論文

• Jyh Yea Chia, Takayuki Miki, Hisakazu Mihara, Hiroshi Tsutsumi. Biofunctional supramolecular hydrogels fabricated from a short self-assembling peptide modified with bioactive sequences for the 3D culture of breast cancer MCF-7 cells, Bioorganic & Medicinal Chemistry, Vol. 46, pp. 116345, Sept. 2021.  公式リンク  
  
• Takayuki Miki, Taichi Nakai, Masahiro Hashimoto, Keigo Kajiwara, Hiroshi Tsutsumi, Hisakazu Mihara. Intracellular artificial supramolecules based on de novo designed Y15 peptides, Nature Communications, Vol. 12, June 2021.  公式リンク  
  
• Hiroshi Tsutsumi, Kunifumi Tanaka, Jyh Yea Chia, Hisakazu Mihara. Short self‐assembling peptides with a urea bond: A new type of supramolecular peptide hydrogel materials, Peptide Science, Vol. 113, No. 2, Mar. 2021.  公式リンク  
  
• Masahiro Hashimoto, Takayuki Miki, Iou Ven Chang, Hiroshi Tsutsumi, Hisakazu Mihara. Selection of fluorescent biosensors against galectin-3 from an NBD-modified phage library displaying designed α-helical peptides, Bioorganic & Medicinal Chemistry Letters, 37, 127835, Feb. 2021.
• Teerapat Anananuchatkul, Hiroshi Tsutsumi, Takayuki Miki, Hisakazu Mihara.. hDM2 Protein-Binding Peptides Screened from Stapled alpha-Helical Peptide Phage Display Libraries with Different Types of Staple Linkers., Bioorganic & Medicinal Chemistry Letters, Vol. 30, 127605, Nov. 2020.
• H. Tsutsumi, D. Matsubara, H. Mihara.. Functionalization of Self-assembling Peptide Materials Using Molecular Recognition of Supramolecular Peptide Nanofibers., Polymer Journal, Vol. 52, 913, May 2020.
• Teerapat Anananuchatkul, Iou Ven Chang, Takayuki Miki, Hiroshi Tsutsumi, Hisakazu Mihara. Construction of a Stapled α‑Helix Peptide Library Displayed on Phage for the Screening of Galectin-3-Binding Peptide Ligands, ACS Omega, ACS Publications, Vol. 5, p. 5666-5674, Mar. 2020.
• Kazuto Fukunaga, Hiroshi Tsutsumi, Hisakazu Mihara. Self-Assembling Peptides as Building Blocks of Functional Materials for Biomedical Applications., Bulletin of the Chemical Society of Japan, The Chemical Society of Japan, Vol. 92, No. 2, pp. 391-399, Feb. 2019.
• H.Tsutsumi, M. Kawamura, H. Mihara. Osteoblastic Differentiation on Hydrogels Fabricated from Ca2+-Responsive Self-Assembling Peptides Functionalized with Bioactive Peptides, Bioorganic & Medicinal Chemistry, Vol. 26, pp. 3126-3132, Apr. 2018.
• H.Tsutsumi, T. Shirai, H. Ohkusa, H. Mihara. Gold Nanoparticles Conjugated with Glycopeptides for Lectin Detection and Imaging on Cell Surface, Protein & Peptide Letters, Vol. 25, pp. 84-89, Jan. 2018.
• I.V. Chang, H.Tsutsumi, H. Mihara. Screening for Concanavalin A Binders from a Mannose-modified α-Helix Peptide Phage Library, Molecular BioSystems, Vol. 13, pp. 2222-2225, Sept. 2017.
• 堤浩, 澤田敏樹, 三原久和. 自己集合性ペプチドナノファイバーを用いたナノバイオ材料の創製, Kobunshi Ronbunshu, 公益社団法人 高分子学会, Vol. 74, No. 3, pp. 162-171, May 2017.  公式リンク  
  
• Kazuto Fukunaga, Hiroshi Tsutsumi, Hisakazu Mihara. Cell Differentiation on Disk- and String-Shaped Hydrogels Fabricated from Ca(2+) Rresponsive Self-Assembling Peptides., Biopolymers, Vol. 106, No. 4, pp. 476-83, July 2016.  公式リンク  
  
