Vol. 10, pp. 1795-1798, 2000.
• KOHJI SEIO. Synthesis and antitumor activities fo phomidosine A and its N-acylated derivatives, Tetrahedron Lett., Vol. 41, pp. 5881-5885, 2000.
• Mitsuo Sekine, Osamu Kurasawa, Kohji Seio, Koh-ichiro Shohda, Takeshi Wada. Synthesis of artificially bent oligonucleotides by incorporation of conformationally rigid 5'-cyclouridylic acid derivatives, Nucleosides & Nucleotides, Vol. 18, No. 6-7, pp. 1163-168, 1999.
• KOHJI SEIO. Chemical synthesis and properties of conformationaly fixed diuridine monophosphatesas building blocks of the RNA turn motif, J. Org. Chem., Vol. 63, pp. 1429-1443, 1998.
• KOHJI SEIO. Synthesis and properties of conformationally rigid cyclicuridylic acids having covalent bonding linkers between the uracil 5-position and the 5'-phosphate group, Nucleosides Nucleotides, Vol. 16, pp. 1023-1032, 1997.
• KOHJI SEIO. chemical synthesis of a 5'-terminal TMG-capped triribonucleotide m3 2,2,7G5'pppAmUmA of U1 RNA, J. Org. Chem., Vol. 61, pp. 4412-4422, 1996.
• KOHJI SEIO. chemical synthesis and conformational properties of a new cyclouridylic acid having an ethylene bridge between the uracil 6-position and 5'-phosphate group, J. Org. Chem, Vol. 61, pp. 1500-1504, 1996.
• KOHJI SEIO. Synthesis of oligonucleotide having a bent structure by incorporation of an interresidually cyclized uridylyl(3'-5')uridine unit, Nucleic Acids Symp. Ser., Vol. 34, pp. 181-182, 1995.
• Seio, K, Wada, T, Sakamoto, K, Yokoyama, S, Sekine, M, KOHJI SEIO. Synthesis and properties of conformationally rigid cyclouridylic acid having a covalent bonding linker between the uracil 5-position and the 5'-phosphate group, Tetrahedron Letters, Vol. 36, No. 52, pp. 9515-9518, 1995.  公式リンク  
  
• KOHJI SEIO. Synthesis and properties of conformationally rigid cycliuridylic acid having a covalent bonding linker between the uracil 5-position and the 5'-phosphate group, Tetrahedron Lett., Vol. 36, No. 52, pp. 934-937, 1994.
• KOHJI SEIO. Chemical synthesis of the 5'-terminal structure of U1 RNA, Nucleic Acids Symp. Ser., Vol. 31, pp. 61-62, 1994.
• KOHJI SEIO. Synthesis of uridylyl(3'-5')uridine derivatives containing 5-(methylaminomethyl)uridine as a modified nucleoside found from E. Coli minor tRNA Arg, Nucleosides Nucleotides, Vol. 12, No. 3-4, pp. 305-321, 1993.
• KOHJI SEIO. Synthesis and properties of N-tritylthio nucleoside derivatives and reductive removal of the tritylthiogroup by use of tributyltin hydride and tris(trimethylsilyl)silane, J. Chem. Soc. Perkin 1, pp. 3087-3093, 1993.
• SEKINE, M, SEIO, K, SATOH, T, SAKAMOTO, K, YOKOYAMA, S, KOHJI SEIO. SYNTHESIS OF URIDYLYL (3'-5') URIDINE DERIVATIVES CONTAINING 5-(METHYLAMINO-METHYL)URIDINE AS A MODIFIED NUCLEOSIDE FOUND FROM ESCHERICHIA-COLI MINOR TRANSFER RNA(ARG), Nucleosides & Nucleotides, Vol. 12, No. 3-4, pp. 305-321, 1993.  公式リンク  
  

著書

• Yoshiaki Masaki, Akihiro Ohkubo, Kohji Seio, Mitsuo Sekine. Effects of 2'-O-Modifications on RNA Duplex Stability, Synthesis of Therapeutic Oligonucleotides, Springer, Jan. 2018.
• 清尾康志, 大窪章寛. 塩基部無保護ホスホロアミダイト法による核酸合成, 中分子創薬に資するペプチド・核酸・糖鎖の合成技術： 千葉一裕 監修, シーエムシー出版, 2018.
• KOHJI SEIO, Takashi Kanamori, Akihiro Ohkubo, MITSUO SEKINE. Synthesis and Fluorescence Properties of Nucleosides with Pyrimimidine-Type Base Moieties, Fluorescent Analogs of Biomolecular Building Blocks, July 2016.
• 清尾康志. 新規蛍光核酸, バイオ研究のフロンティア３：医療・診断をめざす先端バイオテクノロジー: 関根光雄 編, 光学図書株式会社, 2009.
• Ohkubo Akihiro, Okamoto Itaru, Kasuya Rintaro, Sakamoto Kazushi, Sasami Takeshi, Odawara Yoko, Masaki Yoshiaki, Sakaue Toshiyuki, Nagasawa Hiroshi, Tsukahara Toshifumi, Seio Kohji, Sekine Mitsuo. Protected DNA probes (PDP): A new strategy for gene detection, Chemistry of Nucleic Acid Components, Vol. 10, pp. 94-102, 2008.  公式リンク  
• 清尾康志. 蛍光色素の開発動向, 関新しいDNAチップの科学と応用: 関根光雄 編, 講談社サイエンティフィク, 2007.
• 清尾康志, 関根光雄. RNAの基礎知識, RNAi法とアンチセンス法： 関根光雄・多比良和誠 編, 講談社サイエンティフィク, 2005.
• 清尾康志. 人工核酸を用いる新しい遺伝子診断技術, 人工核酸を活用する化学的アプローチ：ゲノムケミストリー: 関根光雄・齋藤烈 編, 2003.

