論文

• Suwatthanarak T, Ito K, Tanaka M, Sugiura K, Hoshino A, Miyamoto Y, Miyado K, Okochi M. A peptide binding to the tetraspanin CD9 reduces cancer metastasis., Biomater. Adv., Vol. 146, Page 213283, Jan. 2023.
• Hashimoto A, Sugiura K, Hoshino A.. Impact of exosome-mediated feto-maternal interactions on pregnancy maintenance and development of obstetric complications., The Journal of Biochemistry, Vol. 169, No. 2, pp. 163-171, May 2021.
• Bojmar L, Kim HS, Tobias GC, Pelissier Vatter FA, Lucotti S, Gyan KE, Kenific CM, Wan Z, Kim KA, Kim D, Hernandez J, Pascual V, Heaton TE, La Quaglia MP, Kelsen D, Trippett TM, Jones DR, Jarnagin WR, Matei IR, Zhang H, Hoshino A, Lyden D.. Extracellular vesicle and particle isolation from human and murine cell lines, tissues, and bodily fluids., STAR Protocols, Vol. 2, No. 1, p. 100225, Dec. 2020.
• Hoshino A, Kim HS, Bojmar L, Gyan KE, Cioffi M, Hernandez J, Zambirinis CP, Rodrigues G, Molina H, Heissel S, Mark MT, Steiner L, Benito-Martin A, Lucotti S, Di Giannatale A, Offer K, Nakajima M, Williams C, Nogués L, Pelissier Vatter FA, Hashimoto A, Davies AE, Freitas D, Kenific CM, Ararso Y, Buehring W, Lauritzen P, Ogitani Y, Sugiura K, Takahashi N, Alečković M, Bailey KA, Jolissant JS, Wang H, Harris A, Schaeffer LM, García-Santos G, Posner Z, Balachandran VP, Khakoo Y, Raju GP, Scherz A, Sagi I, Scherz-Shouval R, Yarden Y, Oren M, Malladi M, Petriccione M, De Braganca KC, Donzelli M, Fischer C, Vitolano S, Wright GP, Ganshaw L, Marrano M, Ahmed A, DeStefano J, Danzer E, Roehrl MHA, Lacayo NJ, Vincent TC, Weiser MR, Brady MS, Meyers PA, Wexler LH, Ambati SR, Chou AJ, Slotkin EK, Modak S, Roberts SS, Basu EM, Diolaiti D, Krantz BA, Cardoso F, Simpson AL, Berger M, Rudin CM, Simeone DM, Jain M, Ghajar CM, Batra SK, Stanger BZ, Bui J, Brown KA, Rajasekhar VK, Healey JH, de Sousa M, Kramer K, Sheth S, Baisch J, Pascual V, Heaton TE, La Quaglia MP, Pisapia DJ, Schwartz R, Zhang H, Liu Y, Shukla A, Blavier L, DeClerck YA, LaBarge M, Bissell MJ, Caffrey TC, Grandgenett PM, Hollingsworth MA, Bromberg J, Costa-Silva B, Peinado H, Kang Y, Garcia BA, O'Reilly EM, Kelsen D, Trippett TM, Jones DR, Matei IR, Jarnagin WR, Lyden D.. Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers, Cell, vol. 182, no. 4, p. 1044-1061.e18, Aug. 2020.
• Rodrigues G, Hoshino A, Kenific CM, Matei IR, Steiner L, Freitas D, Kim HS, Oxley PR, Scandariato I, Casanova-Salas I, Dai J, Badwe CR, Gril B, Tešić Mark M, Dill BD, Molina H, Zhang H, Benito-Martin A, Bojmar L, Ararso Y, Offer K, LaPlant Q, Buehring W, Wang H, Jiang X, Lu TM, Liu Y, Sabari JK, Shin SJ, Narula N, Ginter PS, Rajasekhar VK, Healey JH, Meylan E, Costa-Silva B, Wang SE, Rafii S, Altorki NK, Rudin CM, Jones DR, Steeg PS, Peinado H, Ghajar CM, Bromberg J, de Sousa M, Pisapia D, Lyden D.. Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis, Nat Cell Biol, Vol. 21, No. 11, p. 1403-1412., Nov. 2019.
• Prakash V, Carson BB, Feenstra JM, Dass RA, Sekyrova P, Hoshino A, Petersen J, Guo Y, Parks MM, Kurylo CM, Batchelder JE, Haller K, Hashimoto A, Rundqivst H, Condeelis JS, Allis CD, Drygin D, Nieto MA, Andäng M, Percipalle P, Bergh J, Adameyko I, Farrants AÖ, Hartman J, Lyden D, Pietras K, Blanchard SC, Vincent CT.. Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease, Nat Commun, Vol. 10, No. 1, p. 2110, May 2019.
• Wittkowski KM, Dadurian C, Seybold MP, Kim HS, Hoshino A, Lyden D.. Complex polymorphisms in endocytosis genes suggest alpha-cyclodextrin as a treatment for breast cancer, PLoS One, Vol. 13, No. 7, p. e0199012, July 2018.
• Zhang H, Freitas D, Kim HS, Fabijanic K, Li Z, Chen H, Mark MT, Molina H, Martin AB, Bojmar L, Fang J, Rampersaud S, Hoshino A, Matei I, Kenific CM, Nakajima M, Mutvei AP, Sansone P, Buehring W, Wang H, Jimenez JP, Cohen-Gould L, Paknejad N, Brendel M, Manova-Todorova K, Magalhães A, Ferreira JA, Osório H, Silva AM, Massey A, Cubillos-Ruiz JR, Galletti G, Giannakakou P, Cuervo AM, Blenis J, Schwartz R, Brady MS, Peinado H, Bromberg J, Matsui H, Reis CA, Lyden D.. Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation, Nat Cell Biol, Vol. 20, No. 3, p. 332-343, May 2018.