• Megumi Kawamura, Kazuto Fukunaga, Hiroshi Tsutsumi, Hisakazu Mihara. Cell Proliferation and Differentiation on Functionalized Self-Assembling Peptide Hydrogels., The 52th Japanese Peptide Symposium, Peptide science, The Japanese Peptide Society, 275-276, Mar. 2016.
• Hiroshi Tsutsumi, Kazuhiko Nakano, Hisakazu Mihara. Dihydrofolate Reductase Inhibitory Peptides Screened from a Structured Designed β-Loop Peptide Library Displayed on Phage, Molecular BioSystems, Vol. 11, No. 10, pp. 2713-2716, June 2015.  公式リンク  
  
• Ji Yang, Tadaomi Furuta, Minoru Sakurai, Hiroshi Tsutsumi, Hisakazu Mihara. A Computational Study of the Interaction of Amphiphilic α-Helical Cell-Penetrating Peptides with Heparan Sulfate, Bull. Chem. Soc. Jpn., vol. 87, no. 10, pp. 1074-1082, July 2014.
• Ji Yang, Hiroshi Tsutsumi, Tadaomi Furuta, Minoru Sakurai, Hisakazu Mihara. Interaction of Amphiphilic α-Helical Cell-Penetrating Peptides with Heparan Sulfate, Org. Biomol. Chem., vol. 12, no. 26, pp. 4673-4681, Apr. 2014.
• Hyejin Park, Hiroshi Tsutsumi, Hisakazu Mihara. Cell-Selective Intracellular Drug Delivery Using Doxorubicin and α-Helical Peptides Conjugated to Gold Nanoparticles, Biomaterials, Vol. 35, No. 10, pp. 3480-3487, Mar. 2014.  公式リンク  
  
• Kazuto Fukunaga, Hiroshi Tsutsumi, Hisakazu Mihara. Self-Assembling Peptide Nanofibers Promoting Cell Adhesion and Differentiation, Biopolymers, Vol. 100, No. 6, pp. 731-737, Nov. 2013.  公式リンク  
  
• Chie Hashimoto, Wataru Nomura, Tetsuo Narumi, Fujino, Masayuki, Hiroshi Tsutsumi, Masaki Haseyama, Naoki Yamamoto, Tsutomu Murakami, Hirokazu Tamamura. Anti-HIV-1 Peptide Derivatives Based on the HIV-1 Co-receptor CXCR4, ChemMedChem, Vol. 8, No. 10, pp. 1668-1672, Oct. 2013.  公式リンク  
  
• Kanako Arai, Hiroshi Tsutsumi, Hisakazu Mihara. A Monosaccharide-Modified Peptide Phage Library for Screening of Ligands to Carbohydrate-Binding Proteins, Bioorganic & Medicinal Chemistry Letters, Vol. 23, No. 17, pp. 4940-4943, Sept. 2013.  公式リンク  
  
• Vu, Nhuan T., Yoshitaka Moriwaki, Jose M. M. Caaveiro, Tohru Terada, Hiroshi Tsutsumi, Iraru Hamachi, Kentaro Shimizu, Kouhei Tsumoto. Selective Binding of Antimicrobial Porphyrins to the Heme-Receptor IsdH-HEAT3 of Staphylococcus aureus, Protein Science, Vol. 22, No. 7, pp. 942-953, July 2013.  公式リンク  
  
• Hyejin Park, Hiroshi Tsutsumi, Hisakazu Mihara. Cell Penetration and Cell-Selective Drug Delivery Using -Helix Peptides Conjugated with Gold Nanoparticles, Biomaterials, Vol. 34, No. 20, pp. 4872-4879, July 2013.  公式リンク  
  
• Hiroshi Tsutsumi, Hiroyuki Ohkusa, Hyejin Park, Tsuyoshi Takahashi, HIDEYA YUASA, Hisakazu Mihara. Gold Nanoparticles Conjugated with Monosaccharide-modified Peptide for Lectin Detection, Bioorganic & Medicinal Chemistry Letters, Vol. 22, No. 22, pp. 6825-6827, Sept. 2012.  公式リンク  
  
• T. Sawada, M. Tsuchiya, T. Takahashi, Hiroshi Tsutsumi, H. Mihara. Cell-Adhesive Hydrogels Composed of Peptide Nanofibers Responsive to Biological Ions, Polymer Journal, Vol. 44, pp. 651-657, Apr. 2012.
• Yoshitaka Moriwaki, Jose M. M. Caaveiro, Tanaka, Yoshikazu, Hiroshi Tsutsumi, Iraru Hamachi, Kouhei Tsumoto. Molecular Basis of Recognition of Antibacterial Porphyrins by Heme-Transporter IsdH-NEAT3 of Staphylococcus aureus, Biochemistry, Vol. 50, No. 34, pp. 7311-7320, July 2011.  公式リンク  
  
