論文

• Mikito Owa, Akane Furuta, Jiro Usukura, FUMIO ARISAKA, Stephen, M. King, George B. Witman, Ritsu Kamiya, Ken-Ichi Wakabayashi. Cooperative binding of the outer arm-docking complex underlies the regular arrangement of outer arm dynein in the axoneme, Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, No. 26, pp. 9461-9466, June 2014.
• K. Seio, M. Tokugawa, H. Tsunoda, A. Ohkubo, F. Arisaka, M. Sekine. Assembly of pyrene-modified DNA/RNA duplexes incorporating a G-rich single strand region, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Vol. 23, No. 24, pp. 6822-6824, Dec. 2013.
• Shuji Kanamaru, FUMIO ARISAKA, Mai Nemoto. ORF334 in Vibrio phage KVP40 plays the role of gp27 in T4 phage to form a heterohexameric complex, J Bacteriol, vol. 190, p. 3606-12, Sept. 2008.
• Kozo Morimoto, Eiki Yamashita, Youhei Kondou, Soo Jae Lee, Fumio Arisaka, Tomitake Tsukihara, Masato Nakai. The Asymmetric IscA Homodimer with and Exposed [2Fe-2S] Cluster Suggests the Structural Basis of the Fe-S Cluster Biosyntheric Scaffold, J.Mol.Biol., Vol. 360, pp. 117-132, 2006.
• Takafumi Ueno, Tomomi Koshiyama, Toshimitsu Tsuruga, Toshiaki Goto, Shuji Kanamaru, Fumio Arisaka, Yoshihito Watanabe. Bionanotube Tetrapod Assembly by In Situ Synthesis of a Gold Nanocluster with (gp5-His6)3 from Bacteriophage T4, Angew. Chem. Int. Ed., Vol. 45, pp. 4508-4512, 2006.
• Kenji Sugimoto, Shuji Kanamaru, Kenji Iwasaki, Fumio Arisaka, Ichiro Yamashita. Construction of a Ball-and-Spike Protein Supramolecule, Angew. Chem. Int. Ed., Vol. 45, pp. 2725-2728, 2006.
• Absar N, Yeasmin T, Raza MS, Sarkar SK, Arisaka F. Single step purification, characterization and N-terminal sequences of a mannose specific lectin from mulberry seeds, Protein J., Vol. 24, No. 6, pp. 369-377, 2006.
• Fumi Urano, Hayashi N, FUMIO ARISAKA, Hideki Kurita, Murata Shizuaki, Ichinose H. Molecular mechanism for pterin-mediated inactivation of tyrosine hydroxylase: Formation of insoluble aggregates of tyrosine hydroxylase, J.Biochem., Vol. 139, No. 4, pp. 625-635, 2006.  公式リンク  
  
