The inside cover picture shows diaromatic-substituted icosahedral carborane, a mimic of manassantin A, which induces hypoxia inducible factor (HIF)-1α protein degradation via the proteasome pathway, leading to inhibition of hypoxia-induced HIF-1 transcriptional activity and suppression of angiogenesis necessary for tumor growth. For more details, see the Full Paper by Hiroyuki Nakamura et al. on p. 265
各種検索
サポート
ヘルプ