• Hiroshi Tsutsumi, Seiichiro Abe, Tomoaki Mino, Wataru Nomura, Hirokazu Tamamura. Intense Blue Fluorescence in a Leucine Zipper Assembly, ChemBioChem, Vol. 12, No. 5, pp. 691-694, Feb. 2011.  公式リンク  
  
• Wataru Nomura, Tomoaki Mino, Tetsuo Narumi, Nami Ohashi, Akemi Masuda, Chie Hashimoto, Hiroshi Tsutsumi, Hirokazu Tamamura. Development of Crosslink-Type Tag-Probe Pairs for Fluorescent Imaging of Proteins, Biopolymers, Vol. 94, No. 6, pp. 843-852, Nov. 2010.  公式リンク  
  
• Shintaro Suzuki, Maddali, Kasthuraiah, Chie Hashimoto, Urano, Emiko, Nami Ohashi, Tomohiro Tanaka, Ozaki, Taro, Arai, Hiroshi, Hiroshi Tsutsumi, Tetsuo Narumi, Wataru Nomura, Naoki Yamamoto, Pommier, Yves, Atsushi Komano, Hirokazu Tamamura. Peptidic HIV Integrase Inhibitors Derived from HIV Gene Products: Structure-Activity Relationship Studies, Bioorganic & Medicinal Chemistry, Vol. 18, No. 18, pp. 6771-6775, Sept. 2010.  公式リンク  
  
• Shintaro Suzuki, Urano, Emiko, Chie Hashimoto, Hiroshi Tsutsumi, Toru Nakahara, Tomohiro Tanaka, Yuta Nakanishi, Maddali, Kasthuraiah, Han, Yan, Hamatake, Makiko, Miyauchi, Kosuke, Pommie, Yves, Beutler, John A., Sugiura, Wataru, Fuji, Hideyoshi, Hoshino, Tyuji, Kyoko Itotani, Wataru Nomura, Tetsuo Narumi, Naoki Yamamoto, Atsushi Komano, Hirokazu Tamamura. Peptide HIV-1 Integrase Inhibitors from HIV-1 Gene Products, Journal of Medicinal Chemistry, Vol. 53, No. 14, pp. 5356-5360, July 2010.  公式リンク  
  
• Hiroshi Tsutsumi, Wataru Nomura, Seiichiro Abe, Tomoaki Mino, Akemi Masuda, Nami Ohashi, Tomohiro Tanaka, Kenji Ohba, Naoki Yamamoto, Kazunari Akiyoshi, Hirokazu Tamamura. Fluorogenically Active Leucine Zipper Peptides as Tag-Probe Pairs for Protein Imaging in Living Cells, Angewandte Chemie-International Edition, Vol. 48, No. 48, pp. 9164-9166, Nov. 2009.  公式リンク  
  
• Tomohiro Tanaka, Hiroshi Tsutsumi, Wataru Nomura, Yasuaki Tanabe, Nami Ohashi, Esaka, Ai, Chihiro Ochiai, Sato, Jun, Kyoko Itotani, Tsutomu Murakami, Kenji Ohba, Naoki Yamamoto, Nobutaka Fujii, Hirokazu Tamamura. Structure-Activity Relationship Study of CXCR4 Antagonists Bearing the Cyclic Pentapeptide Scaffold: Identification of the New Pharmacophore, Organic & Biomolecular Chemistry, Vol. 6, No. 23, pp. 4374-4377, Oct. 2008.  公式リンク  
  
• Wataru Nomura, Yasuaki Tanabe, Hiroshi Tsutsumi, Tomohiro Tanaka, Kenji Ohba, Naoki Yamamoto, Hirokazu Tamamura. Fluorophore Labeling Enables Imaging and Evaluation of Specific CXCR4-Ligand Interaction at the Cell Membrane for Fluorescence-Based Screening, Bioconjugate Chemistry, Vol. 19, No. 9, pp. 1917-1920, Aug. 2008.  公式リンク  
  
• Hirokazu Tamamura, Tomohiro Tanaka, Hiroshi Tsutsumi, Nemoto, Koji, Mizokami, Satoko, Nami Ohashi, Shinya Oishi, Nobutaka Fujii. Versatile Use of Acid-Catalyzed Ring-opening of β-Aziridinyl-α, β-Enoates to Stereoselective Synthesis of Peptidomimetics, Tetrahedron, Vol. 63, No. 37, pp. 9243-9254, Sept. 2007.  公式リンク  
  
