Herein, we report a new polymorph of amodiaquine dihydrochloride dihydrate obtained via heterogeneous crystn. This new polymorph exhibits similarity in mol. conformation as well as in its one-dimensional chain structure with a previously known polymorph, however with a difference in its two-dimensional sheet structure. Although crystal DFT-calcns. predict the new form to be thermodynamically less stable compared to the previously known polymorph, the prepn. method applied opened up the access to its metastable zone. [on SciFinder(R)]
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