論文

• Lee W, Hiroshi Iwasaki, Hideo Tsubouchi, HUNG-WEN LI. Hop2-Mnd1 and Swi5-Sfr1 stimulate Dmc1 filament assembly using distinct mechanisms., Nucleic acids research, July 2023.  公式リンク  
  
• Hideo Tsubouchi. The Hop2-Mnd1 Complex and Its Regulation of Homologous Recombination, Biomolecules, Apr. 2023.  公式リンク  
  
• Alfredo Esquivel-Chávez, Takahisa Maki, Hideo Tsubouchi, Testuya Handa, Hiroshi Kimura, James E. Haber, Geneviève Thon, Hiroshi Iwasaki. Euchromatin factors HULC and Set1C affect heterochromatin organization and mating-type switching in fission yeast Schizosaccharomyces pombe, Genes & Genetic Systems, Vol. 97, No. 3, pp. 123-138, June 2022.  公式リンク  
  
• Hideo Tsubouchi. Biochemical properties of fission yeast homologous recombination enzymes, Current Opinion in Genetics & Development, Vol. 71, pp. 19-26, Dec. 2021.  公式リンク  
  
• Hideo Tsubouchi, Bilge Argunhan, Hiroshi Iwasaki. Biochemical properties of fission yeast homologous recombination enzymes, Current Opinion in Genetics & Development, Elsevier, Vol. 71, p. 19-26, Dec. 2021.
• Maierdan Palihati, Hideo Tsubouchi, Bilge Argunhan, Rei Kajitani, Omirgul Bakenova, Yong‑Woon Han, Yasuto Murayama, Takehiko Itoh, Hiroshi Iwasaki. Homology length dictates the requirement for Rad51 and Rad52 in gene targeting in the Basidiomycota yeast Naganishia liquefaciens, Current Genetics, Springer, Vol. 67, no. 6, pp. 919-936, Dec. 2021.  公式リンク  
  
• Jakub Muraszko, Karol Kramarz, Bilge Argunhan, Kentaro Ito, Gabriela Baranowska, Yumiko Kurokawa, Yasuto Murayama, Hideo Tsubouchi, Sarah Lambert, Hiroshi Iwasaki, Dorota Dziadkowiec. Rrp1 translocase and ubiquitin ligase activities restrict the genome destabilising effects of Rad51 in fission yeast, Nucleic Acids Research, Oxford University Press, Volume 49, Issue 12, Page 6832–6848, July 2021.
• Bilge Argunhan, Hiroshi Iwasaki, Hideo Tsubouchi. Post-translational modification of factors involved in homologous recombination, DNA repair (Amst), Volume 104, 103114, June 2021.  公式リンク  
  
• Aleksandar Zdravković, James M. Daley, Arijit Dutta, Tatsuya Niwa, Yasuto Murayama, Shuji Kanamaru, Kentaro Ito, Takahisa Maki, Bilge Argunhan, Masayuki Takahashi, Hideo Tsubouchi, Patrick Sung, Hiroshi Iwasaki. A conserved Ctp1/CtIP C-terminal peptide stimulates Mre11 endonuclease activity, Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, Vol. 118, No. 11, e2016287118, Mar. 2021.  公式リンク  
  
• Negar Afshar, Bilge Argunhan, Maierdan Palihati, Goki Taniguchi, Hideo Tsubouchi, Hiroshi Iwasaki. A novel motif of Rad51 serves as an interaction hub for recombination auxiliary factors, eLife, eLife Sciences Publications, Vol. 10, e64131, Jan. 2021.  公式リンク  
  
• Yong-Woon Han, Rei Kajitani, Hiroya Morimoto, Maierdan Palihati, Yumiko Kurokawa, Rie Ryusui, Bilge Argunhan, Hideo Tsubouchi, Fumiyoshi Abe, Susumu Kajiwara, Hiroshi Iwasaki, Takehiko Itoh. Draft Genome Sequence of Naganishia liquefaciens Strain N6, Isolated from the Japan Trench., Microbiology Resource Announcements, American Society for Microbiology, Vol. 9, Issue 47, e00827-20, Nov. 2020.
• Kentaro Ito, Yasuto Murayama, Yumiko Kurokawa, Shuji Kanamaru, Yuichi Kokabu, Takahisa Maki, Tsutomu Mikawa, Argunhan Bilge, Hideo Tsubouchi, Mitsunori Ikeguchi, Masayuki Takahashi, Hiroshi Iwasaki. Real-time tracking reveals catalytic roles for the two DNA binding sites of Rad51, Nature Communications, Nature Research, Vol. 11, No. 1, June 2020.  公式リンク  
  