• Hirokazu Tamamura, Hiroshi Tsutsumi, Hiroyuki Masuno, Ogawa, T., Kenichi Hiramatsu, Araki, T., Ueda, S., Shinya Oishi, Esaka, A., Wang, Z., Peiper, S. C., Trent, J. O., Nobutaka Fujii. Synthesis and Biological Evaluation of CXCR4 Antagonists as Pharmaceutical Agents, Journal of Peptide Science, Vol. 12, No. S1, pp. 282, Sept. 2006.  公式リンク  
  
• Hirokazu Tamamura, Hiroshi Tsutsumi, Nobutaka Fujii. The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases, Mini-Reviews in Medicinal Chemistry, Vol. 6, No. 9, pp. 989-995, Sept. 2006.  公式リンク  
  
• Hirokazu Tamamura, Akio Ojida, Ogawa, Teppei, Hiroshi Tsutsumi, Hiroyuki Masuno, Nakashima, Hideki, Naoki Yamamoto, Iraru Hamachi, Nobutaka Fujii. Identification of a New Class of Low Molecular Weight Antagonists against the Chemokine Receptor CXCR4 Having the Dipicolylamine-Zinc(II) Complex Structure, Journal of Medicinal Chemistry, Vol. 49, No. 11, pp. 3412-3415, June 2006.  公式リンク  
  
• Hirokazu Tamamura, Hiroshi Tsutsumi, Hiroyuki Masuno, Mizokami, Satoko, Kenichi Hiramatsu, Wang, Zixuan, Trent, John O., Nakashima, Hideki, Naoki Yamamoto, Peiper, Stephen C., Nobutaka Fujii. Development of Linear Type of Low Molecular Weight CXCR4 Antagonists Based on T140 Analogs, Organic & Biomolecular Chemistry, Vol. 4, No. 12, pp. 2354-2357, May 2006.  公式リンク  
  
• Yousuke Takaoka, Hiroshi Tsutsumi, Noriyuki Kasagi, Eiji Nakata, Iraru Hamachi. One-Pot and Sequential Organic Chemistry on an Enzyme Surface to Tether a Fluorescent Probe at the Proximity of the Active Site with Restoring Enzyme Activity, Journal of the American Chemical Society, Vol. 128, No. 10, pp. 3273-3280, Feb. 2006.  公式リンク  
  
• Akio Ojida, Masa-aki Inoue, Mito-oka, Y, Hiroshi Tsutsumi, Sada, K, Iraru Hamachi. Effective Disruption of Phosphoprotein-Protein Surface Interaction Using Zn(II) Dipicolylamine-Based Artificial Receptors via Two-Point Interaction, Journal of the American Chemical Society, Vol. 128, No. 6, pp. 2052-2058, Jan. 2006.  公式リンク  
  
• Hirokazu Tamamura, Esaka, A, Ogawa, T, Araki, T, Ueda, S, Wang, ZX, Trent, JO, Hiroshi Tsutsumi, Hiroyuki Masuno, Nakashima, H, Naoki Yamamoto, Peiper, SC, Akira Otaka, Nobutaka Fujii. Structure-Activity Relationship Studies on CXCR4 Antagonists Having Cyclic Pentapeptide Scaffolds, Organic & Biomolecular Chemistry, Vol. 3, No. 24, pp. 4392-4394, Nov. 2005.  公式リンク  
  
• Akio Ojida, Hiroshi Tsutsumi, Noriyuki Kasagi, Iraru Hamachi. Suzuki Coupling for Protein Modification, Tetrahedron Letters, Vol. 46, No. 19, pp. 3301-3305, May 2005.  公式リンク  
  
• Hiroshi Tsutsumi, Hiroshi Ikeda, Hisakazu Mihara, Akihiko Ueno. Enantioselective Ester Hydrolysis Catalyzed by β-Cyclodextrin Conjugated with β-Hairpin Peptides, Bioorganic & Medicinal Chemistry Letters, Vol. 14, No. 3, pp. 723-726, Feb. 2004.  公式リンク  
  
• Hiroshi Tsutsumi, Keita Hamasaki, Hisakazu Mihara, Akihiko Ueno. Rate Enhancement and Enantioselectivity in Ester Hydrolysis Catalysed by Cyclodextrin-Peptide Hybrids, Journal of the Chemical Society Perkin Transactions 2, No. 9, pp. 1813-1818, Aug. 2000.  公式リンク  
  
• Hiroshi Tsutsumi, Keita Hamasaki, Hisakazu Mihara, Akihiko Ueno. Cyclodextrin-Peptide Hybrid as a Hydrolytic Catalyst Having Multiple Functional Groups, Bioorganic & Medicinal Chemistry Letters, Vol. 10, No. 8, pp. 741-743, Apr. 2000.  公式リンク  
  