• Tsutomu Arakawa, John S. Philo, Daisuke Ejima, Kouhei Tsumoto, Fumio Arisaka. Aggregation Aspects and Techniques for Assessment, Part 1, BioProcess International, Vol. 4, No. 10, pp. 32-42, 2006.
• Shuji Kanamaru, Yasutaka Ishiwata, Toshiharu Suzuki, Michael G. Rossmann, Fumio Arisaka. Control of Bacteriophage T4 Tail Lysozyme Activity During the Infection, J.Mol.Biol., Vol. 346, pp. 1013–1020, 2005.
• Kostyuchenko, V. A., P. R. Chipman, P. G. Leiman, F. Arisaka, V. V. Mesyanzhinov, M. G. Rossmann. The tail structure of bacteriophage T4 and its mechanism of contraction, Nat Struct Mol Biol., Vol. 12, pp. 810-813, 2005.
• Fumio Arisaka. Assembly and Infection Process of Bacteriophage T4, Chaos, Vol. 15, pp. 047502, 2005.
• Youske Shimizu, Hisayasu Mori, Fumio Arisaka, Masaru Tanokura. Stalk region of kinesin-related protein Unc104 has moderate ability to form coiled-coil dimer, Biochem.Biophys.Rres.Comm., Vol. 337, pp. 868-874, 2005.
• Hitomi Takahashi, Eiji Inagaki, Yayoi Fujimoto, Chizu Kuroishi, Yuichi Nodake, Yuki Nakamura, Fumio Arisaka, Katsuhide Yutani, Seiki Kuramitsu, Shigeyuki Yokoya. Structure and implications for the thermal stability of phosphopantetheine adenylyltransferase from Thermus thermophilus, Acta Cryst., Vol. D40, pp. 97-104, 2004.
• Michael G. Rossmann, Vadim V. Mesyanzhinov, Fumio Arisaka, Petr G. Leiman. The bacteriophage T4 DNA injection machine, Current Opinion in Structural Biology, Vol. 14, pp. 171-180, 2004.
• Shigeki Takeda, Makoto Suzuki, Takahito Yamada, Manabu Kageyama, Fumio Arisaka. Mapping of functional sites on the primary structure of the contractile tail sheath protein of bacteriophage T4 by mutation analysis, Biochim.Biophys.Acta, Vol. 1699, No. 1-2, pp. 163-171, 2004.
• Zhao, L., Kanamaru, S., Chaidirek, C., Arisaka, F. P15 and P3, the Tail Completion Proteins of Bacteriophage T4, Both Form Hexameric Rings, J.Bacteriol., Vol. 185, pp. 1693-1700, 2003.
• Fumio Arisaka, Shuji Kanamaru, Petr Leiman, Michael G. Rossmann. The Tail lysozyme complex of bacteriophage T4, Int J Biochem Cell Biol, Vol. 35, No. 1, pp. 16-21, 2003.
• Victor A. Kostychenko, Petr G. Leiman, Paul R. Chipman, Shuji Kanamaru, Mark J van Raaij, Fumio Arisaka, Vadim V. Mesyanzhinov, Michael G. Rossmann. Three-dimensional structure of bacteriophage T4 baseplate, nature structural biology, Vol. 10, No. 9, 2003.
• Said A. Ali, Noriyuki Iwabuchi, Takuro Matsui, Ken Hirota, Shun-ichi Kidokoro, Munehito Arai, Kunihiro Kuwajima, Peter Schuck, Fumio Arisaka. Reversible and Fast Association Equilibria of a Molecular Chaperone, gp57A, of Bacteriophage T4, Biophys. J., Vol. 85, pp. 1-13, 2003.
• D.G. Myszka, Y.N. Abdiche, F. Arisaka, O. Byron, E. Eisenstein, P. Hensley, J.A. Thomson, C.R. Lombardo, F. Schwarz, W. Stafford, M.L. Doyle. The ABRF-MIRG '02 Study: Assembly State, Thermodynamic, and Kinetic Analysis of an Enzyme/Inhibitor Interaction, Journal of Biomolecular Techniques, Vol. 14, No. 4, pp. 199-222, 2003.
• Miller, E., Kutter, E., Mosig, G., Arisaka, F., Kunisawa, T., Rueger, W.. The Bacteriophage T4 Genome, Microbiol. Mol. Biol. Rev., Vol. 67, pp. 86-156, 2003.
• Toshiharu Suzuki, Masako Yasugi, Fumio Arisaka, Tairo Oshima, Akihiko Yamagishi. Cold-adaptation mechanism of mutant enzymes of 3-isopropylmalate dehydrogenase from Thermus thermophilus, Protein Engineering, Vol. 15, No. 6, pp. 471-476, 2002.