国際会議発表 (査読なし・不明)

• Tabira A, Httori S, Seio K, Masaki Y. Extended phosphate backbone of ASO reveals importance of deoxyribose recognition by RNase H, FIBER International Summit for Nucleic Acids (S-FISNA), Feb. 2024.
• Masaki Y, Onishi Y, Seio K. Estimation of synthetic errors toward long DNA chemical synthesis, FIBER International Summit for Nucleic Acids (S-FISNA), Feb. 2024.
• Tachibana S, Kanagawa T, Ohnishi R, Masaki Y, Seio K. Synthesis and the structural analysis of a cyclic sulfonamide thymidine derivative, 第49回国際核酸化学シンポジウム 日本核酸化学会第6回年会, Nov. 2022.
• Uekusa K, Tomori T, Koyama A, Masaki Y, Seio K. Synthesis of nucleoside and oligonucleotide derivatives incorporating 2’-O-sulfamoylpropyl or 2’-O-sulfamoylbutyl modifications, 第49回国際核酸化学シンポジウム 日本核酸化学会第6回年会, Nov. 2022.
• Ohnishi R, Sekiya S, Edamura W, Tachibana S, Masaki Y, Seio K. Synthesis and structural analysis of sulfonamide linkage-containing oligonucleotides for the development of antisense nucleic acids, 第49回国際核酸化学シンポジウム 日本核酸化学会第6回年会, Nov. 2022.
• Yagata T, Masaki Y, Onishi Y, Seio K. Synthesis and property of alkoxytrityl type protecting group having reactive moiety, 第49回国際核酸化学シンポジウム 日本核酸化学会第6回年会, Nov. 2022.
• Masaki Y, Onishi Y, Seio K. Systemic comparison of DNA chemical synthesis conditions by next-generation sequencing, 第49回国際核酸化学シンポジウム 日本核酸化学会第6回年会, Nov. 2022.
• Tabira A, Masaki Y, Hattori S, Wakatsuki S, Seio K. Effects of inserting methylene group in the interaction of RNase H and ASO, 第49回国際核酸化学シンポジウム 日本核酸化学会第6回年会, Nov. 2022.
• Tomori, T., Kishimura T., Uekusa K., Koyama A., Erikawa Y., Masaki Y., Seio K. Synthesis of oligonucleotides with lipophilic residues via 2´-O-carbamoylethyl linker for providing 3´-exonuclease resistance and duplex stability, ISNAC 2021, Nov. 2021.
• Takeshita L, Iwake A, Tomori T, Masaki Y, Seio K. Enzymatic incorporation of 2'-O-alkylcarbamoyl-UTP for development of RNA aptamer, Oct. 2019.
• Yamada Y, Takeshita L, Masaki Y, Seio K. Enzymatic synthesis and photo-deprotection of DNA incorporating photo-caged deoxypseudouridine, Oct. 2019.
• Y. Masaki, T. Inde, A. Maruyama, K. Seio. Tolerance of N2-heteroaryl modifications on guanine bases in G-quadruplex structure, CISNAC 2019日本核酸化学会設立記念国際シンポジウム, July 2019.
• L. Takeshita, Y. Masaki, K. Seio. Synthesis and properties of photo-responsive DNA probes containing photo-cleavable protecting group and thioxanthone as a photo-sensitizer, 第45回国際核酸化学シンポジウム 日本核酸化学会第2回年会, Nov. 2018.
• Maruyama A., Inde T., Masaki Y., Seio K.. Synthesis of oligodeoxyribonucleotides containing 2-N-heteroarylguanine residues and their effect on G-quadruplex structure and stability, 第45回国際核酸化学シンポジウム 日本核酸化学会第2回年会, Nov. 2018.
• Y. Masaki, K. Yamamoto, K. Yoshida, Y. Iriyama, H. Nakajima, T. Kanaki, T. Tomori, K. Seio. Application of 2'-O-carbamoylethyl-type modifications in antisense oligonucleotide, The 14th Annual Meeting of the Oligonucleotide Therapeutics Society, Sept. 2018.
• Y. Masaki, T. Inde, A. Maruyama, K. Seio. Synthesis of oligodeoxyribonucleotides containing N2-heteroarylguanine residues and their properties in G-quadruplex structures, XXIII International Roundtable on Nucleosides, Nucleotides & Nucleic Acids, Aug. 2018.
• T. Inde, Y. Masaki, A. Maruyama, Y. Ito, N. Makio, Y. Miyatake, T. Tomori, M. Sekine, K. Seio. Synthesis of oligodeoxyribonucleotides containing 2-N-heteroarylguanine residues and their effect on higher-order structure stability, The 44th International Symposium on Nucleic Acids Chemistry & The 1st Annual Meeting of Japan Society of Nucleic Acids Chemistry, Nov. 2017.
• D. Sugiyama, T. Shiozawa, K. Ohno, T. Tomori, Y. Masaki, K. Seio. Reaction of H-pyrophosphonic acid toward nucleosides, nucleotides and amino acids, The 44th International Symposium on Nucleic Acids Chemistry & The 1st Annual Meeting of Japan Society of Nucleic Acids Chemistry, Nov. 2017.
• L. Takeshita, K. Ohno, K. Nagaoka, Y. Yamada, Y. Masaki, K. Seio. Photo-regulation of transcription by using enzymatically synthesized photo-caged DNA, The 44th International Symposium on Nucleic Acids Chemistry & The 1st Annual Meeting of Japan Society of Nucleic Acids Chemistry, Nov. 2017.