• Hideo Tsubouchi, Bilge Argunhan, Kentaro Ito, Masayuki Takahashi, Hiroshi Iwasaki. Two auxiliary factors promote Dmc1-driven DNA strand exchange via stepwise mechanisms, Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, Vol. 117, No. 22, pp. 12062-12070, May 2020.  公式リンク  
  
• Argunhan Bilge, Masayoshi Sakakura, Negar Afshar, Kurihara, M., Kentarou Itou, Takahisa Maki, Shuji Kanamaru, Yasuto Murayama, Hideo Tsubouchi, Masayuki Takahashi, Hideo Takahashi, Hiroshi Iwasaki. Cooperative interactions facilitate stimulation of Rad51 by the Swi5-Sfr1 auxiliary factor complex, eLife, eLife Sciences Publications, Vol. 9, No. e52566, Mar. 2020.  公式リンク  
  
• Kentaro Ito, Argunhan Bilge, Hideo Tsubouchi, Hiroshi Iwasaki. Real-time Observation of the DNA Strand Exchange Reaction Mediated by Rad51, Journal of visualized experiments : JoVE, Journal of Visualized Experiments, No. 144, Feb. 2019.  公式リンク  
  
• Argunhan B, Tsubouchi T, Tsubouchi H. Polo is not solo in meiosis., Cell cycle (Georgetown, Tex.), Feb. 2018.  公式リンク  
  
• Tsubouchi H, Argunhan B, Tsubouchi T. Exiting prophase I: no clear boundary., Current genetics, Oct. 2017.  公式リンク  
  
• Bilge Argunhan, Wing-Kit Leung, Negar Afshar, Yaroslav Terentyev, Vijayalakshmi V Subramanian, Yasuto Murayama, Andreas Hochwagen, Hiroshi Iwasaki, Tomomi Tsubouchi, Hideo Tsubouchi. Fundamental cell cycle kinases collaborate to ensure timely destruction of the synaptonemal complex during meiosis, EMBO Journal, EMBO Press, Vol. 36, No. 17, pp. 2488-2509, Sept. 2017.  公式リンク  
  
• Bilge Argunhan, Wing-Kit Leung, Negar Afshar, Yaroslav Terentyev, Vijayalakshmi V Subramanian, Yasuto Murayama, Andreas Hochwagen, Hiroshi Iwasaki, Tomomi Tsubouchi, Hideo Tsubouchi. Fundamental cell cycle kinases collaborate to ensure timely destruction of the synaptonemal complex during meiosis, EMBO Journal, EMBO Press, Vol. 36, No. 17, pp. 2488-2509, Sept. 2017.  公式リンク  
  
• Tsubouchi H, Argunhan B, Tsubouchi T. Shaping meiotic chromosomes with SUMO: a feedback loop controls the assembly of the synaptonemal complex in budding yeast., Microbial cell (Graz, Austria), Feb. 2016.  公式リンク  
  
• Leung WK, Humphryes N, Afshar N, Argunhan B, Terentyev Y, Tsubouchi T, Tsubouchi H. The synaptonemal complex is assembled by a polySUMOylation-driven feedback mechanism in yeast., The Journal of cell biology, Nov. 2015.  公式リンク  
  
• Voelkel-Meiman K, Taylor LF, Mukherjee P, Humphryes N, Tsubouchi H, Macqueen AJ. SUMO localizes to the central element of synaptonemal complex and is required for the full synapsis of meiotic chromosomes in budding yeast., PLoS genetics, Oct. 2013.  公式リンク  
  
