論文

• Gabriele Di Stadio, Izumi Orita, Ryuhei Nakamura, Toshiaki Fukui. Gas fermentation combined with water electrolysis for production of polyhydroxyalkanoate copolymer from carbon dioxide by engineered Ralstonia eutropha, Bioresource Technology, Vol. 394, 130266, Feb. 2024.  公式リンク  
  
• Kai-Hee Huong, Izumi Orita, Toshiaki Fukui. Microaerobic insights into production of polyhydroxyalkanoates containing 3-hydroxyhexanoate via native reverse β-oxidation from glucose in Ralstonia eutropha H16, Microbial Cell Factories, Vol. 23, Jan. 2024.  公式リンク  
  
• Shizuru Ishihara, Izumi Orita, Ken'ichiro Matsumoto, Toshiaki Fukui. (R/S)-lactate/2-hydroxybutyrate dehydrogenases in and biosynthesis of block copolyesters by Ralstonia eutropha, Applied Microbiology and Biotechnology, Vol. 107, No. 24, pp. 7557-7569, Dec. 2023.  公式リンク  
  
• Kenji Tanaka, Izumi Orita, Toshiaki Fukui. Production of Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) from CO2 via pH-Stat Jar Cultivation of an Engineered Hydrogen-Oxidizing Bacterium Cupriavidus necator, Bioengineering, Vol. 10, Nov. 2023.  公式リンク  
  
• Shu Saito, Imai, R., Yuki Miyahara, Nakagawa, M., Orita, I., Tsuge, T., Toshiaki Fukui. Biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) from glucose by Escherichia coli through butyryl-CoA formation driven by Ccr-Emd combination, Frontiers in Bioengineering and Biotechnology, Vol. 10, Apr. 2022.  公式リンク  
  
• Ohira, T., Minowa, K., Sugiyama, K., Yamashita, S., Sakaguchi, Y., Miyauchi, K., Noguchi, R., Akira Kaneko, Izumi Orita, Toshiaki Fukui, Tomita, K., Suzuki, T.. Reversible RNA phosphorylation stabilizes tRNA for cellular thermotolerance, Nature, Vol. 605, No. 7909, pp. 372-379, Apr. 2022.  公式リンク  
  
• Izumi Orita, Gento Unno, Kato, R., Toshiaki Fukui. Correction: Orita et al. Biosynthesis of polyhydroxyalkanoate terpolymer from methanol via the reverse β-oxidation pathway in the presence of lanthanide, Microorganisms, Vol. 10, No. 3, pp. 529, Feb. 2022.  公式リンク  
  
• Izumi Orita, Gento Unno, Kato, R., Toshiaki Fukui. Biosynthesis of Polyhydroxyalkanoate Terpolymer from Methanol via the Reverse β-Oxidation Pathway in the Presence of Lanthanide, Microorganisms, Vol. 10, No. 1, pp. 184, Jan. 2022.  公式リンク  
  
• Kenji Tanaka, Kazamasa Yoshida, Izumi Orita, Toshiaki Fukui. Biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) from CO2 by a recombinant Cupriavidus necator, Bioengineering, Vol. 8, No. 11, Nov. 2021.  公式リンク  
  
• Viviane Carnier Casaroli, Izumi Orita, Shiori Katayama, Hiroya Yurimoto, Yasuyoshi Sakai, Toshiaki Fukui. Methylotrophic bacterium-based molecular sensor for the detection of low concentrations of methanol, Journal of Bioscience and Bioengineering, June 2021.  公式リンク  
  
• Akimitsu Miyaji, Daiki Furuya, Izumi Orita, Toshihide Baba. Growth-promoting effect of cyanocobalamin on Methylosinus trichosporium OB3b culture under high copper concentration for methanol synthesis from methane, Bioresource Technology Reports, Vol. 11, p. 100473, Sept. 2020.
• Nazila Biglari, Izumi Orita, Toshiaki Fukui, Kumar Sudesh. A study on the effects of increment and decrement repeated fed-batch feeding of glucose on the production of poly(3-hydroxybutyrate) [P(3HB)] by a newly engineered Cupriavidus necator NSDG-GG mutant in batch fill-and-draw fermentation, Journal of Biotechnology, Mar. 2020.  公式リンク  
  
• Mengxiao Zhang, Shiyunsuke Kurita, Izumi Orita, Satoshi Nakamura, Toshiaki Fukui. Modification of acetoacetyl-CoA reduction step in Ralstonia eutropha for biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) from structurally unrelated compounds, Microbial Cell Factories, Vol. 18, No. 1, Sept. 2019.  公式リンク  
  