• Yoshiaki Masaki, Mitsuo Sekine, KOHJI SEIO. Relationship between deformability of sugar-modified RNA duplexes and their melting temperatures, 13th Annual Meeting of the Oligonucleotide Therapeutics Society, Sept. 2017.
• Leo Takeshita, Kentaro Ohno, Yoshiaki Masaki, Mitsuo Sekine, Kohji Seio. Chemical and Enzymatic Synthesis of Photo-caged DNA containing N1-Nitrobenzyl-2´-deoxypseudouridine for UV Dependent Regulation of Transcription, The 43rd International Symposium on Nucleic Acids Chemistry, Sept. 2016.
• Takahito Tomori, Kento Nagaoka, Yuya Miyatake, Yoshiaki Masaki, Mitsuo Sekine, Kohji seio. Synthesis and Enzymatic Properties of C-nucleoside Triphosphate Containing Pyridazin-3-one As a Uracil Analog, The 43rd International Symposium on Nucleic Acids Chemistry, Sept. 2016.
• Takeshi Inde, Yoshiaki Masaki, Mitsuo Sekine, Kohji Seio. Base Pair Recognition of Alpha-deoxyribonucleosides with Unmodified Nucleobase and 8-Oxo-adenine in Antiparallel DNA Triplex, The 43rd International Symposium on Nucleic Acids Chemistry, Sept. 2016.
• Yoshiaki Masaki, Ryuta Miyasaka, Keishi Yamamoto, Keita Yoshida, Akihiro Ohkubo, Mitsuo Sekine, Kohji Seio. Deformability analysis of chemically modified RNA and its applicability for estimation of RNA duplex stability, The 43rd International Symposium on Nucleic Acids Chemistry, Sept. 2016.
• Yoshiaki Masaki, Keishi Yamamoto, Takeshi Inde, Tetsuya Nagata, Jun Tanihata, Yusuke Iriyama, Shin'ichi Takeda, Kohji Seio, Mitsuo Sekine. Enhancement of exon skipping by 2´-O-(N-methylcarbamoyl)ethyl (MCE) and/or nucleobase modified nucleosides incorporation into phosphorothioate oligonucleotides, 11th of Annual Meeting of the Oligonucleotide Therapeutics Society, Oct. 2015.
• Yu Ito, Takashi Kanamori, Yoshiaki Masaki, Akihiro Ohkubo, Kohji Seio, Mitsuo Sekine. Synthesis of deoxyuridine derivatives modified with 2,4-diaminopyrimidine moiety for the development of high affinity triplex forming oligonucleotides, The 42nd International Symposium on Nucleic Acids Chemistry 2015, Sept. 2015.
• Ayano Yamazaki, Kei Yamaguchi, Takashi Kanamori, Yoshiaki Masaki, Mitsuo Sekine, Kohji Seio. Synthesis of oligodeoxynucleotides containing 2´-deoxy-pseudoisocytidine for the development of chemically modified DNA duplexes and triplexes, The 42nd International Symposium on Nucleic Acids Chemistry, Sept. 2015.
• Kentaro Ohno, Leo Takeshita, Yoshihiro Iijima, Takashi Kanamori, Yoshiaki Masaki, Mitsuo Sekine, Kohji Seio. Synthesis of oligonucleotides containing photo-caged 2´ -deoxypseudouridine for the regulation of DNA-protein interaction, The 42nd International Symposium on Nucleic Acids Chemistry, Sept. 2015.

国内会議発表 (査読なし・不明)

• 瀧川駿太朗, 友利貴人, 植草宏哉, 正木慶昭, 清尾康志. 2´水酸基にスルホンアミド修飾またはスルホネート修飾を有する5-メチルウリジン誘導体の合成および二重鎖形成能の評価, 日本化学会第104春季年会, Mar. 2024.
• 宮地健人, 羽生愛深, 清尾康志, 正木慶昭. 7位にピリジル基を導入した7-デアザデオキシグアノシンを含むオリゴヌクレオチドの合成と性質, 日本化学会第104春季年会, Mar. 2024.
• 鈴木雄大, 須田雪音, 井分彩乃, 正木慶昭, 清尾 康志. 光架橋ビオチンリンカーを有するグアノシンテトラリン酸類似体の合成, 日本化学会第104春季年会, Mar. 2024.
• 島村大輝, 有江嶺美, 金山朱里, 宮内彩, 清尾康志, 正木慶昭. 細胞選択的送達を目指した糖リガンド修飾アンチセンス核酸の合成と性質, 日本化学会第104春季年会, Mar. 2024.
• 田平彩乃, 若月駿介, 清尾 康志, 正木 慶昭. 置換基を導入した2´-O, 3´-C架橋アラビノフラノシルチミンを含むオリゴヌクレオチドの合成と性質, 日本化学会第104春季年会, Mar. 2024.
• 立花茂載, 大西里絵, 正木慶昭, 清尾康志. 5´位を増炭したスルホンアミド骨格を有するチミジンダイマーの合成と物性評価, 日本化学会第104春季年会, Mar. 2024.
• 田平彩乃, 服部詩萌里, 清尾康志, 正木慶昭. メチレン基のリン酸バックボーンへの挿入がRNase Hによるミスマッチを含む二重差切断に与える影響, 日本核酸医薬学会 第8回年会, July 2023.
• 清尾康志, 大西里絵, 立花茂載, 正木慶昭. スルホンアミド型バックボーンを導入したギャップマーの合成およびアンチセンス核酸としての性質, 日本核酸医薬学会 第8回年会, July 2023.
• 金川峻幸, 立花茂載, 大西里絵, 正木慶昭, 清尾康志. スルホンアミド構造を有する環状チミジン誘導体の合成とその構造解析, 日本核酸医薬学会 第7回年会, Aug. 2022.
