Journal Paper

• Guangzhe Li, Soyoko Azuma, Hidemitsu Minegishi, Hiroyuki Nakamura. Synthesis and biological evaluation of meta-carborane-containing phenoxyacetanilides as inhibitors of hypoxia-inducible factor (HIF)-1 transcriptional activity, Journal of Organometallic Chemistry, Vol. 798, pp. 189-195, Dec. 2015.
• Hiroyuki Nakamura, Shoji Tachikawa, Shinichi Sato, Hisanao Hazama, Kunio Awazu. Localization-dependent cell-killing effects of protoporphyrin (PPIX)-lipid micelles and liposomes in photodynamic therapy, Bioorganic & Medicinal Chemistry, Vol. 23, No. 24, p. 7578-7584, Nov. 2015.
• Shinichi Sato, Kosuke Nakamura, Hiroyuki Nakamura. Tyrosine-Specific Chemical Modification with in situ Hemin-Activated Luminol Derivatives, ACS chemical biology, Vol. 10, No. 11, pp. 2633-2640, Sept. 2015.
• Hiroyuki Nakamura, T Sato, Akira Sato, Tasuku Ito, Syoji Imamichi, Sota Kikuhara, Hiroaki Fujimori, Takahisa Hirai, Soichiro Saito. Proteomic analysis of cellular response induced by boron neutron capture reaction in human squamous cell carcinoma SAS cells, Applied Radiation and Isotopes, Vol. 106, p. 213-219, Aug. 2015.
• Guangzhe Li, Soyoko Azuma, Shinichi Sato, Hidemitsu Minegishi, Hiroyuki Nakamura. ortho-Carboranylphenoxyacetanilides as inhibitors of hypoxia-inducible factor (HIF)-1 transcriptional activity and heat shock protein (HSP) 60 chaperon activity, Bioorganic & Medicinal Chemistry Letters, Vol. 25, No. 13, pp. 2624-2628, July 2015.
• Hiroyuki Nakamura, Hayato Koganei, Shoji Tachikawa, E. El-Zaria Mohamed. Synthesis of Oligo-closo-dodecaborates by Hüisgen Click Reaction as Encapsulated Agents for Preparation of High-Boron-Content Liposomes for Neutron Capture Therapy, New J. Chem, Vol. 39, No. 8, p. 6388 – 6394, June 2015.
• Hiroyuki Nakamura. C(sp3)–H versus C(sp3)–C(sp) in Activation of Propargylic Amines under Transition-Metal Catalysis, Synlett, Vol. 26, No. 12, p. 1649-1664, May 2015.
• Hidemitsu Minegishi, Yushi Futamura§, Shinji Fukashiro, Makoto Muroi, Makoto Kawatani, Hiroyuki Osada, Hiroyuki Nakamura. Methyl 3-((6-Methoxy-1, 4-dihydroindeno [1, 2-c] pyrazol-3-yl) amino) benzoate (GN39482) as a Tubulin Polymerization Inhibitor Identified by MorphoBase and ChemProteoBase Profiling Methods, Journal of medicinal chemistry, Vol. 58, No. 10, pp. 4230-4241, May 2015.
• Mizuho Inai, Masaya Yamauchi, Norihiro Honda, Hisanao Hazama, Shoji Tachikawa, Hiroyuki Nakamura, Tomoki Nishida, Hidehiro Yasuda, Yasufumi Kaneda, Kunio Awazu. Hemagglutinating virus of Japan envelope (HVJ-E) allows targeted and efficient delivery of photosensitizer for photodynamic therapy against advanced prostate cancer, Optical Molecular Probes, Imaging and Drug Delivery, pp. OM2D-3, Apr. 2015.
• Hyun Seung Ban, Hiroyuki Nakamura. Boron-Based Drug Design, The Chemical Record, Vol. 15, No. 3, pp. 616-635, Mar. 2015.
• Hiroyuki Nakamura, Kunio Awazu, Mizuho Inai. Photodynamic therapy using hemagglutinating virus of Japan envelope (HVJ-E): a novel therapeutic approach for the treatment of hormone antagonistic prostate cancer, Proc. SPIE 9308 Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV, Mar. 2015.
• Hiroyuki Nakamura, Lisa Tazaki, Daisuke Kanoh, Shinichi Sato. Diaryl-substituted carboranes as inhibitors of hypoxia inducible factor-1 transcriptional activity, Pure and Applied Chemistry, Vol. 87, No. 2, pp. 143-154, Feb. 2015.
• Hiroyuki Nakamura. ホウ素化合物・薬剤の歴史と現状, RADIOISOTOPES, Vol. 64, No. 1, p. 47-58, Jan. 2015.
• Hiroyuki Nakamura, 山内 将哉, 本多 典広, 立川 将士, 粟津 邦男. 抗腫瘍効果を持つ非ウイルスベクター用いた薬剤耐性前立腺がん細胞に対する高効率な光線力学療法, 日本レーザー医学会誌, Vol. 36, No. 1, p. 18-24, Jan. 2015.

