論文

• 遠藤彬則, 福嶋俊明, 高橋ちかげ, 土屋光, 大竹史明, Sayaka Ono, Ly Tony, 吉田雪子, 田中啓二, 佐伯泰, 駒田雅之. USP8 prevents aberrant NF-kappaB and Nrf2 activation by counteracting ubiquitin signals from endosomes., Journal of Cell Biology, Vol. 223, No. 3, Page e202306013, Mar. 2024.
• Beni Lestari, Satomi Naito, Akinori Endo, Hidenori Nishihara, Akira Kato, Erika Watanabe, Kimitoshi Denda, Masayuki Komada, Toshiaki Fukushima. Placental Mammals Acquired Functional Sequences in NRK for Regulating the CK2–PTEN–AKT Pathway and Placental Cell Proliferation, Molecular Biology and Evolution, Vol. 39, No. 2, p. msab371, Feb. 2022.
• Keijun Kakihara, Kengo Asamizu, Kei Moritsugu, Masahide Kubo, Tetsuya Kitaguchi, Akinori Endo, Akinori Kidera, Mitsunori Ikeguchi, Akira Kato, Masayuki Komada, Toshiaki Fukushima.. Molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain., Commun Biol, 4, 1272, Nov. 2021.
• Satomi Naito, Toshiaki Fukushima, Akinori Endo, Kimitoshi Denda, Masayuki Komada. Nik-related kinase is targeted for proteasomal degradation by the chaperone-dependent ubiquitin ligase CHIP, FEBS Letters, 594, 11, 1778-1786, Mar. 2020.
• Ryohei Sakai, Ryosuke Fukuda, Shin Unida, Misaki Aki, Yuji Ono, Akinori Endo, Satoshi Kusumi, Daisuke Koga, Toshiaki Fukushima, Masayuki Komada, Tsukasa Okiyoneda. The integral function of the endocytic recycling compartment is regulated by RFFL-mediated ubiquitylation of Rab11 effectors, Journal of cell science, Vol. 132, No. 3, pp. 228007, Feb. 2019.
• Ryohei Sakai, Ryosuke Fukuda, Shin Unida, Misaki Aki, Yuji Ono, Akinori Endo, Satoshi Kusumi, Daisuke Koga, Toshiaki Fukushima, Masayuki Komada, Tsukasa Okiyoneda. The integral function of the endocytic recycling compartment is regulated by RFFL-mediated ubiquitylation of Rab11 effectors, Journal of cell science, Vol. 132, No. 3, pp. 228007, Feb. 2019.

国際会議発表 (査読有り)

• Keijun Kakihara, Kei Moritsugu, Tetsuya Kitaguchi, Akinori Endo, Masayuki Komada, Toshiaki Fukushima. Autoinhibition of USP8 by WW-like domain and the dysregulation in Cushing’s disease, EMBO Workshop “Ubiquitin and ubiquitin-like proteins in health and disease”, EMBO Workshop “Ubiquitin and ubiquitin-like proteins in health and disease”, Sept. 2022.
• Satomi Naito, Akinori Endo, Kimitoshi Denda, Yuka Madoka, Akira Kato, Masayuki Komada, Toshiaki Fukushima. Nrk prevents hyperplasia by modulating CK2-PTEN-Akt signaling pathway, The 2019 joint meeting of the American Society for Cell Biology (ASCB) and European Molecular Biology Organization (EMBO), Dec. 2019.
• Keijun Kakihara, Kengo Asamizu, Akinori Endo, Masayuki Komada, Toshiaki Fukushima. A novel autoinhibitory mechanism of ubiquitin-specific protease 8 activity via the intramolecular interaction, The 2019 joint meeting of the American Society for Cell Biology (ASCB) and European Molecular Biology Organization (EMBO), Dec. 2019.
• Toshiaki Fukushima, Yuka Madoka, Akinori Endo, Kohei Kawaguchi, Saki Arakaki, Masayuki Komada. Constitutive formation of USP8-STAM1 complex plays an important role in the onset of Cushing’s disease, The 2019 joint meeting of the American Society for Cell Biology (ASCB) and European Molecular Biology Organization (EMBO), Dec. 2019.
• Xie Xuan, Shunsuke Matsumoto, Akinori Endo, Toshiaki Fukushima, Hiroyuki Kawahara, Yasushi Saeki, Masayuki Komada. Deubiquitinases USP5 and USP13 are recruited to and regulate heat-induced stress granules by deubiquitinating activities., Cold Spring Harbor Asia Conferences, Ubiquitin Family, Autophagy and Diseases, Apr. 2018.