• 金川峻幸, 小山彩, 正木慶昭, 清尾康志. 塩基部修飾グアニン導入によるアンチセンス核酸の標的切断変化とオフターゲット抑制, 日本核酸医薬学会 第7回年会, Aug. 2022.
• 正木慶昭, 田平彩乃, 金川峻幸, 若月駿介, 服部詩萌里, 小山彩, 井上敦, 清尾康志. RNase H依存型アンチセンス核酸の安全性向上に向けた化学修飾の開発, 日本核酸医薬学会 第7回年会, Aug. 2022.
• 植草宏哉, 友利貴人, 正木慶昭, 清尾康志. 2’-O-スルファモイルアルキル修飾を導入したオリゴヌクレオチドの合成と性質, 日本核酸医薬学会 第7回年会, Aug. 2022.
• 正木慶昭, 矢形太一, 清尾康志. 次世代シーケンサーをもちいた化学合成DNAの副生成物解析, 日本化学会 第102春季年会2022, Mar. 2022.
• 大西里絵, 関谷彰太, 枝村亘, 正木慶昭, 清尾康志. スルホンアミド骨格を含む人工核酸の合成とアンチセンス活性の評価, 日本化学会 第102春季年会2022, Mar. 2022.
• 小山彩, 友利貴人, 江利川友紀, 正木慶昭, 清尾康志. 2´カルバモイルエチルリンカーの脂溶性残基を導入したアンチセンスオリゴヌクレオチドの合成と特性評価, 日本化学会 第102春季年会2022, Mar. 2022.
• 井分彩乃, 赤井恒, 友利貴人, 清尾康志, 正木慶昭. リンカーを介して2´-水酸基にビオチンを有するグアノシンテトラリン酸誘導体の合成, 日本化学会 第102春季年会2022, Mar. 2022.
• 正木慶昭, 田平彩乃, 服部詩萌里, 清尾康志. 5´-デオキシ-5´-ヒドロキシメチルチミジン及び3´-デオキシ-3´-ヒドロキシメチルチミジンを含むリン酸骨格を伸長したオリゴヌクレオチドの合成と性質, 日本化学会 第102春季年会2022, Mar. 2022.
• 金川峻幸, 立花茂載, 大西里絵, 正木慶昭, 清尾康志. 塩基部と5´位をスルホンアミド結合で架橋したチミジン誘導体の合成法の検討, 日本化学会 第102春季年会2022, Mar. 2022.
• 矢形太一, 正木慶昭, 清尾康志. 末端アルキンを有するアルコキシトリチル型保護基の開発, 第102春季年会2022, Mar. 2022.
• 清尾康志, 岸村智太, 友利貴人, 正木慶昭. 2'位に種々のカルバモイルエチル基を有する人工核酸の合成とアンチセンス核酸としての性質, 日本核酸医薬学会第6回年会, June 2021.
• 服部詩萌里, 正木慶昭, 清尾康志. リン酸骨格を伸長した5 ́-デオキシ-5 ́-ヒドロキシメチルチミジンを含むオリゴヌクレオチドの合成と性質, 日本化学会第101春季年会2021, Mar. 2021.
• 清尾康志, 大西里絵, 関谷彰太, 枝村亘, 正木慶昭. スルホンアミド結合を含む人工核酸の合成と塩基対形成能, 日本化学会第101春季年会2021, Mar. 2021.
• 若月駿介, 井上敦, 正木慶昭, 清尾康志. 2 ́-O,3 ́-C架橋型 [3.3.0]ビシクロアラビノフラノシルチミン誘導体を含むオリゴヌクレオチドの合成と性質, 日本化学会第101春季年会2021, Mar. 2021.
• 赤井恒, 杉山大樹, 大野健太郎, 友利貴人, 正木慶昭, 清尾康志. 2'水酸基保護基にTBDMS基を用いた緊縮応答分子ppGppの化学合成法の開発, 日本化学会第101春季年会2021, Mar. 2021.
• 岸村智太, 植草宏哉, 友利貴人, 正木慶昭, 清尾康志. 2 ́-O-アルキルカルバモイルエチル型修飾を持つ人工核酸の合成および性質, 日本化学会第101春季年会2021, Mar. 2021.
• 正木慶昭, 矢形太一, 清尾康志. 長鎖 DNA合成に向けたホスホロアミダイト法における副反応の解析, 日本化学会第101春季年会2021, Mar. 2021.
• 岸村智太, 友利貴人, 正木慶昭, 清尾康志. 2´位に種々のアルキルカルバモイルエチル修飾を持つ核酸の合成と二重鎖形成能, Mar. 2020.
• 宮崎翔, 正木慶昭, 清尾康志. 高圧条件下での2 ́,5 ́-ヌクレオチド残機を含んだRNA二重鎖の分子シミュレーション, Mar. 2020.
• 若月駿介, 井上敦, 正木慶昭, 清尾康志. 2 ́-O,3 ́-C架橋型 [3.3.0] ピシクロアラビノフラノシルミチン誘導体の合成, Mar. 2020.
• 赤井恒, 杉山大樹, 大野健太郎, 友利貴人, 正木慶昭, 清尾康志. ホスホロアミダイト化合物を用いた緊縮応答分子ppGppの効率的合成法, Mar. 2020.
• 山田悠司, 竹下玲央, 正木慶昭, 清尾康志. 光ケージされたデオキシシュードウリジンを含むDNA二重鎖および三重鎖構造の安定性の評価, Mar. 2020.
• Edamura W, Sekiya S, Masaki Y, Seio K. Conformation and properties of oligonucleotide with sulfonamide skeleton, Mar. 2020.
• Miyazaki S, Masaki Y, Seio K. The conformational property of RNA duplex including 2 ́,5 ́-linkage under high pressure conditions, Oct. 2019.