International Conference (Reviewed)

• Hiroyuki Nakamura. Discovery of Carboranylphenoxy-acetanilides as Inhibitors of heat shock protein (HSP) 60 chaperon activity, Pacifichem 2015, Dec. 2015.
• Mizuho Inai, Masaya Yamauchi, Norihiro Honda, Hisanao Hazama, Shoji Tachikawa, Hiroyuki Nakamura, Tomoki Nishida, Hidehiro Yasuda, Yasufumi Kaneda, Kunio Awazu. Photodynamic therapy using hemagglutinating virus of Japan envelope (HVJ-E): a novel therapeutic approach for the treatment of hormone antagonistic prostate cancer, SPIE BiOS, pp. 930814-930814, Mar. 2015.

International Conference (Not reviewed / Unknown)

• S. Sato, K. Nakamura, H. Nakamura. Tyrosine-selective chemical modification using single-electron-transfer catalyst, The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015), Dec. 2015.
• Hiroyuki Nakamura. Overview and Prospect of Boron Agents for Neutron Capture Therapy, 1st Academic meeting for Taiwanese Society of Neutron Capture Therapy, Dec. 2015.
• 佐々木悠介, 上原至雅, Hiroyuki Nakamura. Synthesis of Benzamidines as a Specific Inhibitor Targeting to EpidermalGrowthFactor Receptor and Vascular Endothelial Growth Factor Receptor Tyrosine Kinases, Pacifichem, Dec. 2015.
• S. Kikuchi, D. Kanoh, S. Sato, H. Nakamura. Use of serum albumin as an efficient boron delivery carrier for neutron capture therapy, The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015), Dec. 2015.
• Shinichiro Fuse, Yuto Mifune, Nobutake Tanabe, Hiroyuki Nakamura, Takashi Takahashi. Utilization of microflow technology for the site-selective modification of multifunctionalized molecules, The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015), Dec. 2015.
• Taiki Morita, Shinichiro Fuse, Keisuke Matsumura, Hirotaka Sugiyama, Daisuke Kobayashi, Hiroshi Tanaka, Hiroyuki Nakamura, Takashi Takahashi. Rapid synthesis of tri/tetraaryl-substituted pyrazoles via [3+2] cycloadditon and C-H direct arylation approaches, The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015), Dec. 2015.
• Hiroyuki Nakamura. Development of boronated liposomes as efficient boron delivery vehicles for neutron capture therapy,, The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015), Dec. 2015.
• Hiroyuki Nakamura. Target Protein-Selective Labeling and Inactivation Using Ligand-Directed Ru(bpy)3 Photocatalysts, 1st Asian Conference on Chemosensors & Imaging Probe, Nov. 2015.  Official location  
• S. Sato, K. Nakamura, H. Nakamura. Heme-Catalyzed Tyrosine Click Reaction with Luminol Derivatives, 1st Asian Conference on Chemosensors & Imaging Probes, Nov. 2015.
• Hiroyuki Nakamura. Anticancer Drug Design Using the Element Boron, Hankuk University of Foreign Studies, Nov. 2015.
• Hiroyuki Nakamura. Highly Boronated Liposomes as Efficient Boron Delivery Vehicles for Neutron Capture Therapy, Zing Conference: Medicinal Chemistry of Boron Compounds Conference, Oct. 2015.  Official location  
• H. Nakamura, Shinichi Sato. Development of Ligand-directed Ru(bpy)3 Photocatalysts for Target Protein Knockdown and Labeling, An International Symposium on Recent Advances in Chemistry, Mar. 2015.  Official location  
• Hiroyuki Nakamura. Development of Chemical Tools for Target Protein-Selective Identification and Selective Modification, Invited Lecture at Jawaharl Nehru Centre for Advanced Scientific Research(JNCASR), Mar. 2015.
• Hiroyuki Nakamura. Development of Liposomes for Efficient Boron Neutron Capture Therapy, Invited Lecture 15th International Congress of Radiation Research (ICRR2015), Mar. 2015.
• Hiroyuki Nakamura. Development of Chemical Tools for Target Protein-Selective Identification and Modification, invited Lecture at Indian Institute of Technology, Mar. 2015.
• M. Inai, M. Yamauchi, N. Honda, H. Hazama, S. Tachikawa, H. Nakamura, Y. Kaneda, K. Awazu. Therapeutic effect of porphyrus envelope-mediated photodynamic therapy: a novel therapeutic approach for the treatment of hormone antagonistic prostate cancer, Awazu SPIE Photonics West BiOS, Feb. 2015.