• Izumi Orita, Ryohei Futatsuishi, Kyoko Adachi, Ohira, T., Akira Kaneko, Minowa, K., Miho Suzuki, Tamura, T., Satoshi Nakamura, Tadayuki Imanaka, Suzuki, T., Toshiaki Fukui. Random mutagenesis of a hyperthermophilic archaeon identified tRNA modifications associated with cellular hyperthermotolerance, Nucleic Acids Research, Vol. 47, No. 4, pp. 1964-1976, Jan. 2019.  公式リンク  
  
• Mutsumi Segawa, Cheng Wen, Izumi Orita, Satoshi Nakamura, TOSHIAKI FUKUI. Two NADH-dependent (S)-3-hydroxyacyl-CoA dehydrogenases from polyhydroxyalkanoate-producing Ralstonia eutropha, Journal of Bioscience and Bioengineering, Sept. 2018.  公式リンク  
  
• N. Biglari, M. G. Dashti, P. Abdeshahian, Izumi Orita, T. Fukui, Kumar Sudesh. Enhancement of bioplastic polyhydroxybutyrate P(3HB) production from glucose by newly engineered strain Cupriavidus necator NSDG-GG using response surface methodology, 3 Biotech, Vol. 8, No. 8, Aug. 2018.  公式リンク  
  
• Yui Kawashima, Izumi Orita, Satoshi Nakamura, TOSHIAKI FUKUI. Compositional regulation of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by replacement of granule-associated protein in Ralstonia eutropha, Microbial Cell Factories, Vol. 14, Page 187, Nov. 2015.  公式リンク  
  
• Chayatip Insomphun, Huan Xie, Jun Mifune, Yui Kawashima, Izumi Orita, Satoshi Nakamura, Toshiaki Fukui. Improved artificial pathway for biosynthesis of poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) with high C₆-monomer composition from fructose in Ralstonia eutropha, Metabolic Engineering, Vol. 27, pp. 38-45, Jan. 2015.  公式リンク  
  
• Kenta Nohara, Izumi Orita, Satoshi Nakamura, Tadayuki Imanaka, Toshiaki Fukui. Genetic examination and mass balance analysis of pyruvate/amino acid oxidation pathways in the hyperthermophilic archaeon Thermococcus kodakarensis, Journal of Bacteriology, Vol. 196, No. 22, pp. 3831-3839, Nov. 2014.  公式リンク  
  
• TOSHIAKI FUKUI, Mukoyama, Masaharu, Izumi Orita, Satoshi Nakamura. Enhancement of glycerol utilization ability of Ralstonia eutropha H16 for production of polyhydroxyalkanoates, Applied Microbiology and Biotechnology, Vol. 98, No. 17, pp. 7559-7568, Sept. 2014.  公式リンク  
  
• TOSHIAKI FUKUI, Kenta Chou, Kazuo Harada, Izumi Orita, Yasumune Nakayama, Takeshi Bamba, Satoshi Nakamura, Eiichiro Fukusaki,. Metabolite profiles of polyhydroxyalkanoate-producing Ralstonia eutropha H16, Metabolomics, Vol. 10, No. 2, pp. 190-202, Aug. 2014.  公式リンク  
  
• P Harnvoravongchai, Hiroki Kobori, Izumi Orita, Satoshi Nakamura, Tadayuki Imanaka, TOSHIAKI FUKUI. Characterization and gene deletion analysis of four homologues of group 3 pyridine nucleotide disulfide oxidoreductases from Thermococcus kodakarensis, Extremophiles, Vol. 18, No. 3, pp. 603-616, June 2014.  公式リンク  
  
• Izumi Orita, Nishikawa, Kouta, Satoshi Nakamura, TOSHIAKI FUKUI. Biosynthesis of polyhydroxyalkanoate copolymers from methanol by Methylobacterium extorquens AM1 and the engineered strains under cobalt-deficient conditions, Applied Microbiology and Biotechnology, Vol. 98, No. 8, pp. 3715-3725, Apr. 2014.  公式リンク  
  
• Chayatip Insomphun, Jun Mifune, Izumi Orita, Keiji Numata, Satoshi Nakamura, TOSHIAKI FUKUI. Modification of beta-oxidation pathway in Ralstonia eutropha for production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) from soybean oil, Journal of Bioscience and Bioengineering, Vol. 117, No. 2, pp. 184-190, Feb. 2014.  公式リンク  
  