• 竹下玲央, 井分彩乃, 友利貴人, 正木慶昭, 清尾康志. 2´-O-アルキルカルバモイル修飾UTPの合成と転写および逆転写反応への応用, 第13回バイオ関連化学シンポジウム2019, Sept. 2019.
• 正木慶昭, 井上敦, 入山友輔, 金木達朗, 中嶋宏之, 清尾康志. 化学修飾によるアンチセンス核酸のRNase H依存オフターゲット効果の抑制, 第13回バイオ関連化学シンポジウム2019, Sept. 2019.
• Y. Masaki, K. Yamamoto, Y. Yoshida, A. Maruyama, T. Tomori, Y. Iriyama, H. Nakajima, T. Kanaki, K. Seio. Synthesis and properties of 2'-O-modified oligonucleotides having carbamoylethyl linker, 日本核酸医薬学会 第5回年会, July 2019.
• 竹下玲央, 井分彩乃, 友利貴人, 正木慶昭, 清尾康志. アプタマー応用を志向した2´-O-カルバモイル型修飾を有するウリジン三リン酸の開発, 日本核酸医薬学会 第5回年会 若手シンポジウム, July 2019.
• Takeshita, L., Masaki, Y., Seio, K.. Synthesis and properties of photo-responsive DNA probes containing thioxanthone and nitrophenethyl group, 日本化学会 第99春季年会, Mar. 2019.
• Kishimura, T., Tomori, T., Masaki, Y., Seio, K.. Synthesis and properties of oligonucleotides having alkyl carbamoylethyl groups at 2 ́ position, 日本化学会 第99春季年会, Mar. 2019.
• Maruyama, A., Yoshida, K., Masaki, Y., Seio, K.. Incorporation of peptide into 2 ́ position of oligonucleotide by Native Chemical Ligation, 日本化学会 第99春季年会, Mar. 2019.
• 杉山大樹, 大野健太郎, 正木慶昭, 清尾康志. ホスホロアミダイト化合物を利用したグアノシンテトラリン酸の効率的合成法の開発, 日本化学会 第99春季年会, Mar. 2019.
• 井上敦, 正木慶昭, 清尾康志. 2 ́,3 ́-糖部架橋型アラビノフラノシルチミン誘導体の効率的な合成研究, 日本化学会 第99春季年会, Mar. 2019.
• 山田悠司, 竹下玲央, 山田悠司, 竹下玲央, 正木慶昭, 清尾康志. 光ケージされた5-ヒドロキシメチルデオキシウリジンを含むDNAの酵素合成法, 日本化学会 第99春季年会, Mar. 2019.
• L. Takeshita, T. Shiozawa, D. Sugiyama, T. Tomori, Y. Masaki, K. Seio. A structure-activity relationship of incorporation of 2'-O-carbamoyl modified uridine triphosphate by RNA polymerase, 日本核酸医薬学会 第4回年会, July 2018.
• 岸村智太, 吉田圭汰, 友利貴人, 正木慶昭, 清尾康志. 2´位にカルバモイルエチル型修飾を持つ核酸の合成と性質, 生体機能関連化学部会若手の会 第30回サマースクール, July 2018.
• 正木 慶昭, 井上 敦, 入山 友輔, 金木 達朗, 中嶋 宏之, 清尾 康志. RNaseH依存型アンチセンス核酸への応用に向けた化学修飾核酸の開発, 日本核酸医薬学会 第4回年会, July 2018.
• 塩澤貴史, 杉山大樹, 友利貴人, 正木慶昭, 清尾康志. 還元的リン化学種による生体小分子の亜リン酸化反応の検討, 日本化学会第98回春季年会, Mar. 2018.
• 印出健志, 正木慶昭, 宮武佑弥, 関根光雄, 清尾康志. α-デオキシヌクレオシドを含むオリゴヌクレオチドのアンチパラレル型三重鎖形成能と塩基識別能, 日本化学会第98回春季年会, Mar. 2018.
• L. TAKESHITA, Y. MASAKI, K. SEIO. Synthesis of DNA probes containing photo-sensitizer and caged molecule, 日本化学会第98回春季年会, Mar. 2018.
• 岸村智太, 吉田圭汰, 阿野晃大, 友利貴人, 正木慶昭, 清尾康志. 2'水酸基に種々のカルバモイルエチル型修飾を持つ核酸の効率的合成と性質, 日本化学会第98回春季年会, Mar. 2018.
• 関谷彰太, 竹下玲央, 正木慶昭, 清尾康志. スルホンアミド骨格を有するオリゴヌクレオチドを鋳型に用いたDNAポリメラーゼ反応, 日本化学会第98回春季年会, Mar. 2018.
• 井上敦, 正木慶昭, 清尾康志. 2',3'-糖部架橋型化学修飾核酸の合成, 日本化学会第98回春季年会, Mar. 2018.
• 杉山大樹, 塩澤貴史, 大野健太郎, 友利貴人, 正木慶昭, 清尾康志. ピロ亜リン酸による亜リン酸化反応を経由したヌクレオチド合成, 日本化学会第98回春季年会, Mar. 2018.
• 丸山敦也, 印出健志, 正木慶昭, 清尾康志. グアニン塩基部2位にヘテロアリール環修飾を有するオリゴヌクレオチドの合成と高次構造形成, 日本化学会第98回春季年会, Mar. 2018.
• 竹下玲央, 山田悠司, 正木慶昭, 清尾康志. 光ケージされたデオキシシュードウリジンを含むDNAの酵素合成法, 日本化学会第98回春季年会, Mar. 2018.
• 竹下玲央, 大野健太郎, 長岡健斗, 山田悠司, 正木慶昭, 清尾康志. 光分解性保護基を導入したヌクレオシド三リン酸の合成と転写反応の光制御への応用, 第47回複素環化学討論会, Oct. 2017.