著書

• 堤 浩, 三原 久和. 薬剤−ペプチドコンジュゲートとペプチド創薬, CSJカレントレビュー39．生体分子と疾患：ヘルスサイエンスの切り札としての化学, 化学同人, pp. 162-169, Aug. 2021.
• 堤 浩, 三原久和. 化学修飾ペプチドファージライブラリの構築と標的タンパク質に対するリガンドスクリーニング, ペプチド医薬品のスクリーニング・安定化・製剤化技術, 技術情報協会, pp. 67-73, Dec. 2017.
• 堤 浩, 三原久和. ペプチド立体構造の設計と機能, 医療・診断をささえるペプチド科学−再生医療・DDS・診断への応用−, シーエムシー出版, pp. 73-81, Oct. 2017.
• 堤浩, 三原久和. 自己組織化現象を利用したペプチド性足場材料の開発, 再生医療用足場材料の開発と市場, pp. 24-35, Mar. 2016.
• 堤浩, 三原久和. 生体分子解析・細胞解析に向けた設計ペプチドチップ, バイオチップの基礎と応用-原理から最新の研究・開発動向まで-, pp. 143-152, Oct. 2015.
• 堤浩, 築地真也, 浜地格. 天然酵素の特異的修飾, 酵素利用技術大系-基礎・解析から改変・高機能化・産業利用まで-, pp. 269-273, Apr. 2010.
• 堤浩, 濱崎啓太. シクロデキストリン－ペプチドハイブリッド, ナノマテリアル・シクロデキストリン, pp. 129-149, Dec. 2005.

その他の論文・著書など

• Hiroshi Tsutsumi, Hisakazu Mihara. Self-Assembly of Designed Peptides and Their Nanomaterials Applications, Amino Acids, Peptides and Proteins, Vol. 38, pp. 122-150, Nov. 2013.
• Hiroshi Tsutsumi, Hisakazu Mihara. Soft Materials Based on Designed Self-Assembling Peptides: from Design to Application, Molecular Biosystems, Vol. 9, No. 4, pp. 609-617, Apr. 2013.  公式リンク  
  
• Hirokazu Tamamura, Hiroshi Tsutsumi, Wataru Nomura, Tomohiro Tanaka, Nobutaka Fujii. A Future Perspective on the Development of Chemokine Receptor CXCR4 Antagonists, Expert Opinion on Drug Discovery, Vol. 3, No. 10, pp. 1155-1166, Sept. 2008.  公式リンク  
  
• Hirokazu Tamamura, Hiroshi Tsutsumi, Wataru Nomura, Nobutaka Fujii. Exploratory Studies on Development of the Chemokine Receptor CXCR4 Antagonists Toward Downsizing, Perspectives in medicinal chemistry, Vol. 2, pp. 1-9, Jan. 2008.  公式リンク  
  
• Hiroshi Tsutsumi, Tomohiro Tanaka, Nami Ohashi, Hiroyuki Masuno, Hirokazu Tamamura, Kenichi Hiramatsu, Araki, Takanobu, Ueda, Satoshi, Shinya Oishi, Nobutaka Fujii. Therapeutic Potential of the Chemokine Receptor CXCR4 Antagonists as Multifunctional Agents, Biopolymers, Vol. 88, No. 2, pp. 279-289, Mar. 2007.  公式リンク  
  
• Hiroshi Tsutsumi, Hirokazu Tamamura, Nobutaka Fujii. Inhibitors of the Chemokine Receptor CXCR4. Chemotherapy of AIDS, Metastatic Cancer, Leukemia and Rheumatoid Arthritis, Letters in Drug Design & Discovery, Vol. 4, No. 1, pp. 20-26, Jan. 2007.  公式リンク  
  
• Hirokazu Tamamura, Hiroshi Tsutsumi, Hiroyuki Masuno, Nobutaka Fujii. Development of Low Molecular Weight CXCR4 Antagonists by Exploratory Structural Tuning of Cyclic Tetra- and Pentapeptide-Scaffolds towards the Treatment of HIV Infection, Cancer Metastasis and Rheumatoid Arthritis, Current Medicinal Chemistry, Vol. 14, No. 1, pp. 93-102, Jan. 2007.  公式リンク  
  
• Hirokazu Tamamura, Hiroshi Tsutsumi. Specific Probes for Chemokine Receptors, Chemistry & Biology, Vol. 13, No. 1, pp. 8-10, Jan. 2006.  公式リンク  
  

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