• Shuji Kanamaru, Petr G. Leiman, Victor A. Kostychenco, Paul R. Chipman, Vadim V. Mesyanzhinov, Fumio Arisaka, Michael G. Rossmann. The Structure of the Bacteriophage T4 Cell-Puncuring Device, Nature, Vol. 415, No. 6871, pp. 457-560, 2002.
• 金丸周司, 有坂文雄. Ｔ４ファージの構造生物学と感染のメカニズム, 生化学, Vol. 74, No. 2, pp. 131-135, 2002.
• Toshiharu Suzuki, Masao Yasugi, Fumio Arisaka, Akihiko Yamagishi, Tairo Oshima. Adaptation of a thermophilic enzyme, 3-isopropylmalate dehydrogenase, to low temperatures, Protein Engineering, Vol. 14, pp. 85-91, 2001.
• 有坂文雄. Ｔ４ファージの自己集合におけるシャペロンの機能, ウイルス, Vol. 51, No. 1, pp. 57-62, 2001.
• Kimie Asanuma, Fumio Arisaka, Haruko Ogawa. Multimerization and collagen binding of vitronectin is modulated by its glycosylation, International Congress Sereies, Vol. 1223, pp. 97-101, 2001.
• Li Zhao, Shigeki Takeda, Petr G. Leiman, Fumio Arisaka. Stoichiometry and inter-subunit interaction of the wedge initiation complex, gp10-gp11 of bacteriophage T4, Biochim.Biophys.Acta, Vol. 1479, pp. 286-292, 2000.
• Takeshi Kawabata, Fumio Arisaka, Ken Nishikawa. Structural/functional assignment of unknown bacteriophgae T4 proteins by iterative database searches, Gene, Vol. 259, pp. 223-233, 2000.
• Satoshi Inoue, Kazunori Tanaka, Fumio Arisaka, Sumiko Kimura, Kohei Ohtomo, Shigeki Mizuno. Silk Fibroin Bombyx mori is Secreted Assembling a High Molecular-Mass Elementary Unit Consisting of H-chain, L-chain and P25, with 6:6:1 Molar Ratios, J.Biol.Chem., Vol. 275, No. 51, pp. 40517-40528, 2000.
• Shinya Kirihara, Hideo Arakawa, Atsushi Ikai, Shigeki Takeda, Fumio Arisaka. Comparative imaging of T4 phage baseplate with atomic force and electron microscopy, Res.Comm.Biochem.& Mol.Biol., Vol. 3, pp. 181-192, 1999.
• Mainul Hoque, Noriaki Shimizu, Ken-ichiro Ishizu, Hiroaki Yajima, Fumio Arisaka, Kenji Suzuki, Hajime Wabanabe, Hiroshi Handa. Chimeric virus-like particle of adeno-associated virus, Biochem.Biophys.Res.Comm., Vol. 266, pp. 371-376, 1999.
• M. Ushiyama, A. Yoshino, T. Yamamura, Y. Shida, F. Arisaka. A 12-Porphyrin Construction of a System: Synthesis of Peptide Porphyrin with Multiple Histidines and the Aggregation Behavior in the Presence of Hemin, Bull.Chem.Soc.Japan, Vol. 72, pp. 1351-1364, 1999.
• M. Hoque, K.-I. Ishizu, A. Matsumoto, S.-I. Han, F. Arisaka, M. Takayama, K. Suzuki, K. Kato, T. Kanda, H. Watanabe, H. Handa. Nuclear Transport of the Major Capsid Protein Is Essential for Adeno-Associated Virus Capsid Formation, J.Virology, Vol. 73, No. 9, pp. 7912-7915, 1999.
• Ken-ichiro Inamori, Tetsu Saito, Daisuke Iwaki, Tsutomu Nagira, Sadaaki Iwanaga, Fumio Arisaka, Shun-ichiro Kawabata. A Newly Identified Horseshoe Crab Lectin with Specificity for Blood Group A Antigen Recognizes Specific O-Antigens of Bacterial Lipopolysaccharides, J.Biol.Chem., Vol. 274, pp. 3272-3278, 1999.
• Masato Ushiyama, Fumio Arisaka, Takeshi Yamamura. Construction of a Multiple Porphyrin System Using a de novo Designed Peptide Porphyrin and Hemin, Chemistry Letters, No. 2, pp. 127-128, 1999.
• Ken-ichiro Inamori, Tetsu Saito, Daisuke Iwaki, Tsutomu Nagira, Sadaaki Iwanaga, Fumio Arisaka, Shun-ichiro Kawabata. A Newly Identified Horseshoe Crab Lectin with Specificity for Blood Group A Antigen Recognizes Specific O-Antigens of Bacterial Lipopolysaccharides, J.Biol.Chem., Vol. 274, pp. 3272-3278, 1999.