• Sansone P, Savini C, Kurelac I, Chang Q, Amato LB, Strillacci A, Stepanova A, Iommarini L, Mastroleo C, Daly L, Galkin A, Thakur BK, Soplop N, Uryu K, Hoshino A, Norton L, Bonafé M, Cricca M, Gasparre G, Lyden D, Bromberg J.. Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer, Proc Natl Acad Sci U S A, Vol. 114, No. 43, p. E9066-E9075, Oct. 2017.
• Hoshino A, Lyden D.. Metastasis: Lymphatic detours for cancer, Nature, Vol. 546, No. 7660, p. 609-610, June 2017.
• Peinado H, Zhang H, Matei IR, Costa-Silva B, Hoshino A, Rodrigues G, Psaila B, Kaplan RN, Bromberg JF, Kang Y, Bissell MJ, Cox TR, Giaccia AJ, Erler JT, Hiratsuka S, Ghajar CM, Lyden D.. Pre-metastatic niches: organ-specific homes for metastases, Nat Rev Cancer, Vol. 17, No. 5, p. 302-317, May 2017.
• Rampersaud S, Fang J, Wei Z, Fabijanic K, Silver S, Jaikaran T, Ruiz Y, Houssou M, Yin Z, Zheng S, Hashimoto A, Hoshino A, Lyden D, Mahajan S, Matsui H.. The effect of cage shape on nanoparticle-based drug carriers: Anti-cancer drug release and efficacy via receptor blockade using dextran-coated iron oxide nanocages, Nano Lett, Vol. 16, No. 12, p. 7357-7363, Dec. 2016.
• Hoshino A, Costa-Silva B, Shen TL, Rodrigues G, Hashimoto A, Tesic Mark M, Molina H, Kohsaka S, Di Giannatale A, Ceder S, Singh S, Williams C, Soplop N, Uryu K, Pharmer L, King T, Bojmar L, Davies AE, Ararso Y, Zhang T, Zhang H, Hernandez J, Weiss JM, Dumont-Cole VD, Kramer K, Wexler LH, Narendran A, Schwartz GK, Healey JH, Sandstrom P, Labori KJ, Kure EH, Grandgenett PM, Hollingsworth MA, de Sousa M, Kaur S, Jain M, Mallya K, Batra SK, Jarnagin WR, Brady MS, Fodstad O, Muller V, Pantel K, Minn AJ, Bissell MJ, Garcia BA, Kang Y, Rajasekhar VK, Ghajar CM, Matei I, Peinado H, Bromberg J, Lyden D.. Tumour exosome integrins determine organotropic metastasis, Nature, Vol. 527, No. 7578, p. 329-35, Nov. 2015.
• Costa-Silva B, Aiello NM, Ocean AJ, Singh S, Zhang H, Thakur BK, Becker A, Hoshino A, Mark MT, Molina H, Xiang J, Zhang T, Theilen TM, García-Santos G, Williams C, Ararso Y, Huang Y, Rodrigues G, Shen TL, Labori KJ, Lothe IM, Kure EH, Hernandez J, Doussot A, Ebbesen SH, Grandgenett PM, Hollingsworth MA, Jain M, Mallya K, Batra SK, Jarnagin WR, Schwartz RE, Matei I, Peinado H, Stanger BZ, Bromberg J, Lyden D.. Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver,, Nat Cell Biol, Vol. 17, No. 6, p. 816-26, July 2015.
• Ishii G, Hashimoto H, Atsumi N, Hoshino A, Ochiai A.. Morphophenotype of floating colonies derived from a single cancer cell has a critical impact on tumor-forming activity,, Pathol Int, Vol. 63, No. 1, p. 29-36, Jan. 2013.
• Hoshino A, Peinado H, Ale?kovi? M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G, Hergueta-Redondo M, Williams C, Garcia-Santos G, Ghajar CM, Nitadori-Hoshino A, Hoffman C, Badal K, Garcia BA, Callahan MK, Yuan J, Martins VR, Skog J, Kaplan RN, Brady MS, Wolchok JD, Chapman PB, Kang Y, Bromberg J, Lyden D.. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET, Nature Medicine, Vol. 18, No. 6, p. 883-91, June 2012.
• Ito S, Ishii G, Hoshino A, Hashimoto H, Neri S, Kuwata T, Higashi M, Nagai K, Ochiai A.. Tumor promoting effect of podoplanin-positive fibroblasts is mediated by enhanced RhoA activity, Biochem Biophys Res Commun, Vol. 422, No. 1, p. 194-9, May 2012.
• Ayuko Hoshino, Genichiro Ishii, Takashi Ito, Kazuhiko Aoyagi, Yoichi Ohtaki, Kanji Nagai, Hiroki Sasaki, Atsushi Ochiai. Podoplanin-positive fibroblasts enhance lung adenocarcinoma tumor formation: podoplanin in fibroblast functions for tumor progression, Cancer Res, Vol. 71, No. 14, p. 4769-79, July 2011.
• Genichiro Ishii, Hiroko Hashimoto, Kiyoshi Asada, Takashi Ito, Ayuko Hoshino, Satoshi Fujii, Motohiro Kojima, Takeshi Kuwata, Kenichi Harigaya, Kanji Nagai, Toshikazu Ushijima, Atsushi Ochiai. Fibroblasts associated with cancer cells keep enhanced migration activity after separation from cancer cells: a novel character of tumor educated fibroblasts, Int J Oncol, Vol. 37, No. 2, p. 317-25, Aug. 2010.
• Ito TK, Ishii G, Saito S, Yano K, Hoshino A, Suzuki T, Ochiai A.. Degradation of soluble VEGF receptor-1 by MMP-7 allows VEGF access to endothelial cells, Blood, Vol. 113, No. 10, p. 2363-9, May 2009.
• Ayuko Hoshino, Haruki Chiba, Kanji Nagai, Genichiro Ishii, Atsushi Ochiai. Human vascular adventitial fibroblasts contain mesenchymal stem/progenitor cells, Biochem Biophys Res Commun, Vol. 368, No. 2, p. 305-10, Apr. 2008.