• Argunhan B, Farmer S, Leung WK, Terentyev Y, Humphryes N, Tsubouchi T, Toyoizumi H, Tsubouchi H. Direct and indirect control of the initiation of meiotic recombination by DNA damage checkpoint mechanisms in budding yeast., PloS one, June 2013.  公式リンク  
  
• Humphryes N, Leung WK, Argunhan B, Terentyev Y, Dvorackova M, Tsubouchi H. The Ecm11-Gmc2 complex promotes synaptonemal complex formation through assembly of transverse filaments in budding yeast., PLoS genetics, Jan. 2013.  公式リンク  
  
• Toyoizumi H, Tsubouchi H. Estimating the number of double-strand breaks formed during meiosis from partial observation., Journal of computational biology : a journal of computational molecular cell biology, Dec. 2012.  公式リンク  
  
• Farmer S, Hong EE, Leung W, Argunhan B, Terentyev Y, Humphryes N, Toyoizumi H, Tsubouchi H. Correction: Budding Yeast Pch2, a Widely Conserved Meiotic Protein, Is Involved in the Initiation of Meiotic Recombination., PloS one, Oct. 2012.  公式リンク  
  
• Farmer S, Hong EJ, Leung WK, Argunhan B, Terentyev Y, Humphryes N, Toyoizumi H, Tsubouchi H. Budding yeast Pch2, a widely conserved meiotic protein, is involved in the initiation of meiotic recombination., PloS one, June 2012.  公式リンク  
  
• Busygina V, Saro D, Williams G, Leung WK, Say AF, Sehorn MG, Sung P, Tsubouchi H. Novel attributes of Hed1 affect dynamics and activity of the Rad51 presynaptic filament during meiotic recombination., The Journal of biological chemistry, Nov. 2011.  公式リンク  
  
• Say AF, Ledford LL, Sharma D, Singh AK, Leung WK, Sehorn HA, Tsubouchi H, Sung P, Sehorn MG. The budding yeast Mei5-Sae3 complex interacts with Rad51 and preferentially binds a DNA fork structure., DNA repair, May 2011.  公式リンク  
  
• Farmer S, Leung WK, Tsubouchi H. Characterization of meiotic recombination initiation sites using pulsed-field gel electrophoresis., Methods in molecular biology (Clifton, N.J.), Jan. 2011.  公式リンク  
  
• Chi P, Kwon Y, Moses DN, Seong C, Sehorn MG, Singh AK, Tsubouchi H, Greene EC, Klein HL, Sung P. Functional interactions of meiotic recombination factors Rdh54 and Dmc1., DNA repair, Dec. 2008.  公式リンク  
  
• Busygina V, Sehorn MG, Shi IY, Tsubouchi H, Roeder GS, Sung P. Hed1 regulates Rad51-mediated recombination via a novel mechanism., Genes & development, Mar. 2008.  公式リンク  
  
• Tsubouchi H, Roeder GS. Budding yeast Hed1 down-regulates the mitotic recombination machinery when meiotic recombination is impaired., Genes & development, July 2006.  公式リンク  
  
• Tsubouchi H, Roeder GS. The budding yeast mei5 and sae3 proteins act together with dmc1 during meiotic recombination., Genetics, Nov. 2004.  公式リンク  
  
• Tsubouchi H, Roeder GS. The importance of genetic recombination for fidelity of chromosome pairing in meiosis., Developmental cell, Dec. 2003.  公式リンク  
  
• Tsubouchi H, Roeder GS. The Mnd1 protein forms a complex with hop2 to promote homologous chromosome pairing and meiotic double-strand break repair., Molecular and cellular biology, May 2002.  公式リンク  
  
• Tsubouchi H, Ogawa H. Exo1 roles for repair of DNA double-strand breaks and meiotic crossing over in Saccharomyces cerevisiae., Molecular biology of the cell, July 2000.  公式リンク  
  
• Furuse M, Nagase Y, Tsubouchi H, Murakami-Murofushi K, Shibata T, Ohta K. Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination., The EMBO journal, Nov. 1998.  公式リンク  
  
• Tsubouchi H, Ogawa H. A novel mre11 mutation impairs processing of double-strand breaks of DNA during both mitosis and meiosis., Molecular and cellular biology, Jan. 1998.  公式リンク  
  
• 英生 坪内, 英行 小川, 坪内英生. Mechanisms of DSB repair and their roles in meiosis., 生物物理, 1998.