• M. Hoque, K.-I. Ishizu, A. Matsumoto, S.-I. Han, F. Arisaka, M. Takayama, K. Suzuki, K. Kato, T. Kanda, H. Watanabe, H. Handa. Nuclear Transport of the Major Capsid Protein Is Essential for Adeno-Associated Virus Capsid Formation, J. Virol., Vol. 73, No. 9, pp. 7912-7915, 1999.
• Shuji Kanamaru, Nadine C.Gassner, Nanzhang Ye, Shigeki Takeda, Fumio Arisaka. C-terminal Fragment of the Precursor Tail Lysozyme of Bacteriophage T4 Stays as a Strucutral Component of the Baseplate after Cleavage, J.Bacteriol., Vol. 181, pp. 2739-2744, 1999.
• Masato Ushiyama, Fumio Arisaka, Takeshi Yamamura. Construction of a Multiple Porphyrin System Using a de novo Designed Peptide Porphyrin and Hemin, Chemistry Letters, No. 2, pp. 127-128, 1999.
• Shigeki Takeda, Kotaro Hoshida, Fumio Arisaka. Mapping of Functional Sites on the Primary Structure of the Tail Lysozyme of Bacteriophage T4 by Mutation Analysis, Biochim. Biophys. Acta, Vol. 1384, pp. 243-252, 1998.
• Shigeki Takeda, Akishige Ritani, Takayo Sasaki, Fumio Arisaka. Discovery of the tail tube gene of bacteriophage Mu and sequence analysis of the sheath and tube genes., Biochim. Biophys. Acta, Vol. 1399, pp. 88-92, 1998.
• Hiromi Suzuki, Fumio Arisaka, Elizabeth Thomas, Akira Tsugita, Takeshi Kunisawa. A Bacteriophage T4 DNA/Protein Sequence Database Available on the World Wide Web, Res.Comm.Biochem. & Mol.Biol., Vol. 2, pp. 309-332, 1998.
• 有坂文雄. 超遠心分析の基礎と新たな展開(1), 蛋白質核酸酵素, Vol. 4, No. 13, pp. 2024-2032, 1998.
• 有坂文雄. 超遠心分析の基礎と新たな展開(2), 蛋白質核酸酵素, Vol. 43, No. 14, pp. 2145-2152, 1998.
• 有坂文雄. 超遠心分析の基礎と新たな展開(3), 蛋白質核酸酵素, Vol. 43, No. 15, pp. 2238-2244, 1998.
• Hiromi Suzuki, Fumio Arisaka, Elizabeth Kutter, Elizabeth Thomas, Akira Tsugita, Takeshi Kunisawa. A Bacteriophage T4 DNA/Protein Sequence Database Available on the World Wide Web, Res.Comm.Biochem. & Mol.Biol., Vol. 2, pp. 309-332, 1998.
• FUMIO ARISAKA. Isolation and Characterization of a Molecular Chaperone, gp57A, of Bacteriopahge T4., J. Bacteriol., No. 179, pp. 1846-1851, 1997.
• FUMIO ARISAKA. Nucleotide sequences of the Contractile Tail Sheath and Tube Genes of Bacteriophage PS17 and Amino Acid Sequences of Their Products., Res. Comm. Biochem. & Mol. Biol, No. 1, pp. 93-106, 1997.
• FUMIO ARISAKA. Identification of Kinesin Neck Region as a Stable α-Helical Coied-Coil and Its Thermodynamic Charcterization., Biochemistry, Vol. 36, pp. 1933-1942, 1997.
• 有坂文雄. ネガティブ染色---簡便で高分解能の染色法, 細胞工学, Vol. 16, No. 6, pp. 881-889, 1997.
• FUMIO ARISAKA. Purification and Characterization of Virus-Like Particles and Pentamers Produced the Expression of SV40 Capsid Proteins Insect Cells, Biochimica at Biophysica Acta, Vol. 1290, No. 1, pp. 37-45, 1996.
• FUMIO ARISAKA. Synthesis of α-Helix-Forming Peptides by Gene Engineering Methods and Their Characterization by Circular Dichroism Spectra Measurements, Biochimica at Biophysica Acta, Vol. 1294, No. 1, pp. 129-137, 1996.
• FUMIO ARISAKA. Determination and comparison of the primary structure of the contractile tail sheath protein of bacteriophage, Protein Eng., 1994.
• 有坂文雄. 超遠心、蛋白質核酸酵素, 増刊号「バイオ高性能機器導入・共同利用マニュアル」, Vol. 39, No. 11, pp. 38-60, 1994.
• 有坂文雄. 蛋白質集合体の構造学, 嶋本編「ナノバイオロジー入門」, pp. 109-129, 1994.