著書

• 橋本彩子, 星野歩子, 佐藤美香. 血漿中エクソソームのプロテオーム解析によるがん診断バイオマーカーの開発, Dec. 2021.
• 杉浦 圭, 志村 日向子, 星野 歩子. 小さな運び屋エクソソームを介した脳腸相関, BRAIN and NERVE Vol.73 No.8 2021年 08月号, Aug. 2021.
• 橋本彩子, 濵﨑祐斗, 星野歩子. エクソソームによる臓器特異的な腫瘍微小環境, 実験医学増刊 Vol.39 No.12 がん微小環境に１細胞レベルで挑む, July 2021.
• 杉浦圭, 橋本彩子, 星野歩子. 脳転移性がん細胞由来エクソソーム中のタンパク質CEMIPはがん脳転移を促進する 実験医学, 2020.
• 星野歩子. エクソソーム含有インテグリンとがん転移メカニズム パラダイムシフトをもたらすエクソソーム機能研究最前線, 2017.
• 星野歩子. 転移形成におけるExosomeの役割 肝胆膵, 2017.
• 百瀬采音, 星野歩子. がん細胞由来エクソソームに発現するインテグリンによる臓器特異性転移 がん分子標的治療, 2017.
• 星野歩子. エクソソームによるがん転移の新しいストーリー 実験医学, 2016.
• 星野歩子. 転移先を決める接着分子 医学のあゆみ, 2016.