• Rie Shimizu, Kenta Chou, Izumi Orita, Suzuki, Y., Satoshi Nakamura, Toshiaki Fukui. Detection of phase-dependent transcriptomic changes and Rubisco-mediated CO2 fixation into poly (3-hydroxybutyrate) under heterotrophic condition in Ralstonia eutropha H16 based on RNA-seq and gene deletion analyses, BMC Microbiology, Vol. 13, No. 1, p. 169, July 2013.  公式リンク  
  
• Wu, Xi, Zhang, Chong, Izumi Orita, Tadayuki Imanaka, Xing, Xin-Hui, Toshiaki Fukui. Thermostable alcohol dehydrogenase from Thermococcus kodakarensis KOD1 for enantioselective bioconversion of aromatic secondary alcohols, Applied and Environmental Microbiology, Vol. 79, No. 7, pp. 2209-2217, Apr. 2013.  公式リンク  
  
• Wu, Xi, Hiroki Kobori, Izumi Orita, Zhang, Chong, Tadayuki Imanaka, XING Xin-Hui, TOSHIAKI FUKUI. Application of a novel thermostable NAD(P)H oxidase from hyperthermophilic archaeon for the regeneration of both NAD⁺ and NADP⁺, Biotechnology and Bioengineering, Vol. 109, No. 1, pp. 53-62, Jan. 2012.  公式リンク  
  
• Izumi Orita, Reiko Iwazawa, Satoshi Nakamura, TOSHIAKI FUKUI. Identification of mutation points in Cupriavidus necator NCIMB 11599 and genetic reconstitution of glucose-utilization ability in wild strain H16 for polyhydroxyalkanoate production, Journal of Bioscience and Bioengineering, Vol. 113, No. 1, pp. 63-69, Jan. 2012.  公式リンク  
  
• Yui Kawashima, Cheng, Wen, Jun Mifune, Izumi Orita, Satoshi Nakamura, TOSHIAKI FUKUI. Characterization and Functional Analyses of R-Specific Enoyl Coenzyme A Hydratases in Polyhydroxyalkanoate-Producing Ralstonia eutropha, Applied and Environmental Microbiology, Vol. 78, No. 2, pp. 493-502, Jan. 2012.  公式リンク  
  
• TOSHIAKI FUKUI, Kei Osawa, JUN MIFUNE, IZUMI ORITA, Satoshi Nakamura. Evaluation of promoters for gene expression in polyhydroxyalkanoate-producing Cupriavidus necator, Appl. Microbiol. Biotechnol., Springer, Vol. 89, pp. 1257-1536, Apr. 2011.
• Satoshi Nakamura, HIROKI KOBORI, MASAYUKI OGINO, IZUMI ORITA, TADAYUKI IMANAKA, TOSHIAKI FUKUI. Characterization of NADH Oxidase/NADPH Polysulfide Oxidoreductase and Its Unexpected Participation in Oxygen Sensitivity in an Anaerobic Hyperthermophilic Archaeon, Journal of Bacteriology, American Society for Microbiology, Vol. 192, No. 19, pp. 5192-5202, Oct. 2010.  公式リンク  
  

特許など

• 福居俊昭, 折田和泉. 糖質原料からの共重合ポリヒドロキシアルカン酸の製造法. 特許. 公開. 国立大学法人東京工業大学, 株式会社カネカ. 2015/08/04. 特願2016-540249. 2017/05/18. 再表2016/021604. 2017. May
• 福居俊昭, 折田和泉, 川島　由依. ポリエステル顆粒結合タンパク質遺伝子座を改変した組換え株による共重合ポリエステルの製造法. 特許. 公開. 国立大学法人東京工業大学, 株式会社カネカ. 2014/03/04. 特願2014-041787. 2017/04/27. 特開2017-077184. 2017.
• 福居俊昭, 折田和泉. 脂肪酸β－酸化経路改変株による共重合体ポリヒドロキシアルカン酸の製造法. 特許. 公開. 国立大学法人東京工業大学, 株式会社カネカ. 2014/02/27. 特願2015-503023. 2017/02/02. 再表2014/133088. 2017.
• 福居俊昭, 折田和泉, 御船　淳, 川島　由依. エノイル－CoAヒドラターゼ遺伝子を導入した組換え微生物によるポリヒドロキシアルカン酸の製造法. 特許. 登録. 国立大学法人東京工業大学. 2011/02/22. 特願2012-501794. 2013/06/20. 特開（再表）2011/105379. 特許第5807878号. 2015/09/18 2015.

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