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タイトル
和文: 
英文:Convincing Catalytic Performance of Oxo-Tethered Ruthenium Complexes for Asymmetric Transfer Hydrogenation of Cyclic alpha-Halogenated Ketones through Dynamic Kinetic Resolution 
著者
和文: 峠 太一郎, 奈良 秀樹, 喜田 充生, 松村 和彦, 榧木 啓人.  
英文: Taichiro Touge, Hideki Nara, Michio Kida, Kazuhiko Matsumura, Yoshihito Kayaki.  
言語 English 
掲載誌/書名
和文: 
英文:Organic Letters 
巻, 号, ページ Vol. 23    No. 8    pp. 3070-3075
出版年月 2021年3月29日 
出版者
和文: 
英文:American Chemical Society 
会議名称
和文: 
英文: 
開催地
和文: 
英文: 
公式リンク https://pubs.acs.org/doi/10.1021/acs.orglett.1c00739
 
DOI https://doi.org/10.1021/acs.orglett.1c00739
アブストラクト A highly efficient dynamic kinetic resolution of cyclic halohydrins was achieved by the asymmetric transfer hydrogenation of racemic α-haloketones. Bifunctional oxo-tethered Ru(II) catalysts could promote the reduction without deterioration of halogens. By structural tuning of the catalyst, chiral alcohols having halogen, ester, carboxamide, and sulfone functions were obtained variably with excellent diastereo- and enantioselectivities (up to >99:1 d.r. and >99.9 ee), which provided a concise synthetic approach to a dopamine D3 receptor ligand, (+)-PHNO.

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