国内会議発表 (査読有り)

• 西岡 柚香, 遠藤 彬則, 駒田 雅之, 福嶋 俊明. SNAREタンパク質VAMP8・STX17のユビキチン化がオートファジーの進行に果たす役割, 第46回日本分子生物学会年会, Dec. 2023.
• 西岡 柚香, 柿原 慧遵, 遠藤 彬則, 駒田 雅之, 福嶋 俊明. 脱ユビキチン化酵素USP8によるVAMP8の制御とその細胞質分裂における意義の解明, 第45回 日本分子生物学会年会, Nov. 2022.
• BENI Lestari, 内藤 聡美, 遠藤 彬則, 西原 秀典, 加藤 明, 渡邊 恵理香, 傳田 公紀, 駒田 雅之, 福嶋 俊明. Comparative Phylogenetic Analysis and Molecular Characterization Reveal Eutherian-Specific Role of NRK in Regulating Placenta Development, 日本分子生物学会年会, Dec. 2021.
• Keijun Kakihara, Kengo Asamizu, Akinori Endo, Masayuki Komada, Toshiaki Fukushima. A novel autoinhibitory mechanism of ubiquitin-specific protease 8 activity via the intramolecular interaction, The 92nd Annual Meeting of the Japanease Biochemical Society, Sept. 2019.
• 柿原 慧遵, 浅水 謙吾, 遠藤 彬則, 駒田 雅之, 福嶋 俊明. 脱ユビキチン化酵素 USP8 の自己活性抑制機構, 2019年度日本生化学会関東支部例会, June 2019.
• Akinori Endo, Toshiaki Fukushima, Masayuki Komada. A deubiquitinase USP8, a master regulator of endosome-centered membrane traffic, controls inter-cellular signal transduction., Annual Meeting of the Molecular Biology Society of Japan, Nov. 2018.
• Satomi Naito, Akinori Endo, Toshiaki Fukushima, Kimitoshi Denda, Akira Kato, Masayuki Komada. Molecular mechanisms underlying the control of Nrk protein levels and Nrk-mediated anti-proliferation effects, Annual Meeting of the Molecular Biology Society of Japan, Nov. 2018.
• Takahiro Sawada, Kazuya Inoko, Kohei Kawaguchi, Akinori Endo, Yasushi Saeki, Keiji Tanaka, Toshiaki Fukushima, Masayuki Komada. Nuclear localization mechanism of deubiquitinating enzyme USP8 in Cushing’s disease, Annual Meeting of the Molecular Biology Society of Japan, Nov. 2018.
• 福嶋俊明, 澤田崇広, 猪子和也, 待鳥卓, 遠藤彬則, 駒田雅之. 脱ユビキチン化酵素USP8の遺伝子変異に起因するACTH過剰産生の分子機構, 第２回 ＰＯＭＣ研究者の集い, Sept. 2018.
• 待鳥 卓, 猪子 和也, 川口 紘平, 遠藤 彬則, 福嶋 俊明, 駒田 雅之. USP8 遺伝子のゲノム編集によるCushing 病モデル細胞の作製と解析, 第３３回日本下垂体研究会学術集会, Aug. 2018.
• Kohei Kawaguchi, Akinori Endo, Toshiaki Fukushima, Masayuki Komada. Ubiquitin-specific protease 8 suppresses collagen secretion by deubiquitinating Sec31, Cell and Developmental Biology Meeting, June 2018.

国内会議発表 (査読なし・不明)

• 柿原慧遵, 浅水謙吾, 森次圭, 北口哲也, 遠藤彬則, 木寺詔記, 池口満徳, 駒田雅之, 福嶋俊明. 脱ユビキチン化酵素USP8の自己阻害機構とクッシング病関連変異によるその解除, 第44回日本分子生物学会年会, 第44回日本分子生物学会年会要旨集, Dec. 2021.
• 福嶋俊明, 遠藤彬則, 川口紘平, 円由香, 駒田雅之. クッシング病の治療薬開発を目指したUSP8-STAM1複合体を作用点とするACTH分泌制御物質の開発, 第6回橋渡し研究戦略的推進プログラムシンポジウム, Mar. 2021.
• Satomi Naito, Akinori Endo, Kimitoshi Denda, Akira Kato, Masayuki Komada, Toshiaki Fukushima. Nik-related kinase is regulated by quality control ubiquitin ligase CHIP, 新学術領域「ケモユビキチン」第3回班会議, Dec. 2019.
• Keijun Kakihara, Kengo Asamizu, Akinori Endo, Kei Moritsugu, Akira Kato, Masayuki Komada, Toshiaki Fukushima. The enzyme activity of USP8 is regulated by the intramolecular interaction of the USP domain and the WW domain, 新学術領域「ケモユビキチン」第3回班会議, Dec. 2019.
• 柿原慧遵, 浅水謙吾, 遠藤彬則, 駒田雅之, 福嶋俊明. 脱ユビキチン化酵素USP8の自己活性抑制機構, 第2回ユビキチン研究会, Jan. 2019.

その他の論文・著書など

• Keijun Kakihara, Kengo Asamizu, Kei Moritsugu, Masahide Kubo, Tetsuya Kitaguchi, Akinori Endo, Akinori Kidera, Mitsunori Ikeguchi, Akira Kato, Masayuki Komada, Toshiaki Fukushima. The molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain, bioRxiv, May 2021.

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