国際会議発表 (査読有り)

• Ayuko Hoshino. Exosomal proteins in disease etiology and detection ~Exosomes, new players in the field of metastasis~, 2022 CiRA Symposium, Advancing iPS Cells Through Collaboration, Feb. 2022.
• Ayuko Hoshino. Cancer exosomal proteins: Roles in pre-metastatic niche formation and biomarker potential, 日本プロテオーム学会招待講演, July 2021.

国内会議発表 (査読有り)

• 星野歩子. エクソソームを介した臓器連関：がん転移機構と診断バイオマーカー, 第127回日本解剖学会総会・全国学術集会, Mar. 2022.
• 星野歩子. がんの転移先を決めるナノサイズメッセンジャー ＃エクソソーム＃人体のSNS, 文部科学省主催「サイエンス・カンファレンス」オンラインイベント, Mar. 2022.
• 星野歩子. エクソソーム含有タンパク質が司る臓器特異的転移と診断バイオマーカー, 第9回日本腎臓研究会, Jan. 2022.
• 星野歩子. がん関連エクソソームのプロテオミクス︓転移機構とバイオマーカーの解析, 第44回 日本分子生物学会年会, Dec. 2021.
• Ayuko Hoshino. Exosomal proteins in disease etiology and detection, 京都大学医学研究科ヒト・システム生物学セミナー講演, Dec. 2021.
• 星野歩子. 細胞が発するメッセージを読み解く未来 【エクソソームが司る、がん転移の新しいストーリー】, シスメックス イノベーションフォーラム2021, Dec. 2021.
• 星野歩子. 腫瘍関連エクソソームのプロテオミクスから解析する転移機構と診断バイオマーカー, 第74回日本自律神経学会総会, Oct. 2021.
• 星野歩子. エクソソーム含有タンパク質による がん診断と転移促進機構, EXPERT MEETING in Metastasis Research, Oct. 2021.
• 星野歩子. エクソソームによる病態寄与機構と疾患バイオマーカーの解析, Sept. 2021.
• 星野歩子. 細胞が発するメッセージを読み解く未来 【人体のSNS ＃エクソソーム】, フロンティアサロン永瀬賞授賞式・特別講義サイエンスセミナー, Sept. 2021.
• 星野歩子. がんにおけるエクソソーム含有タンパク質: 転移寄与分子と診断バイオマーカーの解析, 第三回 形態解析ワークショップ, Sept. 2021.
• 星野歩子. エクソソーム含有タンパク質によるがん診断と転移促進機構, 第43回日本分子生物学会年会, Dec. 2020.
• 星野歩子. 腫瘍関連エクソソームのプロテオミクス：転移機構とバイオマーカーの解析, 第4回 バイオ医薬 EXPO, Nov. 2020.
• 星野歩子. がんにおけるエクソソームのプロテオミクス: 転移寄与分子とがん診断バイオマーカーの解析, 第79回日本癌学会学術総会, Oct. 2020.
• 平野龍一郎, 岡本浩輝, 門之園哲哉, 星野歩子, 渡邊仁美, 近藤玄, 近藤科江. トリプルネガティブ乳がんの早期悪性化に関与する間質細胞の解析, 第79回日本癌学会学術集会, Oct. 2020.
• Ayuko Hoshino. Exosomal proteins in disease etiology and detection, 第93回日本生化学会大会, Sept. 2020.
• 星野歩子. エクソソームによる病態寄与機構と疾患バイオマーカーの解析, 第43回日本神経科学大会, July 2020.

国内会議発表 (査読なし・不明)

• Kyohei Okubo, Shuyan Zhao, Ken Akiba, Ayuko Hoshino, Yoshitaka Kitamoto. Magnetic Biosensing Using Functionalized Iron-oxide Nanoparticles for Exosome Analysis, STAC - D2MatE 2024, Feb. 2024.

特許など

• 星野歩子, 尾上　弘晃　, 山形　智咲, 板井　駿　, 倉科　佑太　. マイクロウェルアレイ，その製造方法，及び単一細胞由来エクソソームの 解析方法. 特許. 公開. 国立大学法人東京工業大学, 学校法人慶應義塾. 2022/09/30. 特願2022-158454. 2024/04/11. 特開2024-052022. 2024.

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