• FUMIO ARISAKA. T4 Tail Structure and Function Molecular Biology of VacteriophageT4, American Society for Microbiology, Washington, DC., pp. 259-281, 1994.
• FUMIO ARISAKA. Use of Chemical Modification and Limited Proteolysis to Study Structural Change in the Tail Sheath Protein, Gp18. In Molecular Biology of Bacteriophage T4, American Society for Microbiology, Washington, DC., pp. 329-331, 1994.
• 有坂文雄. 蛋白質間相互作用 蛋白質・核酸・酵素, 増刊号「蛋白質の時代構造・物性・機能研究の新局面」, Vol. 39, No. 7, pp. 1036-1051, 1994.
• FUMIO ARISAKA. Mapping of functions on the primary structure of the tail sheath protein of bacteriophage T4, Protein Eng., 1993.
• FUMIO ARISAKA. Stabilization of enzyme proteins : A case study using 3-isopropylamalate dehydrogenase, Protein Eng., 1993.
• FUMIO ARISAKA. Analysis of the denaturation process of chimeric 3-isopropylmalate dehydrogenase Protein Eng., 1993.
• FUMIO ARISAKA. Atonic force microscopy of bactriphage T4 and its tube-gaseplate complex, FEBS Letters, Vol. 326, No. 1, pp. 39-41, 1993.
• FUMIO ARISAKA. Integrated Sequence Database of Bacteriophage T4, Protein Sef. Data Anal., No. 5, pp. 253-260, 1993.
• FUMIO ARISAKA. Replication and Gene Expression of Bacteriophage T4., PROTEIN, NUCLEIC ACID AND ENZYME, Vol. 37, pp. 14, 1992.
• FUMIO ARISAKA. Bacteriophage T4 DNA Packaging Genes 16 and 17., Nuc. Acids Res., Vol. 18, pp. 13, 1990.
• FUMIO ARISAKA. Structural Studies of the Contracile Tail Sheath Protein of Bacteriophage T4 I. A Conformational Change of the Tail Sheath Upon Contraction As Probed by Differential Chemical Modification., Biochemistry, Vol. 29, pp. 21, 1990.
• FUMIO ARISAKA. Structural Studies of the Contractile Tail Sheath Protein of Bacteriophage T4 II. Structural Analyses of the Tail Sheath Protein, gp18, by Limited Proteolysis, Immunoblotting and Immuno-electron Microscopy., Biochemistry, Vol. 29, pp. 21, 1990.
• FUMIO ARISAKA. The Nucleotide Sequence of the Tail Sheath Gene of Bacteriophage T4 and the Amino Acid Sequence of its Product., J. Virology, Vol. 62, pp. 3, 1988.
• FUMIO ARISAKA. Nucleotide Sequence of the Tail Tube Structural Gene of Bacteriophage T4., J. Virology, Vol. 62, pp. 4, 1988.
• FUMIO ARISAKA. Contractile Tail Sheath Protein of Bacteriophage T4 -Gene Structure. Primary Structure. Higher Order Structure-, Biophysics, Vol. 151, pp. 1, 1987.
• FUMIO ARISAKA. Primary Structure of the Tail Sheath Protein of Bacteriophage T4 and its Gene., J. Protein Chem., Vol. 6, pp. 1, 1987.
• FUMIO ARISAKA. A Novel Method for Selective Isolation of C-Terminal Peptides from Tryptic Digests of Proteins by Immobilized Anhydrotrypsin : Application to Structural Analysis of the Tail Sheath and Tube Proteins from Bacteriophage T4., PROTEINS : Struc. , Func. , & Genetics, Vol. 1, pp. 1, 1986.
• FUMIO ARISAKA. Isolation and Characterization of the T4 Phage Tail-Associated Lysozyme., J. Virology, Vol. 54, pp. 2, 1985.
• FUMIO ARISAKA. Reassembly of the Bacteriophage T4 Tail from the Core-Baseplate and the Monomeric Sheath Protein P18 : A Cooperative Association Process., J. Mol. Biol., Vol. 132, pp. 2, 1979.
• FUMIO ARISAKA. Allosteric Properties and the Association Equilibria of Hemocyanin from Callianassa californiensis., J. Mol. Biol., Vol. 134, pp. 1, 1979.
• FUMIO ARISAKA. Purification, Characterization and Reassembly of the Bacteriophage T4D Tail Sheath Protein. P18., J. Mol. Biol., Vol. 128, pp. 1, 1979.