• 印出健志, 丸山敦也, 伊藤 優, 牧尾直明, 友利貴人, 正木慶昭, 関根光雄, 清尾康志. 2 位のアミノ基にヘテロアリール環を導入したデオキシグアノシン誘導体の合成と オリゴヌクレオチド中での性質評価, 第47回複素環化学討論会, Oct. 2017.
• 竹下玲央, 大野健太郎, 長岡健斗, 山田悠司, 正木昭慶, 清尾康志. 酵素合成可能な光ケージド DNA の開発と転写制御への応用, 第11回バイオ関連化学シンポジウム, Sept. 2017.
• 塩澤貴史, 友利貴人, 杉山大樹, 金和平, 正木慶昭, 清尾康志. 還元的リン化学種と生体小分子との反応の検討, 第11回バイオ関連化学シンポジウム, Sept. 2017.
• 大野健太郎, 竹下玲央, 杉山大樹, 正木慶昭, 清尾康志. 6-O-(2-ニトロベンジル)グアノシン三リン酸の合成と転写反応の光制御, 第11回バイオ関連化学シンポジウム, Sept. 2017.
• 関谷彰太, 北川諒, 竹下玲央, 田胡信広, 正木慶昭, 清尾康志. スルホンアミド結合を有する人工核酸の新規合成と性質, 第11回バイオ関連化学シンポジウム, Sept. 2017.
• 清尾康志, 正木慶昭, 山本恵士, 印出健志, 入山友輔, 中島宏之, 金木達朗, 黒田雄介, 古川賢, 谷端 淳, 永田哲也, 武田伸一, 関根 光雄. 2’-水酸基にカルバモイルエチル型修飾を有する人工核酸を用いたアンチセンス核酸の開発, 日本核酸医薬学会 第3回年会, July 2017.
• 正木 慶昭, 宮坂 隆太, 山本 恵士, 吉田 圭汰, 関根 光雄, 清尾 康志. 糖部修飾オリゴヌクレオチドの変形能解析と二重鎖融解温度の関係, 日本核酸医薬学会 第3回年会, July 2017.
• 塩澤 貴史, 正木 慶昭, 金子 和平, チャンガディブラタ ヤン クリスティアン, 徳川 宗史, 清尾 康志. 一本鎖結合タンパク質とDNAの相互作用を検出するための（7-ベンゾフラン-2-イル）-7-デアザ-2´-デオキシグアノシンを有する蛍光プローブ, 第10回バイオ関連化学シンポジウム, Sept. 2016.
• 正木 慶昭, 吉田 圭汰, 山本 恵士, 関根 光雄, 清尾 康志. 糖部化学修飾RNA二重鎖の変形能と二重鎖融解温度の関係, 第10回バイオ関連化学シンポジウム2016, Sept. 2016.
• 北川 諒, 田胡 信広, 関谷 彰太, 正木 慶昭, 関根 光雄, 清尾 康志. スルホンアミド骨格を有するヌクレオシド誘導体の合成と性質, 日本化学会 第96春季年会, Mar. 2016.
• 宮村 大地, 金森 功吏, 正木 慶昭, 関根 光雄, 清尾 康志. 塩基部5位に3-メチルベンゾフラン誘導体を導入した2'-デオキシウリジンの合成と蛍光特性, 日本化学会 第96春季年会, Mar. 2016.
• 竹下 玲央, 大野 健太郎, 正木 慶昭, 関根 光雄, 清尾 康志. DNA-タンパク質相互作用の光制御をめざした光ケージされたデオキシシュードウリジンを含む核酸の合成および性質, 日本化学会 第96春季年会, Mar. 2016.
• Hiroya Asami, Munefumi Tokugawa, Yoshiaki Masaki, Eric Gloaguen, Kohji Seio, Mitsuo Sekine, Michel Mons. An Effective Molecular Model for Nanosecond Laser Spectroscopy of Short-lived Nucleobase: Application to Anharmonic Vibrational Analysis in the Mid-IR Region, 日本化学会 第96春季年会, Mar. 2016.
• 岸村智太, 印出健志, 正木慶昭, 関根光雄, 清尾康志. アンチセンス核酸の5´末端に糖を修飾するためのリンカーの設計と合成, 日本化学会 第96春季年会, Mar. 2016.
• 小田雄貴, 伊藤比佑吾, 金森功吏, 大窪章寛, 正木慶昭, 関根光雄, 清尾康志. 塩基性条件下不安定なヌクレオシド三リン酸の新規合成法の開発, 日本化学会 第96春季年会, Mar. 2016.
• 山本 恵士, 正木 慶昭, 吉田圭汰, 入山 友輔, 中嶋 宏之, 金木 達朗, 関根 光雄, 清尾 康志. 2-(N-エチルカルバモイル）エチル構造を有する糖部修飾核酸の合成と性質, 日本化学会 第96春季年会, Mar. 2016.
• 友利 貴人, 長岡 健斗, 宮武 佑弥, 正木 慶昭, 関根 光雄, 清尾 康志. ピリダジン-3-オンを核酸塩基部に有する/C/ヌクレオシドの合成と性質, 日本化学会 第96春季年会, Mar. 2016.
• Yoshiaki Masaki, Keishi Yamamoto, Takeshi Inde, Tetsuya Nagata, Jun Tanihata, Yusuke Iriyama, Shinishi Takeda, Mitsuo Sekine, KOHJI SEIO. Enhancement of exon skipping efficiency by using antisense oligonucleotides containing 2-thiothymidine derivatives, 日本核酸医薬学会第一回年会, Dec. 2015.
• 大野 健太郎, 正木 慶昭, 金森 功吏, 関根 光雄, 清尾 康志. 光ケージヌクレオシド三リン酸の合成と性質, 第17回日本RNA学会年会, July 2015.