Domestic Conference (Not reviewed / Unknown)

• Taiki Morita, Hiroshi Tanaka, Hiroyuki Nakamura, Shinichiro Fuse. ４連続の直接アリール化による４置換ピラゾールの合成とその発光特性, 第108回有機合成シンポジウム, Nov. 2015.
• Shinichiro Fuse, Yuma Otake, Yuto Mifune, Hiroyuki Nakamura, Hiroshi Tanaka. マイクロフローリアクター内での四連続反応によるαアリールカルボニル化合物合成法の開発, 第70回記念有機合成化学協会関東支部シンポジウム－新潟（長岡）シンポジウム－, Nov. 2015.
• 菊地 俊介, Shinichi Sato, Hiroyuki Nakamura. 血清アルブミンを用いた新しいホウ素送達法の開発, 第12回日本中性子捕捉療法学会学術大会, Sept. 2015.
• Taiki Morita, Hiroshi Tanaka, Hiroyuki Nakamura, Shinichiro Fuse. 連続的C－H結合直接アリール化による４置換ピラゾールの合成, 第62回有機金属化学討論会, Sept. 2015.
• Yuto Mifune, Shinichiro Fuse, Hiroshi Tanaka, Hiroyuki Nakamura, Takashi TAKAHASHI. カルボン酸の迅速かつ強力な活性化を基盤とするマイクロフローペプチド合成法の開発とフェグリマイシンの合成研究, 第32回有機合成化学セミナー, Sept. 2015.
• Hiroyuki Nakamura. ホウ素をつかってがんに挑む 〜ホウ素創薬の最前線〜, 工学院大学 化学応用学特論A、集中講義, Sept. 2015.
• Hiroyuki Nakamura. 何故新しいホウ素薬剤は開発されないのか？—これからのBoron Delivery Systemを考えるー, 第12回中性子捕捉療法学会学術大会, Sept. 2015.
• Hiroyuki Nakamura, 立川将士, Clara Vinas, 鈴木実, 小野公二. ホウ素高集積化リポソームを指向した内封ホウ素薬剤開発, 第31回日本DDS学会学術集会, July 2015.
• 立川将士, Shinichi Sato, 間久直, 金田安史, 粟津邦男, Hiroyuki Nakamura. ポルフィリン脂質リポソームの細胞内局在とPDT効果, 第25回日本光線力学学会 学術講演会, July 2015.
• Hiroyuki Nakamura. 光を使って生命機能を探る・操る, 有機合成化学協会関東支部ミニシンポジウム, June 2015.
• Hiroyuki Nakamura, 峯岸秀光, 室井誠, 二村友史, 川谷誠, 長田裕之. 高い細胞増殖阻害を有するインデノピラゾールの発見とプロファイリング法による阻害機構の解明, 新学術領域研究「天然物ケミカルバイオロジー」第8回公開シンポジウム, June 2015.
• Shinichi Sato, Kosuke Nakamura, Hiroyuki Nakamura. ルミノール誘導体を用いたチロシン残基に選択的な共有結合形成反応の開発, 日本ケミカルバイオロジー学会第10回年会, June 2015.
• Guangzhe Li, 峯岸 秀充, Shinichi Sato, Hiroyuki Nakamura. カルボラン骨格を有する新規Hsp60阻害剤の開発, 第19回日本がん分子標的治療学会学術集会, June 2015.
• 青野晴美, 川谷誠, 二村友史, 室井誠, 峯岸秀充, Hiroyuki Nakamura, 長田裕之. MorphoBaseおよびChemProteoBaseを用いたGN39482の標的同定, 第19回日本がん分子標的治療学会学術集会, June 2015.