著書

• 後藤祐児, 桑島邦博, 谷澤克行編, 著者６０人, 有坂文雄. タンパク質科学, 化学同人, Oct. 2005.
• 有坂文雄. 細胞に穴を開ける分子機械, クバプロ, クバプロ, 2004.
• 有坂文雄. 図解バイオ活用技術のすべて、5-6超遠心分析, 工業調査会（東京工業大学大学院生命理工学研究科編）pp.176-179, 工業調査会（東京工業大学大学院生命理工学研究科編）pp.176-179, 2004.
• 有坂文雄. タンパク質工学の基礎, 東京化学同人（応用生命科学シリーズ６，松沢洋編、第１－３章（pp.1-40）, 東京化学同人（応用生命科学シリーズ６，松沢洋編、第１－３章（pp.1-40）, 2004.
• 有坂文雄. バイオサイエンスのための蛋白質科学入門, 裳華房, 裳華房, 2004.
• K. Inamori, T. Sato, D. Iwaki, T. Nagira, S. Iwanaga, F. Arisaka, S. Kawabata. Horseshoe Crab Hemocyte-derived Lectin Recognizing Specific O-Antigens of Lipopolsaccharides. in “Phylogenetic Perspectives on the Vertebrate Immune System”, ed. by Beck et al., pp. 185-190 (2001) Kluwer Academic/Plenum Publishers., ed. by Beck et al., pp. 185-190 (2001) Kluwer Academic/Plenum Publishers., pp. 185-190, 2001.
• FUMIO ARISAKA. Real-Time Analysis of Biomolecular Interactions (Ed. by K. Nagata and H. Handa), Springer, Springer, 2000.
• 小熊恵二, 有坂文雄　（大里外誉郎編）. バクテリオファージ, 医科ウイルス学（南江堂）, 医科ウイルス学（南江堂）, 2000.
• 有坂文雄. 超遠心分析(第9章2節), 生体物質相互作用のリアルタイム解析実験法(シュプリンガーフェアラーク東京社), 生体物質相互作用のリアルタイム解析実験法(シュプリンガーフェアラーク東京社), 1998.
• 有坂文雄. T4ファージの構造と分子集合(第5章), ウイルス学(朝倉書店), ウイルス学(朝倉書店), 1998.
• 中村春木, 有坂文雄. タンパク質のかたちと物性, 共立出版, 共立出版, 1997.
• 有坂文雄. スタンダード生化学, 裳華房, 裳華房, 1996.
• FUMIO ARISAKA. Separation of Nucleic Acids by Ultracentrifuge, 日本化学会編「分離精製技術ハンドブック」(丸善), 日本化学会編「分離精製技術ハンドブック」(丸善), pp. 629-636, 1993.
• FUMIO ARISAKA. Electrophoresis of NucleicAcids, 日本化学会編「分離精製技術ハンドブック」(丸善), 日本化学会編「分離精製技術ハンドブック」(丸善), pp. 647-655, 1993.
• FUMIO ARISAKA. Genetic Map of Bacteriophage T4, Genetic Map 1993 (Cold Spring Harbor Laboratory), Genetic Map 1993 (Cold Spring Harbor Laboratory), pp. 1-27, 1993.
• FUMIO ARISAKA. Viruses, 東京化学同人(新実験生化学講座), 東京化学同人(新実験生化学講座), 1990.

その他の論文・著書など

• 有坂文雄. バイオ高性能機器・新技術利用マニュアルI-5.超遠心分析, 共立出版、蛋白質核酸酵素増刊号, Vol. 49, No. 11, pp. 1660-1667, 2004.

特許など

• 上野隆史, 稲葉　央, 深井俊宏, 有坂文雄, 金丸周司. 標的タンパク質の細胞内導入剤及び標的タンパク質の細胞内導入方法. 特許. 登録. 国立大学法人東京工業大学. 2014/02/28. 特願2014-039644. 2015/09/10. 特開2015-163056. 特許第6304683号. 2018/03/16 2018.

学位論文

• Allosteric Properties and the Association Equilibria of Hemocyanin from Calianassa Californiensis,  本文,  Doctor,  Graduate School of Science, Oregon State University,  1977/06/--, 

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