• 田胡信広, 北川諒, Adam Kotolik, Nathaniel E. Clark, Eric J. Montemayor, P. John Hart, 正木 慶昭, 金森 功吏, 関根 光雄, 清尾 康志, Masad J. Damha. 5'-アミノグアノシンを分岐部位に導入した2'-5'修飾分岐RNAの合成と性質, 第17回日本RNA学会年会, July 2015.
• 山本 恵士, 正木 慶昭, 石井 陽大, 印出 健志, 金森 功吏, 関根 光雄, 清尾 康志. 2'-O-メチルカルバモイルエチル修飾2-チオリボチミジンを含むオリゴヌクレオチドの合成と性質, 第17回日本RNA学会年会, July 2015.

その他の論文・著書など

• 清尾康志, 岡本到, 関根光雄. 2-チオウリジンを利用したアンチセンス核酸の化学合成と性質, 生物工学会誌, Vol. 82, pp. 139-141, 2004.

特許など

• 清尾康志, 正木慶昭, 友利貴人, 植草宏哉. ２’位にアミノスルホニルアルコキシ基を有する新規人工核酸. 特許. 公開. 国立大学法人東京工業大学. 2022/03/01. 特願2022-031303. 2023/09/13. 特開2023-127483. 2023.
• 清尾康志, 正木慶昭, 金川峻幸, 小山彩. 塩基部修飾ヌクレオシドを含む新規アンチセンス核酸. 特許. 公開. 国立大学法人東京工業大学. 2022/03/01. 特願2022-031307. 2023/09/13. 特開2023-127484. 2023.
• 清尾康志, 正木慶昭, 山本恵士, 吉田圭汰, 入山　友輔, 中嶋　宏之, 金木　達朗. 人工ヌクレオシド及び人工ヌクレオチド並びに人工オリゴヌクレオチド. 特許. 登録. 国立大学法人東京工業大学, 日産化学株式会社. 2020/12/04. 特願2020-202186. 2021/03/25. 特開2021-046433. 特許第7085739号. 2022/06/09 2022.
• 清尾康志, 正木慶昭, 友利貴人. アンチセンス核酸の毒性を軽減する方法. 特許. 公開. 国立大学法人東京工業大学. 2020/11/27. PCT/JP2020/044370. 2021/06/03. WO 2021/107143. 2021.
• 正木慶昭, 清尾康志, 井上敦, 入山友輔, 金木達朗, 中嶋宏之. 毒性が低減されたアンチセンスオリゴヌクレオチド. 特許. 公開. 国立大学法人東京工業大学, 日産化学株式会社. 2019/03/20. 特願2020-507884. 2021/03/11. 再表/2019/182037. 2021.
• 清尾康志, 正木慶昭, 大野健太郎, 友利貴人. グアノシン－３’，５’－ビスジホスフェートの製造方法及びその製造中間体. 特許. 登録. 国立大学法人東京工業大学. 2019/02/08. 特願2019-571182. 2021/01/28. 再表2019/156240. 特許第7205914号. 2023/01/06 2023.
• 清尾康志, 正木慶昭. スルホンアミド骨格をもつオリゴヌクレオチドを鋳型として用いたＤＮＡ複製法. 特許. 公開. 国立大学法人東京工業大学. 2018/02/02. 特願2019-568531. 2021/02/04. 再表2019/150564. 2021.
• 清尾康志, 正木慶昭, 山本恵士, 吉田圭汰, 入山　友輔　, 中嶋　宏之, 金木　達朗　. 人工ヌクレオシド及び人工ヌクレオチド並びに人工オリゴヌクレオチド. 特許. 登録. 国立大学法人東京工業大学, 日産化学株式会社. 2017/02/17. 特願2018-500218. 2018/12/06. 再表2017/142054. 特許第6853537号. 2021/03/16 2021.
• 清尾康志, 正木慶昭, 島崎　猛夫, 山本　聡子. アンチセンスオリゴ核酸化合物およびその配列決定法. 特許. 公開. 国立大学法人東京工業大学, 学校法人金沢医科大学. 2016/03/31. 特願2016-070202. 2017/10/05. 特開2017-176074. 2017.
• 関根光雄, 清尾康志, 大窪章寛, 角田浩佑, 正木慶昭, 金森功吏, 山田　希, 山崎一史, 伊藤比祐吾. 2'-0-カルバモイル修飾ヌクレオシド三リン酸. 特許. 登録. 国立大学法人東京工業大学. 2013/07/23. 特願2013-152578. 2015/02/02. 特開2015-020994. 特許第6261027号. 2017/12/22 2017.
• 清尾康志, 関根光雄, 宮崎　一也, 黒萩　早耶子, 兒玉　恵里佳. オリゴヌクレオチド誘導体. 特許. 公開. 国立大学法人東京工業大学. 2011/02/17. 特願2012-500643. 2013/06/17. 特開（再表）2011/102414. 2013.
• 清尾康志, 関根光雄, 角田　浩佑, 伊勢　美沙子, 八代　洵, 中原　雄二. シリル化ヌクレオシド合成法. 特許. 公開. 国立大学法人東京工業大学, 日本製紙ケミカル株式会社. 2009/10/14. 特願2009-237339. 2011/04/28. 特開2011-084495. 2011.
• 関根光雄, 清尾康志, 大窪章寛, 角田　浩佑, 工藤　智美. ヌクレオシドトリホスフェート誘導体. 特許. 公開. 国立大学法人東京工業大学. 2008/03/07. 特願2008-057295. 2009/09/24. 特開2009-215171. 2009.