国際会議発表 (査読なし・不明)

• Tsubouchi H, Ito K, Argunhan B, Iwasaki H.. Synergistic Activation of Dmc1 by the Sfr1-Swi5 and Meu13-Mcp7 Complexes, 金沢文化ホール, Nov. 2018.
• Argunhan B, Afshar N, Ito, K, Maki, T, Hisato Kurihara, Masayoshi Sakakura, Tsubouchi H, Hideo Takanashi, Iwasaki H. Rad51 Interaction Analysis Reveals a Functional Interplay Among Recombination Auxiliary Factors, Nov. 2018.
• Aleksandar Zdravkovic, Tsubouchi H, Iwasaki H. Phosphorylation-dependent Ctp1 binding to Nbs1 in vitro, Nov. 2018.

国内会議発表 (査読なし・不明)

• Negar Afshar, Bilge Argunhan, Kentaro Ito, Palihati Maierdan, Hideo Tsubouchi, Hiroshi Iwasaki. Pathways of DNA repair by Rad51-mediated homologous recombination in Schizosaccharomyces pombe, 第42回分子生物学会年会, Dec. 2019.
• 谷口 剛樹, Bilge Argunhan, 岩崎 博史, 坪内 英生. 減数分裂期特異的相同組換え酵素Dmc1は体細胞分裂期に機能を持つか？, 第42回分子生物学会年会, Dec. 2019.
• Alexandar Zdravkovic, Hideo Tsubouchi, Shuji Kanamaru, Hiroshi Iwasaki. Molecular mechanism of Ctp 1 mediated Mre11-Rad50-Nbs1 endonuclease activation in S.pombe, 日本遺伝学会第91回大会, Sept. 2019.
• Alfredo Esquivel Chavez, Takahisa Maki, James Edward Haber, Genevieve Thon, Hideo Tsubouchi, Hiroshi Iwasaki. HULC-mediated open chromatin formation and controls of Mating-Type Switching in Fission Yeast, 日本遺伝学会第91回大会, Sept. 2019.
• Palihati Maierdan, Hideo Tsubouchi, Rei Kajitani, 韓龍雲, Takehiko Itoh, Hiroshi Iwasaki. BRCA2 homolog of Cryptococcus liquefaciens required for DNA repair, 酵母遺伝学フォーラム第52回研究報告会, Sept. 2019.
• Chavez EA, Maki T, Tsubouchi H, Iwasaki H. HULC regulates Mating-Type Switching, 第1回日本遺伝学会春季分科会, Mar. 2019.
• Zdravkovic A, Tsubouchi H, Kanamaru S, Iwasaki H. Activation of Mre11 endonuclease by Ctp1, 第1回日本遺伝学会春季分科会, Mar. 2019.
• Palihati M, Tsubouchi H, Han, YW, Ito, T, Iwasaki H. BRCA2 homolog from Cyptococcus liquefaciens, 第1回日本遺伝学会春季分科会, Mar. 2019.
• 遠藤 伶奈, 伊藤 健太郎, Bilge Argunhan, 真木 孝尚, 坪内 英生, 岩崎博史. DNA鎖交換反応におけるDmc1リコンビナーゼのL2ループ上のPro-267残基の役割, 第41回日本分子生物学会年会, Nov. 2018.

特許など

• 岩崎博史, 坪内英生, Aleksandar Zdravkovic. ＭＲＮ複合体のエンドヌクレアーゼ活性上昇剤及びその使用. 特許. 公開. 国立大学法人東京工業大学. 2019/04/16. 特願2019-077613. 2020/10/29. 特開2020-176068. 2020.
• 岩崎博史, 坪内英生, 伊藤武彦, 梶谷嶺, ﾊﾟﾙﾊｯﾄﾏﾙﾀﾞﾝ, 韓　龍雲. 遺伝性乳癌卵巣癌症候群の治療薬のスクリーニング方法. 特許. 公開. 国立大学法人東京工業大学. 2018/04/13. 特願2018-077857. 2019/10/24. 特開2019-184500. 2019.

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