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タイトル
和文: 
英文:Revision of the relative and absolute stereochemistries of 3-hydroxydehydroiso-α-lapachone and its derivatives 
著者
和文: 藤本 善徳, Singh, P., Taniguchi, T., Monde, K., Johmoto, K., 植草秀裕, Masubuti, H., Fujimoto, Y..  
英文: P. Khandelwal, P. Singh, T. Taniguchi, K. Monde, K. Johmoto, H. Masubuti, Y. Fujimoto, Singh, P., Taniguchi, T., Monde, K., Johmoto, K., hidehiro UEKUSA, Masubuti, H., Fujimoto, Y..  
言語 English 
掲載誌/書名
和文: 
英文:Phytochemistry Lett. 
巻, 号, ページ Vol. 10    No. 15    p. 224-229
出版年月 2014年7月1日 
出版者
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会議名称
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開催地
和文: 
英文: 
アブストラクト The C-26 amino group of tomatine, a representative Solanaceae steroidal alkaloid, is introduced in an early step of its biosynthesis from cholesterol. We recently proposed a transamination mechanism for the C-26 amination as opposed to the previously proposed mechanism involving a nitrogen nucleophilic displacement. In the present study, a deuterium labeled C-26 aldehyde, (24,24,27,27,27-2H5)-3b- hydroxycholest-5-en-26-al, was synthesized and fed to a tomato (Solanum lycopersicum) seedling. LC– MS analysis of the biosynthesized tomatine indicated that the labeled aldehyde was incorporated into tomatine. The finding strongly supports the intermediacy of the aldehyde and the transamination mech- anism during C-26 amination.

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