• Hiroyuki Nakamura. インデノピラゾール骨格を基軸とした創薬研究, 平成27年度 環境調和材料・デバイスプロジェクトグループ(G4)分科会, June 2015.
• Hiroyuki Nakamura. Development of Liposomes for Efficient Boron Neutron Capture Therapy,, 15th International Congress of Radiation Research (ICRR2015), May 2015.
• Hiroyuki Nakamura. Development of Liposomes for Efficient Boron Neutron Capture Therapy,, 15th International Congress of Radiation Research (ICRR2015), May 2015.
• Kosuke Nakamura, Shinichi Sato, Hiroyuki Nakamura. Luminol誘導体を用いた鉄触媒存在下でのTyr残基高選択的ラベル化反応, 第69回有機合成化学協会関東支部会シンポジウム, May 2015.
• Hiroyuki Nakamura. Development of Liposomes for Efficient Boron Neutron Capture Therapy,, 15th International Congress of Radiation Research (ICRR2015), May 2015.
• Hiroyuki Nakamura, 峯岸秀充, 室井誠, 二村友史, 川谷誠, 長田裕之. 高い細胞増殖阻害を有するインデノピラゾール化合物の発見とその作用機序解明, 成26年度アライアンス成果報告会, Apr. 2015.
• 峯岸秀充, Hiroyuki Nakamura. ベンゾフロピラゾール化合物の合成とHIF-1転写活性への影響, 本化学会第96回年会, Mar. 2015.
• Shinichi Sato, 森田耕平, Hiroyuki Nakamura. リガンド連結型Ru光触媒を用いたタンパク質ノックダウンとラベル化の制御, 日本薬学会第135年会, Mar. 2015.
• Kosuke Nakamura, Shinichi Sato, Hiroyuki Nakamura. ルミノール誘導体を用いた鉄触媒存在下でのTyr残基特異的タンパク質ラベル化反応, 日本化学会第96回年会, Mar. 2015.
• 菊地俊介, 加納大輔, Shinichi Sato, Hiroyuki Nakamura. 中性子捕捉療法のための血清アルブミンを用いた新しいホウ素送達法の開発, 日本化学会第96回年会, Mar. 2015.
• 大内俊明, 峯岸秀充, Hiroyuki Nakamura. イミダゾピリジン骨格を有する新規HIF-1α阻害剤の開発, 日本化学会第96回年会, Mar. 2015.
• Hiroyuki Nakamura. DDSによるがん治療の最前線, 川崎医科大学川崎医学会セミナー, Feb. 2015.
• Hiroyuki Nakamura. ホウ素でがんに挑む, 第一三共株式会社品川研究開発センターセミナー, Feb. 2015.
• Hiroyuki Nakamura. がん細胞内部で放射線を発生させる次世代治療法〜ホウ素中性子捕捉療法, 第３回次世代がん治療推進専門家養成プランシンポジウム, Jan. 2015.

Patent

• Hiroyuki Nakamura. ベンゾフロピラゾール誘導体. Patent. Published. 国立大学法人東京工業大学. 2015/04/30. 特願2015-092606. 2016/12/15. 特開2016-210687. 2016.

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