• 清尾康志, 関根光雄, 高久　悠介, 宮崎　一也. オリゴヌクレオチド誘導体. 特許. 公開. 国立大学法人東京工業大学. 2008/02/12. 特願2008-030372. 2009/08/27. 特開2009-190983. 2009.
• 関根光雄, 山田　剛史, 実吉　尚郎, 清尾康志. ２’水酸基修飾リボヌクレオシド誘導体. 特許. 登録. 国立大学法人東京工業大学. 2007/03/08. 特願2008-503910. 2009/07/13. 特開(再表）2007/102581. 特許第5194256号. 2013/02/15 2013.
• 関根光雄, 実吉　尚郎, 宮田　健一, 清尾康志. 新規亜リン酸エステルの酸化方法. 特許. 公開. 国立大学法人東京工業大学. 2006/10/20. 特願2006-312193. 2008/05/01. 特開2008-100976. 2008.
• 関根光雄, 清尾康志, 大窪章寛, 田中　邦彦. オリゴヌクレオチド固定化固相担体. 特許. 公開. 国立大学法人東京工業大学. 2006/03/10. 特願2006-066396. 2009/07/16. 特開2009-153381. 2009.
• 関根光雄, 田口　晴彦, 山田　研, 清尾康志. エステル結合を有するヌクレオシド誘導体. 特許. 公開. 国立大学法人東京工業大学. 2006/03/06. 特願2006-059370. 2007/09/20. 特開2007-238462. 2007.
• 清尾康志, 関根光雄, 高久　悠介. オリゴヌクレオチド誘導体. 特許. 公開. 国立大学法人東京工業大学. 2006/03/10. 特願2006-066135. 2007/09/20. 特開2007-238550. 2007.
• 関根光雄, 清尾康志, 大窪章寛, 坂本　一石, 佐々見　武志. オリゴヌクレオチド誘導体、遺伝子検出用プローブ及びＤＮＡチップ. 特許. 登録. 国立大学法人東京工業大学. 2006/02/28. 特願2007-505962. 2008/08/07. 再表2006-093157. 特許第4882074号. 2011/12/16 2011.
• 関根光雄, 宮下　拓平, 清尾康志. ピロリン酸アナログ及びピロリン酸アナログ合成方法. 特許. 公開. 国立大学法人東京工業大学. 2005/09/12. 特願2005-264155. 2007/03/29. 特開2007-077043. 2007.
• 関根光雄, 寺田　武史, 清尾康志. 動的カチオン感受性部位を挿入した新規ヌクレオシド誘導体. 特許. 公開. 国立大学法人東京工業大学. 2005/09/09. 特願2005-261657. 2007/03/22. 特開2007-070308. 2007.
• 関根光雄, KARWOWSKI, 清尾康志, 清尾　康志. RNA合成に有用な水酸基の新規保護基を有する化合物. 特許. 公開. 国立大学法人東京工業大学. 2005/09/08. 特願2005-260564. 2006/03/23. 特開2006-077013. 2006.
• 関根光雄, 清尾康志, 大窪章寛. 固体支持体及びDNAチップ. 特許. 公開. 国立大学法人東京工業大学. 2005/09/12. 特願2005-263722. 2007/03/29. 特開2007-078399. 2007.
• 関根光雄, 田口　晴彦, 成田　岳史, 清尾康志. ヌクレオシド誘導体及びその製造方法. 特許. 公開. 国立大学法人東京工業大学. 2005/09/16. 特願2005-270041. 2007/03/29. 特開2007-077109. 2007.
• 関根光雄, 宮田　健一, 峯尾　良太, 清尾康志. ヌクレオシド誘導体. 特許. 登録. 国立大学法人東京工業大学. 2005/07/05. 特願2005-196680. 2007/01/25. 特開2007-015948. 特許第5017639号. 2012/06/22 2012.
• 関根光雄, 玉木　継吾, 實吉　尚郎, 清尾康志. ２’－O－修飾ヌクレオシドの製造方法. 特許. 公開. 国立大学法人東京工業大学. 2005/03/09. 特願2005-064888. 2006/09/21. 特開2006-248930. 2006.
• 関根光雄, 實吉　尚郎, 清尾康志. リボヌクレオシドの２’水酸基の脱保護方法. 特許. 登録. 国立大学法人東京工業大学. 2005/03/09. 特願2005-064883. 2006/09/21. 特開2006-248929. 特許第4797156号. 2011/08/12 2011.
• 関根光雄, 宮田　健一, 玉虫　隆二, 清尾康志. 置換カルバモイル基を保護基とした核酸の合成方法. 特許. 公開. 国立大学法人東京工業大学. 2005/03/09. 特願2005-064892. 2006/09/21. 特開2006-248931. 2006.
• 関根光雄, 清尾康志, 岡本　到, 尾島　晃司郎. ヌクレオシドホスホロアミダイト化合物. 特許. 公開. 国立大学法人東京工業大学. 2005/03/10. 特願2005-067121. 2006/09/21. 特開2006-248975. 2006.
• 関根光雄, 俵田　隆哉, 清尾康志. ヌクレオシド、ヌクレオシド誘導体、オリゴヌクレオチド、及びオリゴヌクレオチド会合体. 特許. 公開. 国立大学法人東京工業大学. 2005/03/10. 特願2005-067805. 2006/09/21. 特開2006-248987. 2006.
• 関根光雄, 清尾康志, 大窪章寛, 粕谷　林太郎. トリチル型化合物. 特許. 公開. 国立大学法人東京工業大学. 2005/03/10. 特願2005-066555. 2006/09/21. 特開2006-248956. 2006.

学位論文

• 環状構造によりコンホメーションを固定化した核酸の化学合成と高次構造制御に関する研究,  本文,  Doctor of Science,  東京工業大学,  1996/--/--, 

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